{"nodes":[{"id":"Dasatinib+Quercetin","type":"drug"},{"id":"irreversible neuronal loss","type":"phenotype"},{"id":"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152657","type":"debate_session_causal"},{"id":"brain","type":"brain_region","has_wiki":true,"wiki_url":"/wiki/mechanisms-brain-volume-changes-ad","wiki_entity":"Brain Volume Changes in Early Alzheimer's Disease"},{"id":"SIRT1","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-sirt1","wiki_entity":"SIRT1"},{"id":"NAD+ levels","type":"biomarker"},{"id":"senescence-associated secretory phenotype","type":"phenotype"},{"id":"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152542","type":"debate_session_causal"},{"id":"CASP3","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-casp3","wiki_entity":"CASP3"},{"id":"NAD+ biosynthesis","type":"pathway"},{"id":"sess_hypdebate_SDA_2026_04_16_hyp_e_20260427_121300","type":"debate_session_causal"},{"id":"microglial senescence","type":"process"},{"id":"senolytic approaches","type":"process"},{"id":"age-related NAD+ decline","type":"process"},{"id":"mitochondrial function","type":"mechanism","has_wiki":true,"wiki_url":"/entity/mitochondrial-function","wiki_entity":"mitochondrial function"},{"id":"early senescent states","type":"process"},{"id":"CDKN1A","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-cdkn1a","wiki_entity":"CDKN1A"},{"id":"p16^INK4a/RB pathway","type":"pathway"},{"id":"neurodegenerative disease","type":"disease"},{"id":"senescent neurons","type":"cell_type"},{"id":"neurotrophic support","type":"mechanism"},{"id":"NF-κB activity","type":"pathway"},{"id":"SASP modulation","type":"process"},{"id":"neurodegeneration","type":"phenotype"},{"id":"neuronal preservation","type":"phenotype"},{"id":"neurodegeneration progression","type":"disease"},{"id":"glutamate homeostasis","type":"process"},{"id":"BCL2L1","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-bcl2l1","wiki_entity":"BCL2L1"},{"id":"cellular senescence","type":"mechanism"},{"id":"SIRT1 activators","type":"drug class"},{"id":"sess_hypdebate_SDA_2026_04_16_hyp_d_20260426_153245","type":"debate_session_causal"},{"id":"NLRP3","type":"gene","has_wiki":true,"wiki_url":"/wiki/proteins-nlrp3-protein","wiki_entity":"NLRP3"},{"id":"sess_SDA-2026-04-04-gap-senescent-clearance-neuro","type":"debate_session_causal"},{"id":"astrocyte senescence","type":"process"},{"id":"IL-1R","type":"protein"},{"id":"BBB leakage","type":"process"},{"id":"diseases-prion-disease","type":"disease"},{"id":"senomorphics","type":"therapeutic approach"},{"id":"BDNF expression","type":"mechanism"},{"id":"mitochondrial biogenesis","type":"process"},{"id":"sess_SDA-2026-04-04-gap-senescent-clearance-neuro_20260416-151700","type":"debate_session_causal"},{"id":"Anakinra","type":"drug"},{"id":"amyloid-beta accumulation","type":"phenotype"},{"id":"amyloid-beta phagocytosis","type":"process"},{"id":"senescent cells","type":"process"},{"id":"senescent cell clearance","type":"process"},{"id":"neurotoxic inflammation","type":"mechanism"},{"id":"sess_hyp_SDA-2026-04-16-hyp-e5bf6e0d_sirt1_debate","type":"debate_session_causal"},{"id":"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111","type":"debate_session_causal"},{"id":"apoptosis execution","type":"mechanism"},{"id":"neuroinflammation","type":"pathway","has_wiki":true,"wiki_url":"/wiki/mechanisms-pd-neuroinflammation","wiki_entity":"Neuroinflammation in PD"},{"id":"Canakinumab","type":"drug"},{"id":"autophagy pathway","type":"pathway","has_wiki":true,"wiki_url":"/entity/autophagy-pathway","wiki_entity":"autophagy pathway"},{"id":"cellular bioenergetics","type":"process"},{"id":"cellular senescence","type":"process"},{"id":"CNS penetration","type":"process"},{"id":"genes-rpl30","type":"gene"},{"id":"NAD+ precursors","type":"drug"},{"id":"senescence irreversibility","type":"phenotype"},{"id":"SDA-2026-04-16-hyp-e5bf6e0d","type":"hypothesis"},{"id":"SIRT1","type":"enzyme","has_wiki":true,"wiki_url":"/wiki/genes-sirt1","wiki_entity":"SIRT1"},{"id":"neuronal loss","type":"phenotype"},{"id":"processed","type":"sentinel"},{"id":"CASP3","type":"enzyme","has_wiki":true,"wiki_url":"/wiki/genes-casp3","wiki_entity":"CASP3"},{"id":"SASP transcription","type":"pathway"},{"id":"NAD+ decline","type":"mechanism"},{"id":"senescence reversal","type":"mechanism"},{"id":"ATG7","type":"gene","has_wiki":true,"wiki_url":"/wiki/proteins-atg7","wiki_entity":"ATG7"},{"id":"senolytic strategies","type":"therapeutic approach"},{"id":"PDGFRB","type":"gene","has_wiki":true,"wiki_url":"/entity/PDGFRB","wiki_entity":"PDGFRB"},{"id":"tau phosphorylation","type":"mechanism"},{"id":"astrocyte SASP","type":"process"},{"id":"blood-brain barrier","type":"brain_region","has_wiki":true,"wiki_url":"/entity/blood-brain-barrier","wiki_entity":"blood-brain barrier"},{"id":"IL-1β","type":"protein"},{"id":"early-onset dementia","type":"disease"},{"id":"GFAP","type":"protein","has_wiki":true,"wiki_url":"/wiki/genes-gfap","wiki_entity":"GFAP"},{"id":"IL-1β signaling","type":"pathway"},{"id":"senescence","type":"pathway","has_wiki":true,"wiki_url":"https://neurowiki.xyz/senescence","wiki_entity":"senescence"},{"id":"APOE","type":"gene","has_wiki":true,"wiki_url":"/entity/APOE","wiki_entity":"APOE"},{"id":"IL-6","type":"protein","has_wiki":true,"wiki_url":"/wiki/proteins-il6-protein","wiki_entity":"IL-6"},{"id":"TNF-α","type":"protein"},{"id":"BDNF suppression","type":"mechanism"},{"id":"aging","type":"process","has_wiki":true,"wiki_url":"/wiki/mechanisms-aging-vs-neurodegeneration-comparison","wiki_entity":"Aging vs Neurodegeneration: Mechanistic Comparison Matrix"},{"id":"neuronal survival","type":"phenotype"},{"id":"mitochondrial function","type":"process","has_wiki":true,"wiki_url":"/entity/mitochondrial-function","wiki_entity":"mitochondrial function"},{"id":"PGC-1alpha","type":"protein"},{"id":"FOXO","type":"protein","has_wiki":true,"wiki_url":"/wiki/mechanisms-foxo-signaling-neurodegeneration","wiki_entity":"FOXO Signaling Pathway in Neurodegeneration"},{"id":"NAD+ decline","type":"process"},{"id":"PDGFRB downregulation","type":"process"},{"id":"SIRT1-PGC-1α-NAMPT axis","type":"pathway"},{"id":"SASP inflammatory cytokines","type":"mechanism"},{"id":"NAMPT activators","type":"drug"},{"id":"p53","type":"protein"},{"id":"mitochondrial adaptive capacity","type":"mechanism"},{"id":"pericyte senescence","type":"process"},{"id":"IL-1β expression","type":"mechanism"},{"id":"p21","type":"gene"},{"id":"SLC1A3","type":"gene","has_wiki":true,"wiki_url":"/wiki/proteins-slc1a3-protein","wiki_entity":"SLC1A3"},{"id":"senescent microglia","type":"cell_type"},{"id":"NAMPT","type":"enzyme","has_wiki":true,"wiki_url":"/entity/NAMPT","wiki_entity":"NAMPT"},{"id":"BDNF","type":"protein","has_wiki":true,"wiki_url":"/entity/BDNF","wiki_entity":"BDNF"},{"id":"chronic neuroinflammation","type":"phenotype"},{"id":"p21^CIP1/p53 pathway","type":"pathway"},{"id":"senescent neuron burden","type":"cell_type"},{"id":"neurodegenerative burden","type":"disease"},{"id":"diseases-corticobasal-degeneration","type":"disease"},{"id":"NAD+","type":"molecule","has_wiki":true,"wiki_url":"/wiki/therapeutics-nad-precursor-therapy","wiki_entity":"NAD+ Precursor Therapy for Neurodegenerative Diseases"},{"id":"peripheral monocyte infiltration","type":"process"},{"id":"BCL2","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-bcl2","wiki_entity":"BCL2"},{"id":"neurodegeneration","type":"disease"},{"id":"NAD+ decline","type":"biomarker"},{"id":"neurodegenerative pathology","type":"phenotype"},{"id":"PGC1A","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-pgc1a","wiki_entity":"PGC1A"},{"id":"NAD+ boosting strategies","type":"therapeutic approach"},{"id":"ketosis","type":"process"},{"id":"cellular senescence","type":"phenotype"},{"id":"MTOR","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-mtor","wiki_entity":"MTOR"},{"id":"p16INK4a","type":"gene"},{"id":"mitochondrial dysfunction","type":"mechanism","has_wiki":true,"wiki_url":"/entity/mitochondrial-dysfunction","wiki_entity":"mitochondrial dysfunction"},{"id":"apoptotic cell death","type":"mechanism"},{"id":"TNF-α expression","type":"mechanism"},{"id":"FOXO3","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-foxo3","wiki_entity":"FOXO3"},{"id":"quercetin","type":"drug"},{"id":"SASP","type":"process","has_wiki":true,"wiki_url":"/wiki/mechanisms-sasp-senescence-associated-secretory-phenotype","wiki_entity":"SASP (Senescence-Associated Secretory Phenotype) in Neurodegeneration"},{"id":"PGC-1alpha","type":"transcriptional