% Bibliography for hypothesis h-15336069
% Title: APOE Isoform Conversion Therapy
% Generated: 2026-06-07T19:55:02Z

@article{pmid40145985,
  title = {Neuropsychiatric symptoms and apolipoprotein E genotypes in neurocognitive disorders.},
  author = {Lozupone M, Leccisotti I, Mollica A, Berardino G, Moretti MC, Altamura M, Bellomo A, Daniele A, Dibello V, Solfrizzi V, Resta E, Panza F},
  journal = {Neural regeneration research},
  year = {2026},
  pmid = {40145985},
  doi = {10.4103/NRR.NRR-D-24-01274},
  url = {https://pubmed.ncbi.nlm.nih.gov/40145985/},
}

@article{pmid40562635,
  title = {Perioperative polygenic and APOE-based genetic risk assessment for neurocognitive disorders: a biobank study.},
  author = {Thedim M, Hu J, Maher M, Wiener-Kronish J, Saxena R et al.},
  journal = {Br J Anaesth},
  year = {2026},
  pmid = {40562635},
  doi = {doi: 10.1016/j.bja.2025.05.014},
  url = {https://pubmed.ncbi.nlm.nih.gov/40562635/},
}

@article{pmid40615639,
  title = {Increased genetic protection against Alzheimer's disease in centenarians.},
  author = {Bae H, Song Z, Ali A, Sasaki T, Tesi N et al.},
  journal = {Geroscience},
  year = {2026},
  pmid = {40615639},
  doi = {doi: 10.1007/s11357-025-01774-8},
  url = {https://pubmed.ncbi.nlm.nih.gov/40615639/},
}

@article{pmid40864401,
  title = {Integrative machine learning approach to risk prediction for dementia and Alzheimer's disease.},
  author = {Stern A, Linial M},
  journal = {Geroscience},
  year = {2026},
  pmid = {40864401},
  doi = {doi: 10.1007/s11357-025-01828-x},
  url = {https://pubmed.ncbi.nlm.nih.gov/40864401/},
}

@article{pmid40886963,
  title = {Adipose Tissue Macrophage-Derived Proplatelet Basic Protein Exacerbates Psoriasis-Associated Atherosclerosis by Inducing Mitochondrial Dysfunction in Aortic Endothelial Cells.},
  author = {Zhu L, Du L, Wu J, Ding D, Wang J et al.},
  journal = {J Invest Dermatol},
  year = {2026},
  pmid = {40886963},
  doi = {doi: 10.1016/j.jid.2025.05.041},
  url = {https://pubmed.ncbi.nlm.nih.gov/40886963/},
}

@article{pmid41445196,
  title = {Targeting KAT8 alleviates vascular senescence by modulating the INHBA/TGF-β pathway.},
  author = {Lin Z, Xiong J, Zhang F, Zhang H, Zhu M et al.},
  journal = {Mol Ther},
  year = {2026},
  pmid = {41445196},
  doi = {doi: 10.1016/j.ymthe.2025.12.035},
  url = {https://pubmed.ncbi.nlm.nih.gov/41445196/},
}

@article{pmid41531227,
  title = {Menopause, cognition, and Alzheimer's disease risk.},
  author = {Samudra N, Vemuri M, Weitlauf J},
  journal = {Curr Opin Obstet Gynecol},
  year = {2026},
  pmid = {41531227},
  doi = {doi: 10.1097/GCO.0000000000001087},
  url = {https://pubmed.ncbi.nlm.nih.gov/41531227/},
}

@article{pmid41703706,
  title = {Update on genetics of familial hypercholesterolemia.},
  author = {Freiberger T},
  journal = {Curr Opin Lipidol},
  year = {2026},
  pmid = {41703706},
  doi = {doi: 10.1097/MOL.0000000000001027},
  url = {https://pubmed.ncbi.nlm.nih.gov/41703706/},
}

@article{pmid36634180,
  title = {ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy.},
  author = {["Seo D", "O'Donnell D", "Jain N", "Ulrich J", "Herz J", "Li Y", "Lemieux M", "Cheng J", "Hu H", "Serrano J"]},
  journal = {Science (New York, N.Y.)},
  year = {2023},
  pmid = {36634180},
  doi = {10.1126/science.add1236},
}

