% Bibliography for hypothesis h-044ee057
% Title: TREM2 Conformational Stabilizers for Synaptic Discrimination
% Generated: 2026-06-08T09:08:09Z

@article{pmid41435973,
  title = {AI-guided design of cyclic peptide binders targeting TREM2 using CycleRFdiffusion and experimental validation.},
  author = {Cho S, Zhu R, Kuncewicz K, Duan H, Gabr M},
  journal = {Bioorg Med Chem Lett},
  year = {2026},
  pmid = {41435973},
  doi = {doi: 10.1016/j.bmcl.2025.130512},
  url = {https://pubmed.ncbi.nlm.nih.gov/41435973/},
}

@article{pmid41490759,
  title = {ITAM-Syk signaling mediates the rebound phenomenon after anti-RANKL antibody discontinuation.},
  author = {Ishizu H, Hasegawa T, Shimizu T, Yamamoto T, Asano T et al.},
  journal = {Bone},
  year = {2026},
  pmid = {41490759},
  doi = {doi: 10.1016/j.bone.2026.117776},
  url = {https://pubmed.ncbi.nlm.nih.gov/41490759/},
}

@article{pmid41643896,
  title = {Loss of Triggering Receptor Expressed on Myeloid Cells 2 Impairs Microglial Function and Exacerbates Retinal Neurodegeneration in Glaucoma.},
  author = {Chen G, Wang Z, Zhao C, Wang C, Li Y et al.},
  journal = {Am J Pathol},
  year = {2026},
  pmid = {41643896},
  doi = {doi: 10.1016/j.ajpath.2026.01.009},
  url = {https://pubmed.ncbi.nlm.nih.gov/41643896/},
}

@article{pmid41651180,
  title = {Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, and therapeutic implications.},
  author = {Yang FG, Yang H, Han SW, Wang JT, Gao W et al.},
  journal = {Ageing Res Rev},
  year = {2026},
  pmid = {41651180},
  doi = {doi: 10.1016/j.arr.2026.103050},
  url = {https://pubmed.ncbi.nlm.nih.gov/41651180/},
}

@article{pmid41678917,
  title = {Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's disease: Metabolite signaling, neuroimmune circuits, and systems-level regulation.},
  author = {Xue D, Hu X, Li R, Sun T, Qian S et al.},
  journal = {Phytomedicine},
  year = {2026},
  pmid = {41678917},
  doi = {doi: 10.1016/j.phymed.2026.157919},
  url = {https://pubmed.ncbi.nlm.nih.gov/41678917/},
}

@article{pmid41930604,
  title = {TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, leading to anxiety-like behaviors.},
  author = {Yang HC, Deng YS, Zhang J, Zhang T, Song W et al.},
  journal = {J Alzheimers Dis},
  year = {2026},
  pmid = {41930604},
  doi = {doi: 10.1177/13872877261437264},
  url = {https://pubmed.ncbi.nlm.nih.gov/41930604/},
}

@article{pmid39627589,
  title = {Implementation and validation of single-cell genomics experiments in neuroscience.},
  author = {Colonna M, Konopka G, Liddelow SA, Nowakowski T, Awatramani R, Bateup HS, Cadwell CR, Caglayan E, Chen JL, Gillis J, Kampmann M, Krienen F, Marsh SE, Monje M, O'Dea MR, Patani R, Pollen AA, Quintana FJ, Scavuzzo M, Schmitz M, Sloan SA, Tesar PJ, Tollkuhn J, Tosches MA, Urbanek ME, Werner JM, Bayraktar OA, Gokce O, Habib N},
  journal = {Nature neuroscience},
  year = {2024},
  pmid = {39627589},
  doi = {10.1038/s41593-024-01814-0},
  url = {https://pubmed.ncbi.nlm.nih.gov/39627589/},
}

@article{pmid35642214,
  title = {Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases.},
  author = {Wang M, Pan W, Xu Y, Zhang J, Wan J, Jiang H},
  journal = {J Inflamm Res},
  year = {2022},
  pmid = {35642214},
  doi = {10.2147/JIR.S350109},
  url = {https://pubmed.ncbi.nlm.nih.gov/35642214},
}

@article{pmid33154554,
  title = {Population pharmacokinetics of the anti-PD-1 antibody camrelizumab in patients with multiple tumor types and model-informed dosing strategy.},
  author = {["Wang C", "Sheng C", "Ma G", "Xu D", "Liu X", "Wang Y", "Zhang L", "Cui C", "Xu B", "Song Y"]},
  journal = {Acta pharmacologica Sinica},
  year = {2021},
  pmid = {33154554},
  doi = {10.1038/s41401-020-00550-y},
}

@article{pmid33516818,
  title = {TREM2, microglia, and Alzheimer's disease.},
  author = {Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang Y},
  journal = {Mech Ageing Dev},
  year = {2021},
  pmid = {33516818},
  doi = {10.1016/j.mad.2021.111438},
  url = {https://pubmed.ncbi.nlm.nih.gov/33516818},
}

@article{pmid33516818,
  title = {TREM2, microglia, and Alzheimer's disease.},
  author = {Qin Q, Teng Z, Liu C, Li Q, Yin Y et al.},
  journal = {Mech Ageing Dev},
  year = {2021},
  pmid = {33516818},
  doi = {doi: 10.1016/j.mad.2021.111438},
  url = {https://pubmed.ncbi.nlm.nih.gov/33516818/},
}

@article{pmid31740829,
  title = {Choosing a mating site.},
  author = {Mirella Bucci},
  journal = {Nature chemical biology},
  year = {2020},
  pmid = {31740829},
  doi = {10.1038/s41589-019-0418-z},
}

