{"artifact":{"id":"wiki-therapeutics-adiponectin-receptor-modulators","artifact_type":"wiki_page","entity_ids":"[\"therapeutics-adiponectin-receptor-modulators\"]","title":"Adiponectin Receptor Modulator Therapies","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"77a3dc0fa2994b17b7e789f1e96f794cbe49724cc2488b2bfeb31a9e3bb8235d","metadata":{"slug":"therapeutics-adiponectin-receptor-modulators","kg_node_id":null,"entity_type":"therapeutic","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-a2b957474a06","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"therapeutics-adiponectin-receptor-modulators"},"_schema_version":1},"created_at":"2026-04-02T07:19:01-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"839e2a62-cbd6-4671-abac-7172acf40cb8","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-778c1bc2-7c6e-4cdd-81af-56c535ead1e3","link_type":"mentions","strength":0.5,"evidence":"Content: AMPK mentioned 19x in wiki/therapeutics-adiponectin-receptor-modulators"},{"target_artifact_id":"experiment-exp-545ecac0-8b8e-4dc1-b999-1118f810815a","link_type":"mentions","strength":0.5,"evidence":"Content: AMPK mentioned 19x in wiki/therapeutics-adiponectin-receptor-modulators"},{"target_artifact_id":"experiment-exp-bdbae77a-4e67-498f-be15-d4c6c33ac1ec","link_type":"mentions","strength":0.5,"evidence":"Content: AMPK mentioned 19x in wiki/therapeutics-adiponectin-receptor-modulators"},{"target_artifact_id":"hypothesis-h-827a821b","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 5x in wiki/therapeutics-adiponectin-receptor-modulators"},{"target_artifact_id":"experiment-exp-9f358501-0c3d-417e-9b43-1be792ee3638","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 5x in wiki/therapeutics-adiponectin-receptor-modulators"},{"target_artifact_id":"experiment-exp-debate-385d65cb42cb","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CX3CR1 mentioned 2x in wiki/therapeutics-adiponectin-receptor-modulators"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-v2-68d9c9c1: ...D and AD](/analysis/SDA-2026-04-01-gap-v2-68d9c9c1) 🔄\n- [Lipid..."},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-ee5a5023","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-v2-ee5a5023: ...re in AD](/analysis/SDA-2026-04-01-gap-v2-ee5a5023) 🔄\n..."},{"target_artifact_id":"hypothesis-h-aa2d317c","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Receptor'"},{"target_artifact_id":"hypothesis-h-97aa8486","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulators'"},{"target_artifact_id":"hypothesis-h-ba3a948a","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulators'"},{"target_artifact_id":"hypothesis-h-9e9fee95","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Receptor'"},{"target_artifact_id":"hypothesis-h-9d29bfe5","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulators'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'receptor'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutics'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutics'"},{"target_artifact_id":"hypothesis-h-4bb7fd8c","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 4x in wiki/therapeutics-adiponectin-receptor-modulators"},{"target_artifact_id":"experiment-exp-wiki-experiments-epigenetic-clocks-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 4x in wiki/therapeutics-adiponectin-receptor-modulators"},{"target_artifact_id":"hypothesis-h-7bb47d7a","link_type":"mentions","strength":0.9,"evidence":"Wiki page mentions gene TH targeted by hypothesis"},{"target_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ER related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for CT related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-aa2d317c","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-97aa8486","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-ba3a948a","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-9e9fee95","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-9d29bfe5","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-fffd1a74","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene G3BP1"},{"target_artifact_id":"hypothesis-h-ec731b7a","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene G3BP1"},{"target_artifact_id":"hypothesis-h-27bc0569","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene G3BP1"},{"target_artifact_id":"hypothesis-h-782b40b1","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene CX3CR1"},{"target_artifact_id":"hypothesis-h-8597755b","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene HCRTR2"},{"target_artifact_id":"hypothesis-h-6b84d8e2","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene HCRT"},{"target_artifact_id":"hypothesis-h-51e7234f","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene MTOR"},{"target_artifact_id":"hypothesis-h-5ff6c5ca","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: monocarboxylate transport"},{"target_artifact_id":"hypothesis-h-84808267","link_type":"mentions","strength":0.7,"evidence":"Wiki content mentions gene TFR1"},{"target_artifact_id":"analysis-astrocyte-subtypes","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-20260401-225155: ...hogenesi](/analysis/SDA-2026-04-01-gap-20260401-225155) 🔄\n- [RNA b..."},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-84808267","link_type":"related","strength":0.63,"evidence":"Reverse: Wiki content mentions gene TFR1"},{"source_artifact_id":"hypothesis-h-827a821b","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 5x in wiki/therapeutics-adiponectin-receptor-modulators"},{"source_artifact_id":"hypothesis-h-4bb7fd8c","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 4x in wiki/therapeutics-adiponectin-receptor-modulators"},{"source_artifact_id":"hypothesis-h-7bb47d7a","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene TH described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ER described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets CT described in wiki"},{"source_artifact_id":"hypothesis-h-aa2d317c","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-97aa8486","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ba3a948a","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-9e9fee95","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-9d29bfe5","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-therapeutics-adiponectin-receptor-modulators","is_canonical":true,"supersede_chain":["wiki-therapeutics-adiponectin-receptor-modulators"]}