@article{pmid37957317,
  title = {The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation.},
  author = {Maxine R Nelson, Peng Liu, Ayushi Agrawal, Oscar Yip, Jessica Blumenfeld et al.},
  journal = {Nature neuroscience},
  year = {2023},
  pmid = {37957317},
  doi = {10.1038/s41593-023-01480-8},
  url = {https://pubmed.ncbi.nlm.nih.gov/37957317},
}

@article{pmid37957317,
  title = {The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation.},
  author = {Nelson MR, Liu P, Agrawal A, Yip O, Blumenfeld J et al.},
  journal = {Nat Neurosci},
  year = {2023},
  pmid = {37957317},
  doi = {doi: 10.1038/s41593-023-01480-8},
  url = {https://pubmed.ncbi.nlm.nih.gov/37957317/},
}

@article{pmid35273392,
  title = {Museum of spatial transcriptomics.},
  author = {["Moses L", "Pachter L"]},
  journal = {Nature methods},
  year = {2022},
  pmid = {35273392},
  doi = {10.1038/s41592-022-01409-2},
}

@article{pmid35948010,
  title = {Lactate is an epigenetic metabolite that drives survival in model systems of glioblastoma.},
  author = {Torrini C, Nguyen TTT, Shu C, Mela A, Humala N, Mahajan A, Seeley EH, Zhang G, Westhoff MA, Karpel-Massler G, Bruce JN, Canoll P, Siegelin MD},
  journal = {Molecular cell},
  year = {2022},
  pmid = {35948010},
  doi = {10.1016/j.molcel.2022.06.030},
  url = {https://pubmed.ncbi.nlm.nih.gov/35948010/},
}

@article{pmid36348357,
  title = {ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies.},
  author = {Raulin AC, Doss SV, Trottier ZA, Ikezu TC, Bu G, Liu CC},
  journal = {Mol Neurodegener},
  year = {2022},
  pmid = {36348357},
  doi = {10.1186/s13024-022-00574-4},
  url = {https://pubmed.ncbi.nlm.nih.gov/36348357},
}

@article{pmid33432245,
  title = {Cryo-EM structures of Toll-like receptors in complex with UNC93B1.},
  author = {Ishida H, Asami J, Zhang Z, Nishizawa T, Shigematsu H, Ohto U, Shimizu T},
  journal = {Nature structural & molecular biology},
  year = {2021},
  pmid = {33432245},
  doi = {10.1038/s41594-020-00542-w},
  url = {https://pubmed.ncbi.nlm.nih.gov/33432245/},
}

@article{pmid33462442,
  title = {Precision genome editing using cytosine and adenine base editors in mammalian cells.},
  author = {Huang TP, Newby GA, Liu DR},
  journal = {Nature protocols},
  year = {2021},
  pmid = {33462442},
  doi = {10.1038/s41596-020-00450-9},
  url = {https://pubmed.ncbi.nlm.nih.gov/33462442/},
}

@article{pmid33958804,
  title = {Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer's disease.},
  author = {Zalocusky KA, Najm R, Taubes AL, Hao Y, Yoon SY, Koutsodendris N, Nelson MR, Rao A, Bennett DA, Bant J, Amornkul DJ, Xu Q, An A, Cisne-Thomson O, Huang Y},
  journal = {Nature neuroscience},
  year = {2021},
  pmid = {33958804},
  doi = {10.1038/s41593-021-00851-3},
  url = {https://pubmed.ncbi.nlm.nih.gov/33958804/},
}

@article{pmid34157306,
  title = {Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms.},
  author = {Shi Y, Andhey PS, Ising C, Wang K, Snipes LL, Boyer K, Lawson S, Yamada K, Qin W, Manis M, Serrano JR, Benitez BA, Schmidt RE, Artyomov M, Ulrich JD, Holtzman DM},
  journal = {Neuron},
  year = {2021},
  pmid = {34157306},
  doi = {10.1016/j.neuron.2021.05.034},
  url = {https://pubmed.ncbi.nlm.nih.gov/34157306/},
}

