% Bibliography for hypothesis h-541d61c3
% Title: Astrocyte-Selective APOE4 Silencing via Lipid Nanoparticles
% Generated: 2026-06-07T19:55:03Z

@article{pmid40639927,
  title = {Alzheimer's disease basics: we all should know.},
  author = {Das S},
  journal = {Neurological research},
  year = {2026},
  pmid = {40639927},
  doi = {10.1080/01616412.2025.2529560},
  url = {https://pubmed.ncbi.nlm.nih.gov/40639927/},
}

@article{pmid40747850,
  title = {Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized controlled trial.},
  author = {Saadmaan G, Dalmasso MC, Maria M, Lehtisalo J, Hiltunen M et al.},
  journal = {Brain},
  year = {2026},
  pmid = {40747850},
  doi = {doi: 10.1093/brain/awaf277},
  url = {https://pubmed.ncbi.nlm.nih.gov/40747850/},
}

@article{pmid40835432,
  title = {APOE4 reprograms microglial lipid metabolism in Alzheimer's disease: Mechanisms and therapeutic implications.},
  author = {["Chen Jiajie", "Zhao Shuoyan", "Zhou Yingying", "Wang Luyao", "Chen Qin"]},
  journal = {Bioscience trends},
  year = {2026},
  pmid = {40835432},
  doi = {10.5582/bst.2025.01148},
}

@article{pmid41338186,
  title = {Protective ApoE variants support neuronal function by effluxing oxidized phospholipids.},
  author = {Ralhan I, Do AD, Bae JY, Feringa FM, Cai W, Chang J, Chik K, Lee NYJ, Gerry CJ, van der Kant R, Jackson J, Ricq EL, Ioannou MS},
  journal = {Neuron},
  year = {2026},
  pmid = {41338186},
  doi = {10.1016/j.neuron.2025.10.040},
  url = {https://pubmed.ncbi.nlm.nih.gov/41338186/},
}

@article{pmid41679672,
  title = {Postoperative cognitive dysfunction and neurodegeneration: From inflammation to precision medicine.},
  author = {Lin X, Luo Y, Zhu Q},
  journal = {Brain Res Bull},
  year = {2026},
  pmid = {41679672},
  doi = {doi: 10.1016/j.brainresbull.2026.111776},
  url = {https://pubmed.ncbi.nlm.nih.gov/41679672/},
}

@article{pmid41692246,
  title = {Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform.},
  author = {Strickland MR, Wang Z, Golden LR, Wang H, Lu P et al.},
  journal = {J Lipid Res},
  year = {2026},
  pmid = {41692246},
  doi = {doi: 10.1016/j.jlr.2026.101000},
  url = {https://pubmed.ncbi.nlm.nih.gov/41692246/},
}

@article{pmid41720779,
  title = {Genetic modifiers of APOE-ε4-associated cognitive decline.},
  author = {Contreras AG, Walters S, Eissman JM, Archer DB, Regelson AN, Durant A, Clifton M, Mukherjee S, Lee ML, Choi SE, Scollard P, Trittschuh EH, Mez J, Bush WS, Kunkle BW, Cruchaga C, Naj AC, Gifford KA, Bilgel M, Kuzma AB, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer’s Disease Genetics Consortium (ADGC), Alzheimer’s Disease Sequencing Project (ADSP), Cuccaro ML, Pericak-Vance MA, Farrer LA, Wang LS, Schellenberg GD, Haines JL, Jefferson AL},
  journal = {Nature communications},
  year = {2026},
  pmid = {41720779},
  doi = {10.1038/s41467-026-68933-z},
  url = {https://pubmed.ncbi.nlm.nih.gov/41720779/},
}

@article{pmid41772271,
  title = {Modulating LRP1 Pathways in Alzheimer's Disease: Mechanistic Insights and Emerging Therapies.},
  author = {Mushtaq T, Hameed H, Khan MA, Tariq U, Hameed A, Zaman M},
  journal = {Molecular neurobiology},
  year = {2026},
  pmid = {41772271},
  doi = {10.1007/s12035-026-05775-2},
  url = {https://pubmed.ncbi.nlm.nih.gov/41772271/},
}

@article{pmid41931258,
  title = {CRISPR-Cas9 and next-generation gene editing strategies for therapeutic intervention of neurodegenerative pathways in Alzheimer's disease: a state-of-the-art review.},
  author = {Khan MS, Zafar I, Jamal A, Bahwerth FS, Khan S et al.},
  journal = {Acta Neurol Belg},
  year = {2026},
  pmid = {41931258},
  doi = {doi: 10.1007/s13760-026-03033-9},
  url = {https://pubmed.ncbi.nlm.nih.gov/41931258/},
}

@article{pmid41585268,
  title = {Viral and non-viral cellular therapies for neurodegeneration.},
  author = {["Srivastav Jyotsna", "Sharma Sachin"]},
  journal = {Frontiers in medicine},
  year = {2025},
  pmid = {41585268},
  doi = {10.1016/j.addr.2021.113834},
}

@article{pmid37805344,
  title = {The cell biology of APOE in the brain.},
  author = {Windham IA, Cohen S},
  journal = {Trends Cell Biol},
  year = {2024},
  pmid = {37805344},
  doi = {10.1016/j.tcb.2023.09.004},
  url = {https://pubmed.ncbi.nlm.nih.gov/37805344},
}

