{"hypothesis_id":"h-var-3fbcfc0e6c","title":"CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microglial Senescence Reversal","current_price":0.5266,"baseline_score":0.554593,"total_signal_delta":-0.3946,"signals":[{"signal_type":"snapshot","label":"snapshot","event_count":22,"net_delta":0.4208,"direction":"up","last_applied":"2026-04-27T02:53:40.490622-07:00","first_applied":"2026-04-08T18:44:37.927291-07:00"},{"signal_type":"debate","label":"Debate (legacy)","event_count":3,"net_delta":-0.4195,"direction":"down","last_applied":"2026-04-07T17:11:05.589187-07:00","first_applied":"2026-04-07T07:11:05.589187-07:00"},{"signal_type":"duplicate_signal","label":"Duplicate Penalty","event_count":3,"net_delta":-0.36,"direction":"down","last_applied":"2026-04-16T08:23:52.832057-07:00","first_applied":"2026-04-12T16:09:15.224926-07:00"},{"signal_type":"elo_signal","label":"Elo Tournament","event_count":8,"net_delta":0.3418,"direction":"up","last_applied":"2026-04-15T17:40:40.419039-07:00","first_applied":"2026-04-12T15:49:06.729548-07:00"},{"signal_type":"debate_signal","label":"Debate Quality","event_count":3,"net_delta":-0.1757,"direction":"down","last_applied":"2026-04-28T04:48:03.759640-07:00","first_applied":"2026-04-12T17:15:44.800805-07:00"},{"signal_type":"novelty_signal","label":"Research Novelty","event_count":9,"net_delta":-0.1719,"direction":"down","last_applied":"2026-06-09T05:07:56.520275-07:00","first_applied":"2026-04-16T22:26:04.664987-07:00"},{"signal_type":"analysis_complete","label":"analysis_complete","event_count":1,"net_delta":0.1371,"direction":"up","last_applied":"2026-04-17T04:12:13.919880-07:00","first_applied":"2026-04-17T04:12:13.919880-07:00"},{"signal_type":"participant_signal","label":"Participant Signal","event_count":2,"net_delta":-0.1348,"direction":"down","last_applied":"2026-04-23T11:28:36.367636-07:00","first_applied":"2026-04-23T10:39:38.938378-07:00"},{"signal_type":"refresh","label":"Price Refresh","event_count":71,"net_delta":0.1146,"direction":"up","last_applied":"2026-04-17T21:55:53.170832-07:00","first_applied":"2026-04-10T06:04:49.407795-07:00"},{"signal_type":"evidence","label":"Evidence","event_count":7,"net_delta":0.0879,"direction":"up","last_applied":"2026-04-13T02:18:48.997639-07:00","first_applied":"2026-04-07T12:23:05.589187-07:00"},{"signal_type":"reproducibility_signal","label":"Reproducibility","event_count":13,"net_delta":-0.0724,"direction":"down","last_applied":"2026-07-02T18:28:43.082117-07:00","first_applied":"2026-04-13T04:40:00.287611-07:00"},{"signal_type":"elo_recalibration","label":"elo_recalibration","event_count":8,"net_delta":-0.0679,"direction":"down","last_applied":"2026-04-28T20:37:36.563948-07:00","first_applied":"2026-04-16T22:06:38.108953-07:00"},{"signal_type":"validation_signal_recalibration","label":"validation_signal_recalibration","event_count":1,"net_delta":-0.0358,"direction":"down","last_applied":"2026-04-28T19:13:55.723450-07:00","first_applied":"2026-04-28T19:13:55.723450-07:00"},{"signal_type":"evidence_validation_signal","label":"Evidence Validation","event_count":1,"net_delta":-0.0264,"direction":"down","last_applied":"2026-04-12T23:15:38.063873-07:00","first_applied":"2026-04-12T23:15:38.063873-07:00"},{"signal_type":"score_update","label":"Score Update","event_count":3,"net_delta":0.0164,"direction":"up","last_applied":"2026-04-07T16:38:05.589187-07:00","first_applied":"2026-04-07T10:26:05.589187-07:00"},{"signal_type":"resource_efficiency_signal","label":"Resource Efficiency","event_count":10,"net_delta":-0.0128,"direction":"down","last_applied":"2026-07-02T20:52:55.010563-07:00","first_applied":"2026-04-16T20:00:51.354343-07:00"},{"signal_type":"recalibration","label":"Recalibration","event_count":6,"net_delta":-0.0115,"direction":"down","last_applied":"2026-04-13T03:33:45.652056-07:00","first_applied":"2026-04-08T18:39:49.826405-07:00"},{"signal_type":"clinical_relevance_signal","label":"Clinical Relevance","event_count":16,"net_delta":-0.0094,"direction":"down","last_applied":"2026-07-03T11:17:57.912638-07:00","first_applied":"2026-04-12T19:26:12.719553-07:00"},{"signal_type":"kg_connectivity_signal","label":"KG Connectivity","event_count":1,"net_delta":-0.0072,"direction":"down","last_applied":"2026-04-12T19:06:45.562231-07:00","first_applied":"2026-04-12T19:06:45.562231-07:00"},{"signal_type":"convergence_signal","label":"Convergence Score","event_count":1,"net_delta":-0.0047,"direction":"down","last_applied":"2026-04-12T18:26:35.990276-07:00","first_applied":"2026-04-12T18:26:35.990276-07:00"},{"signal_type":"epistemic_status_signal","label":"Epistemic Status","event_count":1,"net_delta":-0.0032,"direction":"down","last_applied":"2026-04-12T20:16:43.885062-07:00","first_applied":"2026-04-12T20:16:43.885062-07:00"},{"signal_type":"ci_snapshot","label":"ci_snapshot","event_count":3,"net_delta":0.0,"direction":"neutral","last_applied":"2026-04-21T07:11:53.075119-07:00","first_applied":"2026-04-12T06:42:00.194342-07:00"}]}