{"nodes":[{"id":"PV+ interneurons","type":"cell_type"},{"id":"tau propagation","type":"process"},{"id":"PV interneuron function","type":"process"},{"id":"amyloid burden","type":"phenotype"},{"id":"temporal coordination of pyramidal cell ensembles","type":"process"},{"id":"early Alzheimer's disease","type":"disease"},{"id":"TREM2","type":"gene","has_wiki":true,"wiki_url":"https://neurowiki.xyz/trem2","wiki_entity":"TREM2"},{"id":"PV interneuron loss","type":"phenotype"},{"id":"PV+ basket cells","type":"cell_type"},{"id":"natural sensory input loss","type":"mechanism"},{"id":"gamma restoration","type":"process"},{"id":"theta_oscillations","type":"physiological_process"},{"id":"synaptic deficits","type":"mechanism"},{"id":"tau_protein","type":"protein"},{"id":"neural activity","type":"process"},{"id":"focused ultrasound","type":"device"},{"id":"gamma collapse","type":"phenotype"},{"id":"GABA release","type":"process"},{"id":"hyperphosphorylated tau","type":"protein"},{"id":"disinhibition of EC-II stellate cells","type":"process"},{"id":"amyloid/tau toxicity","type":"process"},{"id":"sess_ext_h-var-3b982ec3d2_20260428_045746","type":"debate_session_causal"},{"id":"noradrenaline depletion","type":"mechanism"},{"id":"sess_hypdebate_h_var_58e76ac310_20260427_120922","type":"debate_session_causal"},{"id":"glymphatic convective flow","type":"process"},{"id":"calcium influx","type":"mechanism"},{"id":"stellate cell burst firing","type":"phenotype"},{"id":"microglial activation","type":"process"},{"id":"cognitive function","type":"phenotype"},{"id":"hippocampal-cortical disconnection","type":"mechanism"},{"id":"PVALB expression","type":"biomarker"},{"id":"processed","type":"sentinel"},{"id":"neuronal loss","type":"phenotype"},{"id":"pyramidal neuron synchronization","type":"process"},{"id":"gamma entrainment","type":"process"},{"id":"transcranial focused ultrasound","type":"device"},{"id":"theta-gamma coupling","type":"mechanism"},{"id":"tACS","type":"method"},{"id":"mislocalization","type":"mechanism"},{"id":"EC layer II SST interneurons","type":"cell_type"},{"id":"amyloid pathology","type":"mechanism","has_wiki":true,"wiki_url":"/wiki/mechanisms-amyloid-pathology","wiki_entity":"amyloid-pathology"},{"id":"SST interneuron dysfunction","type":"cell_type"},{"id":"tau pathology","type":"protein"},{"id":"early MCI","type":"phenotype"},{"id":"thalamocortical synchronization","type":"mechanism"},{"id":"APP","type":"gene","has_wiki":true,"wiki_url":"/entity/APP","wiki_entity":"APP"},{"id":"Piezo1","type":"protein"},{"id":"glymphatic clearance","type":"process","has_wiki":true,"wiki_url":"/entity/glymphatic-clearance","wiki_entity":"glymphatic clearance"},{"id":"closed-loop neuromodulation","type":"process"},{"id":"deep brain structures","type":"brain_region"},{"id":"TFEB","type":"gene","has_wiki":true,"wiki_url":"https://neurowiki.xyz/search?q=TFEB","wiki_entity":"TFEB"},{"id":"PV interneuron dysfunction","type":"cell_type"},{"id":"VIP_interneurons","type":"cell_type"},{"id":"orthoproteostasis","type":"pathway"},{"id":"SST interneuron dysfunction","type":"mechanism"},{"id":"cognitive_impairment","type":"disease_phenotype"},{"id":"hippocampal_circuit","type":"pathway"},{"id":"theta-gamma coupling disruption","type":"mechanism"},{"id":"CHAT","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-chat","wiki_entity":"CHAT"},{"id":"Amyloid-beta-induced synaptic depression","type":"phenotype"},{"id":"sess-hyp-ec7c58c65ca5","type":"debate_session_causal"},{"id":"calcium buffering","type":"process"},{"id":"PV interneuron fast-spiking phenotype","type":"process"},{"id":"entorhinal cortex layer II","type":"brain_region"},{"id":"feedback inhibition loops","type":"process"},{"id":"inhibition restoration","type":"process"},{"id":"h-var-9c0368bb70","type":"hypothesis"},{"id":"PV interneuron dysfunction","type":"mechanism"},{"id":"sess_hypdebate_h_var_b7e4505525_20260426_163210","type":"debate_session_causal"},{"id":"PVALB","type":"protein","has_wiki":true,"wiki_url":"/wiki/genes-pvalb","wiki_entity":"PVALB"},{"id":"intervention window","type":"process"},{"id":"thalamus","type":"brain_region"},{"id":"direct pharmacological targeting","type":"process"},{"id":"tACS","type":"intervention"},{"id":"h-var-3b982ec3d2","type":"hypothesis"},{"id":"hippocampal-cortical gamma coherence","type":"process"},{"id":"hippocampal_neurogenesis_and_synaptic_plasticity","type":"pathway"},{"id":"PV+ interneuron activity","type":"cell_type"},{"id":"closed-loop gamma modulation","type":"process"},{"id":"Closed-loop tACS","type":"method"},{"id":"glymphatic function","type":"process"},{"id":"EC-II stellate cell disinhibition","type":"process"},{"id":"theta-gamma coupling disruption","type":"biomarker"},{"id":"diseases-vascular-cognitive-impairment","type":"disease"},{"id":"BDNF","type":"gene","has_wiki":true,"wiki_url":"/entity/BDNF","wiki_entity":"BDNF"},{"id":"PV+ interneuron activity","type":"process"},{"id":"neuroscience","type":"domain"},{"id":"excessive entorhinal-hippocampal signaling","type":"process"},{"id":"pyramidal cell network synchronization","type":"process"},{"id":"MAPT","type":"gene","has_wiki":true,"wiki_url":"/wiki/mechanisms-rtg4510-tau-transgenic","wiki_entity":"rTg4510 Tau Transgenic Mouse Model"},{"id":"perisomatic inhibition loss","type":"process"},{"id":"tau pathology","type":"mechanism"},{"id":"amyloid accumulation","type":"biomarker"},{"id":"spine generation","type":"mechanism"},{"id":"accelerated tau propagation","type":"mechanism"},{"id":"microglial phagocytosis","type":"mechanism","has_wiki":true,"wiki_url":"/wiki/mechanisms-microglial-phagocytosis","wiki_entity":"Microglial Phagocytosis in Neurodegeneration"},{"id":"sess_hypdebate_h_var_6612521a02_20260427_162437","type":"debate_session_causal"},{"id":"GABAergic interneuron networks","type":"pathway"},{"id":"excitotoxic cascades","type":"pathway"},{"id":"40Hz gamma entrainment","type":"process"},{"id":"oxidative stress in PV interneurons","type":"mechanism"},{"id":"perforant path input","type":"pathway"},{"id":"gamma_oscillations","type":"physiological_process"},{"id":"PSEN1","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-psen1","wiki_entity":"PSEN1"},{"id":"40Hz sensory stimulation","type":"process"},{"id":"thalamic relay neurons","type":"cell_type"},{"id":"SST_interneurons","type":"cell_type"},{"id":"gamma-frequency stimulation","type":"process"},{"id":"memory deficits","type":"phenotype"},{"id":"CA3","type":"gene"},{"id":"hippocampal-cortical connectivity restoration","type":"process"},{"id":"optogenetic targeting of PV interneurons","type":"drug"},{"id":"theta-gamma coupling restoration","type":"process"},{"id":"PSD95","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-psd95","wiki_entity":"PSD95"},{"id":"VIP","type":"gene"},{"id":"closed-loop tFUS","type":"drug"},{"id":"excitatory network hyperexcitability","type":"mechanism"},{"id":"GRIN2B","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-grin2b","wiki_entity":"GRIN2B"},{"id":"gamma-frequency oscillations","type":"process"},{"id":"synaptic_plasticity","type":"physiological_process","has_wiki":true,"wiki_url":"/wiki/mechanisms-synaptic-plasticity","wiki_entity":"Synaptic Plasticity Pathway"},{"id":"gamma oscillations","type":"process"},{"id":"amyloid-beta","type":"pathway"},{"id":"dendrite ramification","type":"phenotype"},{"id":"PV+ interneuron dysfunction","type":"mechanism"},{"id":"specific cell types","type":"process"},{"id":"Aβ","type":"protein"},{"id":"sess_hypdebate_h_var_58e76ac310_20260426_152757","type":"debate_session_causal"},{"id":"extrasynaptic GluN2B","type":"protein"},{"id":"spatial navigation deficits","type":"phenotype"},{"id":"fast-spiking interneuron firing","type":"phenotype"},{"id":"SST interneuron modulation","type":"mechanism"},{"id":"closed-loop tFUS","type":"device"},{"id":"clinical benefit in AD","type":"phenotype"},{"id":"PV interneuron vulnerability","type":"process"},{"id":"Gamma oscillations","type":"process"},{"id":"synaptic_plasticity","type":"pathway","has_wiki":true,"wiki_url":"/wiki/mechanisms-synaptic-plasticity","wiki_entity":"Synaptic Plasticity Pathway"},{"id":"closed-loop tACS","type":"drug"},{"id":"gamma entrainment responsiveness","type":"phenotype"},{"id":"gamma oscillation disruption","type":"mechanism"},{"id":"sess_ext_h-var-58e76ac310_20260428_050154","type":"debate_session_causal"},{"id":"VIP interneuron stimulation","type":"cell_type"},{"id":"SST interneurons","type":"cell_type"},{"id":"mild-cognitive-impairment","type":"disease","has_wiki":true,"wiki_url":"https://neurowiki.xyz/wiki/diseases/mild-cognitive-impairment","wiki_entity":"mild-cognitive-impairment"},{"id":"tau pathology","type":"pathway"},{"id":"HCN1","type":"protein","has_wiki":true,"wiki_url":"/wiki/genes-hcn1","wiki_entity":"HCN1"},{"id":"NMDA receptors","type":"protein"},{"id":"hippocampal-cortical connectivity","type":"process"},{"id":"pyramidal cells","type":"cell_type"},{"id":"AIS dysfunction","type":"mechanism"},{"id":"GluN2B modulation","type":"protein"},{"id":"CaMKII_protein","type":"protein"},{"id":"SST interneuron dysfunction","type":"process"},{"id":"Tau Pathology","type":"phenotype"},{"id":"pyramidal cell firing synchronization","type":"process"},{"id":"h-a635d4e5","type":"hypothesis"},{"id":"gamma oscillation dynamics","type":"process"},{"id":"Hippocampal electrophysiological disintegration","type":"phenotype"},{"id":"locus_coeruleus_hippocampus_pathway","type":"pathway"},{"id":"prefrontal_inhibitory_circuits","type":"pathway"},{"id":"PVALB/SST","type":"gene"},{"id":"sess_hypdeb_h_var_55da4f915d_20260427_110829","type":"debate_session_causal"},{"id":"hippocampal-cortical coherence","type":"process"},{"id":"CREB shutdown pathways","type":"pathway"},{"id":"PV interneuron dysfunction","type":"process"},{"id":"Alzheimer's disease","type":"disease"},{"id":"PV_interneurons","type":"cell_type"},{"id":"tau release","type":"process"},{"id":"tau pathology","type":"disease"},{"id":"personalized dosing","type":"process"},{"id":"SST+ interneurons","type":"cell_type"},{"id":"thalamocortical_circuit","type":"pathway"},{"id":"neuromodulation","type":"process"},{"id":"sess-hyp-a599791d4367","type":"debate_session_causal"},{"id":"tFUS","type":"drug"},{"id":"Alzheimer's disease pathology","type":"disease"},{"id":"optogenetic activation of SST interneurons","type":"mechanism"},{"id":"amyloid accumulation","type":"phenotype"},{"id":"excitatory transmission","type":"mechanism"},{"id":"pyramidal cell disinhibition","type":"mechanism"},{"id":"Kv3 potassium channels","type":"protein"},{"id":"HDAC","type":"gene","has_wiki":true,"wiki_url":"/entity/HDAC","wiki_entity":"HDAC"},{"id":"CERC-301","type":"drug"},{"id":"memory impairment in Alzheimer's disease","type":"phenotype"},{"id":"theta oscillation restoration","type":"mechanism"},{"id":"tau pathology reduction","type":"mechanism"},{"id":"sess_hypdebate_h_var_e2b5a7e7db_20260427_111653","type":"debate_session_causal"},{"id":"PVALB","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-pvalb","wiki_entity":"PVALB"},{"id":"amyloid plaque burden","type":"phenotype"},{"id":"Kv3.1/3.2 potassium channels","type":"protein"},{"id":"functional circuits","type":"process"},{"id":"slow oscillation synchrony","type":"process"},{"id":"RAB7","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-rab7","wiki_entity":"RAB7"},{"id":"Locus coeruleus to hippocampus spread","type":"phenotype"},{"id":"invasive electrodes","type":"device"},{"id":"Kv3.1/3.2 channel agonists","type":"drug"},{"id":"optogenetic activation of PV interneurons","type":"mechanism"},{"id":"microglial phagocytosis","type":"process","has_wiki":true,"wiki_url":"/wiki/mechanisms-microglial-phagocytosis","wiki_entity":"Microglial Phagocytosis in Neurodegeneration"},{"id":"diseases-ftd","type":"disease"},{"id":"excitatory-inhibitory balance","type":"process"},{"id":"gamma oscillation restoration","type":"mechanism"},{"id":"sess_hypdebate_h_var_58e76ac310_20260427_121018","type":"debate_session_causal"},{"id":"theta_oscillations","type":"phenotype"},{"id":"SST","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-sst","wiki_entity":"SST"},{"id":"AIS disruption","type":"mechanism"},{"id":"tFUS","type":"device"},{"id":"spine generation","type":"phenotype"},{"id":"SST interneuron hyperactivity","type":"process"},{"id":"sess-hyp-87b85c3b19fe","type":"debate_session_causal"},{"id":"AMYLOID BETA OLIGOMERS","type":"protein"},{"id":"SST interneuron activity reduction","type":"process"},{"id":"Gamma frequency stimulation","type":"process"},{"id":"transcranial focused ultrasound (tFUS)","type":"device"},{"id":"Entorhinal cortex layer II","type":"brain_region"},{"id":"HCN1 dysfunction","type":"mechanism"},{"id":"inhibitory tone","type":"process"},{"id":"sess-hyp-9935d8a1fc17","type":"debate_session_causal"},{"id":"theta_oscillation","type":"pathway"},{"id":"PVALB dysfunction","type":"process"},{"id":"pyramidal cell inhibition","type":"process"},{"id":"neuroscience","type":"disease"},{"id":"PV+ interneuron dysfunction","type":"cell_type"},{"id":"neural activity in deep brain structures","type":"process"},{"id":"h-23b94ed8","type":"hypothesis"},{"id":"Parvalbumin","type":"protein"},{"id":"cholinergic_signaling","type":"pathway"},{"id":"hippocampal circuit dysfunction","type":"mechanism"},{"id":"h-var-6612521a02","type":"hypothesis"},{"id":"Tau pathology","type":"protein"},{"id":"neurodegeneration","type":"disease"},{"id":"sess_hypdebate_h_var_e95d2d1d86_20260426_163445","type":"debate_session_causal"},{"id":"neural synchronization","type":"process"},{"id":"closed-loop gamma detection","type":"device"},{"id":"sess_hypdebate_h_var_d749cd28cb_20260427_162943","type":"debate_session_causal"},{"id":"closed-loop tACS","type":"intervention"},{"id":"perforant path","type":"pathway"},{"id":"neuronal activity","type":"process"},{"id":"gamma oscillation disruption","type":"process"},{"id":"AD-related hyperexcitability","type":"phenotype"},{"id":"aberrant gamma oscillations","type":"mechanism"},{"id":"GluN2B_receptor","type":"protein"},{"id":"amyloid-beta oligomers","type":"pathway"},{"id":"Prefrontal inhibitory circuits","type":"pathway"},{"id":"PVALB interneuron recruitment","type":"mechanism"},{"id":"gamma oscillations at 40Hz","type":"mechanism"},{"id":"h-f8316acf","type":"hypothesis"},{"id":"Gamma oscillation disruption","type":"process"},{"id":"PV+ interneuron loss","type":"mechanism"},{"id":"Noradrenergic projections","type":"pathway"},{"id":"rTg4510 model","type":"process"},{"id":"sess-hyp-8a90163989de","type":"debate_session_causal"},{"id":"diseases-corticobasal-syndrome","type":"disease"},{"id":"default_mode_network","type":"brain_network"},{"id":"gamma desynchronization","type":"mechanism"},{"id":"early MCI","type":"disease"},{"id":"dendrite ramification","type":"mechanism"},{"id":"thalamocortical_synchrony","type":"pathway"},{"id":"Thalamocortical circuit dysfunction","type":"phenotype"},{"id":"CA1","type":"gene"},{"id":"pyramidal neuron ensembles","type":"process"},{"id":"EC-II stellate cells","type":"cell_type"},{"id":"P301S model","type":"process"},{"id":"CDK5","type":"gene","has_wiki":true,"wiki_url":"/entity/CDK5","wiki_entity":"CDK5"},{"id":"neural circuit modulation","type":"mechanism"},{"id":"hippocampal-cortical synchrony","type":"process"},{"id":"layer-specific targeting in entorhinal cortex","type":"process"},{"id":"acoustic diffraction","type":"process"},{"id":"closed-loop tACS","type":"device"},{"id":"theta-gamma decoupling","type":"mechanism"},{"id":"PV+ circuit activation","type":"mechanism"},{"id":"fast-spiking gamma oscillations","type":"process"},{"id":"amyloid-beta reduction","type":"phenotype"},{"id":"tau propagation along perforant path","type":"mechanism"},{"id":"Gamma entrainment","type":"process"},{"id":"PV+ interneuron function","type":"process"},{"id":"MAPK","type":"gene"},{"id":"calcium dysregulation in PV interneurons","type":"mechanism"},{"id":"neuronal populations","type":"cell_type"},{"id":"rTg4510 mouse model","type":"model"},{"id":"excitatory transmission","type":"process"},{"id":"gamma synchronization precision","type":"mechanism"},{"id":"h-7110565d","type":"hypothesis"},{"id":"reduced feedforward inhibitory control","type":"process"},{"id":"VGSC clustering at AIS","type":"mechanism"},{"id":"AQP4","type":"gene","has_wiki":true,"wiki_url":"/entity/AQP4","wiki_entity":"AQP4"},{"id":"hippocampal-cortical connectivity disruption","type":"process"},{"id":"dendritic inhibition","type":"process"},{"id":"TRPA1","type":"protein","has_wiki":true,"wiki_url":"/wiki/genes-trpa1","wiki_entity":"TRPA1"},{"id":"gamma_oscillation","type":"pathway"},{"id":"synaptic