{"artifact":{"id":"wiki-therapeutics-pyroptosis-modulation-therapy","artifact_type":"wiki_page","entity_ids":"[\"therapeutics-pyroptosis-modulation-therapy\"]","title":"Pyroptosis Modulation Therapy","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"be37d30e8c57c5ffbb54dba043091c72cbb398be0a52d46a5257e677c40bc22e","metadata":{"slug":"therapeutics-pyroptosis-modulation-therapy","kg_node_id":null,"entity_type":"therapeutic","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-cdc67668df46","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"therapeutics-pyroptosis-modulation-therapy"},"_schema_version":1},"created_at":"2026-04-02T07:19:02-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"4f56a9d4-148c-4ae0-ab3b-41a5549764eb","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-c98631a3-a95e-4621-a68f-9cf145b22b97","link_type":"mentions","strength":0.5,"evidence":"Content: NLRP3 mentioned 17x in wiki/therapeutics-pyroptosis-modulation-therapy"},{"target_artifact_id":"experiment-exp-9d2d59a7-8bc0-4399-aab0-2538f3a07b6f","link_type":"mentions","strength":0.5,"evidence":"Content: NLRP3 mentioned 17x in wiki/therapeutics-pyroptosis-modulation-therapy"},{"target_artifact_id":"hypothesis-h-0e0cc0c1","link_type":"mentions","strength":0.55,"evidence":"Content: ULK1 mentioned 3x in wiki/therapeutics-pyroptosis-modulation-therapy"},{"target_artifact_id":"experiment-exp-9f358501-0c3d-417e-9b43-1be792ee3638","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ACSL4 mentioned 2x in wiki/therapeutics-pyroptosis-modulation-therapy"},{"target_artifact_id":"experiment-exp-wiki-experiments-metal-ion-homeostasis-alzheimers","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CYP46A1 mentioned 2x in wiki/therapeutics-pyroptosis-modulation-therapy"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-012","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-012: ...neration](/analysis/SDA-2026-04-01-gap-012) &#x1f504;\n..."},{"target_artifact_id":"analysis-sda-2026-04-01-gap-006","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-006: ... ALS-FTD](/analysis/SDA-2026-04-01-gap-006) &#x1f504;\n- [Senol..."},{"target_artifact_id":"analysis-sda-2026-04-01-gap-013","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-013: ...neration](/analysis/SDA-2026-04-01-gap-013) &#x1f504;\n- [Digit..."},{"target_artifact_id":"hypothesis-h-83efeed6","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions hypothesis h-83efeed6: ...cation](/hypothesis/h-83efeed6) — <span style=\"col..."},{"target_artifact_id":"hypothesis-h-e7e1f943","link_type":"mentions","strength":0.696,"evidence":"Mechanism wiki 'Pyroptosis Modulation Therapy' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-d40d2659","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-aa8b4952","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-c35493aa","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-69919c49","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-19003961","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-fffd1a74","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-dca3e907","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-23a3cc07","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-3d993b5d","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-725c62e9","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-8ef34c4c","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-b295a9dd","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-ac55ff26","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-c463d225","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-f99ce4ca","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-1fe4ba9b","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-9e9fee95","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-3a901ec3","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-9eae33ba","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-fd1562a3","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'therapy'"},{"target_artifact_id":"hypothesis-h-d7121bcc","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-50a535f9","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-de579caf","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-8597755b","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-6b84d8e2","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-ee1df336","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-6c83282d","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-de0d4364","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-2600483e","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-12599989","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-55ef81c5","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-fdaae8d9","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulation'"},{"target_artifact_id":"hypothesis-h-bdbd2120","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'therapy'"},{"target_artifact_id":"analysis-sda-2026-04-01-002","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapy'"},{"target_artifact_id":"analysis-sda-2026-04-01-003","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'modulation'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutics'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutics'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapy'"},{"target_artifact_id":"experiment-exp-wiki-experiments-nlrp3-inflammasome-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: NLRP3 mentioned 13x in wiki/therapeutics-pyroptosis-modulation-therapy"},{"target_artifact_id":"experiment-exp-wiki-experiments-als-sporadic-initiation-biology","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CASP1 mentioned 2x in wiki/therapeutics-pyroptosis-modulation-therapy"},{"target_artifact_id":"experiment-exp-wiki-experiments-alpha-synuclein-aggregation-triggers-sporadic-pd","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CASP1 mentioned 2x in wiki/therapeutics-pyroptosis-modulation-therapy"},{"target_artifact_id":"experiment-exp-wiki-experiments-microbiome-gut-barrier-als","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CASP1 mentioned 2x in wiki/therapeutics-pyroptosis-modulation-therapy"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.3,"evidence":"Transitive: wiki→hypothesis→analysis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.3,"evidence":"Transitive: wiki→hypothesis→analysis"},{"target_artifact_id":"hypothesis-h-5daecb6e","link_type":"mentions","strength":0.5,"evidence":"Entity 'PYROPTOSIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'PYROPTOSIS'"},{"target_artifact_id":"hypothesis-h-8986b8af","link_type":"mentions","strength":0.5,"evidence":"Entity 'PYROPTOSIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'PYROPTOSIS'"},{"target_artifact_id":"hypothesis-h-1e564178","link_type":"mentions","strength":0.5,"evidence":"Entity 'PYROPTOSIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'PYROPTOSIS'"},{"target_artifact_id":"hypothesis-h-1a34778f","link_type":"mentions","strength":0.5,"evidence":"Entity 'PYROPTOSIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-782b40b1","link_type":"mentions","strength":0.5,"evidence":"Entity 'PYROPTOSIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'PYROPTOSIS'"},{"target_artifact_id":"hypothesis-h-43f72e21","link_type":"mentions","strength":0.5,"evidence":"Entity 'PYROPTOSIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'PYROPTOSIS'"},{"target_artifact_id":"hypothesis-h-74777459","link_type":"mentions","strength":0.5,"evidence":"Entity 'PYROPTOSIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-2e7eb2ea","link_type":"mentions","strength":0.5,"evidence":"Entity 'PYROPTOSIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'PYROPTOSIS'"},{"target_artifact_id":"hypothesis-h-18a0fcc6","link_type":"mentions","strength":0.5,"evidence":"Entity 'PYROPTOSIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-62f9fc90","link_type":"mentions","strength":0.5,"evidence":"Entity 'PYROPTOSIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'PYROPTOSIS'"},{"target_artifact_id":"hypothesis-h-7bb47d7a","link_type":"mentions","strength":0.9,"evidence":"Wiki page mentions gene TH targeted by hypothesis"},{"target_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ER related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-senescent-clearance-neuro","link_type":"mentions","strength":0.4,"evidence":"Keyword match: therapy"},{"target_artifact_id":"wiki-genes-acsl4","link_type":"see_also","strength":0.6,"evidence":"KG edge: causes"},{"target_artifact_id":"wiki-mechanisms-aging-vs-neurodegeneration-comparison","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"target_artifact_id":"wiki-genes-aif","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates"},{"target_artifact_id":"wiki-ideas-payload-aim2-inflammasome-modulation-therapy","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"hypothesis-h-d40d2659","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-c35493aa","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-69919c49","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-19003961","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-8ef34c4c","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-ac55ff26","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-c463d225","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-f99ce4ca","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-1fe4ba9b","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-fd1562a3","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-d7121bcc","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-50a535f9","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-de579caf","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-8597755b","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-6b84d8e2","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-de0d4364","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-2600483e","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-12599989","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-bdbd2120","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-a87702b6","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-91bdb9ad","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-27bc0569","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-7693c291","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-c9c79e3e","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-15336069","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-seaad-v4-26ba859b","link_type":"mentions","strength":0.5,"evidence":"Entity 'PYROPTOSIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v4-20260402065846","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'PYROPTOSIS'"},{"target_artifact_id":"hypothesis-h-seaad-v4-26ba859b","link_type":"related","strength":0.55,"evidence":"Shared KG edge: ACSL4 → PYROPTOSIS"},{"target_artifact_id":"hypothesis-h-83efeed6","link_type":"related","strength":0.55,"evidence":"Shared KG edge: ALOX12 → pyroptosis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'PYROPTOSIS'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-e7e1f943","link_type":"related","strength":0.6264,"evidence":"Reverse: Mechanism wiki 'Pyroptosis Modulation Therapy' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-7bb47d7a","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene TH described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ER described in wiki"},{"source_artifact_id":"hypothesis-h-d40d2659","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-aa8b4952","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-c35493aa","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-69919c49","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-19003961","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-fffd1a74","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-dca3e907","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-23a3cc07","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-3d993b5d","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-725c62e9","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-a20e0cbb","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-8ef34c4c","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-b295a9dd","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ac55ff26","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-c463d225","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-f99ce4ca","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-1fe4ba9b","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-9e9fee95","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-3a901ec3","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-9eae33ba","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-fd1562a3","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-d7121bcc","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-50a535f9","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-de579caf","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-8597755b","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-6b84d8e2","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ee1df336","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-6c83282d","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-de0d4364","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-2600483e","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-12599989","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-55ef81c5","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-fdaae8d9","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-bdbd2120","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-5daecb6e","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-8986b8af","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-1e564178","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-1a34778f","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-782b40b1","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-43f72e21","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-74777459","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-2e7eb2ea","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-18a0fcc6","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-62f9fc90","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v4-20260402065846","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-senescent-clearance-neuro","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-002","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-003","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"open_question-therapeutics-pyroptosis-modulation-therapy-24c5bcee","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-therapeutics-pyroptosis-modulation-therapy-49402d63","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-therapeutics-pyroptosis-modulation-therapy-8119c9e0","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-therapeutics-pyroptosis-modulation-therapy-aea67df5","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"}],"current_artifact_id":"wiki-therapeutics-pyroptosis-modulation-therapy","is_canonical":true,"supersede_chain":["wiki-therapeutics-pyroptosis-modulation-therapy"]}