@article{pmid34261473,
  title = {My mind is still mine: a self-portrait in a photography project for adolescents and young adults with cancer.},
  author = {Ferrari A, Patriccioli A, Silva M, Bonvicini MD, Massimino M},
  journal = {BMC palliative care},
  year = {2021},
  pmid = {34261473},
  doi = {10.1186/s12904-021-00789-0},
  url = {https://pubmed.ncbi.nlm.nih.gov/34261473/},
}

@article{pmid34731344,
  title = {Understanding the visual function symptoms and associated functional impacts of phakic presbyopia.},
  author = {Bentley S, Findley A, Chiva-Razavi S, Naujoks C, Patalano F, Johnson C, Arbuckle R, Wolffsohn JS},
  journal = {Journal of patient-reported outcomes},
  year = {2021},
  pmid = {34731344},
  doi = {10.1186/s41687-021-00383-1},
  url = {https://pubmed.ncbi.nlm.nih.gov/34731344/},
}

@article{pmid34788101,
  title = {Re-identification of individuals in genomic datasets using public face images.},
  author = {Venkatesaramani R, Malin BA, Vorobeychik Y},
  journal = {Science advances},
  year = {2021},
  pmid = {34788101},
  doi = {10.1126/sciadv.abg3296},
  url = {https://pubmed.ncbi.nlm.nih.gov/34788101/},
}

@article{pmid31097668,
  title = {Single-cell genomics identifies cell type-specific molecular changes in autism.},
  author = {Velmeshev D, Schirmer L, Jung D, Haeussler M, Perez Y, Mayer S, Bhaduri A, Goyal N, Rowitch DH, Kriegstein AR},
  journal = {Science (New York, N.Y.)},
  year = {2019},
  pmid = {31097668},
  doi = {10.1126/science.aav8130},
  url = {https://pubmed.ncbi.nlm.nih.gov/31097668/},
}

@article{pmid31564456,
  title = {Alzheimer Disease: An Update on Pathobiology and Treatment Strategies.},
  author = {Long JM, Holtzman DM},
  journal = {Cell},
  year = {2019},
  pmid = {31564456},
  doi = {10.1016/j.cell.2019.09.001},
  url = {https://pubmed.ncbi.nlm.nih.gov/31564456},
}

@article{pmid31564456,
  title = {Alzheimer Disease: An Update on Pathobiology and Treatment Strategies.},
  author = {Long JM, Holtzman DM},
  journal = {Cell},
  year = {2019},
  pmid = {31564456},
  doi = {doi: 10.1016/j.cell.2019.09.001},
  url = {https://pubmed.ncbi.nlm.nih.gov/31564456/},
}

@article{pmid33649586,
  title = {Fast searches of large collections of single-cell data using scfind.},
  author = {Lee JTH, Patikas N, Kiselev VY, Hemberg M},
  journal = {Nature Methods},
  year = {2019},
  pmid = {33649586},
  doi = {10.1038/s41592-021-01076-9},
  url = {https://pubmed.ncbi.nlm.nih.gov/33649586/},
}

@article{pmid29566236,
  title = {Is disability in leprosy still a burden? A cross-sectional study in a rural block in Tamil Nadu, India.},
  author = {Ganesan DK, Muthunarayanan L},
  journal = {Transactions of the Royal Society of Tropical Medicine and Hygiene},
  year = {2018},
  pmid = {29566236},
  doi = {10.1093/trstmh/try021},
  url = {https://pubmed.ncbi.nlm.nih.gov/29566236/},
}

@article{pmid28930663,
  title = {The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.},
  author = {Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z},
  journal = {Immunity},
  year = {2017},
  pmid = {28930663},
  doi = {10.1016/j.immuni.2017.08.008},
  url = {https://pubmed.ncbi.nlm.nih.gov/28930663},
}

@article{pmid23571587,
  title = {Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.},
  author = {Reitz C, Jun G, Naj A, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue M, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RC, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL},
  journal = {JAMA},
  year = {2013},
  pmid = {23571587},
  doi = {10.1001/jama.2013.2973},
  url = {https://pubmed.ncbi.nlm.nih.gov/23571587/},
}