depression","type":"mechanism"},{"id":"Tau propagation","type":"mechanism"},{"id":"TREK-1","type":"protein","has_wiki":true,"wiki_url":"/wiki/proteins-trek1-protein","wiki_entity":"TREK-1"},{"id":"hippocampal CA1 pyramidal neurons","type":"cell_type"},{"id":"cognitive deficits","type":"phenotype"},{"id":"PNN integrity loss","type":"mechanism"},{"id":"major depression","type":"disease"},{"id":"h-cd60e2ec","type":"hypothesis"},{"id":"EC-II","type":"brain_region"},{"id":"cortical slow oscillations","type":"process"},{"id":"neurons in focal volume","type":"cell_type"},{"id":"APOE","type":"gene","has_wiki":true,"wiki_url":"/entity/APOE","wiki_entity":"APOE"},{"id":"tau pathology","type":"process"},{"id":"optogenetic gamma stimulation","type":"method"},{"id":"GABA-A receptor modulators","type":"drug"},{"id":"h-62c78d8b","type":"hypothesis"},{"id":"memory consolidation","type":"phenotype"},{"id":"closed-loop feedback","type":"process"},{"id":"cortical slow oscillation","type":"process"},{"id":"slow-wave sleep","type":"process"},{"id":"thalamic stimulation","type":"process"},{"id":"SST interneuron activity","type":"process"},{"id":"PVALB interneurons","type":"cell_type"},{"id":"cholinergic circuit degeneration","type":"mechanism"},{"id":"amyloid-β oligomers","type":"protein"},{"id":"gabaergic_interneuron_networks","type":"pathway"},{"id":"PS19 mouse model","type":"model"},{"id":"AnkyrinG","type":"protein"},{"id":"gamma rhythm disruption","type":"phenotype"},{"id":"SST+ interneuron dysfunction","type":"process"},{"id":"cognitive decline prevention","type":"phenotype"},{"id":"Memory Impairment","type":"phenotype"},{"id":"brain-wide clearance","type":"process"},{"id":"alzheimer_s_disease","type":"disease"},{"id":"hippocampal-cortical disconnect","type":"mechanism"},{"id":"sess-hyp-85e15db6a836","type":"debate_session_causal"},{"id":"CaMKII","type":"protein"},{"id":"SST peptide signaling","type":"pathway"},{"id":"restoration of gamma oscillations","type":"mechanism"},{"id":"PVALB basket cells","type":"cell_type"},{"id":"Optogenetics","type":"method"},{"id":"PV+ interneuron dysfunction","type":"process"},{"id":"soluble amyloid-beta oligomers","type":"protein"},{"id":"closed-loop transcranial focused ultrasound","type":"device"},{"id":"CAMK2A","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-camk2a","wiki_entity":"CAMK2A"},{"id":"CSF1R","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-csf1r","wiki_entity":"CSF1R"},{"id":"PV interneurons","type":"cell_type"},{"id":"EC layer II","type":"brain_region"},{"id":"choline_acetyltransferase","type":"protein"},{"id":"SST interneuron function","type":"process"},{"id":"RAB5","type":"gene","has_wiki":true,"wiki_url":"/wiki/proteins-rab5-protein","wiki_entity":"RAB5"},{"id":"impaired dendritic integration","type":"mechanism"},{"id":"gamma oscillations (40Hz)","type":"mechanism"},{"id":"cognitive decline in Alzheimer's disease","type":"phenotype"},{"id":"stellate projection neurons","type":"cell_type"},{"id":"PV+ interneuron loss","type":"process"},{"id":"sess_SDA-2026-04-03-26abc5e5f9f2","type":"debate_session_causal"},{"id":"APOE4","type":"gene","has_wiki":true,"wiki_url":"/entity/APOE4","wiki_entity":"APOE4"},{"id":"cognitive decline","type":"phenotype"},{"id":"GAD1","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-gad1","wiki_entity":"GAD1"},{"id":"diseases-psp","type":"disease"}],"edges":[{"source_id":"SST","source_type":"gene","target_id":"GABAergic interneuron networks","target_type":"pathway","relation":"participates_in","evidence_strength":0.7047869230769233,"evidence_sources":null,"analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"Sst","target_canonical_id":"GABAergic interneuron networks","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PVALB","source_type":"gene","target_id":"Prefrontal inhibitory circuits","target_type":"pathway","relation":"participates_in","evidence_strength":0.6919984423076924,"evidence_sources":null,"analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"Pvalb","target_canonical_id":"Prefrontal inhibitory circuits","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST","source_type":"gene","target_id":"neuroscience","target_type":"domain","relation":"studied_in","evidence_strength":0.6,"evidence_sources":null,"analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"Sst","target_canonical_id":"neuroscience","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PVALB","source_type":"gene","target_id":"neuroscience","target_type":"domain","relation":"studied_in","evidence_strength":0.6,"evidence_sources":null,"analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"Pvalb","target_canonical_id":"neuroscience","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BDNF","source_type":"gene","target_id":"neuroscience","target_type":"domain","relation":"studied_in","evidence_strength":0.6,"evidence_sources":null,"analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"ent-gene-8c4c3123","target_canonical_id":"neuroscience","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PVALB","source_type":"gene","target_id":"Alzheimer's disease","target_type":"disease","relation":"associated_with","evidence_strength":0.6919984423076924,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"Pvalb","target_canonical_id":"Alzheimers Disease","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST","source_type":"gene","target_id":"Alzheimer's disease","target_type":"disease","relation":"associated_with","evidence_strength":0.7047869230769233,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"Sst","target_canonical_id":"Alzheimers Disease","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PVALB","source_type":"gene","target_id":"Alzheimer's disease","target_type":"disease","relation":"therapeutic_target","evidence_strength":0.7,"evidence_sources":null,"analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-02T17:42:09.857552-07:00","edge_type":"hypothesis_derived","source_canonical_id":"Pvalb","target_canonical_id":"Alzheimers Disease","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BDNF","source_type":"gene","target_id":"synaptic_plasticity","target_type":"pathway","relation":"activates","evidence_strength":0.9,"evidence_sources":null,"analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-02T17:42:09.857552-07:00","edge_type":"debate_derived","source_canonical_id":"ent-gene-8c4c3123","target_canonical_id":"SYNAPTIC_PLASTICITY","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST","source_type":"gene","target_id":"Alzheimer's disease","target_type":"disease","relation":"therapeutic_target","evidence_strength":0.76,"evidence_sources":null,"analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-02T17:42:09.857552-07:00","edge_type":"hypothesis_derived","source_canonical_id":"Sst","target_canonical_id":"Alzheimers Disease","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST","source_type":"gene","target_id":"gamma_oscillation","target_type":"pathway","relation":"regulates","evidence_strength":0.7,"evidence_sources":null,"analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-02T17:42:09.857552-07:00","edge_type":"debate_derived","source_canonical_id":"Sst","target_canonical_id":"gamma_oscillation","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BDNF","source_type":"gene","target_id":"Alzheimer's disease","target_type":"disease","relation":"targets","evidence_strength":0.71,"evidence_sources":"[\"PMID:40362507\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-02T17:42:09.857552-07:00","edge_type":"hypothesis_derived","source_canonical_id":"ent-gene-8c4c3123","target_canonical_id":"Alzheimers Disease","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"APP","source_type":"gene","target_id":"GAD1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":"hypothesis:h-62f9fc90","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-02T19:16:45.866404-07:00","edge_type":"hypothesis_cooccurrence","source_canonical_id":"ent-gene-961a77ee","target_canonical_id":"ent-gene-3aec55c3","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"RAB5","source_type":"gene","target_id":"TREM2","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":"hypothesis:h-bdbd2120","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-02T19:16:45.866404-07:00","edge_type":"hypothesis_cooccurrence","source_canonical_id":"Rab5","target_canonical_id":"Trem2","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BDNF","source_type":"gene","target_id":"CSF1R","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":"hypothesis:h-856feb98","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-02T19:16:45.866404-07:00","edge_type":"hypothesis_cooccurrence","source_canonical_id":"ent-gene-8c4c3123","target_canonical_id":"ent-gene-16cf4081","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BDNF","source_type":"gene","target_id":"TREM2","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":"hypothesis:h-856feb98","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-02T19:16:45.866404-07:00","edge_type":"hypothesis_cooccurrence","source_canonical_id":"ent-gene-8c4c3123","target_canonical_id":"Trem2","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"APOE4","source_type":"gene","target_id":"BDNF","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":"hypothesis:h-856feb98","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-02T19:16:45.866404-07:00","edge_type":"hypothesis_cooccurrence","source_canonical_id":"ent-prot-edb1aed8","target_canonical_id":"ent-gene-8c4c3123","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BDNF","source_type":"gene","target_id":"PSD95","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":"hypothesis:h-856feb98","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-02T19:16:45.866404-07:00","edge_type":"hypothesis_cooccurrence","source_canonical_id":"ent-gene-8c4c3123","target_canonical_id":"ent-gene-98f9aec0","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"RAB7","source_type":"gene","target_id":"TREM2","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":"hypothesis:h-bdbd2120","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-02T19:16:45.866404-07:00","edge_type":"hypothesis_cooccurrence","source_canonical_id":"Rab7","target_canonical_id":"Trem2","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"GAD1","source_type":"gene","target_id":"PSEN1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":"hypothesis:h-62f9fc90","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-02T19:16:45.866404-07:00","edge_type":"hypothesis_cooccurrence","source_canonical_id":"ent-gene-3aec55c3","target_canonical_id":"ent-gene-5b8aa21c","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"HDAC","source_type":"gene","target_id":"PSD95","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":"hypothesis:h-856feb98","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-02T19:16:45.866404-07:00","edge_type":"hypothesis_cooccurrence","source_canonical_id":"hdac","target_canonical_id":"ent-gene-98f9aec0","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CAMK2A","source_type":"gene","target_id":"neuroscience","target_type":"disease","relation":"associated_with","evidence_strength":0.5,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.032277-07:00","edge_type":"association","source_canonical_id":"Camk2A","target_canonical_id":"neuroscience","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"GRIN2B","source_type":"gene","target_id":"neuroscience","target_type":"disease","relation":"associated_with","evidence_strength":0.5,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.032277-07:00","edge_type":"association","source_canonical_id":"ent-gene-2fd14caf","target_canonical_id":"neuroscience","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"MAPT","source_type":"gene","target_id":"neuroscience","target_type":"disease","relation":"associated_with","evidence_strength":0.5,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.032277-07:00","edge_type":"association","source_canonical_id":"ent-gene-acc6d764","target_canonical_id":"neuroscience","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"VIP","source_type":"gene","target_id":"neuroscience","target_type":"disease","relation":"associated_with","evidence_strength":0.5,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.032277-07:00","edge_type":"association","source_canonical_id":"VIP","target_canonical_id":"neuroscience","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PVALB/SST","source_type":"gene","target_id":"neuroscience","target_type":"disease","relation":"associated_with","evidence_strength":0.5,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.032277-07:00","edge_type":"association","source_canonical_id":"pvalb_sst","target_canonical_id":"neuroscience","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CHAT","source_type":"gene","target_id":"neuroscience","target_type":"disease","relation":"associated_with","evidence_strength":0.5,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.032277-07:00","edge_type":"association","source_canonical_id":"ent-gene-720f3037","target_canonical_id":"neuroscience","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"GRIN2B","source_type":"gene","target_id":"PVALB/SST","target_type":"gene","relation":"co_associated_with","evidence_strength":0.4,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.048900-07:00","edge_type":"association","source_canonical_id":"ent-gene-2fd14caf","target_canonical_id":"pvalb_sst","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BDNF","source_type":"gene","target_id":"SST","target_type":"gene","relation":"co_associated_with","evidence_strength":0.4,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.048900-07:00","edge_type":"association","source_canonical_id":"ent-gene-8c4c3123","target_canonical_id":"Sst","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CAMK2A","source_type":"gene","target_id":"CHAT","target_type":"gene","relation":"co_associated_with","evidence_strength":0.4,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.048900-07:00","edge_type":"association","source_canonical_id":"Camk2A","target_canonical_id":"ent-gene-720f3037","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CAMK2A","source_type":"gene","target_id":"VIP","target_type":"gene","relation":"co_associated_with","evidence_strength":0.4,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.048900-07:00","edge_type":"association","source_canonical_id":"Camk2A","target_canonical_id":"VIP","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CAMK2A","source_type":"gene","target_id":"GRIN2B","target_type":"gene","relation":"co_associated_with","evidence_strength":0.4,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.048900-07:00","edge_type":"association","source_canonical_id":"Camk2A","target_canonical_id":"ent-gene-2fd14caf","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CHAT","source_type":"gene","target_id":"VIP","target_type":"gene","relation":"co_associated_with","evidence_strength":0.4,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.048900-07:00","edge_type":"association","source_canonical_id":"ent-gene-720f3037","target_canonical_id":"VIP","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CHAT","source_type":"gene","target_id":"GRIN2B","target_type":"gene","relation":"co_associated_with","evidence_strength":0.4,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.048900-07:00","edge_type":"association","source_canonical_id":"ent-gene-720f3037","target_canonical_id":"ent-gene-2fd14caf","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CAMK2A","source_type":"gene","target_id":"MAPT","target_type":"gene","relation":"co_associated_with","evidence_strength":0.4,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.048900-07:00","edge_type":"association","source_canonical_id":"Camk2A","target_canonical_id":"ent-gene-acc6d764","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CHAT","source_type":"gene","target_id":"MAPT","target_type":"gene","relation":"co_associated_with","evidence_strength":0.4,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.048900-07:00","edge_type":"association","source_canonical_id":"ent-gene-720f3037","target_canonical_id":"ent-gene-acc6d764","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"MAPT","source_type":"gene","target_id":"VIP","target_type":"gene","relation":"co_associated_with","evidence_strength":0.4,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.048900-07:00","edge_type":"association","source_canonical_id":"ent-gene-acc6d764","target_canonical_id":"VIP","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"GRIN2B","source_type":"gene","target_id":"MAPT","target_type":"gene","relation":"co_associated_with","evidence_strength":0.4,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.048900-07:00","edge_type":"association","source_canonical_id":"ent-gene-2fd14caf","target_canonical_id":"ent-gene-acc6d764","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BDNF","source_type":"gene","target_id":"PVALB","target_type":"gene","relation":"co_associated_with","evidence_strength":0.4,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.048900-07:00","edge_type":"association","source_canonical_id":"ent-gene-8c4c3123","target_canonical_id":"Pvalb","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"GRIN2B","source_type":"gene","target_id":"VIP","target_type":"gene","relation":"co_associated_with","evidence_strength":0.4,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.048900-07:00","edge_type":"association","source_canonical_id":"ent-gene-2fd14caf","target_canonical_id":"VIP","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CAMK2A","source_type":"gene","target_id":"PVALB/SST","target_type":"gene","relation":"co_associated_with","evidence_strength":0.4,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.048900-07:00","edge_type":"association","source_canonical_id":"Camk2A","target_canonical_id":"pvalb_sst","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CHAT","source_type":"gene","target_id":"PVALB/SST","target_type":"gene","relation":"co_associated_with","evidence_strength":0.4,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.048900-07:00","edge_type":"association","source_canonical_id":"ent-gene-720f3037","target_canonical_id":"pvalb_sst","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"MAPT","source_type":"gene","target_id":"PVALB/SST","target_type":"gene","relation":"co_associated_with","evidence_strength":0.4,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.048900-07:00","edge_type":"association","source_canonical_id":"ent-gene-acc6d764","target_canonical_id":"pvalb_sst","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PVALB/SST","source_type":"gene","target_id":"VIP","target_type":"gene","relation":"co_associated_with","evidence_strength":0.4,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T09:49:23.048900-07:00","edge_type":"association","source_canonical_id":"pvalb_sst","target_canonical_id":"VIP","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV_interneurons","source_type":"cell_type","target_id":"gamma_oscillations","target_type":"physiological_process","relation":"generates","evidence_strength":0.5,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:35:57-07:00","edge_type":"association","source_canonical_id":"pv_interneurons","target_canonical_id":"gamma_oscillation","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST_interneurons","source_type":"cell_type","target_id":"theta_oscillations","target_type":"physiological_process","relation":"generates","evidence_strength":0.5,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:35:57-07:00","edge_type":"association","source_canonical_id":"sst_interneurons","target_canonical_id":"theta_oscillations","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"GRIN2B","source_type":"gene","target_id":"GluN2B_receptor","target_type":"protein","relation":"encodes","evidence_strength":0.5,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:35:57-07:00","edge_type":"association","source_canonical_id":"ent-gene-2fd14caf","target_canonical_id":"glun2b_receptor","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"GluN2B_receptor","source_type":"protein","target_id":"thalamocortical_circuit","target_type":"pathway","relation":"modulates","evidence_strength":0.5,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:35:57-07:00","edge_type":"association","source_canonical_id":"glun2b_receptor","target_canonical_id":"Thalamocortical Circuit","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"thalamocortical_circuit","source_type":"pathway","target_id":"cognitive_impairment","target_type":"disease_phenotype","relation":"dysfunction_causes","evidence_strength":0.5,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:35:57-07:00","edge_type":"association","source_canonical_id":"Thalamocortical Circuit","target_canonical_id":"cognitive_impairment","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PVALB","source_type":"gene","target_id":"PV_interneurons","target_type":"cell_type","relation":"expressed_in","evidence_strength":0.5,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:35:57-07:00","edge_type":"association","source_canonical_id":"Pvalb","target_canonical_id":"pv_interneurons","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST","source_type":"gene","target_id":"SST_interneurons","target_type":"cell_type","relation":"expressed_in","evidence_strength":0.5,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:35:57-07:00","edge_type":"association","source_canonical_id":"Sst","target_canonical_id":"sst_interneurons","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"VIP","source_type":"gene","target_id":"VIP_interneurons","target_type":"cell_type","relation":"expressed_in","evidence_strength":0.5,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:35:58-07:00","edge_type":"association","source_canonical_id":"VIP","target_canonical_id":"vip_interneurons","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"choline_acetyltransferase","source_type":"protein","target_id":"cholinergic_signaling","target_type":"pathway","relation":"catalyzes","evidence_strength":0.5,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:35:58-07:00","edge_type":"association","source_canonical_id":"CHOLINEACETYLTRANSFERASE","target_canonical_id":"cholinergic signaling","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"VIP_interneurons","source_type":"cell_type","target_id":"default_mode_network","target_type":"brain_network","relation":"modulates","evidence_strength":0.5,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:35:58-07:00","edge_type":"association","source_canonical_id":"vip_interneurons","target_canonical_id":"default-mode network","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CHAT","source_type":"gene","target_id":"choline_acetyltransferase","target_type":"protein","relation":"encodes","evidence_strength":0.5,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:35:58-07:00","edge_type":"association","source_canonical_id":"ent-gene-720f3037","target_canonical_id":"CHOLINEACETYLTRANSFERASE","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"MAPT","source_type":"gene","target_id":"tau_protein","target_type":"protein","relation":"encodes","evidence_strength":0.5,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:35:58-07:00","edge_type":"association","source_canonical_id":"ent-gene-acc6d764","target_canonical_id":"tau protein","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"tau_protein","source_type":"protein","target_id":"locus_coeruleus_hippocampus_pathway","target_type":"pathway","relation":"propagates_through","evidence_strength":0.5,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:35:58-07:00","edge_type":"association","source_canonical_id":"tau protein","target_canonical_id":"locus_coeruleus_hippocampus_pathway","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CAMK2A","source_type":"gene","target_id":"CaMKII_protein","target_type":"protein","relation":"encodes","evidence_strength":0.5,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:35:58-07:00","edge_type":"association","source_canonical_id":"Camk2A","target_canonical_id":"CAMKIIPROTEIN","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CaMKII_protein","source_type":"protein","target_id":"synaptic_plasticity","target_type":"physiological_process","relation":"promotes","evidence_strength":0.5,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:35:58-07:00","edge_type":"association","source_canonical_id":"CAMKIIPROTEIN","target_canonical_id":"SYNAPTIC_PLASTICITY","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"VIP interneuron stimulation","source_type":"cell_type","target_id":"pyramidal cell disinhibition","target_type":"mechanism","relation":"causes (VIP interneuron-mediated disinhibition allows pyra)","evidence_strength":0.73,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\", \"PMID:34222873\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:36:10-07:00","edge_type":"causal","source_canonical_id":"vip_interneuron_stimulation","target_canonical_id":"pyramidal_cell_disinhibition","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":{"method":"scidex.atlas.edge_quality_scorecard.v1","edge_id":null,"edge_type":"causal","n_studies":1,"study_ids":{"dois":[],"pmids":["34222873"]},"generated_at":"2026-04-28T05:46:31.124446+00:00","retraction_check":{"status":"no_retraction_signal","retracted_ids":[],"checked_studies":1,"retracted_count":0},"instrument_strength":null,"identification_strategy":"literature_causal_claim","contradicting_evidence_count":0}},{"source_id":"noradrenaline depletion","source_type":"mechanism","target_id":"synaptic deficits","target_type":"mechanism","relation":"causes (selective noradrenaline depletion exacerbates syna)","evidence_strength":0.45,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\", \"PMID:22883210\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:36:10-07:00","edge_type":"causal","source_canonical_id":"noradrenaline_depletion","target_canonical_id":"Synaptic Deficits","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":{"method":"scidex.atlas.edge_quality_scorecard.v1","edge_id":null,"edge_type":"causal","n_studies":1,"study_ids":{"dois":[],"pmids":["22883210"]},"generated_at":"2026-04-28T05:46:31.108421+00:00","retraction_check":{"status":"no_retraction_signal","retracted_ids":[],"checked_studies":1,"retracted_count":0},"instrument_strength":null,"identification_strategy":"literature_causal_claim","contradicting_evidence_count":0}},{"source_id":"optogenetic activation of SST interneurons","source_type":"mechanism","target_id":"theta oscillation restoration","target_type":"mechanism","relation":"causes (optogenetic activation selectively restores theta )","evidence_strength":0.82,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\", \"PMID:32107637\", \"PMID:31937327\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:36:10-07:00","edge_type":"causal","source_canonical_id":"optogenetic_activation_of_pv_interneurons","target_canonical_id":"theta_oscillation_restoration","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":{"method":"scidex.atlas.edge_quality_scorecard.v1","edge_id":null,"edge_type":"causal","n_studies":2,"study_ids":{"dois":[],"pmids":["31937327","32107637"]},"generated_at":"2026-04-28T05:46:31.094949+00:00","retraction_check":{"status":"no_retraction_signal","retracted_ids":[],"checked_studies":2,"retracted_count":0},"instrument_strength":null,"identification_strategy":"literature_causal_claim","contradicting_evidence_count":0}},{"source_id":"optogenetic activation of PV interneurons","source_type":"mechanism","target_id":"gamma oscillation restoration","target_type":"mechanism","relation":"causes (optogenetic activation selectively restores gamma )","evidence_strength":0.82,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\", \"PMID:32107637\", \"PMID:31937327\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:36:10-07:00","edge_type":"causal","source_canonical_id":"optogenetic_activation_of_pv_interneurons","target_canonical_id":"gamma_oscillation_restoration","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":{"method":"scidex.atlas.edge_quality_scorecard.v1","edge_id":null,"edge_type":"causal","n_studies":2,"study_ids":{"dois":[],"pmids":["31937327","32107637"]},"generated_at":"2026-04-28T05:46:31.140179+00:00","retraction_check":{"status":"no_retraction_signal","retracted_ids":[],"checked_studies":2,"retracted_count":0},"instrument_strength":null,"identification_strategy":"literature_causal_claim","contradicting_evidence_count":0}},{"source_id":"natural sensory input loss","source_type":"mechanism","target_id":"cholinergic circuit degeneration","target_type":"mechanism","relation":"causes (loss of natural sensory input leads to degeneratio)","evidence_strength":0.65,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\", \"PMID:25452715\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:36:10-07:00","edge_type":"causal","source_canonical_id":"natural_sensory_input_loss","target_canonical_id":"cholinergic_circuit_degeneration","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":{"method":"scidex.atlas.edge_quality_scorecard.v1","edge_id":null,"edge_type":"causal","n_studies":1,"study_ids":{"dois":[],"pmids":["25452715"]},"generated_at":"2026-04-28T05:46:31.116410+00:00","retraction_check":{"status":"no_retraction_signal","retracted_ids":[],"checked_studies":1,"retracted_count":0},"instrument_strength":null,"identification_strategy":"literature_causal_claim","contradicting_evidence_count":0}},{"source_id":"NMDA receptors","source_type":"protein","target_id":"synaptic depression","target_type":"mechanism","relation":"causes (NMDA receptors mediate synaptic depression in amyl)","evidence_strength":0.45,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\", \"PMID:30352630\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:36:10-07:00","edge_type":"causal","source_canonical_id":"NMDA receptors","target_canonical_id":"Synaptic Depression","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":{"method":"scidex.atlas.edge_quality_scorecard.v1","edge_id":null,"edge_type":"causal","n_studies":1,"study_ids":{"dois":[],"pmids":["30352630"]},"generated_at":"2026-04-28T05:46:31.101148+00:00","retraction_check":{"status":"no_retraction_signal","retracted_ids":[],"checked_studies":1,"retracted_count":0},"instrument_strength":null,"identification_strategy":"literature_causal_claim","contradicting_evidence_count":0}},{"source_id":"amyloid-β oligomers","source_type":"protein","target_id":"PV interneurons","target_type":"cell_type","relation":"causes (specifically disrupt parvalbumin-positive interneu)","evidence_strength":0.82,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\", \"PMID:32107637\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:36:10-07:00","edge_type":"causal","source_canonical_id":"AMYLOID-Β OLIGOMERS","target_canonical_id":"pv_interneurons_1","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":{"method":"scidex.atlas.edge_quality_scorecard.v1","edge_id":null,"edge_type":"causal","n_studies":1,"study_ids":{"dois":[],"pmids":["32107637"]},"generated_at":"2026-04-28T05:46:31.205234+00:00","retraction_check":{"status":"no_retraction_signal","retracted_ids":[],"checked_studies":1,"retracted_count":0},"instrument_strength":null,"identification_strategy":"literature_causal_claim","contradicting_evidence_count":0}},{"source_id":"CaMKII","source_type":"protein","target_id":"spine generation","target_type":"mechanism","relation":"causes (CaMKII-dependent process that promotes spine gener)","evidence_strength":0.75,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\", \"PMID:25457025\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:36:10-07:00","edge_type":"causal","source_canonical_id":"CaMKII","target_canonical_id":"spine_generation","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":{"method":"scidex.atlas.edge_quality_scorecard.v1","edge_id":null,"edge_type":"causal","n_studies":1,"study_ids":{"dois":[],"pmids":["25457025"]},"generated_at":"2026-04-28T05:46:31.182332+00:00","retraction_check":{"status":"no_retraction_signal","retracted_ids":[],"checked_studies":1,"retracted_count":0},"instrument_strength":null,"identification_strategy":"literature_causal_claim","contradicting_evidence_count":0}},{"source_id":"GluN2B modulation","source_type":"protein","target_id":"thalamocortical synchronization","target_type":"mechanism","relation":"causes (selective modulation of GluN2B-containing NMDA