@article{pmid37995685,
  title = {Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist.},
  author = {Litvinchuk A, Suh JH, Guo JL, Lin K, Davis SS, Bien-Ly N, Tycksen E, Tabor GT, Remolina Serrano J, Manis M},
  journal = {Neuron},
  year = {2024},
  pmid = {37995685},
  doi = {10.1016/j.neuron.2023.10.023},
  url = {https://pubmed.ncbi.nlm.nih.gov/37995685},
}

@article{pmid38191720,
  title = {Cell type-specific roles of APOE4 in Alzheimer disease.},
  author = {["Blumenfeld Jessica", "Yip Oscar", "Kim Min Joo", "Huang Yadong"]},
  journal = {Nature reviews. Neuroscience},
  year = {2024},
  pmid = {38191720},
  doi = {10.1002/alz.13436},
}

@article{pmid38334983,
  title = {APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size.},
  author = {["Windham Ian A", "Powers Alex E", "Ragusa Joey V", "Wallace E Diane", "Zanellati Maria Clara"]},
  journal = {The Journal of cell biology},
  year = {2024},
  pmid = {38334983},
  doi = {10.1016/S0021-9258(18)91039-2},
}

@article{pmid36849076,
  title = {Regulation of astrocyte lipid metabolism and ApoE secretionby the microglial oxysterol, 25-hydroxycholesterol.},
  author = {["Cashikar Anil G", "Toral-Rios Danira", "Timm David", "Romero Johnathan", "Strickland Michael"]},
  journal = {Journal of lipid research},
  year = {2023},
  pmid = {36849076},
  doi = {10.1016/j.jlr.2023.100350},
}

@article{pmid37749326,
  title = {APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints.},
  author = {Yin Z, Rosenzweig N, Kleemann KL, Zhang X, Brandão W, Margeta MA, Schroeder C, Sivanathan KN, Silveira S, Gauthier C, Mallah D, Pitts KM, Durao A, Herron S, Shorey H, Cheng Y, Barry JL, Krishnan RK, Wakelin S, Rhee J, Yung A, Aronchik M, Wang C, Jain N, Bao X, Gerrits E, Brouwer N, Deik A, Tenen DG, Ikezu T},
  journal = {Nature immunology},
  year = {2023},
  pmid = {37749326},
  doi = {10.1038/s41590-023-01627-6},
  url = {https://pubmed.ncbi.nlm.nih.gov/37749326/},
}

@article{pmid35750033,
  title = {Cholesterol and matrisome pathways dysregulated in astrocytes and microglia.},
  author = {["Tcw J", "Qian L", "Pipalia N", "Chao M", "Liang S", "Shi Y", "Jain B", "Bertelsen S", "Kapoor M", "Marcora E"]},
  journal = {Cell},
  year = {2022},
  pmid = {35750033},
  doi = {10.1016/j.cell.2022.05.017},
}

@article{pmid33340485,
  title = {APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches.},
  author = {Serrano-Pozo A, Das S, Hyman BT},
  journal = {Lancet Neurol},
  year = {2021},
  pmid = {33340485},
  doi = {10.1016/S1474-4422(20)30412-9},
  url = {https://pubmed.ncbi.nlm.nih.gov/33340485},
}

@article{pmid33340485,
  title = {APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches.},
  author = {Serrano-Pozo A, Das S, Hyman BT},
  journal = {Lancet Neurol},
  year = {2021},
  pmid = {33340485},
  doi = {doi: 10.1016/S1474-4422(20)30412-9},
  url = {https://pubmed.ncbi.nlm.nih.gov/33340485/},
}

@article{pmid33406436,
  title = {ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism.},
  author = {["Qi Guoyuan", "Mi Yashi", "Shi Xiaojian", "Gu Haiwei", "Brinton Roberta Diaz"]},
  journal = {Cell reports},
  year = {2021},
  pmid = {33406436},
  doi = {10.1016/j.celrep.2020.108572},
}

@article{pmid33658354,
  title = {APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia.},
  author = {Sienski G, Narayan P, Bonner JM, Kory N, Boland S, Arczewska AA, Ralvenius WT, Akay L, Lockshin E, He L},
  journal = {Sci Transl Med},
  year = {2021},
  pmid = {33658354},
  doi = {10.1126/scitranslmed.aaz4564},
  url = {https://pubmed.ncbi.nlm.nih.gov/33658354},
}

@article{pmid33921683,
  title = {Precision Nutrition for Alzheimer's Prevention in },
  author = {["Norwitz Nicholas G", "Saif Nabeel", "Ariza Ingrid Estrada", "Isaacson Richard S"]},
  journal = {Nutrients},
  year = {2021},
  pmid = {33921683},
  doi = {10.1016/j.jalz.2019.08.198},
}

@article{pmid29861287,
  title = {APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.},
  author = {Lin YT, Seo J, Gao F, Feldman HM, Wen HL, Penney J, Cam HP, Gjoneska E, Raja WK, Cheng J, Rueda R, Kritskiy O, Abdurrob F, Peng Z, Milo B, Yu CJ, Elmsaouri S, Dey D, Ko T, Yankner BA, Tsai LH},
  journal = {Neuron},
  year = {2018},
  pmid = {29861287},
  doi = {10.1016/j.neuron.2018.05.008},
  url = {https://pubmed.ncbi.nlm.nih.gov/29861287/},
}