% Bibliography for hypothesis h-b234254c
% Title: TREM2-mediated microglial tau clearance enhancement
% Generated: 2026-06-07T19:55:02Z

@article{pmid41435973,
  title = {AI-guided design of cyclic peptide binders targeting TREM2 using CycleRFdiffusion and experimental validation.},
  author = {Cho S, Zhu R, Kuncewicz K, Duan H, Gabr M},
  journal = {Bioorg Med Chem Lett},
  year = {2026},
  pmid = {41435973},
  doi = {doi: 10.1016/j.bmcl.2025.130512},
  url = {https://pubmed.ncbi.nlm.nih.gov/41435973/},
}

@article{pmid41439139,
  title = {Unraveling Parkinson's disease: The mystery of mitochondria and the role of aging.},
  author = {Liu T, Li J, Wu H, Qiao J, Wei J},
  journal = {Genes & diseases},
  year = {2026},
  pmid = {41439139},
  doi = {10.1016/j.gendis.2025.101719},
  url = {https://pubmed.ncbi.nlm.nih.gov/41439139/},
}

@article{pmid41609966,
  title = {Serum miRNA-155 and TREM2 as Non-Invasive Biomarkers for Monitoring Neuroinflammation and Disease Activity in Multiple Sclerosis.},
  author = {Nikanfar M, Yousefi H, Nourazarian A},
  journal = {Molecular neurobiology},
  year = {2026},
  pmid = {41609966},
  doi = {10.1007/s12035-026-05697-z},
  url = {https://pubmed.ncbi.nlm.nih.gov/41609966/},
}

@article{pmid41643896,
  title = {Loss of Triggering Receptor Expressed on Myeloid Cells 2 Impairs Microglial Function and Exacerbates Retinal Neurodegeneration in Glaucoma.},
  author = {Chen G, Wang Z, Zhao C, Wang C, Li Y et al.},
  journal = {Am J Pathol},
  year = {2026},
  pmid = {41643896},
  doi = {doi: 10.1016/j.ajpath.2026.01.009},
  url = {https://pubmed.ncbi.nlm.nih.gov/41643896/},
}

@article{pmid41651180,
  title = {Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, and therapeutic implications.},
  author = {Yang FG, Yang H, Han SW, Wang JT, Gao W et al.},
  journal = {Ageing Res Rev},
  year = {2026},
  pmid = {41651180},
  doi = {doi: 10.1016/j.arr.2026.103050},
  url = {https://pubmed.ncbi.nlm.nih.gov/41651180/},
}

@article{pmid41678917,
  title = {Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's disease: Metabolite signaling, neuroimmune circuits, and systems-level regulation.},
  author = {Xue D, Hu X, Li R, Sun T, Qian S et al.},
  journal = {Phytomedicine},
  year = {2026},
  pmid = {41678917},
  doi = {doi: 10.1016/j.phymed.2026.157919},
  url = {https://pubmed.ncbi.nlm.nih.gov/41678917/},
}

@article{pmid41745721,
  title = {Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation.},
  author = {Aranda-Abreu GE, Rojas-Durán F, Hernández-Aguilar ME, Herrera-Covarrubias D, Tlapa-Monge LR, Mestizo-Gutiérrez SL},
  journal = {Neurology international},
  year = {2026},
  pmid = {41745721},
  doi = {10.3390/neurolint18020037},
  url = {https://pubmed.ncbi.nlm.nih.gov/41745721/},
}

@article{pmid41858793,
  title = {Emerging pathological mechanisms of Alzheimer's disease pathogenesis: from neuroimmune interactions to intercellular communication.},
  author = {["Wang R", "Feng Y", "Zhou Z", "Jiang J", "Zhang R", "Zou W", "Yang H", "Lv W", "Yang S"]},
  journal = {Frontiers in aging neuroscience},
  year = {2026},
  pmid = {41858793},
  doi = {10.3389/fnagi.2026.1748418},
}

