{"artifact":{"id":"wiki-therapeutics-bbb-penetrant-antibodies","artifact_type":"wiki_page","entity_ids":"[\"therapeutics-bbb-penetrant-antibodies\"]","title":"BBB-Penetrant Antibody Engineering","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"5f1d1541a25bb275d50208375d659f2c07fff8be19f6b753912a20c8f0ffd580","metadata":{"slug":"therapeutics-bbb-penetrant-antibodies","kg_node_id":null,"entity_type":"therapeutic","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-4bbce37b4132","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"therapeutics-bbb-penetrant-antibodies"},"_schema_version":1},"created_at":"2026-04-02T07:19:00-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"739c9397-18db-4492-a37a-0ff4b312f9d3","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"analysis-SDA-2026-04-04-gap-senescent-clearance-neuro","link_type":"mentions","strength":0.75,"evidence":"Gene mention: BBB"},{"target_artifact_id":"experiment-exp-6a24fc0b-5cf0-43d3-9e5d-c6b88467e0ea","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BBB"},{"target_artifact_id":"hypothesis-h-7a8d7379","link_type":"mentions","strength":0.5,"evidence":"Content: CLDN5 mentioned 2x in wiki/therapeutics-bbb-penetrant-antibodies"},{"target_artifact_id":"hypothesis-h-1acdd55e","link_type":"mentions","strength":0.5,"evidence":"Content: MMP2 mentioned 2x in wiki/therapeutics-bbb-penetrant-antibodies"},{"target_artifact_id":"experiment-exp-wiki-experiments-cgas-sting-parkinsons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: STING mentioned 2x in wiki/therapeutics-bbb-penetrant-antibodies"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-function-alzheimers","link_type":"mentions","strength":0.5,"evidence":"Content: TREM2 mentioned 3x in wiki/therapeutics-bbb-penetrant-antibodies"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: TREM2 mentioned 3x in wiki/therapeutics-bbb-penetrant-antibodies"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-efficacy","link_type":"mentions","strength":0.5,"evidence":"Content: TREM2 mentioned 3x in wiki/therapeutics-bbb-penetrant-antibodies"},{"target_artifact_id":"experiment-exp-3b7faafc-4bd9-407f-ae87-8cfbd6237e51","link_type":"mentions","strength":0.5,"evidence":"Content: APOE4 mentioned 3x in wiki/therapeutics-bbb-penetrant-antibodies"},{"target_artifact_id":"experiment-exp-wiki-experiments-ad-amyloid-resilient-phenotype","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: APOE mentioned 2x in wiki/therapeutics-bbb-penetrant-antibodies"},{"target_artifact_id":"experiment-exp-wiki-experiments-sex-differences-alzheimers","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: APOE mentioned 2x in wiki/therapeutics-bbb-penetrant-antibodies"},{"target_artifact_id":"experiment-exp-wiki-experiments-ad-combination-therapy-trial","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: APOE mentioned 2x in wiki/therapeutics-bbb-penetrant-antibodies"},{"target_artifact_id":"analysis-SDA-2026-04-12-gap-debate-20260410-112908-13c403ee","link_type":"mentions","strength":0.75,"evidence":"Gene mention: BBB"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-691b42f1","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-v2-691b42f1: ...early AD](/analysis/SDA-2026-04-01-gap-v2-691b42f1) &#x1f504;\n- [Autop..."},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-89432b95","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-v2-89432b95: ... neurons](/analysis/SDA-2026-04-01-gap-v2-89432b95) &#x1f504;\n..."},{"target_artifact_id":"analysis-sda-2026-04-01-gap-014","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-014: ...ediators](/analysis/SDA-2026-04-01-gap-014) &#x1f504;\n- [Mitoc..."},{"target_artifact_id":"analysis-sda-2026-04-01-gap-010","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-010: ...rategies](/analysis/SDA-2026-04-01-gap-010) &#x1f504;\n- [Neuro..."},{"target_artifact_id":"analysis-sda-2026-04-01-gap-011","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-011: ...diseases](/analysis/SDA-2026-04-01-gap-011) &#x1f504;\n- [APOE4..."},{"target_artifact_id":"hypothesis-h-d78123d1","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions hypothesis h-d78123d1: ...livery](/hypothesis/h-d78123d1) — <span style=\"col..."},{"target_artifact_id":"hypothesis-h-24e08335","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions hypothesis h-24e08335: ...eering](/hypothesis/h-24e08335) — <span style=\"col..."},{"target_artifact_id":"hypothesis-h-aa2d317c","link_type":"mentions","strength":0.644,"evidence":"Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-84808267","link_type":"mentions","strength":0.694,"evidence":"Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-7e0b5ade","link_type":"mentions","strength":0.66,"evidence":"Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-b948c32c","link_type":"mentions","strength":0.657,"evidence":"Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-44195347","link_type":"mentions","strength":0.672,"evidence":"Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-d0a564e8","link_type":"mentions","strength":0.644,"evidence":"Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-11795af0","link_type":"mentions","strength":0.658,"evidence":"Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-99b4e2d2","link_type":"mentions","strength":0.631,"evidence":"Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"mentions","strength":0.675,"evidence":"Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-044ee057","link_