@article{pmid31932797,
  title = {Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.},
  author = {Zhou Y, Song WM, Andhey PS, Swain A, Levy T, Miller KR, Poliani PL, Cominelli M, Grover S, Gilfillan S},
  journal = {Nat Med},
  year = {2020},
  pmid = {31932797},
  doi = {10.1038/s41591-019-0695-9},
  url = {https://pubmed.ncbi.nlm.nih.gov/31932797},
}

@article{pmid31932797,
  title = {Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.},
  author = {Zhou Y, Song WM, Andhey PS, Swain A, Levy T et al.},
  journal = {Nat Med},
  year = {2020},
  pmid = {31932797},
  doi = {doi: 10.1038/s41591-019-0695-9},
  url = {https://pubmed.ncbi.nlm.nih.gov/31932797/},
}

@article{pmid32579671,
  title = {Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model.},
  author = {Wang S, Mustafa M, Yuede CM, Salazar SV, Kong P, Long H, Ward M, Siddiqui O, Paul R, Gilfillan S, Ibrahim A, Rhinn H, Tassi I, Rosenthal A, Schwabe T, Colonna M},
  journal = {The Journal of experimental medicine},
  year = {2020},
  pmid = {32579671},
  doi = {10.1084/jem.20200785},
  url = {https://pubmed.ncbi.nlm.nih.gov/32579671/},
}

@article{pmid32579671,
  title = {Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model.},
  author = {Wang S, Mustafa M, Yuede CM, Salazar SV, Kong P et al.},
  journal = {J Exp Med},
  year = {2020},
  pmid = {32579671},
  doi = {doi: 10.1084/jem.20200785},
  url = {https://pubmed.ncbi.nlm.nih.gov/32579671/},
}

@article{pmid32879508,
  title = {Oestradiol as a neuromodulator of learning and memory.},
  author = {["Taxier L", "Gross K", "Frick K"]},
  journal = {Nature reviews. Neuroscience},
  year = {2020},
  pmid = {32879508},
  doi = {10.1038/s41583-020-0362-7},
}

@article{pmid30718901,
  title = {Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.},
  author = {["Howard D", "Adams M", "Clarke T", "Hafferty J", "Gibson J", "Shirali M", "Coleman J", "Hagenaars S", "Ward J", "Wigmore E"]},
  journal = {Nature neuroscience},
  year = {2019},
  pmid = {30718901},
  doi = {10.1038/s41593-018-0326-7},
}

@article{pmid29775591,
  title = {Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration.},
  author = {Deczkowska A, Keren-Shaul H, Weiner A, Colonna M, Schwartz M, Amit I},
  journal = {Cell},
  year = {2018},
  pmid = {29775591},
  doi = {10.1016/j.cell.2018.05.003},
  url = {https://pubmed.ncbi.nlm.nih.gov/29775591/},
}

@article{pmid30258234,
  title = {Microglia in neurodegeneration.},
  author = {Hickman S, Izzy S, Sen P, Morsett L, El Khoury J},
  journal = {Nat Neurosci},
  year = {2018},
  pmid = {30258234},
  doi = {10.1038/s41593-018-0242-x},
  url = {https://pubmed.ncbi.nlm.nih.gov/30258234},
}

@article{pmid30258234,
  title = {Microglia in neurodegeneration.},
  author = {Hickman S, Izzy S, Sen P, Morsett L, El Khoury J},
  journal = {Nat Neurosci},
  year = {2018},
  pmid = {30258234},
  doi = {doi: 10.1038/s41593-018-0242-x},
  url = {https://pubmed.ncbi.nlm.nih.gov/30258234/},
}

@article{pmid28067908,
  title = {Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.},
  author = {["de Lange K", "Moutsianas L", "Lee J", "Lamb C", "Luo Y", "Kennedy N", "Jostins L", "Rice D", "Gutierrez-Achury J", "Ji S"]},
  journal = {Nature genetics},
  year = {2017},
  pmid = {28067908},
  doi = {10.1038/ng.3760},
}

@article{pmid28442216,
  title = {TREM2, Microglia, and Neurodegenerative Diseases.},
  author = {Yeh FL, Hansen DV, Sheng M},
  journal = {Trends in molecular medicine},
  year = {2017},
  pmid = {28442216},
  doi = {10.1016/j.molmed.2017.03.008},
  url = {https://pubmed.ncbi.nlm.nih.gov/28442216/},
}

@article{pmid28802038,
  title = {TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.},
  author = {Ulland TK, Song WM, Huang SC, Ulrich JD, Sergushichev A, Beatty WL, Loboda AA, Zhou Y, Cairns NJ, Kambal A},
  journal = {Cell},
  year = {2017},
  pmid = {28802038},
  doi = {10.1016/j.cell.2017.07.023},
  url = {https://pubmed.ncbi.nlm.nih.gov/28802038},
}

@article{pmid28802038,
  title = {TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.},
  author = {Ulland TK, Song WM, Huang SC, Ulrich JD, Sergushichev A et al.},
  journal = {Cell},
  year = {2017},
  pmid = {28802038},
  doi = {doi: 10.1016/j.cell.2017.07.023},
  url = {https://pubmed.ncbi.nlm.nih.gov/28802038/},
}

@article{pmid27540165,
  title = {How neuroinflammation contributes to neurodegeneration.},
  author = {Ransohoff RM},
  journal = {Science},
  year = {2016},
  pmid = {27540165},
  doi = {10.1126/science.aag2590},
  url = {https://pubmed.ncbi.nlm.nih.gov/27540165},
}

@article{pmid27540165,
  title = {How neuroinflammation contributes to neurodegeneration.},
  author = {Ransohoff RM},
  journal = {Science},
  year = {2016},
  pmid = {27540165},
  doi = {doi: 10.1126/science.aag2590},
  url = {https://pubmed.ncbi.nlm.nih.gov/27540165/},
}