coactivator"},{"id":"cognitive preservation","type":"phenotype"},{"id":"CLOCK","type":"gene","has_wiki":true,"wiki_url":"/entity/CLOCK","wiki_entity":"CLOCK"},{"id":"mitochondrial adaptive capacity","type":"process"},{"id":"TP53","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-tp53","wiki_entity":"TP53"},{"id":"central nervous system","type":"brain_region"},{"id":"NAMPT expression","type":"protein"},{"id":"SIRT1 activators","type":"drug"},{"id":"NFKB1","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-nfkb1","wiki_entity":"NFKB1"},{"id":"CDKN2A","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-cdkn2a","wiki_entity":"CDKN2A"},{"id":"diseases-machado-joseph-disease","type":"disease"},{"id":"metabolic reprogramming","type":"therapeutic approach"},{"id":"SIRT1","type":"protein","has_wiki":true,"wiki_url":"/wiki/genes-sirt1","wiki_entity":"SIRT1"},{"id":"p16INK4a+ microglia","type":"cell_type"},{"id":"GFAP","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-gfap","wiki_entity":"GFAP"},{"id":"NMN supplementation","type":"intervention"},{"id":"dasatinib","type":"drug","has_wiki":true,"wiki_url":"/wiki/therapeutics-dasatinib-quercetin-senolytic","wiki_entity":"Dasatinib + Quercetin (D+Q) for Neurodegeneration"},{"id":"NAD+ restoration","type":"process"},{"id":"NAD+ boost strategies","type":"therapeutic approach"},{"id":"clinical efficacy","type":"process"},{"id":"p50-containing NF-κB complexes","type":"protein"},{"id":"TREM2","type":"protein","has_wiki":true,"wiki_url":"https://neurowiki.xyz/trem2","wiki_entity":"TREM2"},{"id":"TREM2 loss-of-function","type":"mutation"},{"id":"senolytic agents plus NAD+ augmentation","type":"drug"},{"id":"brain NAD+ levels","type":"metabolite"},{"id":"IL-6 expression","type":"mechanism"},{"id":"growth arrest","type":"phenotype"},{"id":"senescent cells","type":"cell_state"},{"id":"senolytic_therapy","type":"drug"},{"id":"senomorphic strategies","type":"therapeutic approach"},{"id":"NAD+ depletion","type":"metabolite"},{"id":"NF-κB","type":"protein"},{"id":"diseases-huntingtons","type":"disease"},{"id":"LRP1","type":"gene","has_wiki":true,"wiki_url":"https://neurowiki.xyz/lrp1","wiki_entity":"LRP1"},{"id":"SASP","type":"pathway","has_wiki":true,"wiki_url":"/wiki/mechanisms-sasp-senescence-associated-secretory-phenotype","wiki_entity":"SASP (Senescence-Associated Secretory Phenotype) in Neurodegeneration"},{"id":"neurons","type":"cell_type","has_wiki":true,"wiki_url":"/entity/neurons","wiki_entity":"neurons"},{"id":"NF-κB activation","type":"pathway"},{"id":"PGC1α dysregulation","type":"process"},{"id":"NAD+","type":"metabolite","has_wiki":true,"wiki_url":"/wiki/therapeutics-nad-precursor-therapy","wiki_entity":"NAD+ Precursor Therapy for Neurodegenerative Diseases"},{"id":"SASP modulation paradigm","type":"process"},{"id":"neuronal senescence","type":"mechanism"},{"id":"VEGF-A dysregulation","type":"process"},{"id":"diseases-vascular-cognitive-impairment","type":"disease"},{"id":"apoptosis-senescence decision","type":"mechanism"},{"id":"BBB breakdown","type":"phenotype"},{"id":"SIRT1-PGC-1alpha-NAMPT axis","type":"pathway"},{"id":"PGC1α","type":"protein"},{"id":"PGC-1α","type":"protein"},{"id":"NAD+ salvage pathway","type":"pathway"},{"id":"senescent cells","type":"cell_type"},{"id":"lifespan","type":"phenotype"},{"id":"Alzheimer's disease","type":"disease"},{"id":"NAD+ precursor supplementation","type":"drug"},{"id":"BMAL1","type":"gene","has_wiki":true,"wiki_url":"/entity/BMAL1","wiki_entity":"BMAL1"},{"id":"basement membrane detachment","type":"mechanism"},{"id":"BDNF preservation","type":"mechanism"},{"id":"PGC1alpha","type":"protein"},{"id":"senolytics","type":"drug","has_wiki":true,"wiki_url":"/wiki/therapeutics-senolytics","wiki_entity":"Senolytics and Senotherapeutics in Neurodegeneration"},{"id":"plasma NfL","type":"biomarker"},{"id":"NMN supplementation","type":"therapeutic approach"},{"id":"neurodegenerative pathophysiology","type":"disease"},{"id":"autophagy enhancers","type":"drug"},{"id":"senescent cell accumulation","type":"mechanism"},{"id":"NAMPT decline","type":"process"},{"id":"metabolic reprogramming","type":"mechanism"},{"id":"neurotoxic SASP signaling","type":"process"},{"id":"NF-κB","type":"pathway"},{"id":"cognitive decline","type":"phenotype"},{"id":"BAX","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-bax","wiki_entity":"BAX"},{"id":"senescent cell apoptosis","type":"mechanism"},{"id":"neuronal survival","type":"mechanism"},{"id":"metabolic parameters","type":"process"},{"id":"diseases-psp","type":"disease"}],"edges":[{"source_id":"CLOCK","source_type":"gene","target_id":"FOXO3","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"ent-gene-3926ff00","target_canonical_id":"ent-gene-efcb91ee","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"FOXO3","source_type":"gene","target_id":"NLRP3","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"ent-gene-efcb91ee","target_canonical_id":"ent-gene-304eb5d4","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"GFAP","source_type":"gene","target_id":"BMAL1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"Gfap","target_canonical_id":"Bmal1","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"GFAP","source_type":"gene","target_id":"APOE","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"Gfap","target_canonical_id":"Apoe","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"GFAP","source_type":"gene","target_id":"CLOCK","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"Gfap","target_canonical_id":"ent-gene-3926ff00","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"GFAP","source_type":"gene","target_id":"SIRT1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"Gfap","target_canonical_id":"ent-gene-d3bc7c54","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BMAL1","source_type":"gene","target_id":"LRP1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"Bmal1","target_canonical_id":"ent-gene-08fea9c7","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BMAL1","source_type":"gene","target_id":"APOE","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"Bmal1","target_canonical_id":"Apoe","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BMAL1","source_type":"gene","target_id":"NLRP3","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"Bmal1","target_canonical_id":"ent-gene-304eb5d4","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"LRP1","source_type":"gene","target_id":"CLOCK","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"ent-gene-08fea9c7","target_canonical_id":"ent-gene-3926ff00","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"LRP1","source_type":"gene","target_id":"SIRT1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"ent-gene-08fea9c7","target_canonical_id":"ent-gene-d3bc7c54","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"APOE","source_type":"gene","target_id":"CLOCK","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"Apoe","target_canonical_id":"ent-gene-3926ff00","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CLOCK","source_type":"gene","target_id":"NLRP3","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"ent-gene-3926ff00","target_canonical_id":"ent-gene-304eb5d4","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1","source_type":"gene","target_id":"NLRP3","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"ent-gene-d3bc7c54","target_canonical_id":"ent-gene-304eb5d4","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"GFAP","source_type":"gene","target_id":"BCL2L1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"Gfap","target_canonical_id":"ent-gene-4206f4c6","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"GFAP","source_type":"gene","target_id":"FOXO3","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"Gfap","target_canonical_id":"ent-gene-efcb91ee","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BCL2L1","source_type":"gene","target_id":"LRP1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"ent-gene-4206f4c6","target_canonical_id":"ent-gene-08fea9c7","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BCL2L1","source_type":"gene","target_id":"APOE","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"ent-gene-4206f4c6","target_canonical_id":"Apoe","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BCL2L1","source_type":"gene","target_id":"CLOCK","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"ent-gene-4206f4c6","target_canonical_id":"ent-gene-3926ff00","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BCL2L1","source_type":"gene","target_id":"SIRT1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"ent-gene-4206f4c6","target_canonical_id":"ent-gene-d3bc7c54","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BCL2L1","source_type":"gene","target_id":"FOXO3","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"ent-gene-4206f4c6","target_canonical_id":"ent-gene-efcb91ee","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BCL2L1","source_type":"gene","target_id":"NLRP3","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"ent-gene-4206f4c6","target_canonical_id":"ent-gene-304eb5d4","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"LRP1","source_type":"gene","target_id":"FOXO3","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:50:33.680130-07:00","edge_type":"association","source_canonical_id":"ent-gene-08fea9c7","target_canonical_id":"ent-gene-efcb91ee","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"LRP1","source_type":"gene","target_id":"BMAL1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:53:36.617888-07:00","edge_type":"association","source_canonical_id":"ent-gene-08fea9c7","target_canonical_id":"Bmal1","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1","source_type":"gene","target_id":"LRP1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:53:36.617888-07:00","edge_type":"association","source_canonical_id":"ent-gene-d3bc7c54","target_canonical_id":"ent-gene-08fea9c7","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NLRP3","source_type":"gene","target_id":"APOE","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:53:36.617888-07:00","edge_type":"association","source_canonical_id":"ent-gene-304eb5d4","target_canonical_id":"Apoe","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NLRP3","source_type":"gene","target_id":"LRP1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:53:36.617888-07:00","edge_type":"association","source_canonical_id":"ent-gene-304eb5d4","target_canonical_id":"ent-gene-08fea9c7","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NLRP3","source_type":"gene","target_id":"BMAL1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:53:36.617888-07:00","edge_type":"association","source_canonical_id":"ent-gene-304eb5d4","target_canonical_id":"Bmal1","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NLRP3","source_type":"gene","target_id":"CLOCK","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:53:36.617888-07:00","edge_type":"association","source_canonical_id":"ent-gene-304eb5d4","target_canonical_id":"ent-gene-3926ff00","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"APOE","source_type":"gene","target_id":"BMAL1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:53:36.617888-07:00","edge_type":"association","source_canonical_id":"Apoe","target_canonical_id":"Bmal1","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"FOXO3","source_type":"gene","target_id":"BCL2L1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:53:36.617888-07:00","edge_type":"association","source_canonical_id":"ent-gene-efcb91ee","target_canonical_id":"ent-gene-4206f4c6","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"FOXO3","source_type":"gene","target_id":"GFAP","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:53:36.617888-07:00","edge_type":"association","source_canonical_id":"ent-gene-efcb91ee","target_canonical_id":"Gfap","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"FOXO3","source_type":"gene","target_id":"LRP1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:53:36.617888-07:00","edge_type":"association","source_canonical_id":"ent-gene-efcb91ee","target_canonical_id":"ent-gene-08fea9c7","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"FOXO3","source_type":"gene","target_id":"CLOCK","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:53:36.617888-07:00","edge_type":"association","source_canonical_id":"ent-gene-efcb91ee","target_canonical_id":"ent-gene-3926ff00","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BCL2L1","source_type":"gene","target_id":"GFAP","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T13:53:36.617888-07:00","edge_type":"association","source_canonical_id":"ent-gene-4206f4c6","target_canonical_id":"Gfap","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"senescence","source_type":"pathway","target_id":"neurodegeneration","target_type":"disease","relation":"contributes_to","evidence_strength":0.8,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T17:42:09.857552-07:00","edge_type":"debate_derived","source_canonical_id":"senescence","target_canonical_id":"ent-rese-6f3dc74d","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"quercetin","source_type":"drug","target_id":"senolytic_therapy","target_type":"drug","relation":"associated_with","evidence_strength":0.75,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T17:42:09.857552-07:00","edge_type":"debate_derived","source_canonical_id":"Quercetin","target_canonical_id":"senolytic_therapy","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"dasatinib","source_type":"drug","target_id":"senolytic_therapy","target_type":"drug","relation":"associated_with","evidence_strength":0.75,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T17:42:09.857552-07:00","edge_type":"debate_derived","source_canonical_id":"DASATINIB","target_canonical_id":"senolytic_therapy","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"senolytic_therapy","source_type":"drug","target_id":"senescence","target_type":"pathway","relation":"inhibits","evidence_strength":0.7,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T17:42:09.857552-07:00","edge_type":"debate_derived","source_canonical_id":"senolytic_therapy","target_canonical_id":"senescence","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"p21","source_type":"gene","target_id":"senescence","target_type":"pathway","relation":"activates","evidence_strength":0.8,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T17:42:09.857552-07:00","edge_type":"debate_derived","source_canonical_id":"p21","target_canonical_id":"senescence","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SASP","source_type":"pathway","target_id":"neuroinflammation","target_type":"pathway","relation":"activates","evidence_strength":0.8,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T17:42:09.857552-07:00","edge_type":"debate_derived","source_canonical_id":"ent-proc-26ab961f","target_canonical_id":"ent-proc-f21faf77","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"p16INK4a","source_type":"gene","target_id":"senescence","target_type":"pathway","relation":"activates","evidence_strength":0.85,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T17:42:09.857552-07:00","edge_type":"debate_derived","source_canonical_id":"p16INK4A","target_canonical_id":"senescence","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CLOCK","source_type":"gene","target_id":"GFAP","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T22:29:36.768955-07:00","edge_type":"association","source_canonical_id":"ent-gene-3926ff00","target_canonical_id":"Gfap","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CLOCK","source_type":"gene","target_id":"APOE","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T22:29:36.769095-07:00","edge_type":"association","source_canonical_id":"ent-gene-3926ff00","target_canonical_id":"Apoe","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NLRP3","source_type":"gene","target_id":"SIRT1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T22:29:36.769167-07:00","edge_type":"association","source_canonical_id":"ent-gene-304eb5d4","target_canonical_id":"ent-gene-d3bc7c54","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NLRP3","source_type":"gene","target_id":"GFAP","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T22:29:36.769244-07:00","edge_type":"association","source_canonical_id":"ent-gene-304eb5d4","target_canonical_id":"Gfap","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1","source_type":"gene","target_id":"GFAP","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T22:29:36.769288-07:00","edge_type":"association","source_canonical_id":"ent-gene-d3bc7c54","target_canonical_id":"Gfap","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BMAL1","source_type":"gene","target_id":"GFAP","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T22:29:36.769334-07:00","edge_type":"association","source_canonical_id":"Bmal1","target_canonical_id":"Gfap","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CLOCK","source_type":"gene","target_id":"MTOR","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T22