type":"mentions","strength":0.658,"evidence":"Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-4dd0d19b","link_type":"mentions","strength":0.718,"evidence":"Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-b234254c","link_type":"mentions","strength":0.7,"evidence":"Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"target_artifact_id":"experiment-exp-wiki-experiments-vascular-contribution-alzheimers","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BBB"},{"target_artifact_id":"experiment-exp-wiki-experiments-blood-brain-barrier-aging-neurodegeneration","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BBB"},{"target_artifact_id":"experiment-exp-debate-b68856276b4a","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BBB"},{"target_artifact_id":"experiment-exp-debate-385d65cb42cb","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BBB"},{"target_artifact_id":"hypothesis-h-23a3cc07","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Antibodies'"},{"target_artifact_id":"hypothesis-h-62e56eb9","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Antibody'"},{"target_artifact_id":"hypothesis-h-0791836f","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Engineering'"},{"target_artifact_id":"hypothesis-h-13bbfdc5","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Engineering'"},{"target_artifact_id":"hypothesis-h-250b34ab","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'engineering'"},{"target_artifact_id":"hypothesis-h-13ef5927","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'engineering'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'antibodies'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutics'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'antibody'"},{"target_artifact_id":"experiment-exp-wiki-experiments-tau-pet-therapeutic-response-prediction","link_type":"mentions","strength":0.5,"evidence":"Content: LRP1 mentioned 4x in wiki/therapeutics-bbb-penetrant-antibodies"},{"target_artifact_id":"experiment-exp-wiki-experiments-tau-propagation-causality","link_type":"mentions","strength":0.5,"evidence":"Content: LRP1 mentioned 4x in wiki/therapeutics-bbb-penetrant-antibodies"},{"target_artifact_id":"experiment-exp-wiki-experiments-anti-tau-immunotherapy-dosing","link_type":"mentions","strength":0.5,"evidence":"Content: LRP1 mentioned 4x in wiki/therapeutics-bbb-penetrant-antibodies"},{"target_artifact_id":"experiment-exp-wiki-experiments-aaav-serotype-lrrk2-gene-therapy","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BBB"},{"target_artifact_id":"experiment-exp-wiki-experiments-aav-serotype-lrrk2-knockdown","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BBB"},{"target_artifact_id":"experiment-exp-wiki-experiments-lrrk2-aav-gene-therapy-comparison","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BBB"},{"target_artifact_id":"experiment-exp-wiki-experiments-blood-biomarker-ad-detection","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BBB"},{"target_artifact_id":"experiment-exp-debate-0303c1c48688","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BBB"},{"target_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ER related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-24e08335","link_type":"related","strength":0.7,"evidence":"Cross-linked via Engineering match"},{"target_artifact_id":"hypothesis-h-d78123d1","link_type":"related","strength":0.7,"evidence":"Cross-linked via Engineering match"},{"target_artifact_id":"hypothesis-h-seaad-fa5ea82d","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"wiki-genes-abca1","link_type":"see_also","strength":0.6,"evidence":"KG edge: co_discussed"},{"target_artifact_id":"wiki-mechanisms-aging-vs-neurodegeneration-comparison","link_type":"see_also","strength":0.6,"evidence":"KG edge: co_discussed"},{"target_artifact_id":"wiki-institutions-packard-center-als","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"target_artifact_id":"wiki-institutions-alzheimer-indonesia","link_type":"see_also","strength":0.6,"evidence":"KG edge: co_discussed"},{"target_artifact_id":"wiki-entities-ampk","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"wiki-entities-aria-imaging","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"hypothesis-h-23a3cc07","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"hypothesis-h-c9c79e3e","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene APOE"},{"target_artifact_id":"hypothesis-h-15336069","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene APOE"},{"target_artifact_id":"hypothesis-h-seaad-51323624","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-61196ade","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-3460f820","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-180807e5","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-de579caf","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene MTNR1A"},{"target_artifact_id":"hypothesis-h-e3506e5a","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Synthetic