% Bibliography for hypothesis h-addc0a61
% Title: Chromatin Accessibility Restoration via BRD4 Modulation
% Generated: 2026-04-28T18:42:53Z

@article{pmid41707797,
  title = {Molecular insights for the tumor suppressor role of SPOP in prostate cancer.},
  author = {Yan P, Xue X, Hou T, Wang J, Jiang W et al.},
  journal = {Biochim Biophys Acta Rev Cancer},
  year = {2026},
  pmid = {41707797},
  doi = {doi: 10.1016/j.bbcan.2026.189560},
  url = {https://pubmed.ncbi.nlm.nih.gov/41707797/},
}

@article{pmid41786244,
  title = {Nutrient-driven histone acetylation underlies energy storage and mobilization.},
  author = {Chen L, Zhu L, Xiao H, Wang X, Xia F et al.},
  journal = {Mol Metab},
  year = {2026},
  pmid = {41786244},
  doi = {doi: 10.1016/j.molmet.2026.102344},
  url = {https://pubmed.ncbi.nlm.nih.gov/41786244/},
}

@article{pmid41807492,
  title = {Punicalagin with anti-inflammatory activities affects Brd-4 mediated chromatin remodeling for attenuating inflammatory osteolysis.},
  author = {Li H, Li Q, Wan T, Wang Y, Zhang S},
  journal = {Scientific reports},
  year = {2026},
  pmid = {41807492},
  doi = {10.1038/s41598-026-41262-3},
  url = {https://pubmed.ncbi.nlm.nih.gov/41807492/},
}

@article{pmid41828493,
  title = {Targeting BRD4-A Promising Therapeutic Option for Glioblastoma?},
  author = {Lindner M, Lisińska D, Kędzierzyńska A, Majchrzak-Celińska A},
  journal = {International journal of molecular sciences},
  year = {2026},
  pmid = {41828493},
  doi = {10.3390/ijms27052268},
  url = {https://pubmed.ncbi.nlm.nih.gov/41828493/},
}

@article{pmid41852276,
  title = {Alkyne Two-Phase Strategy: Rapid Generation of TK-285-Derived PROTACs as BRD4 Degraders.},
  author = {Yamakoshi H, Watanabe R, Segawa R, Ishihara R, Tachibana R, Kudo G, Nagasawa S, Yamanaka S, Ito A, Takeda H, Sawasaki T, Yoshino R, Hirokawa T, Doi T, Hirasawa N, Iwabuchi Y},
  journal = {Journal of medicinal chemistry},
  year = {2026},
  pmid = {41852276},
  doi = {10.1021/acs.jmedchem.5c03771},
  url = {https://pubmed.ncbi.nlm.nih.gov/41852276/},
}

@article{pmid41865095,
  title = {High-intensity interval training alleviates COPD-induced gastrocnemius muscle dysfunction via the BRD4/PGC-1α axis through restoring mitochondrial function and oxidative fiber composition.},
  author = {Zhu C, Peng W, Yang L, Zhang W},
  journal = {Journal of muscle research and cell motility},
  year = {2026},
  pmid = {41865095},
  doi = {10.1007/s10974-026-09723-4},
  url = {https://pubmed.ncbi.nlm.nih.gov/41865095/},
}

@article{pmid41874277,
  title = {Hsp70-Targeting Chimeras Enable Dual Proteasomal and Lysosomal Degradation of Intracellular and Extracellular Proteins.},
  author = {Wang Z, Li P, Yin F, Zhang H, Wang S, Teng Y, Fan X, Wang K, Zhang Y, Lun H, Song T, Wang Z, Zhang Z},
  journal = {Journal of medicinal chemistry},
  year = {2026},
  pmid = {41874277},
  doi = {10.1021/acs.jmedchem.5c03784},
  url = {https://pubmed.ncbi.nlm.nih.gov/41874277/},
}

@article{pmid41877232,
  title = {A photothermal immune hydrogel dressing for enhanced post-melanoma resection treatment.},
  author = {Tan D, Zhu W, Liu S, Liao F, Xu X, Luo J, Zhang S, Xie Q, Liang Y, Yu Z, Zhang P},
  journal = {Journal of nanobiotechnology},
  year = {2026},
  pmid = {41877232},
  doi = {10.1186/s12951-026-04292-7},
  url = {https://pubmed.ncbi.nlm.nih.gov/41877232/},
}

