{"recommendations":[{"id":2085,"recommendation_type":"merge_gaps","source_ids":"[\"gap-20260410-172514\", \"gap-v2-68d9c9c1\"]","similarity_score":0.889,"similarity_details":"{\"g1_title\": \"RNA binding protein dysregulation across ALS FTD AD\", \"g2_title\": \"RNA binding protein dysregulation across ALS FTD and AD\", \"g1_domain\": \"neurodegeneration\", \"g2_domain\": \"neurodegeneration\", \"title_sim\": 0.889, \"desc_sim\": 0.889}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-16 08:29:33"},{"id":2073,"recommendation_type":"merge_wiki_pages","source_ids":"[\"cell-types-ca3-pyramidal-epilepsy\", \"cell-types-hippocampal-ca3-pyramidal-alzheimers\"]","similarity_score":0.812,"similarity_details":"{\"w1_title\": \"Hippocampal CA3 Pyramidal Neurons in Epilepsy\", \"w2_title\": \"Hippocampal CA3 Pyramidal Neurons in Alzheimer's Disease\", \"w1_type\": \"cell\", \"w2_type\": \"cell\", \"same_kg_node\": true}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-16 08:29:31"},{"id":2074,"recommendation_type":"merge_wiki_pages","source_ids":"[\"events-adpd-2026-company-presentations\", \"events-adpd-2026-scientific-sessions\"]","similarity_score":0.8,"similarity_details":"{\"w1_title\": \"AD/PD 2026 Scientific Sessions\", \"w2_title\": \"AD/PD 2026 Company Presentations\", \"w1_type\": \"event\", \"w2_type\": \"event\", \"same_kg_node\": true}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-16 08:29:31"},{"id":2082,"recommendation_type":"merge_gaps","source_ids":"[\"gap-debate-20260410-100405-abac24bc\", \"gap-debate-20260410-100409-e0118210\"]","similarity_score":0.787,"similarity_details":"{\"g1_title\": \"What are the optimal temporal windows for TREM2 inhibition vs activation in Alzh\", \"g2_title\": \"What are the optimal timing windows for TREM2 inhibition vs activation in Alzhei\", \"g1_domain\": \"neurodegeneration\", \"g2_domain\": \"neurodegeneration\", \"title_sim\": 0.882, \"desc_sim\": 0.644}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-16 08:29:32"},{"id":2080,"recommendation_type":"merge_gaps","source_ids":"[\"gap-20260404-120802\", \"gap-20260410-091107\"]","similarity_score":0.778,"similarity_details":"{\"g1_title\": \"Investigate mechanisms of epigenetic reprogramming in aging neurons\", \"g2_title\": \"Investigate mechanisms of epigenetic reprogramming in aging neurons\", \"g1_domain\": \"neurodegeneration\", \"g2_domain\": \"neurodegeneration\", \"title_sim\": 1.0, \"desc_sim\": 0.444}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-16 08:29:32"},{"id":2078,"recommendation_type":"merge_gaps","source_ids":"[\"gap-tau-prop-20260402003221\", \"gap-tau-propagation-20260402\"]","similarity_score":0.771,"similarity_details":"{\"g1_title\": \"Tau propagation mechanisms and therapeutic interception points\", \"g2_title\": \"Tau propagation mechanisms and therapeutic interception points\", \"g1_domain\": \"neurodegeneration\", \"g2_domain\": \"neurodegeneration\", \"title_sim\": 1.0, \"desc_sim\": 0.429}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-16 08:29:31"},{"id":2076,"recommendation_type":"merge_gaps","source_ids":"[\"gap-seaad-20260402025452\", \"gap-seaad-v2-20260402032945\"]","similarity_score":0.755,"similarity_details":"{\"g1_title\": \"Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)\", \"g2_title\": \"Cell type vulnerability in Alzheimer's Disease (SEA-AD data)\", \"g1_domain\": \"neurodegeneration\", \"g2_domain\": \"neurodegeneration\", \"title_sim\": 0.909, \"desc_sim\": 0.523}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-16 08:29:31"},{"id":2081,"recommendation_type":"merge_gaps","source_ids":"[\"gap-20260410-094512\", \"gap-20260410-095113\"]","similarity_score":0.735,"similarity_details":"{\"g1_title\": \"Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in\", \"g2_title\": \"Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci\", \"g1_domain\": \"neurodegeneration\", \"g2_domain\": \"neurodegeneration\", \"title_sim\": 0.645, \"desc_sim\": 