:29:36.905894-07:00","edge_type":"association","source_canonical_id":"ent-gene-3926ff00","target_canonical_id":"ent-gene-7b80a607","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CLOCK","source_type":"gene","target_id":"BCL2L1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T22:29:36.906046-07:00","edge_type":"association","source_canonical_id":"ent-gene-3926ff00","target_canonical_id":"ent-gene-4206f4c6","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NLRP3","source_type":"gene","target_id":"MTOR","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T22:29:36.906099-07:00","edge_type":"association","source_canonical_id":"ent-gene-304eb5d4","target_canonical_id":"ent-gene-7b80a607","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NLRP3","source_type":"gene","target_id":"FOXO3","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T22:29:36.906133-07:00","edge_type":"association","source_canonical_id":"ent-gene-304eb5d4","target_canonical_id":"ent-gene-efcb91ee","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NLRP3","source_type":"gene","target_id":"BCL2L1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T22:29:36.906186-07:00","edge_type":"association","source_canonical_id":"ent-gene-304eb5d4","target_canonical_id":"ent-gene-4206f4c6","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1","source_type":"gene","target_id":"MTOR","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T22:29:36.906212-07:00","edge_type":"association","source_canonical_id":"ent-gene-d3bc7c54","target_canonical_id":"ent-gene-7b80a607","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1","source_type":"gene","target_id":"BCL2L1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T22:29:36.906245-07:00","edge_type":"association","source_canonical_id":"ent-gene-d3bc7c54","target_canonical_id":"ent-gene-4206f4c6","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"MTOR","source_type":"gene","target_id":"FOXO3","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T22:29:36.906291-07:00","edge_type":"association","source_canonical_id":"ent-gene-7b80a607","target_canonical_id":"ent-gene-efcb91ee","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"MTOR","source_type":"gene","target_id":"GFAP","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T22:29:36.906331-07:00","edge_type":"association","source_canonical_id":"ent-gene-7b80a607","target_canonical_id":"Gfap","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"MTOR","source_type":"gene","target_id":"LRP1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T22:29:36.906362-07:00","edge_type":"association","source_canonical_id":"ent-gene-7b80a607","target_canonical_id":"ent-gene-08fea9c7","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"MTOR","source_type":"gene","target_id":"BCL2L1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T22:29:36.906395-07:00","edge_type":"association","source_canonical_id":"ent-gene-7b80a607","target_canonical_id":"ent-gene-4206f4c6","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"LRP1","source_type":"gene","target_id":"BCL2L1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":null,"analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-02T22:29:36.906501-07:00","edge_type":"association","source_canonical_id":"ent-gene-08fea9c7","target_canonical_id":"ent-gene-4206f4c6","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"diseases-psp","source_type":"disease","target_id":"SDA-2026-04-16-hyp-e5bf6e0d","target_type":"hypothesis","relation":"investigated_in","evidence_strength":0.75,"evidence_sources":"[]","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-16T16:17:57.981304-07:00","edge_type":"wiki_link","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"diseases-corticobasal-degeneration","source_type":"disease","target_id":"SDA-2026-04-16-hyp-e5bf6e0d","target_type":"hypothesis","relation":"investigated_in","evidence_strength":0.75,"evidence_sources":"[]","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-16T16:17:58.096459-07:00","edge_type":"wiki_link","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"diseases-huntingtons","source_type":"disease","target_id":"SDA-2026-04-16-hyp-e5bf6e0d","target_type":"hypothesis","relation":"investigated_in","evidence_strength":0.75,"evidence_sources":"[]","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-16T16:17:58.151635-07:00","edge_type":"wiki_link","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"diseases-vascular-cognitive-impairment","source_type":"disease","target_id":"SDA-2026-04-16-hyp-e5bf6e0d","target_type":"hypothesis","relation":"investigated_in","evidence_strength":0.75,"evidence_sources":"[]","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-16T16:17:58.201898-07:00","edge_type":"wiki_link","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"diseases-prion-disease","source_type":"disease","target_id":"SDA-2026-04-16-hyp-e5bf6e0d","target_type":"hypothesis","relation":"investigated_in","evidence_strength":0.75,"evidence_sources":"[]","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-16T16:17:58.232665-07:00","edge_type":"wiki_link","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"diseases-machado-joseph-disease","source_type":"disease","target_id":"SDA-2026-04-16-hyp-e5bf6e0d","target_type":"hypothesis","relation":"investigated_in","evidence_strength":0.75,"evidence_sources":"[]","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-16T16:17:58.263756-07:00","edge_type":"wiki_link","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"genes-rpl30","source_type":"gene","target_id":"SDA-2026-04-16-hyp-e5bf6e0d","target_type":"hypothesis","relation":"investigated_in","evidence_strength":0.75,"evidence_sources":"[]","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-16T16:17:58.295809-07:00","edge_type":"wiki_link","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CASP3","source_type":"gene","target_id":"TP53","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":"hypothesis:SDA-2026-04-16-hyp-a44afba2","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-16T18:27:54.037460-07:00","edge_type":"hypothesis_cooccurrence","source_canonical_id":"ent-gene-697939bf","target_canonical_id":"Tp53","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAD+ boosting strategies","source_type":"therapeutic approach","target_id":"brain","target_type":"brain_region","relation":"blood-brain_barrier_penetration_limitation","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:53.580583-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"metabolic reprogramming","source_type":"therapeutic approach","target_id":"neuronal senescence","target_type":"mechanism","relation":"reverses","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:53.580583-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"senomorphic strategies","source_type":"therapeutic approach","target_id":"senescent cells","target_type":"cell_state","relation":"attenuates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:53.580583-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"senolytic strategies","source_type":"therapeutic approach","target_id":"senescent cells","target_type":"cell_state","relation":"eliminates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:53.580583-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAD+","source_type":"metabolite","target_id":"aging","target_type":"process","relation":"declines_with","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:53.580583-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BMAL1","source_type":"gene","target_id":"cellular senescence","target_type":"mechanism","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:53.580583-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"neuronal senescence","source_type":"mechanism","target_id":"neurodegeneration","target_type":"disease","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:53.580583-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAD+ precursors","source_type":"drug","target_id":"neurons","target_type":"cell_type","relation":"cns_penetration_limitation","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:53.580583-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAD+","source_type":"metabolite","target_id":"cellular senescence","target_type":"mechanism","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:53.580583-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1","source_type":"enzyme","target_id":"cellular