{"artifact":{"id":"wiki-therapeutics-bioactive-compound-autophagy-modulation","artifact_type":"wiki_page","entity_ids":"[\"therapeutics-bioactive-compound-autophagy-modulation\"]","title":"bioactive-compound-autophagy-modulation","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"f55c5afd4025e819e781ba7404e14e7f0d68d9910352494c3ff5a318d806bbb7","metadata":{"slug":"therapeutics-bioactive-compound-autophagy-modulation","kg_node_id":null,"entity_type":"therapeutic","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-a3778d60a2e0","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"therapeutics-bioactive-compound-autophagy-modulation"},"_schema_version":1},"created_at":"2026-04-02T07:18:59-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"5faf3797-f8f9-4470-92d8-86fff751c396","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-778c1bc2-7c6e-4cdd-81af-56c535ead1e3","link_type":"mentions","strength":0.5,"evidence":"Content: AMPK mentioned 5x in wiki/therapeutics-bioactive-compound-autophagy-modulation"},{"target_artifact_id":"experiment-exp-545ecac0-8b8e-4dc1-b999-1118f810815a","link_type":"mentions","strength":0.5,"evidence":"Content: AMPK mentioned 5x in wiki/therapeutics-bioactive-compound-autophagy-modulation"},{"target_artifact_id":"experiment-exp-bdbae77a-4e67-498f-be15-d4c6c33ac1ec","link_type":"mentions","strength":0.5,"evidence":"Content: AMPK mentioned 5x in wiki/therapeutics-bioactive-compound-autophagy-modulation"},{"target_artifact_id":"experiment-exp-546a7e07-4a45-4e78-b0f9-50f2f2fd7e05","link_type":"mentions","strength":0.5,"evidence":"Content: SNCA mentioned 4x in wiki/therapeutics-bioactive-compound-autophagy-modulation"},{"target_artifact_id":"experiment-exp-2e59e044-73e6-418e-9728-5c3a30daa75e","link_type":"mentions","strength":0.5,"evidence":"Content: SNCA mentioned 4x in wiki/therapeutics-bioactive-compound-autophagy-modulation"},{"target_artifact_id":"experiment-exp-cd85e950-e169-432f-a651-510fdde03f01","link_type":"mentions","strength":0.5,"evidence":"Content: SNCA mentioned 4x in wiki/therapeutics-bioactive-compound-autophagy-modulation"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-012","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-012: ...neration](/analysis/SDA-2026-04-01-gap-012) &#x1f504;\n- [Tau p..."},{"target_artifact_id":"analysis-sda-2026-04-01-gap-008","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-008: ...apeutics](/analysis/SDA-2026-04-01-gap-008) &#x1f504;\n- [What ..."},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-ee5a5023","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-v2-ee5a5023: ...re in AD](/analysis/SDA-2026-04-01-gap-v2-ee5a5023) &#x1f504;\n..."},{"target_artifact_id":"hypothesis-h-0e0cc0c1","link_type":"mentions","strength":0.678,"evidence":"Mechanism wiki 'bioactive-compound-autophagy-modulation' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-072b2f5d","link_type":"mentions","strength":0.66,"evidence":"Mechanism wiki 'bioactive-compound-autophagy-modulation' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-74777459","link_type":"mentions","strength":0.653,"evidence":"Mechanism wiki 'bioactive-compound-autophagy-modulation' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-2e7eb2ea","link_type":"mentions","strength":0.644,"evidence":"Mechanism wiki 'bioactive-compound-autophagy-modulation' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-aa8b4952","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-fffd1a74","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-dca3e907","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-23a3cc07","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-3d993b5d","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-725c62e9","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-ae1b2beb","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Autophagy'"},{"target_artifact_id":"hypothesis-h-8ef34c4c","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-b295a9dd","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-9e9fee95","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-3a901ec3","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-9eae33ba","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-b7898b79","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Autophagy'"},{"target_artifact_id":"hypothesis-h-8597755b","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-ee1df336","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-6c83282d","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-de0d4364","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-55ef81c5","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-18a0fcc6","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Autophagy'"},{"target_artifact_id":"hypothesis-h-fdaae8d9","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"analysis-sda-2026-04-01-003","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'modulation'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-011","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'autophagy'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutics'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutics'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'autophagy'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.3,"evidence":"Transitive: wiki→hypothesis→analysis"},{"target_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for CT related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-18a0fcc6","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-51e7234f","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"hypothesis-h-5dbfd3aa","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene HSPA1A"},{"target_artifact_id":"hypothesis-h-5d943bfc","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene HSPA1A"},{"target_artifact_id":"hypothesis-h-019ad538","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene CLOCK"},{"target_artifact_id":"hypothesis-h-782e55f6","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene DNMT1"},{"target_artifact_id":"hypothesis-h-6b84d8e2","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene HCRT"},{"target_artifact_id":"hypothesis-h-856feb98","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene BDNF"},{"target_artifact_id":"hypothesis-h-4bb7fd8c","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene SIRT1"},{"target_artifact_id":"hypothesis-h-f3fb3b91","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TLR4"},{"target_artifact_id":"hypothesis-h-637a53c9","link_type":"mentions","strength":0.7,"evidence":"Wiki content mentions gene HSPA1A"},{"target_artifact_id":"analysis-astrocyte-subtypes","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-20260401-225155: ...hogenesi](/analysis/SDA-2026-04-01-gap-20260401-225155) &#x1f504;\n- [Periv..."},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-637a53c9","link_type":"related","strength":0.63,"evidence":"Reverse: Wiki content mentions gene HSPA1A"},{"source_artifact_id":"hypothesis-h-0e0cc0c1","link_type":"related","strength":0.6102000000000001,"evidence":"Reverse: Mechanism wiki 'bioactive-compound-autophagy-modulation' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-072b2f5d","link_type":"related","strength":0.5940000000000001,"evidence":"Reverse: Mechanism wiki 'bioactive-compound-autophagy-modulation' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-74777459","link_type":"related","strength":0.5877,"evidence":"Reverse: Mechanism wiki 'bioactive-compound-autophagy-modulation' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-2e7eb2ea","link_type":"related","strength":0.5796,"evidence":"Reverse: Mechanism wiki 'bioactive-compound-autophagy-modulation' references gene/pathway from hypothesis"},{"source_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets CT described in wiki"},{"source_artifact_id":"hypothesis-h-aa8b4952","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-fffd1a74","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-dca3e907","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-23a3cc07","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-3d993b5d","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-725c62e9","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ae1b2beb","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-8ef34c4c","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-b295a9dd","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-9e9fee95","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-3a901ec3","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-9eae33ba","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-b7898b79","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-8597755b","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ee1df336","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-6c83282d","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-de0d4364","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-55ef81c5","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-18a0fcc6","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-fdaae8d9","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-003","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-therapeutics-bioactive-compound-autophagy-modulation","is_canonical":true,"supersede_chain":["wiki-therapeutics-bioactive-compound-autophagy-modulation"]}