0.87}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-16 08:29:32"},{"id":434,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-var-3fbcfc0e6c\", \"h-var-e0e82ff2e2\"]","similarity_score":0.729,"similarity_details":"{\"h1_title\": \"TREM2-Mediated Cholesterol Dysregulation in Microglial Senescence\", \"h2_title\": \"CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microglial Senescence Revers\", \"h1_score\": 0.6006612940651671, \"h2_score\": 0.5773903807851933, \"h1_gene\": \"CYP46A1\", \"h2_gene\": \"CYP46A1\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 06:34:14"},{"id":2075,"recommendation_type":"merge_gaps","source_ids":"[\"gap-seaad-v2-20260402032945\", \"gap-seaad-v3-20260402063622\"]","similarity_score":0.715,"similarity_details":"{\"g1_title\": \"Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)\", \"g2_title\": \"Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)\", \"g1_domain\": \"neurodegeneration\", \"g2_domain\": \"neurodegeneration\", \"title_sim\": 0.615, \"desc_sim\": 0.864}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-16 08:29:31"},{"id":1639,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-7c3c0f40\", \"h-c69709f5\"]","similarity_score":0.698,"similarity_details":"{\"h1_title\": \"Astrocyte Metabolic Memory Reprogramming\", \"h2_title\": \"Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromatin Remodeling\", \"h1_score\": 0.647, \"h2_score\": 0.5197455458759024, \"h1_gene\": \"SIRT1\", \"h2_gene\": \"SIRT1, FOXO3, NRF2, TFAM\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:08:54"},{"id":1672,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-28d5b559\", \"h-420db533\"]","similarity_score":0.684,"similarity_details":"{\"h1_title\": \"Mitochondrial Biogenesis Rate as a Dynamic Biomarker of Neuroprotection\", \"h2_title\": \"CRISPR-Mediated Mitochondrial Genome Editing for Complex I Dysfunction\", \"h1_score\": 0.586, \"h2_score\": 0.4937559876429708, \"h1_gene\": \"TFAM, MT-CO1\", \"h2_gene\": \"MT-ND1, MT-ND4, MT-ND6\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:41:47"},{"id":1641,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-28d5b559\", \"h-5626c1f2\"]","similarity_score":0.683,"similarity_details":"{\"h1_title\": \"Temporal Metabolic Window Therapy\", \"h2_title\": \"Mitochondrial Biogenesis Rate as a Dynamic Biomarker of Neuroprotection\", \"h1_score\": 0.64, \"h2_score\": 0.586, \"h1_gene\": \"HMGCS2\", \"h2_gene\": \"TFAM, MT-CO1\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:08:54"},{"id":1654,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-420db533\", \"h-5626c1f2\"]","similarity_score":0.683,"similarity_details":"{\"h1_title\": \"Temporal Metabolic Window Therapy\", \"h2_title\": \"CRISPR-Mediated Mitochondrial Genome Editing for Complex I Dysfunction\", \"h1_score\": 0.64, \"h2_score\": 0.4937559876429708, \"h1_gene\": \"HMGCS2\", \"h2_gene\": \"MT-ND1, MT-ND4, MT-ND6\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:41:47"},{"id":2086,"recommendation_type":"merge_gaps","source_ids":"[\"gap-debate-20260410-111936-664a043f\", \"gap-debate-20260410-111943-d684a515\"]","similarity_score":0.677,"similarity_details":"{\"g1_title\": \"Does IL-10 receptor activation in microglia impair amyloid clearance capacity wh\", \"g2_title\": \"Does IL-10 receptor activation in microglia impair amyloid clearance capacity wh\", \"g1_domain\": \"neuroinflammation\", \"g2_domain\": \"neuroinflammation\", \"title_sim\": 0.812, \"desc_sim\": 0.474}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-16 08:29:36"},{"id":475,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-62e56eb9\", \"h-c8ccbee8\"]","similarity_score":0.666,"similarity_details":"{\"h1_title\": \"Glymphatic System-Enhanced Antibody Clearance Reversal\", \"h2_title\": \"Aquaporin-4 Polarization Rescue\", \"h1_score\": 0.5366278533187234, \"h2_score\": 0.5076685543679251, \"h1_gene\": \"AQP4\", \"h2_gene\": \"AQP4\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 