senescence","target_type":"mechanism","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:53.580583-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1-PGC-1α-NAMPT axis","source_type":"pathway","target_id":"mitochondrial adaptive capacity","target_type":"mechanism","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:53.580583-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAMPT","source_type":"enzyme","target_id":"NAD+","target_type":"metabolite","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:53.580583-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1","source_type":"enzyme","target_id":"NF-κB","target_type":"protein","relation":"deacetylates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:53.580583-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1","source_type":"enzyme","target_id":"FOXO","target_type":"protein","relation":"deacetylates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:53.580583-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1","source_type":"enzyme","target_id":"p53","target_type":"protein","relation":"deacetylates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:53.580583-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:53.608712-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1 activators","source_type":"drug","target_id":"SIRT1","target_type":"protein","relation":"activates","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.112659-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"cellular senescence","source_type":"process","target_id":"irreversible neuronal loss","target_type":"phenotype","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.112659-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1","source_type":"enzyme","target_id":"neuronal senescence","target_type":"mechanism","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.112659-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAD+ decline","source_type":"biomarker","target_id":"neurodegeneration","target_type":"disease","relation":"risk_factor_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.112659-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NMN supplementation","source_type":"therapeutic approach","target_id":"NAD+ levels","target_type":"biomarker","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.112659-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"senomorphics","source_type":"therapeutic approach","target_id":"senescence reversal","target_type":"mechanism","relation":"therapeutic_target_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.112659-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"senolytic strategies","source_type":"therapeutic approach","target_id":"senescent cells","target_type":"process","relation":"prevents","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.112659-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1","source_type":"enzyme","target_id":"NF-κB","target_type":"protein","relation":"modulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.112659-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1","source_type":"enzyme","target_id":"FOXO","target_type":"protein","relation":"modulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.112659-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1","source_type":"enzyme","target_id":"p53","target_type":"protein","relation":"modulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.112659-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"aging","source_type":"process","target_id":"NAD+ decline","target_type":"mechanism","relation":"causes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.112659-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PGC-1α","source_type":"protein","target_id":"mitochondrial biogenesis","target_type":"process","relation":"activates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.112659-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAMPT","source_type":"enzyme","target_id":"NAD+ biosynthesis","target_type":"pathway","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.112659-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"early senescent states","source_type":"process","target_id":"neurodegenerative disease","target_type":"disease","relation":"risk_factor_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.112659-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAD+ boost strategies","source_type":"therapeutic approach","target_id":"blood-brain barrier","target_type":"brain_region","relation":"causes","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.112659-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"senolytic strategies","source_type":"therapeutic approach","target_id":"senescence reversal","target_type":"mechanism","relation":"prevents","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.112659-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAD+","source_type":"metabolite","target_id":"aging","target_type":"process","relation":"associated_with","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.378647-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"metabolic reprogramming","source_type":"mechanism","target_id":"cellular senescence","target_type":"process","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.378647-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1-PGC-1alpha-NAMPT axis","source_type":"pathway","target_id":"metabolic reprogramming","target_type":"mechanism","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.378647-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NMN supplementation","source_type":"intervention","target_id":"NAMPT","target_type":"enzyme","relation":"bypasses","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.378647-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1 activators","source_type":"drug class","target_id":"clinical efficacy","target_type":"process","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.378647-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAD+ boosting strategies","source_type":"therapeutic approach","target_id":"blood-brain barrier","target_type":"brain_region","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.378647-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"senolytic strategies","source_type":"therapeutic approach","target_id":"cellular senescence","target_type":"process","relation":"prevents","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.378647-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAD+","source_type":"metabolite","target_id":"mitochondrial adaptive capacity","target_type":"process","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.378647-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1","source_type":"enzyme","target_id":"PGC-1alpha","target_type":"protein","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.378647-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PGC-1alpha","source_type":"transcriptional coactivator","target_id":"mitochondrial biogenesis","target_type":"process","relation":"causes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.378647-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1","source_type":"enzyme","target_id":"FOXO","target_type":"protein","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.378647-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1","source_type":"enzyme","target_id":"p53","target_type":"protein","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_ext_SDA-2026-04-16-hyp-e_20260428_051111\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T02:44:59.378647-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1","source_type":"gene","target_id":"cellular senescence","target_type":"mechanism","relation":"inhibits","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:23:26.552903-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PGC1A","source_type":"gene","target_id":"mitochondrial function","target_type":"mechanism","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:23:26.552903-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAMPT","source_type":"enzyme","target_id":"NAD+ restoration","target_type":"process","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:23:26.552903-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NFKB1","source_type":"gene","target_id":"SASP inflammatory cytokines","target_type":"mechanism","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:23:26.552903-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BDNF","source_type":"protein","target_id":"neuronal