{"nodes":[{"id":"sess_SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974_20260416-134419","type":"debate_session_causal"},{"id":"MAPT","type":"gene","has_wiki":true,"wiki_url":"/wiki/mechanisms-rtg4510-tau-transgenic","wiki_entity":"rTg4510 Tau Transgenic Mouse Model"},{"id":"NMDA receptor trafficking","type":"process"},{"id":"tau exosomes","type":"protein"},{"id":"CTSD","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-cathespin-d","wiki_entity":"CTSD"},{"id":"tau fragments","type":"protein"},{"id":"lysosomal permeabilization","type":"process"},{"id":"seed-competent tau","type":"protein"},{"id":"TREM2, TYROBP (DAP12), PLCG2, SYK","type":"gene"},{"id":"neurodegeneration","type":"disease"},{"id":"dendritic spine stability","type":"process"},{"id":"tau propagation","type":"process"},{"id":"tau pathology independence","type":"phenotype"},{"id":"processed","type":"sentinel"},{"id":"Alzheimer's disease progression","type":"disease"},{"id":"astrocyte activation","type":"process"},{"id":"anti-Aβ monotherapy resistance","type":"phenotype"},{"id":"C1QA, C1QB, C3, IL1B, NFKB1","type":"gene"},{"id":"seed-competent tau conformations","type":"protein"},{"id":"tau missorting","type":"process"},{"id":"Aβ-independent neurodegeneration","type":"phenotype"},{"id":"combined anti-Aβ and anti-tau therapy","type":"therapy"},{"id":"tau propagation to neurons","type":"process"},{"id":"GFAP","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-gfap","wiki_entity":"GFAP"},{"id":"tau-laden exosome release","type":"process"},{"id":"tau pathology","type":"phenotype"},{"id":"Aβ-tau synergy","type":"mechanism"},{"id":"Aβ","type":"protein"},{"id":"tau proteolysis","type":"process"},{"id":"early anti-Aβ intervention","type":"therapy"},{"id":"tau fragment release","type":"process"},{"id":"anti-Aβ therapy","type":"therapy"}],"edges":[{"source_id":"TREM2, TYROBP (DAP12), PLCG2, SYK","source_type":"gene","target_id":"neurodegeneration","target_type":"disease","relation":"promoted: TREM2 Agonism to Restore Microglial Phagocytosis Across Both Pathologies","evidence_strength":0.602,"evidence_sources":"[\"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974\", \"{'claim': 'Small molecule agonists of TREM2 reprogram microglia and protect synapses in human AD models', 'pmid': '41648425'}\", \"{'claim': 'Structure-based virtual screening identifies TREM2-targeted small molecules enhancing phagocytosis', 'pmid': '41604675'}\", \"{'claim': 'TREM2 bridging microglia and extracellular microenvironment offers therapeutic prospects', 'pmid': '39608728'}\", \"{'claim': 'Gain-of-function TREM2-T96K mutation increases AD risk by impairing microglial function', 'pmid': '41109213'}\", \"{'claim': 'TREM2 on microglia enables A\\u03b2 phagocytosis and may also facilitate tau clearance', 'pmid': '29784049'}\"]","analysis_id":"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974","created_at":"2026-04-16T17:35:50-07:00","edge_type":"promoted_hypothesis","source_canonical_id":"trem2,_tyrobp_(dap12),_plcg2,_syk","target_canonical_id":"ent-rese-6f3dc74d","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":"promoted-h-15a8468c","trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"C1QA, C1QB, C3, IL1B, NFKB1","source_type":"gene","target_id":"neurodegeneration","target_type":"disease","relation":"promoted: Complement-SASP Amplification Cascade as Mechanistic Link","evidence_strength":0.608,"evidence_sources":"[\"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974\", \"{'claim': 'Young adult microglial deletion of C1Q reduces synapse engulfment and prevents cognitive impairment', 'pmid': '41000995'}\", \"{'claim': 'SASP-mediated mechanisms drive neuroinflammation in AD', 'pmid': '37814508'}\", \"{'claim': 'Complement plays a role in synaptic pruning and neurodegeneration', 'pmid': '34595138'}\", \"{'claim': 'SASP exacerbates synaptic remodeling in tauopathy', 'pmid': '36906076'}\", \"{'claim': 'ANX005 (Annexon) anti-C1Q antibody completed Phase 1 in non-neurological indications', 'pmid': '29202623'}\"]","analysis_id":"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974","created_at":"2026-04-16T17:43:51-07:00","edge_type":"promoted_hypothesis","source_canonical_id":"c1qa,_c1qb,_c3,_il1b,_nfkb1","target_canonical_id":"ent-rese-6f3dc74d","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":"promoted-h-f4a63646","trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Aβ","source_type":"protein","target_id":"tau missorting","target_type":"process","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974_20260416-134419\"}","analysis_id":"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974","created_at":"2026-04-28T13:36:23.640655-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Aβ","source_type":"protein","target_id":"lysosomal permeabilization","target_type":"process","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974_20260416-134419\"}","analysis_id":"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974","created_at":"2026-04-28T13:36:23.640655-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Aβ","source_type":"protein","target_id":"astrocyte