07:31:57"},{"id":1652,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-3bfa414a\", \"h-c69709f5\"]","similarity_score":0.654,"similarity_details":"{\"h1_title\": \"Astrocyte Metabolic Memory Reprogramming\", \"h2_title\": \"Astrocyte-Mediated Microglial Memory Erasure\", \"h1_score\": 0.647, \"h2_score\": 0.4622222222222222, \"h1_gene\": \"SIRT1\", \"h2_gene\": \"GFAP, S100B\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:41:47"},{"id":2079,"recommendation_type":"merge_gaps","source_ids":"[\"gap-20260404-microglial-priming-early-ad\", \"gap-neuro-microglia-early-ad-20260404\"]","similarity_score":0.646,"similarity_details":"{\"g1_title\": \"Neuroinflammation and microglial priming in early Alzheimer's Disease\", \"g2_title\": \"Neuroinflammation and microglial priming in early Alzheimer's Disease\", \"g1_domain\": \"neurodegeneration\", \"g2_domain\": \"neurodegeneration\", \"title_sim\": 1.0, \"desc_sim\": 0.116}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-16 08:29:31"},{"id":1968,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-11ba42d0\", \"h-a20e0cbb\"]","similarity_score":0.643,"similarity_details":"{\"h1_title\": \"APOE4-Specific Lipidation Enhancement Therapy\", \"h2_title\": \"Targeted APOE4-to-APOE3 Base Editing Therapy\", \"h1_score\": 0.845, \"h2_score\": 0.5258192061541369, \"h1_gene\": \"APOE\", \"h2_gene\": \"APOE\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-13 22:22:46"},{"id":1655,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-5626c1f2\", \"h-e003a35e\"]","similarity_score":0.642,"similarity_details":"{\"h1_title\": \"Temporal Metabolic Window Therapy\", \"h2_title\": \"Oligodendrocyte Remyelination Enhancement\", \"h1_score\": 0.64, \"h2_score\": 0.4742859141237619, \"h1_gene\": \"HMGCS2\", \"h2_gene\": \"TREM2\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:41:47"},{"id":2077,"recommendation_type":"merge_gaps","source_ids":"[\"gap-seaad-20260402025452\", \"gap-seaad-v3-20260402063622\"]","similarity_score":0.642,"similarity_details":"{\"g1_title\": \"Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)\", \"g2_title\": \"Cell type vulnerability in Alzheimer's Disease (SEA-AD data)\", \"g1_domain\": \"neurodegeneration\", \"g2_domain\": \"neurodegeneration\", \"title_sim\": 0.667, \"desc_sim\": 0.605}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-16 08:29:31"},{"id":1653,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-1e4bba56\", \"h-5626c1f2\"]","similarity_score":0.641,"similarity_details":"{\"h1_title\": \"Temporal Metabolic Window Therapy\", \"h2_title\": \"TFEB-Independent Autophagy Bypass\", \"h1_score\": 0.64, \"h2_score\": 0.510267159147721, \"h1_gene\": \"HMGCS2\", \"h2_gene\": \"ULK1\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:41:47"},{"id":1642,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-5626c1f2\", \"h-7c3c0f40\"]","similarity_score":0.634,"similarity_details":"{\"h1_title\": \"Temporal Metabolic Window Therapy\", \"h2_title\": \"Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromatin Remodeling\", \"h1_score\": 0.64, \"h2_score\": 0.5197455458759024, \"h1_gene\": \"HMGCS2\", \"h2_gene\": \"SIRT1, FOXO3, NRF2, TFAM\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:08:54"},{"id":1638,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-28d5b559\", \"h-c69709f5\"]","similarity_score":0.633,"similarity_details":"{\"h1_title\": \"Astrocyte Metabolic Memory Reprogramming\", \"h2_title\": \"Mitochondrial Biogenesis Rate as a Dynamic Biomarker of Neuroprotection\", \"h1_score\": 0.647, \"h2_score\": 0.586, \"h1_gene\": \"SIRT1\", \"h2_gene\": \"TFAM, MT-CO1\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:08:54"},{"id":1650,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-420db533\", \"h-c69709f5\"]","similarity_score":0.633,"similarity_details":"{\"h1_title\": \"Astrocyte Metabolic Memory Reprogramming\", \"h2_title\": \"CRISPR-Mediated Mitochondrial Genome Editing for Complex I Dysfunction\", \"h1_score\": 0.647, \"h2_score\": 