rec)","evidence_strength":0.78,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\", \"PMID:19449329\", \"PMID:23431156\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:36:10-07:00","edge_type":"causal","source_canonical_id":"glun2b_modulation","target_canonical_id":"thalamocortical_synchronization","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":{"method":"scidex.atlas.edge_quality_scorecard.v1","edge_id":null,"edge_type":"causal","n_studies":2,"study_ids":{"dois":[],"pmids":["19449329","23431156"]},"generated_at":"2026-04-28T05:46:31.156625+00:00","retraction_check":{"status":"no_retraction_signal","retracted_ids":[],"checked_studies":2,"retracted_count":0},"instrument_strength":null,"identification_strategy":"literature_causal_claim","contradicting_evidence_count":0}},{"source_id":"amyloid-β oligomers","source_type":"protein","target_id":"SST interneurons","target_type":"cell_type","relation":"causes (specifically disrupt somatostatin-positive interne)","evidence_strength":0.82,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\", \"PMID:32107637\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:36:10-07:00","edge_type":"causal","source_canonical_id":"AMYLOID-Β OLIGOMERS","target_canonical_id":"sst_interneurons","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":{"method":"scidex.atlas.edge_quality_scorecard.v1","edge_id":null,"edge_type":"causal","n_studies":1,"study_ids":{"dois":[],"pmids":["32107637"]},"generated_at":"2026-04-28T05:46:31.085377+00:00","retraction_check":{"status":"no_retraction_signal","retracted_ids":[],"checked_studies":1,"retracted_count":0},"instrument_strength":null,"identification_strategy":"literature_causal_claim","contradicting_evidence_count":0}},{"source_id":"CaMKII","source_type":"protein","target_id":"dendrite ramification","target_type":"mechanism","relation":"causes (CaMKII enhancement promotes dendrite ramification )","evidence_strength":0.75,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\", \"PMID:25457025\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:36:10-07:00","edge_type":"causal","source_canonical_id":"CaMKII","target_canonical_id":"dendrite_ramification","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":{"method":"scidex.atlas.edge_quality_scorecard.v1","edge_id":null,"edge_type":"causal","n_studies":1,"study_ids":{"dois":[],"pmids":["25457025"]},"generated_at":"2026-04-28T05:46:31.193373+00:00","retraction_check":{"status":"no_retraction_signal","retracted_ids":[],"checked_studies":1,"retracted_count":0},"instrument_strength":null,"identification_strategy":"literature_causal_claim","contradicting_evidence_count":0}},{"source_id":"tau pathology","source_type":"protein","target_id":"hippocampal circuit dysfunction","target_type":"mechanism","relation":"causes (tau pathology spreads from locus coeruleus to hipp)","evidence_strength":0.79,"evidence_sources":"[\"SDA-2026-04-03-26abc5e5f9f2\", \"PMID:31285742\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T13:36:10-07:00","edge_type":"causal","source_canonical_id":"tau pathology","target_canonical_id":"hippocampal_circuit_dysfunction","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":{"method":"scidex.atlas.edge_quality_scorecard.v1","edge_id":null,"edge_type":"causal","n_studies":1,"study_ids":{"dois":[],"pmids":["31285742"]},"generated_at":"2026-04-28T05:46:31.170188+00:00","retraction_check":{"status":"no_retraction_signal","retracted_ids":[],"checked_studies":1,"retracted_count":0},"instrument_strength":null,"identification_strategy":"literature_causal_claim","contradicting_evidence_count":0}},{"source_id":"BDNF","source_type":"gene","target_id":"alzheimer_s_disease","target_type":"disease","relation":"associated_with","evidence_strength":0.4,"evidence_sources":"[\"SDA-2026-04-02-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T16:45:23-07:00","edge_type":"association","source_canonical_id":"ent-gene-8c4c3123","target_canonical_id":"ent-dise-8fedf7f1","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BDNF","source_type":"gene","target_id":"hippocampal_neurogenesis_and_synaptic_plasticity","target_type":"pathway","relation":"involved_in","evidence_strength":0.4,"evidence_sources":"[\"SDA-2026-04-02-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T16:45:23-07:00","edge_type":"association","source_canonical_id":"ent-gene-8c4c3123","target_canonical_id":"Hippocampal neurogenesis and synaptic plasticity","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BDNF","source_type":"gene","target_id":"CA3","target_type":"gene","relation":"co_associated_with","evidence_strength":0.3,"evidence_sources":"[\"SDA-2026-04-02-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T16:45:23-07:00","edge_type":"association","source_canonical_id":"ent-gene-8c4c3123","target_canonical_id":"Ca3","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BDNF","source_type":"gene","target_id":"CA1","target_type":"gene","relation":"co_associated_with","evidence_strength":0.3,"evidence_sources":"[\"SDA-2026-04-02-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T16:45:23-07:00","edge_type":"association","source_canonical_id":"ent-gene-8c4c3123","target_canonical_id":"ca1","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PVALB","source_type":"gene","target_id":"prefrontal_inhibitory_circuits","target_type":"pathway","relation":"involved_in","evidence_strength":0.4,"evidence_sources":"[\"SDA-2026-04-02-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T16:45:23-07:00","edge_type":"association","source_canonical_id":"Pvalb","target_canonical_id":"Prefrontal inhibitory circuits","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PVALB","source_type":"gene","target_id":"neurodegeneration","target_type":"disease","relation":"implicated_in","evidence_strength":0.4,"evidence_sources":"[\"SDA-2026-04-02-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T16:45:23-07:00","edge_type":"association","source_canonical_id":"Pvalb","target_canonical_id":"ent-rese-6f3dc74d","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST","source_type":"gene","target_id":"gabaergic_interneuron_networks","target_type":"pathway","relation":"involved_in","evidence_strength":0.4,"evidence_sources":"[\"SDA-2026-04-02-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T16:45:23-07:00","edge_type":"association","source_canonical_id":"Sst","target_canonical_id":"GABAergic interneuron networks","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PVALB","source_type":"gene","target_id":"alzheimer_s_disease","target_type":"disease","relation":"associated_with","evidence_strength":0.4,"evidence_sources":"[\"SDA-2026-04-02-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T16:45:23-07:00","edge_type":"association","source_canonical_id":"Pvalb","target_canonical_id":"ent-dise-8fedf7f1","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST","source_type":"gene","target_id":"alzheimer_s_disease","target_type":"disease","relation":"associated_with","evidence_strength":0.4,"evidence_sources":"[\"SDA-2026-04-02-26abc5e5f9f2\"]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T16:45:23-07:00","edge_type":"association","source_canonical_id":"Sst","target_canonical_id":"ent-dise-8fedf7f1","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"h-23b94ed8","source_type":"hypothesis","target_id":"neuroscience","target_type":"disease","relation":"implicated_in","evidence_strength":0.7,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T16:52:16.158822-07:00","edge_type":"association","source_canonical_id":"h_23b94ed8","target_canonical_id":"neuroscience","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"h-cd60e2ec","source_type":"hypothesis","target_id":"neuroscience","target_type":"disease","relation":"implicated_in","evidence_strength":0.6,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T16:52:16.158822-07:00","edge_type":"association","source_canonical_id":"h_cd60e2ec","target_canonical_id":"neuroscience","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"h-f8316acf","source_type":"hypothesis","target_id":"neuroscience","target_type":"disease","relation":"implicated_in","evidence_strength":0.7,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T16:52:16.158822-07:00","edge_type":"association","source_canonical_id":"h_f8316acf","target_canonical_id":"neuroscience","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"h-62c78d8b","source_type":"hypothesis","target_id":"neuroscience","target_type":"disease","relation":"implicated_in","evidence_strength":0.65,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T16:52:16.158822-07:00","edge_type":"association","source_canonical_id":"h_62c78d8b","target_canonical_id":"neuroscience","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"h-a635d4e5","source_type":"hypothesis","target_id":"VIP","target_type":"gene","relation":"targets","evidence_strength":0.55,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T16:52:16.158822-07:00","edge_type":"association","source_canonical_id":"h_a635d4e5","target_canonical_id":"VIP","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"h-a635d4e5","source_type":"hypothesis","target_id":"neuroscience","target_type":"disease","relation":"implicated_in","evidence_strength":0.55,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T16:52:16.158822-07:00","edge_type":"association","source_canonical_id":"h_a635d4e5","target_canonical_id":"neuroscience","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"h-7110565d","source_type":"hypothesis","target_id":"neuroscience","target_type":"disease","relation":"implicated_in","evidence_strength":0.2,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-04T16:52:16.158822-07:00","edge_type":"association","source_canonical_id":"h_7110565d","target_canonical_id":"neuroscience","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"diseases-psp","source_type":"disease","target_id":"h-var-6612521a02","target_type":"hypothesis","relation":"investigated_in","evidence_strength":0.75,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-16T16:17:57.992550-07:00","edge_type":"wiki_link","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"diseases-corticobasal-syndrome","source_type":"disease","target_id":"h-var-9c0368bb70","target_type":"hypothesis","relation":"investigated_in","evidence_strength":0.75,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-16T16:17:58.030302-07:00","edge_type":"wiki_link","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"diseases-ftd","source_type":"disease","target_id":"h-var-3b982ec3d2","target_type":"hypothesis","relation":"investigated_in","evidence_strength":0.75,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-16T16:17:58.136417-07:00","edge_type":"wiki_link","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"diseases-vascular-cognitive-impairment","source_type":"disease","target_id":"h-var-6612521a02","target_type":"hypothesis","relation":"investigated_in","evidence_strength":0.75,"evidence_sources":"[]","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-16T16:17:58.206441-07:00","edge_type":"wiki_link","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CDK5","source_type":"gene","target_id":"MAPK","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":"hypothesis:h-var-1906e102cf","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-16T18:27:54.037460-07:00","edge_type":"hypothesis_cooccurrence","source_canonical_id":"Cdk5","target_canonical_id":"MAPk","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"APOE","source_type":"gene","target_id":"TFEB","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":"hypothesis:h-var-ce41f0efd7","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-16T18:27:54.037460-07:00","edge_type":"hypothesis_cooccurrence","source_canonical_id":"Apoe","target_canonical_id":"ent-gene-72ca22d2","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"AQP4","source_type":"gene","target_id":"MAPT","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":"hypothesis:h-var-95b0f9a6bc","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-16T18:27:54.037460-07:00","edge_type":"hypothesis_cooccurrence","source_canonical_id":"ent-gene-7e3d2cc6","target_canonical_id":"ent-gene-acc6d764","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"APP","source_type":"gene","target_id":"PSD95","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":"hypothesis:h-var-9c0368bb70","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-16T18:27:54.037460-07:00","edge_type":"hypothesis_cooccurrence","source_canonical_id":"ent-gene-961a77ee","target_canonical_id":"ent-gene-98f9aec0","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"AQP4","source_type":"gene","target_id":"TREM2","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":"hypothesis:h-var-7c976d9fb7","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-16T18:27:54.037460-07:00","edge_type":"hypothesis_cooccurrence","source_canonical_id":"ent-gene-7e3d2cc6","target_canonical_id":"Trem2","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PVALB","source_type":"gene","target_id":"gamma_oscillation","target_type":"pathway","relation":"generates","evidence_strength":0.9,"evidence_sources":"Allen Neural Dynamics circuit analysis; PMIDs 27929004, 39747869","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-24T09:02:14.535822-07:00","edge_type":null,"source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"established","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":"ke-8ca6429f2dcf","trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"MAPT","source_type":"gene","target_id":"hippocampal_circuit","target_type":"pathway","relation":"disrupts","evidence_strength":0.8,"evidence_sources":"Allen Neural Dynamics circuit analysis; PMID 31285742","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-24T09:02:14.535822-07:00","edge_type":null,"source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"established","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":"ke-6d6e548490da","trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"GRIN2B","source_type":"gene","target_id":"thalamocortical_synchrony","target_type":"pathway","relation":"modulates","evidence_strength":0.75,"evidence_sources":"Allen Neural Dynamics circuit analysis; PMIDs 19449329, 23431156","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-24T09:02:14.535822-07:00","edge_type":null,"source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"supported","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":"ke-c181f01aba89","trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST","source_type":"gene","target_id":"theta_oscillation","target_type":"pathway","relation":"generates","evidence_strength":0.82,"evidence_sources":"Allen Neural Dynamics circuit analysis; PMID 39747869","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-24T09:02:14.535822-07:00","edge_type":null,"source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"established","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":"ke-733ae958f20d","trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess_ext_h-var-58e76ac310_20260428_050154","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:41:55.506087-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST interneurons","source_type":"cell_type","target_id":"gamma oscillations","target_type":"process","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-3b982ec3d2_20260428_045746\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:43:03.669169-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST interneuron dysfunction","source_type":"cell_type","target_id":"accelerated tau propagation","target_type":"mechanism","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-3b982ec3d2_20260428_045746\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:43:03.669169-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"tau pathology","source_type":"process","target_id":"SST interneuron dysfunction","target_type":"mechanism","relation":"causes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-3b982ec3d2_20260428_045746\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:43:03.669169-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"gamma-frequency stimulation","source_type":"process","target_id":"tau pathology","target_type":"mechanism","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-3b982ec3d2_20260428_045746\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:43:03.669169-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"optogenetic gamma stimulation","source_type":"method","target_id":"tau pathology reduction","target_type":"mechanism","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-3b982ec3d2_20260428_045746\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:43:03.669169-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST interneuron dysfunction","source_type":"cell_type","target_id":"gamma