{"hypothesis_id":"h-SDA-2026-04-26-gap-pubmed-20260412-094853-199f4f1b-01-dominant-negative-spliceosome-titration-20b316433d","gene_symbol":"U2AF2, SF3B1, PRPF8; splicing snRNPs","dataset_version":"gtex_v10","tissues":[{"tissue_id":"Cells_EBV-transformed_lymphocytes","tissue_name":"Cells EBV-transformed lymphocytes","median_tpm":202.236,"is_brain":false},{"tissue_id":"Cervix_Endocervix","tissue_name":"Cervix Endocervix","median_tpm":172.606,"is_brain":false},{"tissue_id":"Uterus","tissue_name":"Uterus","median_tpm":169.905,"is_brain":false},{"tissue_id":"Cells_Cultured_fibroblasts","tissue_name":"Cells Cultured fibroblasts","median_tpm":167.501,"is_brain":false},{"tissue_id":"Ovary","tissue_name":"Ovary","median_tpm":161.328,"is_brain":false},{"tissue_id":"Pituitary","tissue_name":"Pituitary","median_tpm":158.024,"is_brain":false},{"tissue_id":"Spleen","tissue_name":"Spleen","median_tpm":156.8,"is_brain":false},{"tissue_id":"Fallopian_Tube","tissue_name":"Fallopian Tube","median_tpm":151.581,"is_brain":false},{"tissue_id":"Thyroid","tissue_name":"Thyroid","median_tpm":147.729,"is_brain":false},{"tissue_id":"Testis","tissue_name":"Testis","median_tpm":147.44,"is_brain":false},{"tissue_id":"Brain_Cerebellum","tissue_name":"Brain Cerebellum","median_tpm":145.403,"is_brain":true},{"tissue_id":"Brain_Cerebellar_Hemisphere","tissue_name":"Brain Cerebellar Hemisphere","median_tpm":140.575,"is_brain":true},{"tissue_id":"Cervix_Ectocervix","tissue_name":"Cervix Ectocervix","median_tpm":137.4,"is_brain":false},{"tissue_id":"Vagina","tissue_name":"Vagina","median_tpm":124.774,"is_brain":false},{"tissue_id":"Prostate","tissue_name":"Prostate","median_tpm":121.82,"is_brain":false},{"tissue_id":"Lung","tissue_name":"Lung","median_tpm":121.353,"is_brain":false},{"tissue_id":"Nerve_Tibial","tissue_name":"Nerve Tibial","median_tpm":116.953,"is_brain":false},{"tissue_id":"Bladder","tissue_name":"Bladder","median_tpm":116.845,"is_brain":false},{"tissue_id":"Small_Intestine_Terminal_Ileum","tissue_name":"Small Intestine Terminal Ileum","median_tpm":109.853,"is_brain":false},{"tissue_id":"Colon_Sigmoid","tissue_name":"Colon Sigmoid","median_tpm":105.42,"is_brain":false},{"tissue_id":"Esophagus_Mucosa","tissue_name":"Esophagus Mucosa","median_tpm":104.431,"is_brain":false},{"tissue_id":"Esophagus_Gastroesophageal_Junction","tissue_name":"Esophagus Gastroesophageal Junction","median_tpm":104.18,"is_brain":false},{"tissue_id":"Esophagus_Muscularis","tissue_name":"Esophagus Muscularis","median_tpm":102.547,"is_brain":false},{"tissue_id":"Artery_Coronary","tissue_name":"Artery Coronary","median_tpm":99.6952,"is_brain":false},{"tissue_id":"Artery_Aorta","tissue_name":"Artery Aorta","median_tpm":98.0136,"is_brain":false},{"tissue_id":"Breast_Mammary_Tissue","tissue_name":"Breast Mammary Tissue","median_tpm":97.2606,"is_brain":false},{"tissue_id":"Colon_Transverse","tissue_name":"Colon Transverse","median_tpm":96.8424,"is_brain":false},{"tissue_id":"Artery_Tibial","tissue_name":"Artery Tibial","median_tpm":95.3957,"is_brain":false},{"tissue_id":"Skin_Not_Sun_Exposed_Suprapubic","tissue_name":"Skin Not Sun Exposed Suprapubic","median_tpm":94.4979,"is_brain":false},{"tissue_id":"Kidney_Medulla","tissue_name":"Kidney Medulla","median_tpm":93.4183,"is_brain":false},{"tissue_id":"Adipose_Visceral_Omentum","tissue_name":"Adipose Visceral Omentum","median_tpm":91.9405,"is_brain":false},{"tissue_id":"Skin_Sun_Exposed_Lower_leg","tissue_name":"Skin Sun Exposed Lower leg","median_tpm":91.9101,"is_brain":false},{"tissue_id":"Minor_Salivary_Gland","tissue_name":"Minor Salivary Gland","median_tpm":88.9561,"is_brain":false},{"tissue_id":"Adipose_Subcutaneous","tissue_name":"Adipose