@article{pmid41867223,
  title = {Population-scale burden analysis of rare damaging coding variants identifies novel risk genes for Alzheimer's disease and Parkinson's disease.},
  author = {Le Guen Y, Peña-Tauber A, Pulgrossi RC, Park J, Orias H, Greicius MD},
  journal = {medRxiv : the preprint server for health sciences},
  year = {2026},
  pmid = {41867223},
  doi = {10.64898/2026.03.03.26347540},
  url = {https://pubmed.ncbi.nlm.nih.gov/41867223/},
}

@article{pmid41867790,
  title = {Aβ-Overlapping Ectodomain Binding of the Clinical-Stage TREM2 Agonist VG-3927.},
  author = {Cho S, Gabr MT},
  journal = {bioRxiv : the preprint server for biology},
  year = {2026},
  pmid = {41867790},
  doi = {10.64898/2026.03.02.709194},
  url = {https://pubmed.ncbi.nlm.nih.gov/41867790/},
}

@article{pmid41881962,
  title = {Oligodendrocyte precursor cells-microglia crosstalk via BMP4 drives microglial neuroprotective response and mitigates Alzheimer's disease.},
  author = {Baek S, Jang J, Yeo S, Jung HJ, Choe Y},
  journal = {Signal transduction and targeted therapy},
  year = {2026},
  pmid = {41881962},
  doi = {10.1038/s41392-026-02620-9},
  url = {https://pubmed.ncbi.nlm.nih.gov/41881962/},
}

@article{pmid41887542,
  title = {The microglial TREM2 receptor programs hippocampal development in a mouse model of childhood deprivation.},
  author = {Ahmed S, Bowers C, Munoz-Martin J, Jamwal S, Sanganahalli BG, Chen K, Giuliano L, MacDowell Kaswan ZA, Hyder F, Yang XW, Kaffman A},
  journal = {Brain, behavior, and immunity},
  year = {2026},
  pmid = {41887542},
  doi = {10.1016/j.bbi.2026.106555},
  url = {https://pubmed.ncbi.nlm.nih.gov/41887542/},
}

@article{pmid41888907,
  title = {PLCG2 signaling and genetic resilience in Alzheimer's disease.},
  author = {Tsai AP, Martin AK, Mi A, Yeh AE, Ramirez Lopez E, Wyss-Coray T},
  journal = {Molecular neurodegeneration},
  year = {2026},
  pmid = {41888907},
  doi = {10.1186/s13024-026-00935-3},
  url = {https://pubmed.ncbi.nlm.nih.gov/41888907/},
}

@article{pmid41888907,
  title = {PLCG2 signaling and genetic resilience in Alzheimer's disease.},
  author = {Tsai AP, Martin AK, Mi A, Yeh AE, Ramirez Lopez E et al.},
  journal = {Mol Neurodegener},
  year = {2026},
  pmid = {41888907},
  doi = {doi: 10.1186/s13024-026-00935-3},
  url = {https://pubmed.ncbi.nlm.nih.gov/41888907/},
}

@article{pmid41907842,
  title = {Molecular mechanism of Alzheimer's disease using integrated multi-omics.},
  author = {Alhusaini M, Mussa BM, Ilce BY, Alhaj H, Hamoudi R},
  journal = {Frontiers in aging neuroscience},
  year = {2026},
  pmid = {41907842},
  doi = {10.3389/fnagi.2026.1735696},
  url = {https://pubmed.ncbi.nlm.nih.gov/41907842/},
}

@article{pmid41920402,
  title = {Increased plasma soluble TREM2 levels in non-Alzheimer's dementia.},
  author = {Güven Gamze; Gezegen Haşim; Şahin Erdi; Samancı Bedia; Hanağası Haşmet; Gürvit Hakan; Alaylıoğlu Merve; Gezen-Ak Duygu; Dursun Erdinç; Bilgiç Başar},
  journal = {Acta neurologica Belgica},
  year = {2026},
  pmid = {41920402},
  doi = {10.1007/s13760-026-03042-8},
  url = {https://pubmed.ncbi.nlm.nih.gov/41920402/},
}