desynchronization","target_type":"mechanism","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-3b982ec3d2_20260428_045746\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:43:03.669169-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess_ext_h-var-3b982ec3d2_20260428_045746","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:43:03.681078-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Tau pathology","source_type":"protein","target_id":"SST interneuron dysfunction","target_type":"mechanism","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-3b982ec3d2_20260428_045746\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:18.410495-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST interneurons","source_type":"cell_type","target_id":"Gamma oscillations","target_type":"process","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-3b982ec3d2_20260428_045746\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:18.410495-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Gamma frequency stimulation","source_type":"process","target_id":"Alzheimer's disease pathology","target_type":"disease","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-3b982ec3d2_20260428_045746\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:18.410495-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Optogenetics","source_type":"method","target_id":"SST interneuron modulation","target_type":"mechanism","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-3b982ec3d2_20260428_045746\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:18.410495-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Tau pathology","source_type":"protein","target_id":"Tau propagation","target_type":"mechanism","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-3b982ec3d2_20260428_045746\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:18.410495-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST interneuron dysfunction","source_type":"mechanism","target_id":"Tau propagation","target_type":"mechanism","relation":"accelerates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-3b982ec3d2_20260428_045746\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:18.410495-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"tACS","source_type":"method","target_id":"EC layer II SST interneurons","target_type":"cell_type","relation":"inhibits","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-3b982ec3d2_20260428_045746\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:18.410495-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Closed-loop tACS","source_type":"method","target_id":"Gamma entrainment","target_type":"process","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-3b982ec3d2_20260428_045746\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:18.410495-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Gamma oscillation disruption","source_type":"process","target_id":"Alzheimer's disease","target_type":"disease","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-3b982ec3d2_20260428_045746\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:18.410495-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST interneurons","source_type":"cell_type","target_id":"Entorhinal cortex layer II","target_type":"brain_region","relation":"associated_with","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-3b982ec3d2_20260428_045746\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:18.410495-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"closed-loop tFUS","source_type":"drug","target_id":"PV+ interneuron activity","target_type":"cell_type","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-58e76ac310_20260428_050154\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:47.638308-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV+ interneurons","source_type":"cell_type","target_id":"gamma oscillations at 40Hz","target_type":"mechanism","relation":"activates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-58e76ac310_20260428_050154\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:47.638308-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV+ interneuron dysfunction","source_type":"cell_type","target_id":"gamma collapse","target_type":"phenotype","relation":"causes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-58e76ac310_20260428_050154\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:47.638308-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"gamma collapse","source_type":"phenotype","target_id":"hippocampal-cortical disconnect","target_type":"mechanism","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-58e76ac310_20260428_050154\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:47.638308-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"40Hz gamma entrainment","source_type":"process","target_id":"restoration of gamma oscillations","target_type":"mechanism","relation":"activates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-58e76ac310_20260428_050154\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:47.638308-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV+ interneuron activity","source_type":"cell_type","target_id":"excitatory transmission","target_type":"mechanism","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-58e76ac310_20260428_050154\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:47.638308-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"gamma collapse","source_type":"phenotype","target_id":"early MCI","target_type":"disease","relation":"biomarker_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-58e76ac310_20260428_050154\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:47.638308-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"gamma oscillations at 40Hz","source_type":"mechanism","target_id":"glymphatic clearance","target_type":"process","relation":"enhances","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-58e76ac310_20260428_050154\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:47.638308-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"gamma oscillations at 40Hz","source_type":"mechanism","target_id":"microglial phagocytosis","target_type":"mechanism","relation":"activates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-58e76ac310_20260428_050154\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:47.638308-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"amyloid accumulation","source_type":"phenotype","target_id":"PV+ interneuron dysfunction","target_type":"cell_type","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-58e76ac310_20260428_050154\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:47.638308-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PVALB","source_type":"gene","target_id":"PV+ interneurons","target_type":"cell_type","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-58e76ac310_20260428_050154\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:50.929728-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"transcranial focused ultrasound (tFUS)","source_type":"device","target_id":"deep brain structures","target_type":"brain_region","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-58e76ac310_20260428_050154\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:50.929728-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV+ interneuron activity","source_type":"process","target_id":"Alzheimer's disease","target_type":"disease","relation":"therapeutic_target_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-58e76ac310_20260428_050154\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:50.929728-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"gamma oscillations (40Hz)","source_type":"mechanism","target_id":"glymphatic clearance","target_type":"process","relation":"enhances","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-58e76ac310_20260428_050154\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:50.929728-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"gamma oscillations (40Hz)","source_type":"mechanism","target_id":"microglial phagocytosis","target_type":"process","relation":"modulates","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-58e76ac310_20260428_050154\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:50.929728-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"amyloid accumulation","source_type":"biomarker","target_id":"PV+ interneurons","target_type":"cell_type","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-58e76ac310_20260428_050154\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:50.929728-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"gamma oscillations (40Hz)","source_type":"mechanism","target_id":"excitatory transmission","target_type":"process","relation":"modulates","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-58e76ac310_20260428_050154\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:50.929728-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"gamma oscillations (40Hz)","source_type":"mechanism","target_id":"hippocampal-cortical connectivity","target_type":"process","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-58e76ac310_20260428_050154\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:50.929728-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV+ interneurons","source_type":"cell_type","target_id":"gamma oscillations (40Hz)","target_type":"mechanism","relation":"activates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-58e76ac310_20260428_050154\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:50.929728-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"40Hz gamma entrainment","source_type":"process","target_id":"early MCI","target_type":"disease","relation":"therapeutic_target_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_h-var-58e76ac310_20260428_050154\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T02:45:50.929728-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST_interneurons","source_type":"cell_type","target_id":"theta_oscillations","target_type":"phenotype","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-03-26abc5e5f9f2\", \"extraction_task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\", \"grounding\": \"canonical_entities_at_least_one_endpoint\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:04.156560-07:00","edge_type":"debate_extracted","source_canonical_id":"sst_interneurons","target_canonical_id":"theta_oscillations","epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Tau Pathology","source_type":"phenotype","target_id":"Hippocampal electrophysiological disintegration","target_type":"phenotype","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-03-26abc5e5f9f2\", \"extraction_task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\", \"grounding\": \"canonical_entities_at_least_one_endpoint\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:04.156560-07:00","edge_type":"debate_extracted","source_canonical_id":"Tau Pathology","target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"AMYLOID BETA OLIGOMERS","source_type":"protein","target_id":"SST_interneurons","target_type":"cell_type","relation":"inhibits","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-03-26abc5e5f9f2\", \"extraction_task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\", \"grounding\": \"canonical_entities_at_least_one_endpoint\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:04.156560-07:00","edge_type":"debate_extracted","source_canonical_id":"AMYLOID BETA OLIGOMERS","target_canonical_id":"sst_interneurons","epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"AMYLOID BETA OLIGOMERS","source_type":"protein","target_id":"PVALB interneurons","target_type":"cell_type","relation":"inhibits","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-03-26abc5e5f9f2\", \"extraction_task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\", \"grounding\": \"canonical_entities_at_least_one_endpoint\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:04.156560-07:00","edge_type":"debate_extracted","source_canonical_id":"AMYLOID BETA OLIGOMERS","target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"GRIN2B","source_type":"gene","target_id":"Thalamocortical circuit dysfunction","target_type":"phenotype","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-03-26abc5e5f9f2\", \"extraction_task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\", \"grounding\": \"canonical_entities_at_least_one_endpoint\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:04.156560-07:00","edge_type":"debate_extracted","source_canonical_id":"ent-gene-2fd14caf","target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NMDA receptors","source_type":"protein","target_id":"Amyloid-beta-induced synaptic depression","target_type":"phenotype","relation":"mediates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-03-26abc5e5f9f2\", \"extraction_task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\", \"grounding\": \"canonical_entities_at_least_one_endpoint\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:04.156560-07:00","edge_type":"debate_extracted","source_canonical_id":"NMDA receptors","target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"MAPT","source_type":"gene","target_id":"Locus coeruleus to hippocampus spread","target_type":"phenotype","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-03-26abc5e5f9f2\", \"extraction_task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\", \"grounding\": \"canonical_entities_at_least_one_endpoint\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:04.156560-07:00","edge_type":"debate_extracted","source_canonical_id":"ent-gene-acc6d764","target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Noradrenergic projections","source_type":"pathway","target_id":"Memory Impairment","target_type":"phenotype","relation":"decreases_risk","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-03-26abc5e5f9f2\", \"extraction_task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\", \"grounding\": \"canonical_entities_at_least_one_endpoint\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:04.156560-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":"Memory Impairment","epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Thalamocortical circuit dysfunction","source_type":"phenotype","target_id":"mild-cognitive-impairment","target_type":"disease","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-03-26abc5e5f9f2\", \"extraction_task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\", \"grounding\": \"canonical_entities_at_least_one_endpoint\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:04.156560-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":"ent-dise-c6410ecb","epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CAMK2A","source_type":"gene","target_id":"spine generation","target_type":"phenotype","relation":"activates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-03-26abc5e5f9f2\", \"extraction_task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\", \"grounding\": \"canonical_entities_at_least_one_endpoint\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:04.156560-07:00","edge_type":"debate_extracted","source_canonical_id":"ent-gene-e5069ce7","target_canonical_id":"spine_generation","epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CAMK2A","source_type":"gene","target_id":"dendrite ramification","target_type":"phenotype","relation":"activates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-03-26abc5e5f9f2\", \"extraction_task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\", \"grounding\": \"canonical_entities_at_least_one_endpoint\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:04.156560-07:00","edge_type":"debate_extracted","source_canonical_id":"ent-gene-e5069ce7","target_canonical_id":"dendrite_ramification","epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess_SDA-2026-04-03-26abc5e5f9f2","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:04.174682-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PVALB","source_type":"protein","target_id":"PV interneuron function","target_type":"process","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-ec7c58c65ca5\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:12.991131-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"gamma restoration","source_type":"process","target_id":"clinical benefit in