0.4937559876429708, \"h1_gene\": \"SIRT1\", \"h2_gene\": \"MT-ND1, MT-ND4, MT-ND6\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:41:47"},{"id":1671,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-1e4bba56\", \"h-28d5b559\"]","similarity_score":0.633,"similarity_details":"{\"h1_title\": \"Mitochondrial Biogenesis Rate as a Dynamic Biomarker of Neuroprotection\", \"h2_title\": \"TFEB-Independent Autophagy Bypass\", \"h1_score\": 0.586, \"h2_score\": 0.510267159147721, \"h1_gene\": \"TFAM, MT-CO1\", \"h2_gene\": \"ULK1\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:41:47"},{"id":1673,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-28d5b559\", \"h-e003a35e\"]","similarity_score":0.633,"similarity_details":"{\"h1_title\": \"Mitochondrial Biogenesis Rate as a Dynamic Biomarker of Neuroprotection\", \"h2_title\": \"Oligodendrocyte Remyelination Enhancement\", \"h1_score\": 0.586, \"h2_score\": 0.4742859141237619, \"h1_gene\": \"TFAM, MT-CO1\", \"h2_gene\": \"TREM2\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:41:47"},{"id":1644,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-28d5b559\", \"h-7c3c0f40\"]","similarity_score":0.632,"similarity_details":"{\"h1_title\": \"Mitochondrial Biogenesis Rate as a Dynamic Biomarker of Neuroprotection\", \"h2_title\": \"Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromatin Remodeling\", \"h1_score\": 0.586, \"h2_score\": 0.5197455458759024, \"h1_gene\": \"TFAM, MT-CO1\", \"h2_gene\": \"SIRT1, FOXO3, NRF2, TFAM\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:08:54"},{"id":493,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-seaad-51323624\", \"h-trem2-3374766c\"]","similarity_score":0.629,"similarity_details":"{\"h1_title\": \"Cell-Type Specific TREM2 Upregulation in DAM Microglia\", \"h2_title\": \"Stage-Selective TREM2 Agonism \\u2014 Boosting DAM Phagocytosis in Early Amyloid Phase\", \"h1_score\": 0.5111092392142317, \"h2_score\": 0.4629727942033197, \"h1_gene\": \"TREM2\", \"h2_gene\": \"TREM2\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 07:31:57"},{"id":1640,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-5626c1f2\", \"h-5afacdfe\"]","similarity_score":0.628,"similarity_details":"{\"h1_title\": \"Temporal Metabolic Window Therapy\", \"h2_title\": \"Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammation-Metabolism Interfa\", \"h1_score\": 0.64, \"h2_score\": 0.616, \"h1_gene\": \"HMGCS2\", \"h2_gene\": \"LDHA, TREM2\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:08:54"},{"id":1658,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-420db533\", \"h-5afacdfe\"]","similarity_score":0.627,"similarity_details":"{\"h1_title\": \"Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammation-Metabolism Interfa\", \"h2_title\": \"CRISPR-Mediated Mitochondrial Genome Editing for Complex I Dysfunction\", \"h1_score\": 0.616, \"h2_score\": 0.4937559876429708, \"h1_gene\": \"LDHA, TREM2\", \"h2_gene\": \"MT-ND1, MT-ND4, MT-ND6\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:41:47"},{"id":437,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-62e56eb9\", \"h-807d7a82\"]","similarity_score":0.625,"similarity_details":"{\"h1_title\": \"SASP-Driven Aquaporin-4 Dysregulation\", \"h2_title\": \"Glymphatic System-Enhanced Antibody Clearance Reversal\", \"h1_score\": 0.5890214174943402, \"h2_score\": 0.5366278533187234, \"h1_gene\": \"AQP4\", \"h2_gene\": \"AQP4\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 06:34:38"},{"id":1967,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-11ba42d0\", \"h-44195347\"]","similarity_score":0.619,"similarity_details":"{\"h1_title\": \"APOE4-Specific Lipidation Enhancement Therapy\", \"h2_title\": \"APOE4 Allosteric Rescue via Small Molecule Chaperones\", \"h1_score\": 0.845, \"h2_score\": 0.5417094030819009, \"h1_gene\": \"APOE\", \"h2_gene\": \"APOE\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-13 22:22:46"},{"id":1965,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-11795af0\", \"h-11ba42d0\"]","similarity_score":0.616,"similarity_details":"{\"h1_title\": \"APOE4-Specific