{"artifact":{"id":"wiki-therapeutics-psp-cbs-therapeutic-target-index","artifact_type":"wiki_page","entity_ids":"[\"therapeutics-psp-cbs-therapeutic-target-index\"]","title":"PSP/CBS Therapeutic Target Index","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"826a5bc84b2334a5ccae5e9420952c7855144fd78ac55059f957975567c5e39e","metadata":{"slug":"therapeutics-psp-cbs-therapeutic-target-index","kg_node_id":null,"entity_type":"therapeutic","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-91ae8c17daec","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"therapeutics-psp-cbs-therapeutic-target-index"},"_schema_version":1},"created_at":"2026-04-02T07:19:01-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"a9ab8efd-3b6e-4659-9558-24fff0c9f8cd","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-32576dcf-a6c7-4ff9-b7b8-37903a89693e","link_type":"mentions","strength":0.5,"evidence":"Content: MAPT mentioned 5x in wiki/therapeutics-psp-cbs-therapeutic-target-index"},{"target_artifact_id":"experiment-exp-65257309-482b-4700-8d80-284109e46653","link_type":"mentions","strength":0.5,"evidence":"Content: MAPT mentioned 5x in wiki/therapeutics-psp-cbs-therapeutic-target-index"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-691b42f1","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-v2-691b42f1: ...early AD](/analysis/SDA-2026-04-01-gap-v2-691b42f1) &#x1f504;\n- [Mitoc..."},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-89432b95","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-v2-89432b95: ... neurons](/analysis/SDA-2026-04-01-gap-v2-89432b95) &#x1f504;\n- [What ..."},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"mentions","strength":0.6,"evidence":"Gene mention: PSP"},{"target_artifact_id":"experiment-exp-wiki-experiments-anti-tau-intracellular-vs-extracellular-comparis","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PSP"},{"target_artifact_id":"experiment-exp-wiki-experiments-tau-pet-therapeutic-response-prediction","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PSP"},{"target_artifact_id":"experiment-exp-wiki-experiments-n-of-1-clinical-trial-cbs-psp","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PSP"},{"target_artifact_id":"experiment-exp-wiki-experiments-brainstem-circuit-modulation-psp","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PSP"},{"target_artifact_id":"experiment-exp-wiki-experiments-tau-spreading-network-mapping-psp","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PSP"},{"target_artifact_id":"experiment-exp-wiki-experiments-4r-tau-targeting-psp-cbs","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PSP"},{"target_artifact_id":"experiment-exp-wiki-experiments-levodopa-response-psp-biomarkers","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PSP"},{"target_artifact_id":"experiment-exp-wiki-experiments-cbs-psp-phenotype-determinants","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PSP"},{"target_artifact_id":"experiment-exp-wiki-experiments-tau-pathology-initiation-zone","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PSP"},{"target_artifact_id":"experiment-exp-wiki-experiments-psp-cbs-biomarker-validation","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PSP"},{"target_artifact_id":"experiment-exp-wiki-experiments-anti-tau-therapy-failure-psp","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PSP"},{"target_artifact_id":"experiment-exp-wiki-experiments-crispr-gene-correction-cbs-psp","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PSP"},{"target_artifact_id":"experiment-exp-debate-c69b54839399","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PSP"},{"target_artifact_id":"hypothesis-h-346639e8","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'therapeutic'"},{"target_artifact_id":"analysis-sda-2026-04-01-001","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-007","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-011","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-20260402-003058","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-v2-5d0e3052","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutics'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutics'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"experiment-exp-wiki-experiments-pre-symptomatic-tau-detection-mapt","link_type":"mentions","strength":0.5,"evidence":"Content: MAPT mentioned 5x in wiki/therapeutics-psp-cbs-therapeutic-target-index"},{"target_artifact_id":"hypothesis-h-b234254c","link_type":"mentions","strength":0.5,"evidence":"Content: TREM2 mentioned 2x in wiki/therapeutics-psp-cbs-therapeutic-target-index"},{"target_artifact_id":"hypothesis-h-044ee057","link_type":"mentions","strength":0.5,"evidence":"Content: TREM2 mentioned 2x in wiki/therapeutics-psp-cbs-therapeutic-target-index"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-function-alzheimers","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: TREM2 mentioned 2x in wiki/therapeutics-psp-cbs-therapeutic-target-index"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-parkinsons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: TREM2 mentioned 2x in wiki/therapeutics-psp-cbs-therapeutic-target-index"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-efficacy","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: TREM2 mentioned 2x in wiki/therapeutics-psp-cbs-therapeutic-target-index"},{"target_artifact_id":"hypothesis-h-7bb47d7a","link_type":"mentions","strength":0.9,"evidence":"Wiki page mentions gene TH targeted by hypothesis"},{"target_artifact_id":"experiment-exp-wiki-experiments-n-of-1-clinical-trial-cbs-psp","link_type":"related","strength":0.7,"evidence":"Wiki page for CBS related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-brainstem-circuit-modulation-psp","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-tau-spreading-network-mapping-psp","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-4r-tau-targeting-psp-cbs","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-levodopa-response-psp-biomarkers","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-cbs-psp-phenotype-determinants","link_type":"related","strength":0.7,"evidence":"Wiki