survival","target_type":"mechanism","relation":"protective_against","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:23:26.552903-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"ATG7","source_type":"gene","target_id":"autophagy pathway","target_type":"pathway","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:23:26.552903-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BCL2","source_type":"gene","target_id":"senescent cell apoptosis","target_type":"mechanism","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:23:26.552903-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"senolytics","source_type":"drug","target_id":"senescent cell accumulation","target_type":"mechanism","relation":"prevents","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:23:26.552903-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"TREM2 loss-of-function","source_type":"mutation","target_id":"early-onset dementia","target_type":"disease","relation":"causes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:23:26.552903-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"TP53","source_type":"gene","target_id":"apoptosis-senescence decision","target_type":"mechanism","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:23:26.552903-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BAX","source_type":"gene","target_id":"apoptotic cell death","target_type":"mechanism","relation":"activates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:23:26.552903-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CASP3","source_type":"enzyme","target_id":"apoptosis execution","target_type":"mechanism","relation":"activates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:23:26.552903-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CDKN1A","source_type":"gene","target_id":"cellular senescence","target_type":"mechanism","relation":"biomarker_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:23:26.552903-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"ketosis","source_type":"process","target_id":"cellular senescence","target_type":"mechanism","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:23:26.552903-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"senescent microglia","source_type":"cell_type","target_id":"chronic neuroinflammation","target_type":"phenotype","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:23:26.552903-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"autophagy enhancers","source_type":"drug","target_id":"neuronal preservation","target_type":"phenotype","relation":"protective_against","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:23:26.552903-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess_SDA-2026-04-04-gap-senescent-clearance-neuro","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:23:26.572240-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"p21^CIP1/p53 pathway","source_type":"pathway","target_id":"senescence irreversibility","target_type":"phenotype","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152657\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:25:46.774280-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"cellular senescence","source_type":"phenotype","target_id":"neurodegeneration","target_type":"disease","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152657\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:25:46.774280-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"senolytic agents plus NAD+ augmentation","source_type":"drug","target_id":"neurodegeneration","target_type":"disease","relation":"therapeutic_target_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152657\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:25:46.774280-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PGC1α","source_type":"protein","target_id":"mitochondrial biogenesis","target_type":"process","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152657\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:25:46.774280-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"cellular bioenergetics","source_type":"process","target_id":"neuronal survival","target_type":"phenotype","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152657\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:25:46.774280-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAMPT activators","source_type":"drug","target_id":"neurodegeneration","target_type":"disease","relation":"therapeutic_target_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152657\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:25:46.774280-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"senescence-associated secretory phenotype","source_type":"phenotype","target_id":"neurodegenerative burden","target_type":"disease","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152657\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:25:46.774280-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAD+","source_type":"molecule","target_id":"lifespan","target_type":"phenotype","relation":"protective_against","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152657\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:25:46.774280-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAMPT","source_type":"enzyme","target_id":"neurodegenerative pathophysiology","target_type":"disease","relation":"causes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152657\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:25:46.774280-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1","source_type":"enzyme","target_id":"PGC1α","target_type":"protein","relation":"activates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152657\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:25:46.774280-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAD+","source_type":"molecule","target_id":"mitochondrial function","target_type":"process","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152657\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:25:46.774280-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAD+ precursor supplementation","source_type":"drug","target_id":"cognitive decline","target_type":"phenotype","relation":"protective_against","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152657\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:25:46.774280-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAD+ precursors","source_type":"drug","target_id":"central nervous system","target_type":"brain_region","relation":"associated_with","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152657\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:25:46.774280-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"age-related NAD+ decline","source_type":"process","target_id":"neurodegenerative pathophysiology","target_type":"disease","relation":"risk_factor_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152657\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:25:46.774280-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"p16^INK4a/RB pathway","source_type":"pathway","target_id":"senescence irreversibility","target_type":"phenotype","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152657\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:25:46.774280-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152657","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:25:46.793752-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"VEGF-A dysregulation","source_type":"process","target_id":"BBB breakdown","target_type":"phenotype","relation":"causes","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro_20260416-151700\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:30:16.024999-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PDGFRB downregulation","source_type":"process","target_id":"basement membrane detachment","target_type":"mechanism","relation":"causes","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro_20260416-151700\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:30:16.024999-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PDGFRB","source_type":"gene","target_id":"pericyte senescence","target_type":"process","relation":"regulates","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro_20260416-151700\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:30:16.024999-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"astrocyte SASP","source_type":"process","target_id":"neuronal loss","target_type":"phenotype","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro_20260416-151700\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:30:16.024999-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"astrocyte