% Bibliography for hypothesis h-9e9fee95
% Title: Circadian Glymphatic Entrainment via Targeted Orexin Receptor Modulation
% Generated: 2026-04-28T15:12:08Z

@article{pmid40439868,
  title = {Combined effects of HCRTR1/2 gene variants and non-genetic factors on sleep-wake transition and hemodynamic stability during propofol, dexmedetomidine, and remifentanil anesthesia.},
  author = {Zheng Z, Xue F, Wang H, Gu Q, Hu R, Li X, Huang M, Huang W, Wang Z, Li J},
  journal = {Pharmacol Rep},
  year = {2025},
  pmid = {40439868},
  doi = {10.1007/s43440-025-00740-7},
  url = {https://pubmed.ncbi.nlm.nih.gov/40439868},
}

@article{pmid41383480,
  title = {Signal transduction, dimerization, and therapeutic targeting of Orexin and receptor systems.},
  author = {Zhang S, Wang P, Ji B, Shao Y, Hou S et al.},
  journal = {Front Pharmacol},
  year = {2025},
  pmid = {41383480},
  doi = {doi: 10.3389/fphar.2025.1697406},
  url = {https://pubmed.ncbi.nlm.nih.gov/41383480/},
}

@article{pmid39437604,
  title = {Bioinformatic analysis of neuropeptide related genes in patients diagnosed with invasive breast carcinoma.},
  author = {Yay F, Ayan D},
  journal = {Comput Biol Med},
  year = {2024},
  pmid = {39437604},
  doi = {doi: 10.1016/j.compbiomed.2024.109304},
  url = {https://pubmed.ncbi.nlm.nih.gov/39437604/},
}

@article{pmid39698172,
  title = {Effects of Paradoxical Sleep Deprivation on MCH and Hypocretin Systems.},
  author = {Agamme ALDA, Tufik S, Torterolo P, D'Almeida V},
  journal = {Sleep science (Sao Paulo, Brazil)},
  year = {2024},
  pmid = {39698172},
  doi = {10.1055/s-0044-1782171},
  url = {https://pubmed.ncbi.nlm.nih.gov/39698172/},
}

@article{pmid41127649,
  title = {Blast Exposure Induces Acute Alterations in Circadian Clock Genes in the Hypothalamus and Pineal Gland in Rats: An Exploratory Study.},
  author = {Govindarajulu M, Patel MY, Krishnan J, Long JB, Arun P},
  journal = {Neurotrauma reports},
  year = {2023},
  pmid = {41127649},
  doi = {10.1089/neur.2023.0048},
  url = {https://pubmed.ncbi.nlm.nih.gov/41127649/},
}

@article{pmid34686377,
  title = {Outcomes of a telemedicine bowel management program during COVID-19.},
  author = {["Knaus M", "Ahmad H", "Metzger G", "Beyene T", "Thomas J", "Weaver L", "Gasior A", "Wood R", "Halaweish I"]},
  journal = {Journal of pediatric surgery},
  year = {2022},
  pmid = {34686377},
  doi = {10.1016/j.jpedsurg.2021.09.012},
}

@article{pmid35568783,
  title = {Evaluation of the α-casein (CSN1S1) locus as a potential target for a site-specific transgene integration.},
  author = {["Smirnov A", "Kontsevaya G", "Shnaider T", "Yunusova A", "Feofanova N", "Gerlinskaya L", "Serova I", "Serov O", "Battulin N"]},
  journal = {Scientific reports},
  year = {2022},
  pmid = {35568783},
  doi = {10.1038/s41598-022-12071-1},
}

@article{pmid35724928,
  title = {Contextual generalization of social stress learning is modulated by orexin receptors in basolateral amygdala.},
  author = {Yaeger JDW, Krupp KT, Summers TR, Summers CH},
  journal = {Neuropharmacology},
  year = {2022},
  pmid = {35724928},
  doi = {10.1016/j.neuropharm.2022.109168},
  url = {https://pubmed.ncbi.nlm.nih.gov/35724928/},
}

@article{pmid33568662,
  title = {Genetic determinants of daytime napping and effects on cardiometabolic health.},
  author = {Dashti HS, Daghlas I, Lane JM, Huang Y, Udler MS, Wang H, Ollila HM, Jones SE, Kim J, Wood AR},
  journal = {Nat Commun},
  year = {2021},
  pmid = {33568662},
  doi = {10.1038/s41467-020-20585-3},
  url = {https://pubmed.ncbi.nlm.nih.gov/33568662},
}

@article{pmid33661831,
  title = {Sleep interventions in AD trials show inconsistent cognitive benefits, possibly due to disease stage heterogeneity},
  journal = {Sleep Medicine Reviews},
  year = {2021},
  pmid = {33661831},
}

@article{pmid34052813,
  title = {Hypocretin/Orexin Receptor Pharmacology and Sleep Phases.},
  author = {Sun Y, Tisdale RK, Kilduff TS},
  journal = {Front Neurol Neurosci},
  year = {2021},
  pmid = {34052813},
  doi = {10.1159/000514963},
  url = {https://pubmed.ncbi.nlm.nih.gov/34052813},
}

