% Bibliography for hypothesis h-c9c79e3e
% Title: APOE4-Selective Lipid Nanoemulsion Therapy
% Generated: 2026-06-08T18:00:04Z

@article{pmid40145985,
  title = {Neuropsychiatric symptoms and apolipoprotein E genotypes in neurocognitive disorders.},
  author = {Lozupone M, Leccisotti I, Mollica A, Berardino G, Moretti MC, Altamura M, Bellomo A, Daniele A, Dibello V, Solfrizzi V, Resta E, Panza F},
  journal = {Neural regeneration research},
  year = {2026},
  pmid = {40145985},
  doi = {10.4103/NRR.NRR-D-24-01274},
  url = {https://pubmed.ncbi.nlm.nih.gov/40145985/},
}

@article{pmid40562635,
  title = {Perioperative polygenic and APOE-based genetic risk assessment for neurocognitive disorders: a biobank study.},
  author = {Thedim M, Hu J, Maher M, Wiener-Kronish J, Saxena R et al.},
  journal = {Br J Anaesth},
  year = {2026},
  pmid = {40562635},
  doi = {doi: 10.1016/j.bja.2025.05.014},
  url = {https://pubmed.ncbi.nlm.nih.gov/40562635/},
}

@article{pmid40615639,
  title = {Increased genetic protection against Alzheimer's disease in centenarians.},
  author = {Bae H, Song Z, Ali A, Sasaki T, Tesi N et al.},
  journal = {Geroscience},
  year = {2026},
  pmid = {40615639},
  doi = {doi: 10.1007/s11357-025-01774-8},
  url = {https://pubmed.ncbi.nlm.nih.gov/40615639/},
}

@article{pmid40864401,
  title = {Integrative machine learning approach to risk prediction for dementia and Alzheimer's disease.},
  author = {Stern A, Linial M},
  journal = {Geroscience},
  year = {2026},
  pmid = {40864401},
  doi = {doi: 10.1007/s11357-025-01828-x},
  url = {https://pubmed.ncbi.nlm.nih.gov/40864401/},
}

@article{pmid41503702,
  title = {Multimodal Antiatherosclerotic Effects of Clinical-Grade Mesenchymal Stem Cell-Derived Extracellular Vesicles.},
  author = {Kim J, Park D, Yoo J, Kim JE, Kim EH et al.},
  journal = {Stroke},
  year = {2026},
  pmid = {41503702},
  doi = {doi: 10.1161/STROKEAHA.125.052894},
  url = {https://pubmed.ncbi.nlm.nih.gov/41503702/},
}

@article{pmid41531227,
  title = {Menopause, cognition, and Alzheimer's disease risk.},
  author = {Samudra N, Vemuri M, Weitlauf J},
  journal = {Curr Opin Obstet Gynecol},
  year = {2026},
  pmid = {41531227},
  doi = {doi: 10.1097/GCO.0000000000001087},
  url = {https://pubmed.ncbi.nlm.nih.gov/41531227/},
}

@article{pmid41565199,
  title = {DPP4-regulated endothelial cell ferroptosis modulates atherosclerosis progression by ferritinophagy.},
  author = {Zheng L, Liang K, Peng Y, Jin M, Chen X et al.},
  journal = {J Mol Cell Cardiol},
  year = {2026},
  pmid = {41565199},
  doi = {doi: 10.1016/j.yjmcc.2026.01.006},
  url = {https://pubmed.ncbi.nlm.nih.gov/41565199/},
}

@article{pmid41884619,
  title = {Age at natural menopause, reproductive lifespan and Alzheimer's disease in females: is APOE ε4 the missing link?},
  author = {Bruno F, Spadafora P, Abondio P, Qualtieri A, Paparazzo E, Aceto MA, Veltri I, De Benedittis S, Greco BM, Cerantonio A, Citrigno L, Di Palma G, Gallo O, Passarino G, Montesanto A, Cavalcanti F},
  journal = {Frontiers in genetics},
  year = {2026},
  pmid = {41884619},
  doi = {10.3389/fgene.2026.1733593},
  url = {https://pubmed.ncbi.nlm.nih.gov/41884619/},
}

@article{pmid41910460,
  title = {Effects of APOE ε4 and amyloid pathology on longitudinal tau biomarkers, neurodegeneration, and cognitive decline in mild cognitive impairment.},
  author = {Wang X, Zhang C, Liu X, Tai Y, Ma G, Kong M, Ba M, for Alzheimer's Disease Neuroimaging Initiative},
  journal = {Journal of Alzheimer's disease : JAD},
  year = {2026},
  pmid = {41910460},
  doi = {10.1177/13872877261435429},
  url = {https://pubmed.ncbi.nlm.nih.gov/41910460/},
}

@article{pmid41912201,
  title = {Cognitive Decline and Neurodegenerative Markers in Psoriasis: The Role of APOE4 and Beta-Amyloid.},
  author = {Sabry HH, Kadhum BQ, Abdulmohsin GN, El-Ghafar AOA, Mahmoud MM, Shams GM},
  journal = {Dermatology practical & conceptual},
  year = {2026},
  pmid = {41912201},
  doi = {10.5826/dpc.1601a5957},
  url = {https://pubmed.ncbi.nlm.nih.gov/41912201/},
}