biology"},{"target_artifact_id":"experiment-exp-wiki-experiments-tbi-alzheimers-mechanism","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BBB"},{"target_artifact_id":"experiment-exp-wiki-experiments-autophagy-enhancement-drug-screening","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BBB"},{"target_artifact_id":"experiment-exp-debate-0a5edc59c7b9","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BBB"},{"target_artifact_id":"wiki-clinical-trials-admsc-stem-cell-early-ad-nct06775964","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-clinical-trials-probiotics-mild-alzheimers-nct06181513","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"}],"incoming_links":[{"source_artifact_id":"experiment-exp-wiki-experiments-aaav-serotype-lrrk2-gene-therapy","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BBB"},{"source_artifact_id":"experiment-exp-wiki-experiments-aav-serotype-lrrk2-knockdown","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BBB"},{"source_artifact_id":"experiment-exp-wiki-experiments-lrrk2-aav-gene-therapy-comparison","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BBB"},{"source_artifact_id":"experiment-exp-wiki-experiments-blood-biomarker-ad-detection","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BBB"},{"source_artifact_id":"experiment-exp-debate-0303c1c48688","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BBB"},{"source_artifact_id":"experiment-exp-wiki-experiments-tbi-alzheimers-mechanism","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BBB"},{"source_artifact_id":"experiment-exp-wiki-experiments-autophagy-enhancement-drug-screening","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BBB"},{"source_artifact_id":"experiment-exp-debate-0a5edc59c7b9","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BBB"},{"source_artifact_id":"analysis-SDA-2026-04-04-gap-senescent-clearance-neuro","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: BBB"},{"source_artifact_id":"experiment-exp-6a24fc0b-5cf0-43d3-9e5d-c6b88467e0ea","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BBB"},{"source_artifact_id":"analysis-SDA-2026-04-12-gap-debate-20260410-112908-13c403ee","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: BBB"},{"source_artifact_id":"hypothesis-h-84808267","link_type":"related","strength":0.6245999999999999,"evidence":"Reverse: Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-7e0b5ade","link_type":"related","strength":0.5940000000000001,"evidence":"Reverse: Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-b948c32c","link_type":"related","strength":0.5913,"evidence":"Reverse: Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-aa2d317c","link_type":"related","strength":0.5796,"evidence":"Reverse: Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-44195347","link_type":"related","strength":0.6048,"evidence":"Reverse: Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-d0a564e8","link_type":"related","strength":0.5796,"evidence":"Reverse: Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-11795af0","link_type":"related","strength":0.5922000000000001,"evidence":"Reverse: Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-99b4e2d2","link_type":"related","strength":0.5679000000000001,"evidence":"Reverse: Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-a20e0cbb","link_type":"related","strength":0.6075,"evidence":"Reverse: Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-044ee057","link_type":"related","strength":0.5922000000000001,"evidence":"Reverse: Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-4dd0d19b","link_type":"related","strength":0.6462,"evidence":"Reverse: Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-b234254c","link_type":"related","strength":0.63,"evidence":"Reverse: Mechanism wiki 'BBB-Penetrant Antibody Engineering' references gene/pathway from hypothesis"},{"source_artifact_id":"experiment-exp-wiki-experiments-vascular-contribution-alzheimers","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BBB"},{"source_artifact_id":"experiment-exp-wiki-experiments-blood-brain-barrier-aging-neurodegeneration","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BBB"},{"source_artifact_id":"experiment-exp-debate-b68856276b4a","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BBB"},{"source_artifact_id":"experiment-exp-debate-385d65cb42cb","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BBB"},{"source_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ER described in wiki"},{"source_artifact_id":"hypothesis-h-23a3cc07","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-62e56eb9","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-0791836f","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-13bbfdc5","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-250b34ab","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-13ef5927","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-24e08335","link_type":"related","strength":0.7,"evidence":"Cross-linked via Engineering match"},{"source_artifact_id":"hypothesis-h-d78123d1","link_type":"related","strength":0.7,"evidence":"Cross-linked via Engineering match"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"wiki-clinical-trials-admsc-stem-cell-early-ad-nct06775964","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-clinical-trials-probiotics-mild-alzheimers-nct06181513","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"open_question-therapeutics-bbb-penetrant-antibodies-2ce045c8","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-therapeutics-bbb-penetrant-antibodies-8aece859","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-therapeutics-bbb-penetrant-antibodies-25e9e94d","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-therapeutics-bbb-penetrant-antibodies-9e8419fe","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"}],"current_artifact_id":"wiki-therapeutics-bbb-penetrant-antibodies","is_canonical":true,"supersede_chain":["wiki-therapeutics-bbb-penetrant-antibodies"]}