{"artifact":{"id":"wiki-therapeutics-inotersen-tegsedi","artifact_type":"wiki_page","entity_ids":"[\"therapeutics-inotersen-tegsedi\"]","title":"Inotersen (Tegsedi) - Therapeutic Overview","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"13fd66b8287adb85bece68090b444ceb80b2b81a0784a1e41145d770bdc657f8","metadata":{"slug":"therapeutics-inotersen-tegsedi","kg_node_id":null,"entity_type":"therapeutic","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-cb7e10074bfb","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"therapeutics-inotersen-tegsedi"},"_schema_version":1},"created_at":"2026-04-02T07:18:58-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"8a4474c9-2613-484a-a087-c8ad81d6c1a2","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-546a7e07-4a45-4e78-b0f9-50f2f2fd7e05","link_type":"mentions","strength":0.5,"evidence":"Content: SNCA mentioned 4x in wiki/therapeutics-inotersen-tegsedi"},{"target_artifact_id":"experiment-exp-2e59e044-73e6-418e-9728-5c3a30daa75e","link_type":"mentions","strength":0.5,"evidence":"Content: SNCA mentioned 4x in wiki/therapeutics-inotersen-tegsedi"},{"target_artifact_id":"experiment-exp-cd85e950-e169-432f-a651-510fdde03f01","link_type":"mentions","strength":0.5,"evidence":"Content: SNCA mentioned 4x in wiki/therapeutics-inotersen-tegsedi"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-89432b95","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-v2-89432b95: ... neurons](/analysis/SDA-2026-04-01-gap-v2-89432b95) 🔄\n..."},{"target_artifact_id":"analysis-sda-2026-04-01-gap-012","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-012: ...neration](/analysis/SDA-2026-04-01-gap-012) 🔄\n- [What ..."},{"target_artifact_id":"analysis-astrocyte-subtypes","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-20260401-225155: ...hogenesi](/analysis/SDA-2026-04-01-gap-20260401-225155) 🔄\n- [Mitoc..."},{"target_artifact_id":"hypothesis-h-072b2f5d","link_type":"mentions","strength":0.66,"evidence":"Mechanism wiki 'Inotersen (Tegsedi) - Therapeutic Overview' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-74777459","link_type":"mentions","strength":0.653,"evidence":"Mechanism wiki 'Inotersen (Tegsedi) - Therapeutic Overview' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-2e7eb2ea","link_type":"mentions","strength":0.644,"evidence":"Mechanism wiki 'Inotersen (Tegsedi) - Therapeutic Overview' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-346639e8","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'therapeutic'"},{"target_artifact_id":"analysis-sda-2026-04-01-001","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-007","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-011","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-20260402-003058","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-v2-5d0e3052","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutics'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutics'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"hypothesis-h-7bb47d7a","link_type":"mentions","strength":0.9,"evidence":"Wiki page mentions gene TH targeted by hypothesis"},{"target_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ER related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-5dbfd3aa","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene HSPA1A"},{"target_artifact_id":"hypothesis-h-5d943bfc","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene HSPA1A"},{"target_artifact_id":"hypothesis-h-782e55f6","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene DNMT1"},{"target_artifact_id":"hypothesis-h-f3fb3b91","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TLR4"},{"target_artifact_id":"hypothesis-h-d78123d1","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: mitochondrial transfer"},{"target_artifact_id":"hypothesis-h-637a53c9","link_type":"mentions","strength":0.7,"evidence":"Wiki content mentions gene HSPA1A"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-20260402-003058","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-637a53c9","link_type":"related","strength":0.63,"evidence":"Reverse: Wiki content mentions gene HSPA1A"},{"source_artifact_id":"hypothesis-h-072b2f5d","link_type":"related","strength":0.5940000000000001,"evidence":"Reverse: Mechanism wiki 'Inotersen (Tegsedi) - Therapeutic Overview' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-74777459","link_type":"related","strength":0.5877,"evidence":"Reverse: Mechanism wiki 'Inotersen (Tegsedi) - Therapeutic Overview' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-2e7eb2ea","link_type":"related","strength":0.5796,"evidence":"Reverse: Mechanism wiki 'Inotersen (Tegsedi) - Therapeutic Overview' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-7bb47d7a","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene TH described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ER described in wiki"},{"source_artifact_id":"hypothesis-h-346639e8","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-20260402-003058","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-v2-5d0e3052","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-001","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-20260402-003058","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-therapeutics-inotersen-tegsedi","is_canonical":true,"supersede_chain":["wiki-therapeutics-inotersen-tegsedi"]}