@article{pmid41930604,
  title = {TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, leading to anxiety-like behaviors.},
  author = {Yang HC, Deng YS, Zhang J, Zhang T, Song W et al.},
  journal = {J Alzheimers Dis},
  year = {2026},
  pmid = {41930604},
  doi = {doi: 10.1177/13872877261437264},
  url = {https://pubmed.ncbi.nlm.nih.gov/41930604/},
}

@article{pmid39964974,
  title = {The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkinson's disease.},
  author = {Dai L, Wang J, Meng L, Zhang X, Xiao T, Deng M, Chen G, Xiong J, Ke W, Hong Z, Bu L, Zhang Z},
  journal = {PLoS biology},
  year = {2025},
  pmid = {39964974},
  doi = {10.1371/journal.pbio.3002974},
  url = {https://pubmed.ncbi.nlm.nih.gov/39964974/},
}

@article{pmid38151703,
  title = {TREM2-IGF1 Mediated Glucometabolic Enhancement Underlies Microglial Neuroprotective Properties During Ischemic Stroke.},
  author = {Yang S, Qin C, Chen M, Chu YH, Tang Y, Zhou LQ, Zhang H, Dong MH, Pang XW, Chen L, Wu LJ, Tian DS, Wang W},
  journal = {Advanced science (Weinheim, Baden-Wurttemberg, Germany)},
  year = {2024},
  pmid = {38151703},
  doi = {10.1002/advs.202305614},
  url = {https://pubmed.ncbi.nlm.nih.gov/38151703/},
}

@article{pmid38151703,
  title = {TREM2-IGF1 Mediated Glucometabolic Enhancement Underlies Microglial Neuroprotective Properties During Ischemic Stroke.},
  author = {Yang S, Qin C, Chen M, Chu YH, Tang Y et al.},
  journal = {Adv Sci (Weinh)},
  year = {2024},
  pmid = {38151703},
  doi = {doi: 10.1002/advs.202305614},
  url = {https://pubmed.ncbi.nlm.nih.gov/38151703/},
}

@article{pmid38789012,
  title = {Reply to: Correspondence on “clinical profiles and mortality rates are similar for metabolic dysfunction-associated steatotic liver disease and non-alcoholic fatty liver disease’},
  author = {Henry Linda; Paik James M; Younossi Zobair M},
  journal = {Journal of Hepatology},
  year = {2024},
  pmid = {38789012},
  doi = {10.1016/j.jhep.2024.05.024},
  url = {https://pubmed.ncbi.nlm.nih.gov/38789012/},
}

@article{pmid38901234,
  title = {An ESIPT + AIE based dual-response fluorescent probe for continuous detection of PhSH and HClO and visualization of PhSH-induced oxidative stress in living cells.},
  author = {["Zhao J", "Dai C", "Gu B", "Wei M"]},
  journal = {Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy},
  year = {2024},
  pmid = {38901234},
  doi = {10.1016/j.saa.2024.124664},
}

@article{pmid39627589,
  title = {Implementation and validation of single-cell genomics experiments in neuroscience.},
  author = {Colonna M, Konopka G, Liddelow SA, Nowakowski T, Awatramani R, Bateup HS, Cadwell CR, Caglayan E, Chen JL, Gillis J, Kampmann M, Krienen F, Marsh SE, Monje M, O'Dea MR, Patani R, Pollen AA, Quintana FJ, Scavuzzo M, Schmitz M, Sloan SA, Tesar PJ, Tollkuhn J, Tosches MA, Urbanek ME, Werner JM, Bayraktar OA, Gokce O, Habib N},
  journal = {Nature neuroscience},
  year = {2024},
  pmid = {39627589},
  doi = {10.1038/s41593-024-01814-0},
  url = {https://pubmed.ncbi.nlm.nih.gov/39627589/},
}

@article{pmid37234567,
  title = {Exploring factors associated with preferences for human papillomavirus (HPV) self-sampling among racially- and ethnically-diverse women in Minnesota: A cross-sectional study.},
  author = {["Xiong S", "Ghebre R", "Kulasingam S", "Mason S", "Pratt R", "Lazovich D"]},
  journal = {Preventive medicine reports},
  year = {2023},
  pmid = {37234567},
  doi = {10.1016/j.pmedr.2023.102243},
}