Lipidation Enhancement Therapy\", \"h2_title\": \"Selective APOE4 Degradation via Proteolysis Targeting Chimeras (PROTACs)\", \"h1_score\": 0.845, \"h2_score\": 0.5949978977528586, \"h1_gene\": \"APOE\", \"h2_gene\": \"APOE\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-13 22:22:46"},{"id":1832,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-2531ed61\", \"h-seaad-51323624\"]","similarity_score":0.613,"similarity_details":"{\"h1_title\": \"Disease-Associated Microglia Metabolic Reprogramming\", \"h2_title\": \"Cell-Type Specific TREM2 Upregulation in DAM Microglia\", \"h1_score\": 0.651, \"h2_score\": 0.4996093158168519, \"h1_gene\": \"TREM2\", \"h2_gene\": \"TREM2\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 13:44:51"},{"id":2084,"recommendation_type":"merge_gaps","source_ids":"[\"gap-debate-20260410-112718-0b78e493\", \"gap-debate-20260410-112741-51d89235\"]","similarity_score":0.613,"similarity_details":"{\"g1_title\": \"What specific gene expression signatures in aging mouse white matter predict hum\", \"g2_title\": \"What specific gene expression signatures in aging mouse brain predict human AD v\", \"g1_domain\": \"neurodegeneration\", \"g2_domain\": \"neurodegeneration\", \"title_sim\": 0.8, \"desc_sim\": 0.333}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-16 08:29:33"},{"id":1651,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-c69709f5\", \"h-e003a35e\"]","similarity_score":0.612,"similarity_details":"{\"h1_title\": \"Astrocyte Metabolic Memory Reprogramming\", \"h2_title\": \"Oligodendrocyte Remyelination Enhancement\", \"h1_score\": 0.647, \"h2_score\": 0.4742859141237619, \"h1_gene\": \"SIRT1\", \"h2_gene\": \"TREM2\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:41:47"},{"id":1649,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-1e4bba56\", \"h-c69709f5\"]","similarity_score":0.611,"similarity_details":"{\"h1_title\": \"Astrocyte Metabolic Memory Reprogramming\", \"h2_title\": \"TFEB-Independent Autophagy Bypass\", \"h1_score\": 0.647, \"h2_score\": 0.510267159147721, \"h1_gene\": \"SIRT1\", \"h2_gene\": \"ULK1\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:41:47"},{"id":1656,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-3bfa414a\", \"h-5626c1f2\"]","similarity_score":0.61,"similarity_details":"{\"h1_title\": \"Temporal Metabolic Window Therapy\", \"h2_title\": \"Astrocyte-Mediated Microglial Memory Erasure\", \"h1_score\": 0.64, \"h2_score\": 0.4622222222222222, \"h1_gene\": \"HMGCS2\", \"h2_gene\": \"GFAP, S100B\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:41:47"},{"id":2067,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-2ff49342\", \"h-61196ade\"]","similarity_score":0.604,"similarity_details":"{\"h1_title\": \"TREM2-Dependent Microglial Senescence Transition\", \"h2_title\": \"TREM2-Microglial Clearance Enhancement as Common Mechanism for Injury Prevention\", \"h1_score\": 0.692336, \"h2_score\": 0.604, \"h1_gene\": \"TREM2\", \"h2_gene\": \"TREM2\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-16 08:29:30"},{"id":1674,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-28d5b559\", \"h-3bfa414a\"]","similarity_score":0.603,"similarity_details":"{\"h1_title\": \"Mitochondrial Biogenesis Rate as a Dynamic Biomarker of Neuroprotection\", \"h2_title\": \"Astrocyte-Mediated Microglial Memory Erasure\", \"h1_score\": 0.586, \"h2_score\": 0.4622222222222222, \"h1_gene\": \"TFAM, MT-CO1\", \"h2_gene\": \"GFAP, S100B\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:41:47"},{"id":2083,"recommendation_type":"merge_gaps","source_ids":"[\"gap-debate-20260410-112700-e284319e\", \"gap-debate-20260410-112741-51d89235\"]","similarity_score":0.6,"similarity_details":"{\"g1_title\": \"Which specific aging-related gene expression changes in mouse brain predict huma\", \"g2_title\": \"What specific gene expression signatures in aging mouse brain predict human AD