activation","target_type":"process","relation":"activates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974_20260416-134419\"}","analysis_id":"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974","created_at":"2026-04-28T13:36:23.640655-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"MAPT","source_type":"gene","target_id":"NMDA receptor trafficking","target_type":"process","relation":"disrupts","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974_20260416-134419\"}","analysis_id":"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974","created_at":"2026-04-28T13:36:23.640655-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"MAPT","source_type":"gene","target_id":"dendritic spine stability","target_type":"process","relation":"disrupts","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974_20260416-134419\"}","analysis_id":"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974","created_at":"2026-04-28T13:36:23.640655-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"CTSD","source_type":"gene","target_id":"tau proteolysis","target_type":"process","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974_20260416-134419\"}","analysis_id":"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974","created_at":"2026-04-28T13:36:23.640655-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"lysosomal permeabilization","source_type":"process","target_id":"tau fragment release","target_type":"process","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974_20260416-134419\"}","analysis_id":"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974","created_at":"2026-04-28T13:36:23.640655-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"tau fragments","source_type":"protein","target_id":"seed-competent tau conformations","target_type":"protein","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974_20260416-134419\"}","analysis_id":"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974","created_at":"2026-04-28T13:36:23.640655-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"seed-competent tau","source_type":"protein","target_id":"anti-Aβ therapy","target_type":"therapy","relation":"impervious_to","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974_20260416-134419\"}","analysis_id":"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974","created_at":"2026-04-28T13:36:23.640655-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"GFAP","source_type":"gene","target_id":"tau-laden exosome release","target_type":"process","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974_20260416-134419\"}","analysis_id":"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974","created_at":"2026-04-28T13:36:23.640655-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"tau exosomes","source_type":"protein","target_id":"tau propagation to neurons","target_type":"process","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974_20260416-134419\"}","analysis_id":"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974","created_at":"2026-04-28T13:36:23.640655-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Aβ","source_type":"protein","target_id":"Alzheimer's disease progression","target_type":"disease","relation":"initiates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974_20260416-134419\"}","analysis_id":"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974","created_at":"2026-04-28T13:36:23.640655-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"tau pathology","source_type":"phenotype","target_id":"anti-Aβ monotherapy resistance","target_type":"phenotype","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974_20260416-134419\"}","analysis_id":"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974","created_at":"2026-04-28T13:36:23.640655-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"tau propagation","source_type":"process","target_id":"Aβ-independent neurodegeneration","target_type":"phenotype","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974_20260416-134419\"}","analysis_id":"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974","created_at":"2026-04-28T13:36:23.640655-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"early anti-Aβ intervention","source_type":"therapy","target_id":"tau pathology independence","target_type":"phenotype","relation":"prevents","evidence_strength":0.5,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974_20260416-134419\"}","analysis_id":"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974","created_at":"2026-04-28T13:36:23.640655-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.5,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"combined anti-Aβ and anti-tau therapy","source_type":"therapy","target_id":"Aβ-tau synergy","target_type":"mechanism","relation":"prevents","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974_20260416-134419\"}","analysis_id":"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974","created_at":"2026-04-28T13:36:23.640655-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess_SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974_20260416-134419","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974","created_at":"2026-04-28T13:36:23.656131-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null}],"pagination":{"limit":5000,"offset":0,"total_edges":19,"total_nodes":32,"has_more":false}}