SASP","source_type":"process","target_id":"tau phosphorylation","target_type":"mechanism","relation":"causes","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro_20260416-151700\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:30:16.024999-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SLC1A3","source_type":"gene","target_id":"glutamate homeostasis","target_type":"process","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro_20260416-151700\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:30:16.024999-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"GFAP","source_type":"protein","target_id":"astrocyte senescence","target_type":"process","relation":"biomarker_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro_20260416-151700\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:30:16.024999-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"microglial senescence","source_type":"process","target_id":"amyloid-beta accumulation","target_type":"phenotype","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro_20260416-151700\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:30:16.024999-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"TREM2","source_type":"protein","target_id":"amyloid-beta phagocytosis","target_type":"process","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro_20260416-151700\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:30:16.024999-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SASP","source_type":"process","target_id":"neurodegenerative pathology","target_type":"phenotype","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro_20260416-151700\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:30:16.024999-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Dasatinib+Quercetin","source_type":"drug","target_id":"neurotoxic SASP signaling","target_type":"process","relation":"prevents","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro_20260416-151700\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:30:16.024999-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CDKN2A","source_type":"gene","target_id":"microglial senescence","target_type":"process","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro_20260416-151700\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:30:16.024999-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"senolytics","source_type":"drug","target_id":"p16INK4a+ microglia","target_type":"cell_type","relation":"inhibits","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro_20260416-151700\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:30:16.024999-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"cellular senescence","source_type":"process","target_id":"neurodegenerative pathology","target_type":"phenotype","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro_20260416-151700\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:30:16.024999-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"BBB leakage","source_type":"process","target_id":"peripheral monocyte infiltration","target_type":"process","relation":"activates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro_20260416-151700\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:30:16.024999-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"plasma NfL","source_type":"biomarker","target_id":"neurodegeneration","target_type":"phenotype","relation":"biomarker_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro_20260416-151700\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:30:16.024999-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Dasatinib+Quercetin","source_type":"drug","target_id":"Alzheimer's disease","target_type":"disease","relation":"therapeutic_target_for","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-04-gap-senescent-clearance-neuro_20260416-151700\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:30:16.024999-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess_SDA-2026-04-04-gap-senescent-clearance-neuro_20260416-151700","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:30:16.040586-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAMPT","source_type":"enzyme","target_id":"NAD+ salvage pathway","target_type":"pathway","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260427_121300\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:31:15.907435-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"cellular senescence","source_type":"process","target_id":"neurodegeneration progression","target_type":"disease","relation":"risk_factor_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260427_121300\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:31:15.907435-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"cellular senescence","source_type":"process","target_id":"growth arrest","target_type":"phenotype","relation":"causes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260427_121300\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:31:15.907435-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAD+","source_type":"metabolite","target_id":"mitochondrial function","target_type":"process","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260427_121300\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:31:15.907435-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"mitochondrial dysfunction","source_type":"mechanism","target_id":"neurodegenerative disease","target_type":"disease","relation":"causes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260427_121300\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:31:15.907435-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAD+ precursors","source_type":"drug","target_id":"CNS penetration","target_type":"process","relation":"inhibits","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260427_121300\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:31:15.907435-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PGC1α dysregulation","source_type":"process","target_id":"neurodegenerative disease","target_type":"disease","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260427_121300\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:31:15.907435-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PGC1α dysregulation","source_type":"process","target_id":"mitochondrial dysfunction","target_type":"mechanism","relation":"causes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260427_121300\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:31:15.907435-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1","source_type":"enzyme","target_id":"metabolic parameters","target_type":"process","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260427_121300\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:31:15.907435-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAD+ decline","source_type":"process","target_id":"aging","target_type":"process","relation":"associated_with","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260427_121300\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:31:15.907435-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess_hypdebate_SDA_2026_04_16_hyp_e_20260427_121300","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:31:15.919179-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"IL-1R","source_type":"protein","target_id":"NF-κB activation","target_type":"pathway","relation":"activates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_d_20260426_153245\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:32:16.713475-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"senolytic approaches","source_type":"process","target_id":"neurotrophic support","target_type":"mechanism","relation":"inhibits","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_d_20260426_153245\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:32:16.713475-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SASP modulation paradigm","source_type":"process","target_id":"neurotoxic inflammation","target_type":"mechanism","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_d_20260426_153245\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:32:16.713475-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SASP modulation","source_type":"process","target_id":"cognitive preservation","target_type":"phenotype","relation":"protective_against","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_d_20260426_153245\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:32:16.713475-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"p50-containing