@article{pmid41889836,
  title = {Sertad4 Regulates Pathological Cardiac Remodeling.},
  author = {Francois A, Bermeo-Blanco O, Nguyen BT, Marcho LM, Elbon A, Ambardekar AV, Bristow MR, Zhang Y, Gumina RJ, Stratton MS},
  journal = {bioRxiv : the preprint server for biology},
  year = {2026},
  pmid = {41889836},
  doi = {10.64898/2026.03.18.708586},
  url = {https://pubmed.ncbi.nlm.nih.gov/41889836/},
}

@article{pmid41904167,
  title = {Cartilage targeting hydrogel nanoplatform degrades BRD4 to alleviate osteoarthritis via Nav1.7 axis.},
  author = {Zhao Q, Xu T, Du Z, Lu X, Zhang Y, Peng L, Gao Z, Wang W, Zhu B, Liu Z, Yang G, Zhao H, Song Z, Lou Q, Li J, Ren Z, Yu Z, Wang W, Liu Y, Liang H, de la Fuente JM, Cui D},
  journal = {Nature communications},
  year = {2026},
  pmid = {41904167},
  doi = {10.1038/s41467-026-71246-w},
  url = {https://pubmed.ncbi.nlm.nih.gov/41904167/},
}

@article{pmid41917296,
  title = {The epigenetic and epitranscriptomic regulation of Brd4-Mettl3 axis on STING mediated vascular calcification.},
  author = {Zhao J, Luo X, Wang Z, Luo W, Wu S, Ma X, Liu H, Chen Y, Pi S, Zhang J, Zhang J, Liu C, Bi X, Qin Z},
  journal = {Inflammation research : official journal of the European Histamine Research Society ... [et al.]},
  year = {2026},
  pmid = {41917296},
  doi = {10.1007/s00011-026-02225-6},
  url = {https://pubmed.ncbi.nlm.nih.gov/41917296/},
}

@article{pmid40959274,
  title = {Recovery of FAM134A-mediated ER-phagy through BRD4 inhibition alleviates ethanol-induced neurodegeneration.},
  author = {["Lim J", "Chae C", "Yoon J", "Cho J", "Park J", "Han S", "Chang H", "Kim S", "Kim H", "Jung Y"]},
  journal = {International journal of biological sciences},
  year = {2025},
  pmid = {40959274},
  doi = {10.7150/ijbs.116673},
}

@article{pmid38561350,
  title = {Targeted Protein O-GlcNAcylation Using Bifunctional Small Molecules.},
  author = {["Ma B", "Khan K", "Xu T", "Xeque Amada J", "Guo Z", "Huang Y", "Yan Y", "Lam H", "Cheng A", "Ng B"]},
  journal = {Journal of the American Chemical Society},
  year = {2024},
  pmid = {38561350},
  doi = {10.1021/jacs.3c14380},
}

@article{pmid38643236,
  title = {Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia.},
  author = {["Rosenthal Z", "Fass D", "Payne N", "She A", "Patnaik D", "Hennig K", "Tesla R", "Werthmann G", "Guhl C", "Reis S"]},
  journal = {Scientific reports},
  year = {2024},
  pmid = {38643236},
  doi = {10.1038/s41598-024-59110-7},
}

@article{pmid39002520,
  title = {A novel PROTAC molecule dBET1 alleviates pathogenesis of experimental autoimmune encephalomyelitis in mice by degrading BRD4.},
  author = {["Song Z", "Li J", "He Y", "Wang X", "Tian J", "Wu Y"]},
  journal = {International immunopharmacology},
  year = {2024},
  pmid = {39002520},
  doi = {10.1016/j.intimp.2024.112646},
}

@article{pmid39294122,
  title = {A human Tau expressing zebrafish model of progressive supranuclear palsy identifies Brd4 as a regulator of microglial synaptic elimination.},
  author = {["Bai Q", "Shao E", "Ma D", "Jiao B", "Scheetz S", "Hartnett-Scott K", "Ilin V", "Aizenman E", "Kofler J", "Burton E"]},
  journal = {Nature communications},
  year = {2024},
  pmid = {39294122},
  doi = {10.1038/s41467-024-52173-0},
}

@article{pmid39315698,
  title = {Chem-CRISPR/dCas9FCPF: a platform for chemically induced epigenome editing.},
  author = {["Altinbay M", "Wang J", "Chen J", "Sch\u00e4fer D", "Sprang M", "Blagojevic B", "W\u00f6lfl S", "Andrade-Navarro M", "Dikic I", "Knapp S"]},
  journal = {Nucleic acids research},
  year = {2024},
  pmid = {39315698},
  doi = {10.1093/nar/gkae798},
}

