{"artifact":{"id":"wiki-therapeutics-advanced-immunotherapy-platforms-cbs-psp","artifact_type":"wiki_page","entity_ids":"[\"therapeutics-advanced-immunotherapy-platforms-cbs-psp\"]","title":"Advanced Immunotherapy Platforms for CBS/PSP","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"e2ab5b00ccdee133cf12ec50ab78f30d347f5553f23c88ad6fa45edba13291fa","metadata":{"slug":"therapeutics-advanced-immunotherapy-platforms-cbs-psp","kg_node_id":null,"entity_type":"therapeutic","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-30de577aa36d","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"therapeutics-advanced-immunotherapy-platforms-cbs-psp"},"_schema_version":1},"created_at":"2026-04-02T07:18:59-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"502bde77-e20a-4336-9040-877b5bc5e4e9","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-function-alzheimers","link_type":"mentions","strength":0.5,"evidence":"Content: TREM2 mentioned 5x in wiki/therapeutics-advanced-immunotherapy-platforms-cbs-psp"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: TREM2 mentioned 5x in wiki/therapeutics-advanced-immunotherapy-platforms-cbs-psp"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-efficacy","link_type":"mentions","strength":0.5,"evidence":"Content: TREM2 mentioned 5x in wiki/therapeutics-advanced-immunotherapy-platforms-cbs-psp"},{"target_artifact_id":"experiment-exp-wiki-experiments-crispr-gene-correction-cbs-psp","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CRISPR mentioned 2x in wiki/therapeutics-advanced-immunotherapy-platforms-cbs-psp"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-691b42f1","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-v2-691b42f1: ...early AD](/analysis/SDA-2026-04-01-gap-v2-691b42f1) &#x1f504;\n- [CRISP..."},{"target_artifact_id":"hypothesis-h-e23f05fb","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions hypothesis h-e23f05fb: ...toring](/hypothesis/h-e23f05fb) — <span style=\"col..."},{"target_artifact_id":"hypothesis-h-044ee057","link_type":"mentions","strength":0.658,"evidence":"Mechanism wiki 'Advanced Immunotherapy Platforms for CBS/PSP' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-b234254c","link_type":"mentions","strength":0.7,"evidence":"Mechanism wiki 'Advanced Immunotherapy Platforms for CBS/PSP' references gene/pathway from hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"mentions","strength":0.6,"evidence":"Gene mention: PSP"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutics'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutics'"},{"target_artifact_id":"hypothesis-h-7bb47d7a","link_type":"mentions","strength":0.9,"evidence":"Wiki page mentions gene TH targeted by hypothesis"},{"target_artifact_id":"experiment-exp-wiki-experiments-n-of-1-clinical-trial-cbs-psp","link_type":"related","strength":0.7,"evidence":"Wiki page for CBS related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-brainstem-circuit-modulation-psp","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-tau-spreading-network-mapping-psp","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-4r-tau-targeting-psp-cbs","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-levodopa-response-psp-biomarkers","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-cbs-psp-phenotype-determinants","link_type":"related","strength":0.7,"evidence":"Wiki page for CBS related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-tau-pathology-initiation-zone","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-psp-cbs-biomarker-validation","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-anti-tau-therapy-failure-psp","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ER related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-e23f05fb","link_type":"related","strength":0.7,"evidence":"Cross-linked via Platform match"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-crispr-neurodegeneration-20260402","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"hypothesis-h-seaad-51323624","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-61196ade","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-3460f820","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-180807e5","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-005","link_type":"mentions","strength":0.6,"evidence":"Gene mention: PSP"},{"target_artifact_id":"wiki-clinical-trials-nct07177352","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-clinical-trials-nct07062198","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-mechanisms-neurovascular-ad-pathway","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"analysis-astrocyte-subtypes","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-20260401-225155: ...hogenesi](/analysis/SDA-2026-04-01-gap-20260401-225155) &#x1f504;\n- [Synap..."},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"}],"incoming_links":[{"source_artifact_id":"analysis-sda-2026-04-01-gap-005","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: PSP"},{"source_artifact_id":"hypothesis-h-044ee057","link_type":"related","strength":0.5922000000000001,"evidence":"Reverse: Mechanism wiki 'Advanced Immunotherapy Platforms for CBS/PSP' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-b234254c","link_type":"related","strength":0.63,"evidence":"Reverse: Mechanism wiki 'Advanced Immunotherapy Platforms for CBS/PSP' references gene/pathway from hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: PSP"},{"source_artifact_id":"hypothesis-h-7bb47d7a","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene TH described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-n-of-1-clinical-trial-cbs-psp","link_type":"related","strength":0.7,"evidence":"Experiment targets CBS described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-brainstem-circuit-modulation-psp","link_type":"related","strength":0.7,"evidence":"Experiment targets PSP described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-tau-spreading-network-mapping-psp","link_type":"related","strength":0.7,"evidence":"Experiment targets PSP described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-4r-tau-targeting-psp-cbs","link_type":"related","strength":0.7,"evidence":"Experiment targets PSP described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-levodopa-response-psp-biomarkers","link_type":"related","strength":0.7,"evidence":"Experiment targets PSP described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-cbs-psp-phenotype-determinants","link_type":"related","strength":0.7,"evidence":"Experiment targets CBS described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-tau-pathology-initiation-zone","link_type":"related","strength":0.7,"evidence":"Experiment targets PSP described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-psp-cbs-biomarker-validation","link_type":"related","strength":0.7,"evidence":"Experiment targets PSP described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-anti-tau-therapy-failure-psp","link_type":"related","strength":0.7,"evidence":"Experiment targets PSP described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ER described in wiki"},{"source_artifact_id":"hypothesis-h-e23f05fb","link_type":"related","strength":0.7,"evidence":"Cross-linked via Platform match"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"wiki-clinical-trials-nct07177352","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-clinical-trials-nct07062198","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-mechanisms-neurovascular-ad-pathway","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-therapeutics-advanced-immunotherapy-platforms-cbs-psp","is_canonical":true,"supersede_chain":["wiki-therapeutics-advanced-immunotherapy-platforms-cbs-psp"]}