Subcutaneous","median_tpm":87.5334,"is_brain":false},{"tissue_id":"Adrenal_Gland","tissue_name":"Adrenal Gland","median_tpm":85.5365,"is_brain":false},{"tissue_id":"Stomach","tissue_name":"Stomach","median_tpm":76.5814,"is_brain":false},{"tissue_id":"Brain_Spinal_cord_cervical_c-1","tissue_name":"Brain Spinal cord cervical c-1","median_tpm":59.184,"is_brain":true},{"tissue_id":"Brain_Cortex","tissue_name":"Brain Cortex","median_tpm":59.0999,"is_brain":true},{"tissue_id":"Brain_Frontal_Cortex_BA9","tissue_name":"Brain Frontal Cortex BA9","median_tpm":57.2104,"is_brain":true},{"tissue_id":"Whole_Blood","tissue_name":"Whole Blood","median_tpm":56.1656,"is_brain":false},{"tissue_id":"Kidney_Cortex","tissue_name":"Kidney Cortex","median_tpm":52.6284,"is_brain":false},{"tissue_id":"Brain_Nucleus_accumbens_basal_ganglia","tissue_name":"Brain Nucleus accumbens basal ganglia","median_tpm":50.7181,"is_brain":true},{"tissue_id":"Brain_Hypothalamus","tissue_name":"Brain Hypothalamus","median_tpm":49.4364,"is_brain":true},{"tissue_id":"Brain_Caudate_basal_ganglia","tissue_name":"Brain Caudate basal ganglia","median_tpm":48.6266,"is_brain":true},{"tissue_id":"Heart_Atrial_Appendage","tissue_name":"Heart Atrial Appendage","median_tpm":46.2017,"is_brain":false},{"tissue_id":"Liver","tissue_name":"Liver","median_tpm":44.0928,"is_brain":false},{"tissue_id":"Brain_Anterior_cingulate_cortex_BA24","tissue_name":"Brain Anterior cingulate cortex BA24","median_tpm":43.333,"is_brain":true},{"tissue_id":"Brain_Substantia_nigra","tissue_name":"Brain Substantia nigra","median_tpm":40.9752,"is_brain":true},{"tissue_id":"Brain_Putamen_basal_ganglia","tissue_name":"Brain Putamen basal ganglia","median_tpm":39.4736,"is_brain":true},{"tissue_id":"Brain_Amygdala","tissue_name":"Brain Amygdala","median_tpm":38.5222,"is_brain":true},{"tissue_id":"Brain_Hippocampus","tissue_name":"Brain Hippocampus","median_tpm":38.4484,"is_brain":true},{"tissue_id":"Muscle_Skeletal","tissue_name":"Muscle Skeletal","median_tpm":36.7395,"is_brain":false},{"tissue_id":"Pancreas","tissue_name":"Pancreas","median_tpm":34.7779,"is_brain":false},{"tissue_id":"Heart_Left_Ventricle","tissue_name":"Heart Left Ventricle","median_tpm":31.9799,"is_brain":false}],"brain_tissues":[{"tissue_id":"Brain_Cerebellum","tissue_name":"Brain Cerebellum","median_tpm":145.403,"is_brain":true},{"tissue_id":"Brain_Cerebellar_Hemisphere","tissue_name":"Brain Cerebellar Hemisphere","median_tpm":140.575,"is_brain":true},{"tissue_id":"Brain_Spinal_cord_cervical_c-1","tissue_name":"Brain Spinal cord cervical c-1","median_tpm":59.184,"is_brain":true},{"tissue_id":"Brain_Cortex","tissue_name":"Brain Cortex","median_tpm":59.0999,"is_brain":true},{"tissue_id":"Brain_Frontal_Cortex_BA9","tissue_name":"Brain Frontal Cortex BA9","median_tpm":57.2104,"is_brain":true},{"tissue_id":"Brain_Nucleus_accumbens_basal_ganglia","tissue_name":"Brain Nucleus accumbens basal ganglia","median_tpm":50.7181,"is_brain":true},{"tissue_id":"Brain_Hypothalamus","tissue_name":"Brain Hypothalamus","median_tpm":49.4364,"is_brain":true},{"tissue_id":"Brain_Caudate_basal_ganglia","tissue_name":"Brain Caudate basal ganglia","median_tpm":48.6266,"is_brain":true},{"tissue_id":"Brain_Anterior_cingulate_cortex_BA24","tissue_name":"Brain Anterior cingulate cortex BA24","median_tpm":43.333,"is_brain":true},{"tissue_id":"Brain_Substantia_nigra","tissue_name":"Brain Substantia nigra","median_tpm":40.9752,"is_brain":true},{"tissue_id":"Brain_Putamen_basal_ganglia","tissue_name":"Brain Putamen basal ganglia","median_tpm":39.4736,"is_brain":true},{"tissue_id":"Brain_Amygdala","tissue_name":"Brain Amygdala","median_tpm":38.5222,"is_brain":true},{"tissue_id":"Brain_Hippocampus","tissue_name":"Brain Hippocampus","median_tpm":38.4484,"is_brain":true}]}