NF-κB complexes","source_type":"protein","target_id":"IL-6 expression","target_type":"mechanism","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_d_20260426_153245\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:32:16.713475-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"p50-containing NF-κB complexes","source_type":"protein","target_id":"IL-1β expression","target_type":"mechanism","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_d_20260426_153245\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:32:16.713475-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SASP modulation","source_type":"process","target_id":"BDNF preservation","target_type":"mechanism","relation":"protective_against","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_d_20260426_153245\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:32:16.713475-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SASP","source_type":"process","target_id":"BDNF expression","target_type":"mechanism","relation":"inhibits","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_d_20260426_153245\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:32:16.713475-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Canakinumab","source_type":"drug","target_id":"IL-1β signaling","target_type":"pathway","relation":"inhibits","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_d_20260426_153245\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:32:16.713475-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Anakinra","source_type":"drug","target_id":"IL-1β signaling","target_type":"pathway","relation":"inhibits","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_d_20260426_153245\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:32:16.713475-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"senescent cells","source_type":"cell_type","target_id":"SASP","target_type":"process","relation":"activates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_d_20260426_153245\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:32:16.713475-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NF-κB","source_type":"pathway","target_id":"SASP transcription","target_type":"pathway","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_d_20260426_153245\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:32:16.713475-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NFKB1","source_type":"gene","target_id":"SASP transcription","target_type":"pathway","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_d_20260426_153245\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:32:16.713475-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"TNF-α","source_type":"protein","target_id":"neurotoxic inflammation","target_type":"mechanism","relation":"causes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_d_20260426_153245\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:32:16.713475-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"IL-6","source_type":"protein","target_id":"neurotoxic inflammation","target_type":"mechanism","relation":"causes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_d_20260426_153245\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:32:16.713475-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"IL-1β","source_type":"protein","target_id":"neurotoxic inflammation","target_type":"mechanism","relation":"causes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_d_20260426_153245\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:32:16.713475-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SASP","source_type":"process","target_id":"neurotoxic inflammation","target_type":"mechanism","relation":"causes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_d_20260426_153245\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:32:16.713475-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"IL-1β","source_type":"protein","target_id":"BDNF suppression","target_type":"mechanism","relation":"causes","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_d_20260426_153245\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:32:16.713475-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"aging","source_type":"process","target_id":"NF-κB activity","target_type":"pathway","relation":"activates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_d_20260426_153245\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:32:16.713475-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"p50-containing NF-κB complexes","source_type":"protein","target_id":"TNF-α expression","target_type":"mechanism","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_d_20260426_153245\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:32:16.713475-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess_hypdebate_SDA_2026_04_16_hyp_d_20260426_153245","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:32:16.728212-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"PGC1alpha","source_type":"protein","target_id":"mitochondrial biogenesis","target_type":"process","relation":"regulates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152542\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:34:55.103656-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAMPT","source_type":"enzyme","target_id":"NAD+","target_type":"metabolite","relation":"activates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152542\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:34:55.103656-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"aging","source_type":"process","target_id":"NAMPT expression","target_type":"protein","relation":"inhibits","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152542\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:34:55.103656-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAMPT decline","source_type":"process","target_id":"NAD+ depletion","target_type":"metabolite","relation":"causes","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152542\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:34:55.103656-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAD+","source_type":"metabolite","target_id":"neurodegeneration","target_type":"disease","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152542\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:34:55.103656-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"SIRT1","source_type":"protein","target_id":"PGC1alpha","target_type":"protein","relation":"activates","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152542\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:34:55.103656-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"NAD+ precursor supplementation","source_type":"drug","target_id":"brain NAD+ levels","target_type":"metabolite","relation":"activates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152542\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:34:55.103656-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"senescent cell clearance","source_type":"process","target_id":"neurodegeneration","target_type":"disease","relation":"protective_against","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152542\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:34:55.103656-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"cognitive decline","source_type":"phenotype","target_id":"senescent neuron burden","target_type":"cell_type","relation":"biomarker_for","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152542\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:34:55.103656-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"senescent neurons","source_type":"cell_type","target_id":"cognitive decline","target_type":"phenotype","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152542\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:34:55.103656-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess_hypdebate_SDA_2026_04_16_hyp_e_20260426_152542","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:34:55.114487-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess_hyp_SDA-2026-04-16-hyp-e5bf6e0d_sirt1_debate","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-04-gap-senescent-clearance-neuro","created_at":"2026-04-28T13:49:06.541443-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null}],"pagination":{"limit":5000,"offset":0,"total_edges":207,"total_nodes":197,"has_more":false}}