{"artifact":{"id":"wiki-therapeutics-bace-inhibitors","artifact_type":"wiki_page","entity_ids":"[\"therapeutics-bace-inhibitors\"]","title":"BACE Inhibitors","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"9e4b90f02f7178906e140b3c8659fbb5ca76a5adcf2ed07c90991de5b4b243d1","metadata":{"slug":"therapeutics-bace-inhibitors","kg_node_id":null,"entity_type":"therapeutic","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-d08df374e48a","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"therapeutics-bace-inhibitors"},"_schema_version":1},"created_at":"2026-04-02T07:19:02-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"0ee90a5d-71e4-48ef-8240-8e978b59c0df","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-debate-385d65cb42cb","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CX3CR1 mentioned 2x in wiki/therapeutics-bace-inhibitors"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-18cf98ca","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-v2-18cf98ca: ...neration](/analysis/SDA-2026-04-01-gap-v2-18cf98ca) &#x1f504;\n..."},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-691b42f1","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-v2-691b42f1: ...early AD](/analysis/SDA-2026-04-01-gap-v2-691b42f1) &#x1f504;\n- [Sleep..."},{"target_artifact_id":"hypothesis-h-de579caf","link_type":"mentions","strength":0.65,"evidence":"Title match: BACE Inhibitors"},{"target_artifact_id":"hypothesis-h-441b25ba","link_type":"mentions","strength":0.644,"evidence":"Mechanism wiki 'BACE Inhibitors' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-ba3a948a","link_type":"mentions","strength":0.65,"evidence":"Title match: BACE Inhibitors"},{"target_artifact_id":"hypothesis-h-9d29bfe5","link_type":"mentions","strength":0.65,"evidence":"Title match: BACE Inhibitors"},{"target_artifact_id":"hypothesis-h-bdbd2120","link_type":"mentions","strength":0.65,"evidence":"Title match: BACE Inhibitors"},{"target_artifact_id":"hypothesis-h-62f9fc90","link_type":"mentions","strength":0.65,"evidence":"Title match: BACE Inhibitors"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutics'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutics'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-44195347","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene APOE"},{"target_artifact_id":"hypothesis-h-d0a564e8","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene APOE"},{"target_artifact_id":"hypothesis-h-11795af0","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene APOE"},{"target_artifact_id":"hypothesis-h-99b4e2d2","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene APOE"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene APOE"},{"target_artifact_id":"hypothesis-h-seaad-fa5ea82d","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene APOE"},{"target_artifact_id":"hypothesis-h-c9c79e3e","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene APOE"},{"target_artifact_id":"hypothesis-h-15336069","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene APOE"},{"target_artifact_id":"hypothesis-h-782b40b1","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene CX3CR1"},{"target_artifact_id":"hypothesis-h-7e0b5ade","link_type":"mentions","strength":0.7,"evidence":"Wiki content mentions gene MTNR1A"},{"target_artifact_id":"hypothesis-h-b948c32c","link_type":"mentions","strength":0.7,"evidence":"Wiki content mentions gene APOE"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-7e0b5ade","link_type":"related","strength":0.63,"evidence":"Reverse: Wiki content mentions gene MTNR1A"},{"source_artifact_id":"hypothesis-h-b948c32c","link_type":"related","strength":0.63,"evidence":"Reverse: Wiki content mentions gene APOE"},{"source_artifact_id":"hypothesis-h-441b25ba","link_type":"related","strength":0.5796,"evidence":"Reverse: Mechanism wiki 'BACE Inhibitors' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-ba3a948a","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: BACE Inhibitors"},{"source_artifact_id":"hypothesis-h-de579caf","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: BACE Inhibitors"},{"source_artifact_id":"hypothesis-h-9d29bfe5","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: BACE Inhibitors"},{"source_artifact_id":"hypothesis-h-bdbd2120","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: BACE Inhibitors"},{"source_artifact_id":"hypothesis-h-62f9fc90","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: BACE Inhibitors"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"open_question-therapeutics-bace-inhibitors-af8b25c0","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-therapeutics-bace-inhibitors-855392a9","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-therapeutics-bace-inhibitors-af2694ed","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-therapeutics-bace-inhibitors-df3538e1","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-therapeutics-bace-inhibitors-2352d92e","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-therapeutics-bace-inhibitors-8ef33ac7","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"}],"current_artifact_id":"wiki-therapeutics-bace-inhibitors","is_canonical":true,"supersede_chain":["wiki-therapeutics-bace-inhibitors"]}