@article{pmid36710583,
  title = {Bromodomain-containing protein 4 (BRD4): a key player in inflammatory bowel disease and potential to inspire epigenetic therapeutics.},
  author = {["Ma Z", "Bolinger A", "Zhou J", "Tian B"]},
  journal = {Expert opinion on therapeutic targets},
  year = {2023},
  pmid = {36710583},
  doi = {10.1080/14728222.2023.2175317},
}

@article{pmid36979729,
  title = {Bromodomain and Extra-Terminal Proteins in Brain Physiology and Pathology: BET-ing on Epigenetic Regulation.},
  author = {["Martella N", "Pensabene D", "Varone M", "Colardo M", "Petraroia M", "Sergio W", "La Rosa P", "Moreno S", "Segatto M"]},
  journal = {Biomedicines},
  year = {2023},
  pmid = {36979729},
  doi = {10.3390/biomedicines11030750},
}

@article{pmid37486983,
  title = {First-in-human Study of AZD5153, A Small-molecule Inhibitor of Bromodomain Protein 4, in Patients with Relapsed/Refractory Malignant Solid Tumors and Lymphoma.},
  author = {["Hamilton E", "Wang J", "Oza A", "Patel M", "Ulahannan S", "Bauer T", "Karlix J", "Zeron-Medina J", "Fabbri G", "Marco-Casanova P"]},
  journal = {Molecular cancer therapeutics},
  year = {2023},
  pmid = {37486983},
  doi = {10.1158/1535-7163.MCT-23-0065},
}

@article{pmid37846362,
  title = {Genetic and epigenetic regulators of retinal Müller glial cell reprogramming.},
  author = {["Xiao X", "Liao Z", "Zou J"]},
  journal = {Advances in ophthalmology practice and research},
  year = {2023},
  pmid = {37846362},
  doi = {10.1016/j.aopr.2023.05.004},
}

@article{pmid35645713,
  title = {Bromodomains in Human-Immunodeficiency Virus-Associated Neurocognitive Disorders: A Model of Ferroptosis-Induced Neurodegeneration.},
  author = {["Sfera A", "Thomas K", "Andronescu C", "Jafri N", "Sfera D", "Sasannia S", "Zapata-Mart\u00edn Del Campo C", "Maldonado J"]},
  journal = {Frontiers in neuroscience},
  year = {2022},
  pmid = {35645713},
  doi = {10.3389/fnins.2022.904816},
}

@article{pmid32647323,
  title = {Fedratinib, a newly approved treatment for patients with myeloproliferative neoplasm-associated myelofibrosis.},
  author = {["Talpaz M", "Kiladjian J"]},
  journal = {Leukemia},
  year = {2021},
  pmid = {32647323},
  doi = {10.1038/s41375-020-0954-2},
}

@article{pmid33369245,
  title = {Neuron type-specific increase in lamin B1 contributes to nuclear dysfunction in Huntington's disease.},
  author = {["Alcal\u00e1-Vida R", "Garcia-Forn M", "Castany-Pladevall C", "Creus-Muncunill J", "Ito Y", "Blanco E", "Golbano A", "Cresp\u00ed-V\u00e1zquez K", "Parry A", "Slater G"]},
  journal = {EMBO molecular medicine},
  year = {2021},
  pmid = {33369245},
  doi = {10.15252/emmm.202012105},
}

@article{pmid33767445,
  title = {Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice.},
  author = {["De Gasparo R", "Pedotti M", "Simonelli L", "Nickl P", "Muecksch F", "Cassaniti I", "Percivalle E", "Lorenzi J", "Mazzola F", "Magr\u00ec D"]},
  journal = {Nature},
  year = {2021},
  pmid = {33767445},
  doi = {10.1038/s41586-021-03461-y},
}

@article{pmid34108480,
  title = {Chromosome compartments on the inactive X guide TAD formation independently of transcription during X-reactivation.},
  author = {["Bauer M", "Vidal E", "Zorita E", "\u00dcresin N", "Pinter S", "Filion G", "Payer B"]},
  journal = {Nature communications},
  year = {2021},
  pmid = {34108480},
  doi = {10.1038/s41467-021-23610-1},
}

@article{pmid34216895,
  title = {The design, synthesis and cellular imaging of a tumor-anchored, potent and cell-permeable BRD4-targeted fluorescent ligands.},
  author = {["Zhang H", "Zhang M", "Zheng Y", "Zhang J", "Xu H"]},
  journal = {Bioorganic chemistry},
  year = {2021},
  pmid = {34216895},
  doi = {10.1016/j.bioorg.2021.105120},
}

