{"artifact":{"id":"wiki-therapeutics-section-191-advanced-lipid-signaling-modulators-cbs-psp","artifact_type":"wiki_page","entity_ids":"[\"therapeutics-section-191-advanced-lipid-signaling-modulators-cbs-psp\"]","title":"Section 191: Advanced Lipid Signaling Modulators in CBS/PSP","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"3fc1aebc2e58d946d07e5e4b42bca7129d052e93914f5b07084428a2b70dcb73","metadata":{"slug":"therapeutics-section-191-advanced-lipid-signaling-modulators-cbs-psp","kg_node_id":null,"entity_type":"therapeutic","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-6f7d9be7989f","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"therapeutics-section-191-advanced-lipid-signaling-modulators-cbs-psp"},"_schema_version":1},"created_at":"2026-04-02T07:19:00-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"2881a04a-8dad-4451-a47b-554d058b5794","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-debate-385d65cb42cb","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CX3CR1 mentioned 2x in wiki/therapeutics-section-191-advanced-lipid-signaling-modulators-cbs-psp"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-007","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-007: ...neration](/analysis/SDA-2026-04-01-gap-007) 🔄\n- [Micro..."},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-v2-68d9c9c1: ...D and AD](/analysis/SDA-2026-04-01-gap-v2-68d9c9c1) 🔄\n..."},{"target_artifact_id":"analysis-sda-2026-04-01-gap-013","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-013: ...neration](/analysis/SDA-2026-04-01-gap-013) 🔄\n- [RNA b..."},{"target_artifact_id":"analysis-sda-2026-04-01-gap-009","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-009: ...neration](/analysis/SDA-2026-04-01-gap-009) 🔄\n- [Senol..."},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"mentions","strength":0.6,"evidence":"Gene mention: PSP"},{"target_artifact_id":"hypothesis-h-0758b337","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Signaling'"},{"target_artifact_id":"hypothesis-h-7d4a24d3","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Lipid'"},{"target_artifact_id":"hypothesis-h-3d993b5d","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Lipid'"},{"target_artifact_id":"hypothesis-h-99b4e2d2","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Lipid'"},{"target_artifact_id":"hypothesis-h-7957bb2a","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Lipid'"},{"target_artifact_id":"hypothesis-h-bb518928","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Lipid'"},{"target_artifact_id":"hypothesis-h-97aa8486","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulators'"},{"target_artifact_id":"hypothesis-h-ba3a948a","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulators'"},{"target_artifact_id":"hypothesis-h-9d29bfe5","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Modulators'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-010","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'lipid'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'lipid'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutics'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapeutics'"},{"target_artifact_id":"experiment-exp-wiki-experiments-oligodendrocyte-myelin-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-n-of-1-clinical-trial-cbs-psp","link_type":"related","strength":0.7,"evidence":"Wiki page for CBS related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-neural-oscillation-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-brainstem-circuit-modulation-psp","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-proteasome-ubiquitin-system-dysfunction-parkinso","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-microbiome-alpha-synuclein-propagation","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-tau-spreading-network-mapping-psp","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-4r-tau-targeting-psp-cbs","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-stress-granule-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-animal-model-comparison-neurodegeneration","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-levodopa-response-psp-biomarkers","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-cbs-psp-phenotype-determinants","link_type":"related","strength":0.7,"evidence":"Wiki page for CBS related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-tau-pathology-initiation-zone","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-protein-aggregation-kinetic-validation","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-psp-cbs-biomarker-validation","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-tht-validation-protein-aggregation","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-endocannabinoid-system-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-glymphatic-circadian-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-anti-tau-therapy-failure-psp","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-regulated-necrosis-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for CT related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-purinergic-signaling-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-7d4a24d3","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-3d993b5d","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-99b4e2d2","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-7957bb2a","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-bb518928","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-97aa8486","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-ba3a948a","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-9d29bfe5","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-c9c79e3e","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-58e655ee","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"hypothesis-h-fffd1a74","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene G3BP1"},{"target_artifact_id":"hypothesis-h-ec731b7a","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene G3BP1"},{"target_artifact_id":"hypothesis-h-27bc0569","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene G3BP1"},{"target_artifact_id":"hypothesis-h-782b40b1","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene CX3CR1"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-005","link_type":"mentions","strength":0.6,"evidence":"Gene mention: PSP"}],"incoming_links":[{"source_artifact_id":"analysis-sda-2026-04-01-gap-005","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: PSP"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: PSP"},{"source_artifact_id":"experiment-exp-wiki-experiments-oligodendrocyte-myelin-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-n-of-1-clinical-trial-cbs-psp","link_type":"related","strength":0.7,"evidence":"Experiment targets CBS described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-neural-oscillation-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-brainstem-circuit-modulation-psp","link_type":"related","strength":0.7,"evidence":"Experiment targets PSP described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-proteasome-ubiquitin-system-dysfunction-parkinso","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-microbiome-alpha-synuclein-propagation","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-tau-spreading-network-mapping-psp","link_type":"related","strength":0.7,"evidence":"Experiment targets PSP described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-4r-tau-targeting-psp-cbs","link_type":"related","strength":0.7,"evidence":"Experiment targets PSP described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-stress-granule-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-animal-model-comparison-neurodegeneration","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-levodopa-response-psp-biomarkers","link_type":"related","strength":0.7,"evidence":"Experiment targets PSP described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-cbs-psp-phenotype-determinants","link_type":"related","strength":0.7,"evidence":"Experiment targets CBS described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-tau-pathology-initiation-zone","link_type":"related","strength":0.7,"evidence":"Experiment targets PSP described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-protein-aggregation-kinetic-validation","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-psp-cbs-biomarker-validation","link_type":"related","strength":0.7,"evidence":"Experiment targets PSP described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-tht-validation-protein-aggregation","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-endocannabinoid-system-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-glymphatic-circadian-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-anti-tau-therapy-failure-psp","link_type":"related","strength":0.7,"evidence":"Experiment targets PSP described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-regulated-necrosis-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets CT described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-purinergic-signaling-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"hypothesis-h-0758b337","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-7d4a24d3","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-3d993b5d","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-99b4e2d2","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-7957bb2a","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-bb518928","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-97aa8486","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ba3a948a","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-9d29bfe5","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-therapeutics-section-191-advanced-lipid-signaling-modulators-cbs-psp","is_canonical":true,"supersede_chain":["wiki-therapeutics-section-191-advanced-lipid-signaling-modulators-cbs-psp"]}