v\", \"g1_domain\": \"neurodegeneration\", \"g2_domain\": \"neurodegeneration\", \"title_sim\": 0.688, \"desc_sim\": 0.468}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-16 08:29:33"},{"id":1637,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-5afacdfe\", \"h-c69709f5\"]","similarity_score":0.598,"similarity_details":"{\"h1_title\": \"Astrocyte Metabolic Memory Reprogramming\", \"h2_title\": \"Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammation-Metabolism Interfa\", \"h1_score\": 0.647, \"h2_score\": 0.616, \"h1_gene\": \"SIRT1\", \"h2_gene\": \"LDHA, TREM2\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:08:54"},{"id":1657,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-1e4bba56\", \"h-5afacdfe\"]","similarity_score":0.597,"similarity_details":"{\"h1_title\": \"Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammation-Metabolism Interfa\", \"h2_title\": \"TFEB-Independent Autophagy Bypass\", \"h1_score\": 0.616, \"h2_score\": 0.510267159147721, \"h1_gene\": \"LDHA, TREM2\", \"h2_gene\": \"ULK1\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:41:47"},{"id":1659,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-5afacdfe\", \"h-e003a35e\"]","similarity_score":0.597,"similarity_details":"{\"h1_title\": \"Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammation-Metabolism Interfa\", \"h2_title\": \"Oligodendrocyte Remyelination Enhancement\", \"h1_score\": 0.616, \"h2_score\": 0.4742859141237619, \"h1_gene\": \"LDHA, TREM2\", \"h2_gene\": \"TREM2\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:41:47"},{"id":477,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-d2722680\", \"h-d7121bcc\"]","similarity_score":0.596,"similarity_details":"{\"h1_title\": \"Epigenetic Memory Erasure via TET2 Activation\", \"h2_title\": \"TET2-Mediated Demethylation Rejuvenation Therapy\", \"h1_score\": 0.5289782753330702, \"h2_score\": 0.4706852221349085, \"h1_gene\": \"TET2\", \"h2_gene\": \"TET2\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 07:31:57"},{"id":1643,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-5afacdfe\", \"h-7c3c0f40\"]","similarity_score":0.596,"similarity_details":"{\"h1_title\": \"Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammation-Metabolism Interfa\", \"h2_title\": \"Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromatin Remodeling\", \"h1_score\": 0.616, \"h2_score\": 0.5197455458759024, \"h1_gene\": \"LDHA, TREM2\", \"h2_gene\": \"SIRT1, FOXO3, NRF2, TFAM\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 08:08:54"},{"id":1808,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-2531ed61\", \"h-722ec547\"]","similarity_score":0.59,"similarity_details":"{\"h1_title\": \"Disease-Associated Microglia Metabolic Reprogramming\", \"h2_title\": \"TREM2-Mediated Microglial Checkpoint Therapy\", \"h1_score\": 0.651, \"h2_score\": 0.593, \"h1_gene\": \"TREM2\", \"h2_gene\": \"TREM2\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 13:07:20"},{"id":447,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-61196ade\", \"h_seaad_001\"]","similarity_score":0.589,"similarity_details":"{\"h1_title\": \"TREM2-Dependent Microglial Senescence Transition\", \"h2_title\": \"Microglial TREM2 downregulation impairs damage-associated response in late-stage\", \"h1_score\": 0.6582789999966631, \"h2_score\": 0.5114280649218587, \"h1_gene\": \"TREM2\", \"h2_gene\": \"TREM2\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 07:31:57"},{"id":1831,"recommendation_type":"merge_hypotheses","source_ids":"[\"h-2531ed61\", \"h_seaad_001\"]","similarity_score":0.584,"similarity_details":"{\"h1_title\": \"Disease-Associated Microglia Metabolic Reprogramming\", \"h2_title\": \"Microglial TREM2 downregulation impairs damage-associated response in late-stage\", \"h1_score\": 0.651, \"h2_score\": 0.5066663404251993, \"h1_gene\": \"TREM2\", \"h2_gene\": \"TREM2\"}","recommended_action":"merge","status":"pending","reviewed_by":null,"reviewed_at":null,"execution_transform_id":null,"created_at":"2026-04-12 13:44:51"}],"count":50}