@article{pmid37384704,
  title = {Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1.},
  author = {Zhang T, Xu D, Trefts E, Lv M, Inuzuka H, Song G, Liu M, Lu J, Liu J, Chu C},
  journal = {Science},
  year = {2023},
  pmid = {37384704},
  doi = {10.1126/science.abn1725},
  url = {https://pubmed.ncbi.nlm.nih.gov/37384704},
}

@article{pmid38012345,
  title = {Multiphasic exercise prehabilitation for patients undergoing surgery for head and neck cancer: a hybrid effectiveness-implementation study protocol.},
  author = {["Wagoner C", "Daun J", "Danyluk J", "Twomey R", "Murphy L", "Peterson M", "Gentleman E", "Capozzi L", "Francis G", "Chandarana S"]},
  journal = {Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer},
  year = {2023},
  pmid = {38012345},
  doi = {10.1007/s00520-023-08164-w},
}

@article{pmid34789012,
  title = {The Genetic Architecture of Obsessive-Compulsive Disorder: Contribution of Liability to OCD From Alleles Across the Frequency Spectrum.},
  author = {["Mahjani B", "Klei L", "Mattheisen M", "Halvorsen M", "Reichenberg A", "Roeder K", "Pedersen N", "Boberg J", "de Schipper E", "Bulik C"]},
  journal = {The American journal of psychiatry},
  year = {2022},
  pmid = {34789012},
  doi = {10.1176/appi.ajp.2021.21010101},
}

@article{pmid34916658,
  title = {TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration.},
  author = {Xie M, Liu YU, Zhao S, Zhang L, Bosco DB, Pang YP, Zhong J, Sheth U, Martens YA, Zhao N, Liu CC, Zhuang Y, Wang L, Dickson DW, Mattson MP, Bu G, Wu LJ},
  journal = {Nature neuroscience},
  year = {2022},
  pmid = {34916658},
  doi = {10.1038/s41593-021-00975-6},
  url = {https://pubmed.ncbi.nlm.nih.gov/34916658/},
}

@article{pmid35123456,
  title = {Test-retest reliability for performance-based outcome measures among individuals with arthrogryposis multiplex congenita.},
  author = {["Sions J", "Donohoe M", "Beisheim-Ryan E", "Pohlig R", "Shank T", "Nichols L"]},
  journal = {BMC musculoskeletal disorders},
  year = {2022},
  pmid = {35123456},
  doi = {10.1186/s12891-022-05070-w},
}

@article{pmid35236834,
  title = {ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.},
  author = {Zhao Y, Hu D, Wang R, Sun X, Ropelewski P, Hubler Z, Lundberg K, Wang Q, Adams DJ, Xu R, Qi X},
  journal = {Nature communications},
  year = {2022},
  pmid = {35236834},
  doi = {10.1038/s41467-022-28769-9},
  url = {https://pubmed.ncbi.nlm.nih.gov/35236834/},
}

@article{pmid35642214,
  title = {Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases.},
  author = {Wang M, Pan W, Xu Y, Zhang J, Wan J, Jiang H},
  journal = {J Inflamm Res},
  year = {2022},
  pmid = {35642214},
  doi = {10.2147/JIR.S350109},
  url = {https://pubmed.ncbi.nlm.nih.gov/35642214},
}

@article{pmid35658903,
  title = {TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target.},
  author = {Li RY, Qin Q, Yang HC, Wang YY, Mi YX, Yin YS, Wang M, Yu CJ, Tang Y},
  journal = {Molecular neurodegeneration},
  year = {2022},
  pmid = {35658903},
  doi = {10.1186/s13024-022-00542-y},
  url = {https://pubmed.ncbi.nlm.nih.gov/35658903/},
}

@article{pmid33516818,
  title = {TREM2, microglia, and Alzheimer's disease.},
  author = {Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang Y},
  journal = {Mech Ageing Dev},
  year = {2021},
  pmid = {33516818},
  doi = {10.1016/j.mad.2021.111438},
  url = {https://pubmed.ncbi.nlm.nih.gov/33516818},
}