page for CBS related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-tau-pathology-initiation-zone","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-psp-cbs-biomarker-validation","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-anti-tau-therapy-failure-psp","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ER related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"mentions","strength":0.4,"evidence":"Keyword match: therapeutic"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-crispr-neurodegeneration-20260402","link_type":"mentions","strength":0.4,"evidence":"Keyword match: therapeutic"},{"target_artifact_id":"hypothesis-h-346639e8","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-aa8b4952","link_type":"mentions","strength":0.65,"evidence":"Wiki page content mentions hypothesis target gene: MCU"},{"target_artifact_id":"hypothesis-h-a1b56d74","link_type":"mentions","strength":0.65,"evidence":"Wiki page content mentions hypothesis target gene: HK2"},{"target_artifact_id":"hypothesis-h-38292315","link_type":"mentions","strength":0.65,"evidence":"Wiki page content mentions hypothesis target gene: HK2"},{"target_artifact_id":"hypothesis-h-seaad-51323624","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-61196ade","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-3460f820","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-180807e5","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-856feb98","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene BDNF"},{"target_artifact_id":"hypothesis-h-e5a1c16b","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TFEB"},{"target_artifact_id":"hypothesis-h-e3e8407c","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TFEB"},{"target_artifact_id":"hypothesis-h-51e7234f","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene MTOR"},{"target_artifact_id":"hypothesis-h-d78123d1","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: mitochondrial transfer"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-005","link_type":"mentions","strength":0.75,"evidence":"Gene mention: PSP"},{"target_artifact_id":"experiment-exp-debate-ca942ead922d","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PSP"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-20260402-003058","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutic'"},{"target_artifact_id":"analysis-astrocyte-subtypes","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-20260401-225155: ...hogenesi](/analysis/SDA-2026-04-01-gap-20260401-225155) &#x1f504;\n- [Tau p..."},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-38292315","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Wiki page content mentions hypothesis target gene: HK2"},{"source_artifact_id":"hypothesis-h-aa8b4952","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Wiki page content mentions hypothesis target gene: MCU"},{"source_artifact_id":"hypothesis-h-a1b56d74","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Wiki page content mentions hypothesis target gene: HK2"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-005","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: PSP"},{"source_artifact_id":"experiment-exp-debate-ca942ead922d","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PSP"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: PSP"},{"source_artifact_id":"experiment-exp-wiki-experiments-anti-tau-intracellular-vs-extracellular-comparis","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PSP"},{"source_artifact_id":"experiment-exp-wiki-experiments-tau-pet-therapeutic-response-prediction","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PSP"},{"source_artifact_id":"experiment-exp-wiki-experiments-n-of-1-clinical-trial-cbs-psp","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PSP"},{"source_artifact_id":"experiment-exp-wiki-experiments-brainstem-circuit-modulation-psp","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PSP"},{"source_artifact_id":"experiment-exp-wiki-experiments-tau-spreading-network-mapping-psp","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PSP"},{"source_artifact_id":"experiment-exp-wiki-experiments-4r-tau-targeting-psp-cbs","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PSP"},{"source_artifact_id":"experiment-exp-wiki-experiments-levodopa-response-psp-biomarkers","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PSP"},{"source_artifact_id":"experiment-exp-wiki-experiments-cbs-psp-phenotype-determinants","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PSP"},{"source_artifact_id":"experiment-exp-wiki-experiments-tau-pathology-initiation-zone","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PSP"},{"source_artifact_id":"experiment-exp-wiki-experiments-psp-cbs-biomarker-validation","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PSP"},{"source_artifact_id":"experiment-exp-wiki-experiments-anti-tau-therapy-failure-psp","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PSP"},{"source_artifact_id":"experiment-exp-wiki-experiments-crispr-gene-correction-cbs-psp","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PSP"},{"source_artifact_id":"experiment-exp-debate-c69b54839399","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PSP"},{"source_artifact_id":"hypothesis-h-7bb47d7a","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene TH described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ER described in wiki"},{"source_artifact_id":"hypothesis-h-346639e8","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-b234254c","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-044ee057","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-20260402-003058","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-crispr-neurodegeneration-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-v2-5d0e3052","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-001","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-20260402-003058","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-therapeutics-psp-cbs-therapeutic-target-index","is_canonical":true,"supersede_chain":["wiki-therapeutics-psp-cbs-therapeutic-target-index"]}