@article{pmid31539636,
  title = {Machine learning for clinical decision support in infectious diseases: a narrative review of current applications.},
  author = {["Peiffer-Smadja N", "Rawson T", "Ahmad R", "Buchard A", "Georgiou P", "Lescure F", "Birgand G", "Holmes A"]},
  journal = {Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases},
  year = {2020},
  pmid = {31539636},
  doi = {10.1016/j.cmi.2019.09.009},
}

@article{pmid32513823,
  title = {Complexities of Understanding Function from CKD-Associated DNA Variants.},
  author = {["Lin J", "Susztak K"]},
  journal = {Clinical journal of the American Society of Nephrology : CJASN},
  year = {2020},
  pmid = {32513823},
  doi = {10.2215/CJN.15771219},
}

@article{pmid30513028,
  title = {Prostaglandin D},
  author = {["Marone G", "Galdiero M", "Pecoraro A", "Pucino V", "Criscuolo G", "Triassi M", "Varricchi G"]},
  journal = {Expert opinion on investigational drugs},
  year = {2019},
  pmid = {30513028},
  doi = {10.1080/13543784.2019.1555237},
}

@article{pmid31852950,
  title = {CF-PA},
  author = {["Morishita R", "Sugiyama S", "Denda M", "Tokunaga S", "Kido K", "Shioya R", "Ozawa S", "Sawasaki T"]},
  journal = {Scientific reports},
  year = {2019},
  pmid = {31852950},
  doi = {10.1038/s41598-019-55785-5},
}

@article{pmid29476079,
  title = {Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms.},
  author = {["Pierce B", "Tong L", "Argos M", "Demanelis K", "Jasmine F", "Rakibuz-Zaman M", "Sarwar G", "Islam M", "Shahriar H", "Islam T"]},
  journal = {Nature communications},
  year = {2018},
  pmid = {29476079},
  doi = {10.1038/s41467-018-03209-9},
}

@article{pmid29795050,
  title = {Transitions from Single- to Multi-Locus Processes during Speciation with Gene Flow.},
  author = {["Schilling M", "Mullen S", "Kronforst M", "Safran R", "Nosil P", "Feder J", "Gompert Z", "Flaxman S"]},
  journal = {Genes},
  year = {2018},
  pmid = {29795050},
  doi = {10.3390/genes9060274},
}

@article{pmid28877966,
  title = {T-Cell Mediation of Pregnancy Analgesia Affecting Chronic Pain in Mice.},
  author = {["Rosen S", "Ham B", "Drouin S", "Boachie N", "Chabot-Dore A", "Austin J", "Diatchenko L", "Mogil J"]},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year = {2017},
  pmid = {28877966},
  doi = {10.1523/JNEUROSCI.2053-17.2017},
}

@article{pmid23852314,
  title = {Pentylenetetrazol-induced seizures are exacerbated by sleep deprivation through orexin receptor-mediated hippocampal cell proliferation.},
  author = {Ni LY, Zhu MJ, Song Y, Liu XM, Tang JY},
  journal = {Neurol Sci},
  year = {2014},
  pmid = {23852314},
  doi = {doi: 10.1007/s10072-013-1495-5},
  url = {https://pubmed.ncbi.nlm.nih.gov/23852314/},
}

@article{pmid24969517,
  title = {Is HCRTR2 a genetic risk factor for Alzheimer's disease?},
  author = {Gallone S, Boschi S, Rubino E, De Martino P, Scarpini E, Galimberti D, Fenoglio C, Acutis PL, Maniaci MG, Pinessi L, Rainero I},
  journal = {Dementia and geriatric cognitive disorders},
  year = {2014},
  pmid = {24969517},
  doi = {10.1159/000359964},
  url = {https://pubmed.ncbi.nlm.nih.gov/24969517/},
}

@article{pmid26085845,
  title = {PreImplantation factor (PIF*) promotes embryotrophic and neuroprotective decidual genes: effect negated by epidermal growth factor.},
  author = {Duzyj CM, Paidas MJ, Jebailey L, Huang JS, Barnea ER},
  journal = {Journal of neurodevelopmental disorders},
  year = {2014},
  pmid = {26085845},
  doi = {10.1186/1866-1955-6-36},
  url = {https://pubmed.ncbi.nlm.nih.gov/26085845/},
}

@article{pmid24136970,
  title = {Sleep drives metabolite clearance from the adult brain.},
  author = {Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, O'Donnell J, Christensen DJ, Nicholson C, Iliff JJ},
  journal = {Science},
  year = {2013},
  pmid = {24136970},
  doi = {10.1126/science.1241224},
  url = {https://pubmed.ncbi.nlm.nih.gov/24136970},
}

@article{pmid11682267,
  title = {A commentary on the neurobiology of the hypocretin/orexin system.},
  author = {Mignot E},
  journal = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year = {2001},
  pmid = {11682267},
  doi = {10.1016/S0893-133X(01)00316-5},
  url = {https://pubmed.ncbi.nlm.nih.gov/11682267/},
}