@article{pmid31844326,
  title = {An intrinsic role of IL-33 in T},
  author = {["Hatzioannou A", "Banos A", "Sakelaropoulos T", "Fedonidis C", "Vidali M", "K\u00f6hne M", "H\u00e4ndler K", "Boon L", "Henriques A", "Koliaraki V"]},
  journal = {Nature immunology},
  year = {2020},
  pmid = {31844326},
  doi = {10.1038/s41590-019-0555-2},
}

@article{pmid32220285,
  title = {Management of pregnant women infected with COVID-19.},
  author = {Yongwen Luo; Kai Yin},
  journal = {The Lancet. Infectious diseases},
  year = {2020},
  pmid = {32220285},
  doi = {10.1016/S1473-3099(20)30191-2},
  url = {https://pubmed.ncbi.nlm.nih.gov/32220285/},
}

@article{pmid33015071,
  title = {Bromodomain Protein BRD4 Is Essential for Hair Cell Function and Survival.},
  author = {["Kannan-Sundhari A", "Abad C", "Maloof M", "Ayad N", "Young J", "Liu X", "Walz K"]},
  journal = {Frontiers in cell and developmental biology},
  year = {2020},
  pmid = {33015071},
  doi = {10.3389/fcell.2020.576654},
}

@article{pmid30190372,
  title = {Does TMB Impact the Effectiveness of TKIs in },
  author = {["Cheng M", "Oxnard G"]},
  journal = {Clinical cancer research : an official journal of the American Association for Cancer Research},
  year = {2019},
  pmid = {30190372},
  doi = {10.1158/1078-0432.CCR-18-2368},
}

@article{pmid30711772,
  title = {First-in-human phase I study of the bromodomain and extraterminal motif inhibitor BAY 1238097: emerging pharmacokinetic/pharmacodynamic relationship and early termination due to unexpected toxicity.},
  author = {["Postel-Vinay S", "Herbschleb K", "Massard C", "Woodcock V", "Soria J", "Walter A", "Ewerton F", "Poelman M", "Benson N", "Ocker M"]},
  journal = {European journal of cancer (Oxford, England : 1990)},
  year = {2019},
  pmid = {30711772},
  doi = {10.1016/j.ejca.2018.12.020},
}

@article{pmid30842877,
  title = {Serum IgA1 shows increased levels of },
  author = {["Lomax-Browne H", "Robertson C", "Antonopoulos A", "Leathem A", "Haslam S", "Dell A", "Dwek M"]},
  journal = {Interface focus},
  year = {2019},
  pmid = {30842877},
  doi = {10.1098/rsfs.2018.0079},
}

@article{pmid28424511,
  title = {Response of peanut Arachis hypogaea roots to the presence of beneficial and pathogenic fungi by transcriptome analysis.},
  author = {["Hao K", "Wang F", "Nong X", "McNeill M", "Liu S", "Wang G", "Cao G", "Zhang Z"]},
  journal = {Scientific reports},
  year = {2017},
  pmid = {28424511},
  doi = {10.1038/s41598-017-01029-3},
}

@article{pmid27063978,
  title = {Bromodomain inhibitor OTX015 in patients with lymphoma or multiple myeloma: a dose-escalation, open-label, pharmacokinetic, phase 1 study.},
  author = {["Amorim S", "Stathis A", "Gleeson M", "Iyengar S", "Magarotto V", "Leleu X", "Morschhauser F", "Karlin L", "Broussais F", "Rezai K"]},
  journal = {The Lancet. Haematology},
  year = {2016},
  pmid = {27063978},
  doi = {10.1016/S2352-3026(16)00021-1},
}

@article{pmid25303525,
  title = {γCaMKII shuttles Ca²⁺/CaM to the nucleus to trigger CREB phosphorylation and gene expression.},
  author = {["Ma H", "Groth R", "Cohen S", "Emery J", "Li B", "Hoedt E", "Zhang G", "Neubert T", "Tsien R"]},
  journal = {Cell},
  year = {2014},
  pmid = {25303525},
  doi = {10.1016/j.cell.2014.09.019},
}

@article{pmid25383899,
  title = {Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome.},
  author = {["Lee Y", "Ehninger D", "Zhou M", "Oh J", "Kang M", "Kwak C", "Ryu H", "Butz D", "Araki T", "Cai Y"]},
  journal = {Nature neuroscience},
  year = {2014},
  pmid = {25383899},
  doi = {10.1038/nn.3863},
}