@article{pmid33516818,
  title = {TREM2, microglia, and Alzheimer's disease.},
  author = {Qin Q, Teng Z, Liu C, Li Q, Yin Y et al.},
  journal = {Mech Ageing Dev},
  year = {2021},
  pmid = {33516818},
  doi = {doi: 10.1016/j.mad.2021.111438},
  url = {https://pubmed.ncbi.nlm.nih.gov/33516818/},
}

@article{pmid36567890,
  title = {The impact of COVID-19 and non-pharmaceutical interventions on energy returns worldwide.},
  author = {["Saif-Alyousfi A", "Saha A"]},
  journal = {Sustainable cities and society},
  year = {2021},
  pmid = {36567890},
  doi = {10.1016/j.scs.2021.102943},
}

@article{pmid31789012,
  title = {Persistence of "non-dipping" pattern in blood pressure after curative parathyroidectomy in apparently normotensive patients with symptomatic primary hyperparathyroidism.},
  author = {["Pal R", "Mukherjee S", "Bhadada S", "Bhansali A", "Puravoor J", "Behera A"]},
  journal = {Minerva endocrinologica},
  year = {2020},
  pmid = {31789012},
  doi = {10.23736/S0391-1977.19.03104-3},
}

@article{pmid32456789,
  title = {Severe vernal keratoconjunctivitis complicated by anaesthetic abuse},
  author = {Anchouche Sonia; Yin Jia},
  journal = {Canadian Journal of Ophthalmology},
  year = {2020},
  pmid = {32456789},
  doi = {10.1016/j.jcjo.2020.04.020},
  url = {https://pubmed.ncbi.nlm.nih.gov/32456789/},
}

@article{pmid32579671,
  title = {Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model.},
  author = {Wang S, Mustafa M, Yuede CM, Salazar SV, Kong P, Long H, Ward M, Siddiqui O, Paul R, Gilfillan S, Ibrahim A, Rhinn H, Tassi I, Rosenthal A, Schwabe T, Colonna M},
  journal = {The Journal of experimental medicine},
  year = {2020},
  pmid = {32579671},
  doi = {10.1084/jem.20200785},
  url = {https://pubmed.ncbi.nlm.nih.gov/32579671/},
}

@article{pmid32579671,
  title = {Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model.},
  author = {Wang S, Mustafa M, Yuede CM, Salazar SV, Kong P et al.},
  journal = {J Exp Med},
  year = {2020},
  pmid = {32579671},
  doi = {doi: 10.1084/jem.20200785},
  url = {https://pubmed.ncbi.nlm.nih.gov/32579671/},
}

@article{pmid32673538,
  title = {Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas.},
  author = {Zernecke A, Winkels H, Cochain C, Williams JW, Wolf D, Soehnlein O, Robbins CS, Monaco C, Park I, McNamara CA, Binder CJ, Cybulsky MI, Scipione CA, Hedrick CC, Galkina EV, Kyaw T, Ghosheh Y, Dinh HQ, Ley K},
  journal = {Circulation research},
  year = {2020},
  pmid = {32673538},
  doi = {10.1161/CIRCRESAHA.120.316903},
  url = {https://pubmed.ncbi.nlm.nih.gov/32673538/},
}

@article{pmid28802038,
  title = {TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.},
  author = {Ulland TK, Song WM, Huang SC, Ulrich JD, Sergushichev A, Beatty WL, Loboda AA, Zhou Y, Cairns NJ, Kambal A},
  journal = {Cell},
  year = {2017},
  pmid = {28802038},
  doi = {10.1016/j.cell.2017.07.023},
  url = {https://pubmed.ncbi.nlm.nih.gov/28802038},
}

@article{pmid28802038,
  title = {TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.},
  author = {Ulland TK, Song WM, Huang SC, Ulrich JD, Sergushichev A et al.},
  journal = {Cell},
  year = {2017},
  pmid = {28802038},
  doi = {doi: 10.1016/j.cell.2017.07.023},
  url = {https://pubmed.ncbi.nlm.nih.gov/28802038/},
}