AD","target_type":"phenotype","relation":"therapeutic_target_for","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-ec7c58c65ca5\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:12.991131-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"tFUS","source_type":"drug","target_id":"neuromodulation","target_type":"process","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-ec7c58c65ca5\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:12.991131-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV interneurons","source_type":"cell_type","target_id":"gamma oscillations","target_type":"process","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-ec7c58c65ca5\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:12.991131-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"tau pathology","source_type":"pathway","target_id":"AIS disruption","target_type":"mechanism","relation":"causes","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-ec7c58c65ca5\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:12.991131-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"hyperphosphorylated tau","source_type":"protein","target_id":"mislocalization","target_type":"mechanism","relation":"causes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-ec7c58c65ca5\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:12.991131-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"AnkyrinG","source_type":"protein","target_id":"VGSC clustering at AIS","target_type":"mechanism","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-ec7c58c65ca5\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:12.991131-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess-hyp-ec7c58c65ca5","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:13.003162-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"hyperphosphorylated tau","source_type":"protein","target_id":"HCN1 dysfunction","target_type":"mechanism","relation":"causes","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-9935d8a1fc17\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:32.339232-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"HCN1 dysfunction","source_type":"mechanism","target_id":"impaired dendritic integration","target_type":"mechanism","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-9935d8a1fc17\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:32.339232-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"impaired dendritic integration","source_type":"mechanism","target_id":"theta-gamma decoupling","target_type":"mechanism","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-9935d8a1fc17\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:32.339232-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"tau pathology","source_type":"pathway","target_id":"cognitive deficits","target_type":"phenotype","relation":"causes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-9935d8a1fc17\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:32.339232-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"theta-gamma decoupling","source_type":"mechanism","target_id":"spatial navigation deficits","target_type":"phenotype","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-9935d8a1fc17\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:32.339232-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST interneurons","source_type":"cell_type","target_id":"Alzheimer's disease","target_type":"disease","relation":"vulnerable_in","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-9935d8a1fc17\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:32.339232-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"HCN1","source_type":"protein","target_id":"SST interneuron function","target_type":"process","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-9935d8a1fc17\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:32.339232-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"closed-loop tACS","source_type":"intervention","target_id":"theta-gamma coupling","target_type":"mechanism","relation":"modulates","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-9935d8a1fc17\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:32.339232-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"tACS","source_type":"intervention","target_id":"EC layer II SST interneurons","target_type":"cell_type","relation":"targets","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-9935d8a1fc17\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:32.339232-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess-hyp-9935d8a1fc17","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:21:32.349262-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"gamma oscillations","source_type":"process","target_id":"cognitive decline","target_type":"phenotype","relation":"associated_with","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdeb_h_var_55da4f915d_20260427_110829\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:29.874176-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV+ basket cells","source_type":"cell_type","target_id":"gamma oscillations","target_type":"process","relation":"drives","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdeb_h_var_55da4f915d_20260427_110829\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:29.874176-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST interneurons","source_type":"cell_type","target_id":"gamma rhythm disruption","target_type":"phenotype","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdeb_h_var_55da4f915d_20260427_110829\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:29.874176-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"focused ultrasound","source_type":"device","target_id":"neural activity in deep brain structures","target_type":"process","relation":"modulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdeb_h_var_55da4f915d_20260427_110829\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:29.874176-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"feedback inhibition loops","source_type":"process","target_id":"gamma-frequency oscillations","target_type":"process","relation":"generates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdeb_h_var_55da4f915d_20260427_110829\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:29.874176-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"dendritic inhibition","source_type":"process","target_id":"pyramidal cells","target_type":"cell_type","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdeb_h_var_55da4f915d_20260427_110829\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:29.874176-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"gamma oscillation disruption","source_type":"process","target_id":"Alzheimer's disease","target_type":"disease","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdeb_h_var_55da4f915d_20260427_110829\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:29.874176-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST interneurons","source_type":"cell_type","target_id":"EC layer II","target_type":"brain_region","relation":"modulates","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_hypdeb_h_var_55da4f915d_20260427_110829\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:29.874176-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"stellate projection neurons","source_type":"cell_type","target_id":"EC layer II","target_type":"brain_region","relation":"composes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdeb_h_var_55da4f915d_20260427_110829\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:29.874176-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"inhibition restoration","source_type":"process","target_id":"tau propagation","target_type":"process","relation":"prevents","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdeb_h_var_55da4f915d_20260427_110829\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:29.874176-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"tau propagation","source_type":"process","target_id":"functional circuits","target_type":"process","relation":"follows","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdeb_h_var_55da4f915d_20260427_110829\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:29.874176-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"focused ultrasound","source_type":"device","target_id":"neurons in focal volume","target_type":"cell_type","relation":"affects","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdeb_h_var_55da4f915d_20260427_110829\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:29.874176-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess_hypdeb_h_var_55da4f915d_20260427_110829","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:29.889453-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"perisomatic inhibition loss","source_type":"process","target_id":"stellate cell burst firing","target_type":"phenotype","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-a599791d4367\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:50.054191-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PNN integrity loss","source_type":"mechanism","target_id":"perisomatic inhibition loss","target_type":"process","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-a599791d4367\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:50.054191-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"AIS dysfunction","source_type":"mechanism","target_id":"perisomatic inhibition loss","target_type":"process","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-a599791d4367\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:50.054191-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV interneuron vulnerability","source_type":"process","target_id":"PNN integrity loss","target_type":"mechanism","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-a599791d4367\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:50.054191-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV interneuron vulnerability","source_type":"process","target_id":"AIS dysfunction","target_type":"mechanism","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-a599791d4367\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:50.054191-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"tau pathology","source_type":"pathway","target_id":"PV interneuron vulnerability","target_type":"process","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-a599791d4367\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:50.054191-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"stellate cell burst firing","source_type":"phenotype","target_id":"calcium influx","target_type":"mechanism","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-a599791d4367\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:50.054191-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"calcium influx","source_type":"mechanism","target_id":"tau release","target_type":"process","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-a599791d4367\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:50.054191-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"rTg4510 model","source_type":"process","target_id":"PV interneuron loss","target_type":"phenotype","relation":"biomarker_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-a599791d4367\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:50.054191-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"P301S model","source_type":"process","target_id":"PV interneuron loss","target_type":"phenotype","relation":"biomarker_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-a599791d4367\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:50.054191-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"closed-loop tACS","source_type":"drug","target_id":"PV interneurons","target_type":"cell_type","relation":"modulates","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-a599791d4367\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:50.054191-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"EC-II","source_type":"brain_region","target_id":"PV interneuron vulnerability","target_type":"process","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-a599791d4367\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:50.054191-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PVALB","source_type":"protein","target_id":"PV interneuron function","target_type":"process","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-a599791d4367\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:50.054191-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV interneurons","source_type":"cell_type","target_id":"tau propagation","target_type":"process","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-a599791d4367\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:50.054191-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"closed-loop tACS","source_type":"drug","target_id":"stellate cell burst firing","target_type":"phenotype","relation":"inhibits","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-a599791d4367\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:50.054191-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess-hyp-a599791d4367","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:24:50.067036-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"EC-II stellate cell disinhibition","source_type":"process","target_id":"aberrant gamma oscillations","target_type":"mechanism","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-87b85c3b19fe\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:07.688901-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST+ interneurons","source_type":"cell_type","target_id":"EC-II stellate cells","target_type":"cell_type","relation":"inhibits","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-87b85c3b19fe\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:07.688901-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST+ interneuron dysfunction","source_type":"process","target_id":"disinhibition of EC-II stellate cells","target_type":"process","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-87b85c3b19fe\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:07.688901-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST+ interneurons","source_type":"cell_type","target_id":"excitatory-inhibitory balance","target_type":"process","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-87b85c3b19fe\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:07.688901-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"closed-loop tACS","source_type":"device","target_id":"inhibitory tone","target_type":"process","relation":"modulates","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-87b85c3b19fe\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:07.688901-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST+ interneurons","source_type":"cell_type","target_id":"tau pathology","target_type":"mechanism","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-87b85c3b19fe\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:07.688901-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"tau propagation","source_type":"process","target_id":"Alzheimer's disease","target_type":"disease","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-87b85c3b19fe\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:07.688901-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"EC-II","source_type":"brain_region","target_id":"perforant path","target_type":"pathway","relation":"associated_with","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-87b85c3b19fe\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:07.688901-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST interneuron dysfunction","source_type":"process","target_id":"tau propagation along perforant path","target_type":"mechanism","relation":"associated_with","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-87b85c3b19fe\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:07.688901-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"rTg4510 mouse model","source_type":"model","target_id":"SST interneuron dysfunction","target_type":"process","relation":"biomarker_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-87b85c3b19fe\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:07.688901-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PS19 mouse model","source_type":"model","target_id":"SST interneuron dysfunction","target_type":"process","relation":"biomarker_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-87b85c3b19fe\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:07.688901-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess-hyp-87b85c3b19fe","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:07.700015-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV+ interneuron loss","source_type":"process","target_id":"gamma oscillation disruption","target_type":"mechanism","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-8a90163989de\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:43.968962-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Aβ","source_type":"protein","target_id":"PV+ interneurons","target_type":"cell_type","relation":"inhibits","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-8a90163989de\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:43.968962-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Aβ","source_type":"protein","target_id":"PV interneuron dysfunction","target_type":"mechanism","relation":"causes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-8a90163989de\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:43.968962-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST peptide signaling","source_type":"pathway","target_id":"SST+ interneurons","target_type":"cell_type","relation":"associated_with","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-8a90163989de\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:43.968962-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV+ interneuron dysfunction","source_type":"mechanism","target_id":"Alzheimer's disease","target_type":"disease","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-8a90163989de\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:43.968962-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV+ interneuron loss","source_type":"process","target_id":"excitatory network hyperexcitability","target_type":"mechanism","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-8a90163989de\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:43.968962-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST interneuron hyperactivity","source_type":"process","target_id":"pyramidal cell inhibition","target_type":"process","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-8a90163989de\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:43.968962-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST interneuron hyperactivity","source_type":"process","target_id":"excitatory network hyperexcitability","target_type":"mechanism","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-8a90163989de\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:43.968962-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST interneurons","source_type":"cell_type","target_id":"gamma oscillations","target_type":"process","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-8a90163989de\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:43.968962-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"closed-loop tFUS","source_type":"drug","target_id":"SST interneuron activity","target_type":"process","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-8a90163989de\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:43.968962-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV+ interneurons","source_type":"cell_type","target_id":"gamma oscillations","target_type":"process","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-8a90163989de\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:43.968962-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST interneuron activity reduction","source_type":"process","target_id":"gamma oscillation restoration","target_type":"mechanism","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-8a90163989de\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:43.968962-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST interneurons","source_type":"cell_type","target_id":"PV+ interneurons","target_type":"cell_type","relation":"inhibits","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-8a90163989de\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:43.968962-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess-hyp-8a90163989de","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:25:43.980137-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess_hypdebate_h_var_d749cd28cb_20260427_162943","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:27:20.329705-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"transcranial focused ultrasound","source_type":"device","target_id":"neuronal activity","target_type":"process","relation":"modulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_6612521a02_20260427_162437\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:27:34.615459-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"gamma entrainment","source_type":"process","target_id":"Alzheimer's disease","target_type":"disease","relation":"therapeutic_target_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_6612521a02_20260427_162437\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:27:34.615459-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Piezo1","source_type":"protein","target_id":"PV interneurons","target_type":"cell_type","relation":"associated_with","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_6612521a02_20260427_162437\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:27:34.615459-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Piezo1","source_type":"protein","target_id":"neuronal populations","target_type":"cell_type","relation":"expressed_in","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_6612521a02_20260427_162437\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:27:34.615459-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"TRPA1","source_type":"protein","target_id":"neuronal populations","target_type":"cell_type","relation":"expressed_in","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_6612521a02_20260427_162437\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:27:34.615459-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"TREK-1","source_type":"protein","target_id":"neuronal populations","target_type":"cell_type","relation":"expressed_in","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_6612521a02_20260427_162437\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:27:34.615459-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV interneurons","source_type":"cell_type","target_id":"gamma restoration","target_type":"process","relation":"therapeutic_target_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_6612521a02_20260427_162437\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:27:34.615459-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"closed-loop gamma detection","source_type":"device","target_id":"personalized dosing","target_type":"process","relation":"enables","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_6612521a02_20260427_162437\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:27:34.615459-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"gamma oscillations","source_type":"process","target_id":"Alzheimer's disease","target_type":"disease","relation":"associated_with","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_6612521a02_20260427_162437\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:27:34.615459-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"gamma oscillations","source_type":"process","target_id":"cognitive decline","target_type":"phenotype","relation":"biomarker_for","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_6612521a02_20260427_162437\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:27:34.615459-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV interneurons","source_type":"cell_type","target_id":"gamma oscillations","target_type":"process","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_6612521a02_20260427_162437\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:27:34.615459-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV interneurons","source_type":"cell_type","target_id":"pyramidal neuron synchronization","target_type":"process","relation":"modulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_6612521a02_20260427_162437\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:27:34.615459-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV interneuron dysfunction","source_type":"process","target_id":"AD-related hyperexcitability","target_type":"phenotype","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_6612521a02_20260427_162437\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:27:34.615459-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess_hypdebate_h_var_6612521a02_20260427_162437","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:27:34.638714-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PVALB expression","source_type":"biomarker","target_id":"gamma entrainment responsiveness","target_type":"phenotype","relation":"biomarker_for","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260426_152757\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:28:55.217444-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"GABA release","source_type":"process","target_id":"neural synchronization","target_type":"process","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260426_152757\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:28:55.217444-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"early MCI","source_type":"disease","target_id":"intervention window","target_type":"process","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260426_152757\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:28:55.217444-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PVALB interneurons","source_type":"cell_type","target_id":"pyramidal neuron ensembles","target_type":"process","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260426_152757\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:28:55.217444-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV+ interneuron dysfunction","source_type":"process","target_id":"early Alzheimer's disease","target_type":"disease","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260426_152757\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:28:55.217444-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV+ interneuron dysfunction","source_type":"process","target_id":"neuronal loss","target_type":"phenotype","relation":"precedes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260426_152757\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:28:55.217444-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PVALB interneurons","source_type":"cell_type","target_id":"gamma oscillations","target_type":"process","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260426_152757\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:28:55.217444-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"closed-loop tFUS","source_type":"device","target_id":"PV+ interneuron function","target_type":"process","relation":"restores","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260426_152757\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:28:55.217444-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"gamma entrainment","source_type":"process","target_id":"hippocampal-cortical synchrony","target_type":"process","relation":"normalizes","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260426_152757\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:28:55.217444-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"40Hz gamma entrainment","source_type":"process","target_id":"amyloid burden","target_type":"phenotype","relation":"reduces","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260426_152757\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:28:55.217444-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"tFUS","source_type":"device","target_id":"neuronal activity","target_type":"process","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260426_152757\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:28:55.217444-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"amyloid/tau toxicity","source_type":"process","target_id":"PVALB dysfunction","target_type":"process","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260426_152757\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:28:55.217444-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"amyloid burden","source_type":"phenotype","target_id":"hippocampal-cortical connectivity disruption","target_type":"process","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260426_152757\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:28:55.217444-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess_hypdebate_h_var_58e76ac310_20260426_152757","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:28:55.228747-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"extrasynaptic GluN2B","source_type":"protein","target_id":"CREB shutdown pathways","target_type":"pathway","relation":"activates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_e2b5a7e7db_20260427_111653\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:33:18.402050-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"extrasynaptic GluN2B","source_type":"protein","target_id":"excitotoxic cascades","target_type":"pathway","relation":"activates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_e2b5a7e7db_20260427_111653\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:33:18.402050-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"slow-wave sleep","source_type":"process","target_id":"glymphatic clearance","target_type":"process","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_e2b5a7e7db_20260427_111653\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:33:18.402050-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"thalamic stimulation","source_type":"process","target_id":"cortical slow oscillations","target_type":"process","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_e2b5a7e7db_20260427_111653\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:33:18.402050-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"cortical slow oscillation","source_type":"process","target_id":"glymphatic convective flow","target_type":"process","relation":"causes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_e2b5a7e7db_20260427_111653\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:33:18.402050-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"thalamus","source_type":"brain_region","target_id":"brain-wide clearance","target_type":"process","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_e2b5a7e7db_20260427_111653\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:33:18.402050-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"thalamus","source_type":"brain_region","target_id":"glymphatic function","target_type":"process","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_e2b5a7e7db_20260427_111653\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:33:18.402050-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CERC-301","source_type":"drug","target_id":"major depression","target_type":"disease","relation":"therapeutic_target_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_e2b5a7e7db_20260427_111653\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:33:18.402050-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"GRIN2B","source_type":"gene","target_id":"tau pathology","target_type":"disease","relation":"therapeutic_target_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_e2b5a7e7db_20260427_111653\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:33:18.402050-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"thalamic relay neurons","source_type":"cell_type","target_id":"slow oscillation synchrony","target_type":"process","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_e2b5a7e7db_20260427_111653\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:33:18.402050-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess_hypdebate_h_var_e2b5a7e7db_20260427_111653","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:33:18.413856-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"soluble amyloid-beta oligomers","source_type":"protein","target_id":"SST interneuron function","target_type":"process","relation":"inhibits","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_b7e4505525_20260426_163210\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:05.571465-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST interneurons","source_type":"cell_type","target_id":"hippocampal CA1 pyramidal neurons","target_type":"cell_type","relation":"inhibits","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_b7e4505525_20260426_163210\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:05.571465-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST interneuron dysfunction","source_type":"process","target_id":"reduced feedforward inhibitory control","target_type":"process","relation":"causes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_b7e4505525_20260426_163210\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:05.571465-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"reduced feedforward inhibitory control","source_type":"process","target_id":"excessive entorhinal-hippocampal signaling","target_type":"process","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_b7e4505525_20260426_163210\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:05.571465-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST interneurons","source_type":"cell_type","target_id":"gamma oscillation dynamics","target_type":"process","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_b7e4505525_20260426_163210\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:05.571465-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"gamma oscillations","source_type":"process","target_id":"memory deficits","target_type":"phenotype","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_b7e4505525_20260426_163210\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:05.571465-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Alzheimer's disease","source_type":"disease","target_id":"gamma oscillations","target_type":"process","relation":"impairs","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_b7e4505525_20260426_163210\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:05.571465-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"transcranial focused ultrasound","source_type":"device","target_id":"neural activity","target_type":"process","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_b7e4505525_20260426_163210\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:05.571465-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"transcranial focused ultrasound","source_type":"device","target_id":"specific cell types","target_type":"process","relation":"inhibits","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_b7e4505525_20260426_163210\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:05.571465-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"acoustic diffraction","source_type":"process","target_id":"layer-specific targeting in entorhinal cortex","target_type":"process","relation":"prevents","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_b7e4505525_20260426_163210\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:05.571465-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"entorhinal cortex layer II","source_type":"brain_region","target_id":"hippocampal CA1 pyramidal neurons","target_type":"cell_type","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_b7e4505525_20260426_163210\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:05.571465-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"closed-loop gamma modulation","source_type":"process","target_id":"invasive electrodes","target_type":"device","relation":"requires","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_b7e4505525_20260426_163210\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:05.571465-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"closed-loop neuromodulation","source_type":"process","target_id":"neural activity","target_type":"process","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_b7e4505525_20260426_163210\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:05.571465-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"perforant path","source_type":"pathway","target_id":"hippocampal CA1 pyramidal neurons","target_type":"cell_type","relation":"activates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_b7e4505525_20260426_163210\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:05.571465-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SST interneurons","source_type":"cell_type","target_id":"perforant path input","target_type":"pathway","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_b7e4505525_20260426_163210\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:05.571465-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess_hypdebate_h_var_b7e4505525_20260426_163210","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:05.585587-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PVALB basket cells","source_type":"cell_type","target_id":"pyramidal cell firing synchronization","target_type":"process","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_121018\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:19.458681-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"hippocampal-cortical coherence","source_type":"process","target_id":"amyloid plaque burden","target_type":"phenotype","relation":"modulates","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_121018\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:19.458681-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"gamma entrainment","source_type":"process","target_id":"PVALB interneuron recruitment","target_type":"mechanism","relation":"activates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_121018\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:19.458681-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"closed-loop feedback","source_type":"process","target_id":"gamma synchronization precision","target_type":"mechanism","relation":"enhances","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_121018\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:19.458681-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PVALB interneurons","source_type":"cell_type","target_id":"hippocampal-cortical coherence","target_type":"process","relation":"activates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_121018\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:19.458681-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"gamma oscillations","source_type":"process","target_id":"hippocampal-cortical coherence","target_type":"process","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_121018\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:19.458681-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"microglial activation","source_type":"process","target_id":"orthoproteostasis","target_type":"pathway","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_121018\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:19.458681-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"40Hz sensory stimulation","source_type":"process","target_id":"microglial activation","target_type":"process","relation":"activates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_121018\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:19.458681-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"hippocampal-cortical gamma coherence","source_type":"process","target_id":"memory consolidation","target_type":"phenotype","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_121018\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:19.458681-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"40Hz sensory stimulation","source_type":"process","target_id":"amyloid-beta reduction","target_type":"phenotype","relation":"causes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_121018\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:19.458681-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess_hypdebate_h_var_58e76ac310_20260427_121018","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:34:19.468617-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"amyloid-beta","source_type":"pathway","target_id":"cognitive decline in Alzheimer's disease","target_type":"phenotype","relation":"causes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_e95d2d1d86_20260426_163445\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:10.437379-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV interneuron dysfunction","source_type":"cell_type","target_id":"theta-gamma coupling disruption","target_type":"mechanism","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_e95d2d1d86_20260426_163445\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:10.437379-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"theta-gamma coupling disruption","source_type":"biomarker","target_id":"memory impairment in Alzheimer's disease","target_type":"phenotype","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_e95d2d1d86_20260426_163445\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:10.437379-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"theta-gamma coupling restoration","source_type":"process","target_id":"cognitive decline prevention","target_type":"phenotype","relation":"therapeutic_target_for","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_e95d2d1d86_20260426_163445\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:10.437379-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"amyloid-beta oligomers","source_type":"pathway","target_id":"oxidative stress in PV interneurons","target_type":"mechanism","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_e95d2d1d86_20260426_163445\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:10.437379-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"amyloid-beta oligomers","source_type":"pathway","target_id":"calcium dysregulation in PV interneurons","target_type":"mechanism","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_e95d2d1d86_20260426_163445\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:10.437379-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Kv3 potassium channels","source_type":"protein","target_id":"PV interneuron fast-spiking phenotype","target_type":"process","relation":"modulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_e95d2d1d86_20260426_163445\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:10.437379-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV interneurons","source_type":"cell_type","target_id":"temporal coordination of pyramidal cell ensembles","target_type":"process","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_e95d2d1d86_20260426_163445\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:10.437379-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"optogenetic targeting of PV interneurons","source_type":"drug","target_id":"theta-gamma coupling restoration","target_type":"process","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_e95d2d1d86_20260426_163445\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:10.437379-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess_hypdebate_h_var_e95d2d1d86_20260426_163445","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:10.447017-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"GABA-A receptor modulators","source_type":"drug","target_id":"PV+ interneuron function","target_type":"process","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_120922\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:43.082848-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PVALB","source_type":"protein","target_id":"direct pharmacological targeting","target_type":"process","relation":"inhibits","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_120922\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:43.082848-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV+ basket cells","source_type":"cell_type","target_id":"pyramidal cell network synchronization","target_type":"process","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_120922\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:43.082848-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Kv3.1/3.2 potassium channels","source_type":"protein","target_id":"fast-spiking gamma oscillations","target_type":"process","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_120922\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:43.082848-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"transcranial focused ultrasound","source_type":"device","target_id":"neural circuit modulation","target_type":"mechanism","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_120922\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:43.082848-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV+ interneurons","source_type":"cell_type","target_id":"Alzheimer's disease","target_type":"disease","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_120922\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:43.082848-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PV+ interneurons","source_type":"cell_type","target_id":"hippocampal-cortical disconnection","target_type":"mechanism","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_120922\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:43.082848-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PVALB","source_type":"protein","target_id":"calcium buffering","target_type":"process","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_120922\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:43.082848-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"closed-loop transcranial focused ultrasound","source_type":"device","target_id":"PV+ circuit activation","target_type":"mechanism","relation":"activates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_120922\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:43.082848-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"early MCI","source_type":"phenotype","target_id":"hippocampal-cortical connectivity restoration","target_type":"process","relation":"therapeutic_target_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_120922\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:43.082848-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"amyloid pathology","source_type":"mechanism","target_id":"PV+ interneuron loss","target_type":"mechanism","relation":"causes","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_120922\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:43.082848-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"gamma oscillations","source_type":"process","target_id":"cognitive function","target_type":"phenotype","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_120922\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:43.082848-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Kv3.1/3.2 channel agonists","source_type":"drug","target_id":"PV+ interneuron function","target_type":"process","relation":"activates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_h_var_58e76ac310_20260427_120922\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:43.082848-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess_hypdebate_h_var_58e76ac310_20260427_120922","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:35:43.093214-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PVALB","source_type":"gene","target_id":"Parvalbumin","target_type":"protein","relation":"encodes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-85e15db6a836\", \"extraction_task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\", \"grounding\": \"canonical_entities_at_least_one_endpoint\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:55:18.648252-07:00","edge_type":"debate_extracted","source_canonical_id":"ent-gene-43a17cd1","target_canonical_id":"Parvalbumin","epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Parvalbumin","source_type":"protein","target_id":"fast-spiking interneuron firing","target_type":"phenotype","relation":"associated_with","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess-hyp-85e15db6a836\", \"extraction_task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\", \"grounding\": \"canonical_entities_at_least_one_endpoint\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:55:18.648252-07:00","edge_type":"debate_extracted","source_canonical_id":"Parvalbumin","target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess-hyp-85e15db6a836","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-03-26abc5e5f9f2","created_at":"2026-04-28T13:55:18.654590-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null}],"pagination":{"limit":5000,"offset":0,"total_edges":317,"total_nodes":349,"has_more":false}}