@article{pmid41916957,
  title = {Astrocytic APOE3-Christchurch expression ameliorates brain amyloid-β pathology in 5xFAD mice.},
  author = {Raulin AC, Alnobani A, Rodriguez-Martinez P, Lee E, Linares C, Yslas AR, Li M, Ren Y, Doss SV, Roy B, Kuchenbecker LA, Martens YA, Liu CC, Bu G, Kanekiyo T},
  journal = {Translational psychiatry},
  year = {2026},
  pmid = {41916957},
  doi = {10.1038/s41398-026-04002-9},
  url = {https://pubmed.ncbi.nlm.nih.gov/41916957/},
}

@article{pmid41930593,
  title = {Inflammation-related miR-155-5p as an APOE ε4-modulated biomarker for amyloid pathology in mild cognitive impairment.},
  author = {Yoshida K, Saito N, Takahashi R, Ando S, Kashibayashi T et al.},
  journal = {J Alzheimers Dis},
  year = {2026},
  pmid = {41930593},
  doi = {doi: 10.1177/13872877261437135},
  url = {https://pubmed.ncbi.nlm.nih.gov/41930593/},
}

@article{pmid39962245,
  title = {Blood-brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system.},
  author = {Wang C, Xue Y, Markovic T, Li H, Wang S, Zhong Y, Du S, Zhang Y, Hou X, Yu Y, Liu Z, Tian M, Kang DD, Wang L, Guo K, Cao D, Yan J, Deng B, McComb DW, Parsons RE, Minier-Toribio AM, Holt LM, Pan J, Hashemi A, Kopell BH, Charney AW, Nestler EJ, Peng PC, Dong Y},
  journal = {Nature materials},
  year = {2025},
  pmid = {39962245},
  doi = {10.1038/s41563-024-02114-5},
  url = {https://pubmed.ncbi.nlm.nih.gov/39962245/},
}

@article{pmid36634180,
  title = {ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy.},
  author = {["Seo D", "O'Donnell D", "Jain N", "Ulrich J", "Herz J", "Li Y", "Lemieux M", "Cheng J", "Hu H", "Serrano J"]},
  journal = {Science (New York, N.Y.)},
  year = {2023},
  pmid = {36634180},
  doi = {10.1126/science.add1236},
}

@article{pmid37957317,
  title = {The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation.},
  author = {Maxine R Nelson, Peng Liu, Ayushi Agrawal, Oscar Yip, Jessica Blumenfeld et al.},
  journal = {Nature neuroscience},
  year = {2023},
  pmid = {37957317},
  doi = {10.1038/s41593-023-01480-8},
  url = {https://pubmed.ncbi.nlm.nih.gov/37957317},
}

@article{pmid37957317,
  title = {The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation.},
  author = {Nelson MR, Liu P, Agrawal A, Yip O, Blumenfeld J et al.},
  journal = {Nat Neurosci},
  year = {2023},
  pmid = {37957317},
  doi = {doi: 10.1038/s41593-023-01480-8},
  url = {https://pubmed.ncbi.nlm.nih.gov/37957317/},
}

@article{pmid33712478,
  title = {Extension study of the safety and efficacy of CLS-TA for treatment of macular oedema associated with non-infectious uveitis (MAGNOLIA).},
  author = {Khurana RN, Merrill P, Yeh S, Suhler E, Barakat MR, Uchiyama E, Henry CR, Shah M, Wang RC, Kapik B, Ciulla T},
  journal = {The British journal of ophthalmology},
  year = {2022},
  pmid = {33712478},
  doi = {10.1136/bjophthalmol-2020-317560},
  url = {https://pubmed.ncbi.nlm.nih.gov/33712478/},
}

@article{pmid35948010,
  title = {Lactate is an epigenetic metabolite that drives survival in model systems of glioblastoma.},
  author = {Torrini C, Nguyen TTT, Shu C, Mela A, Humala N, Mahajan A, Seeley EH, Zhang G, Westhoff MA, Karpel-Massler G, Bruce JN, Canoll P, Siegelin MD},
  journal = {Molecular cell},
  year = {2022},
  pmid = {35948010},
  doi = {10.1016/j.molcel.2022.06.030},
  url = {https://pubmed.ncbi.nlm.nih.gov/35948010/},
}

@article{pmid33432245,
  title = {Cryo-EM structures of Toll-like receptors in complex with UNC93B1.},
  author = {Ishida H, Asami J, Zhang Z, Nishizawa T, Shigematsu H, Ohto U, Shimizu T},
  journal = {Nature structural & molecular biology},
  year = {2021},
  pmid = {33432245},
  doi = {10.1038/s41594-020-00542-w},
  url = {https://pubmed.ncbi.nlm.nih.gov/33432245/},
}

@article{pmid33958804,
  title = {Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer's disease.},
  author = {Zalocusky KA, Najm R, Taubes AL, Hao Y, Yoon SY, Koutsodendris N, Nelson MR, Rao A, Bennett DA, Bant J, Amornkul DJ, Xu Q, An A, Cisne-Thomson O, Huang Y},
  journal = {Nature neuroscience},
  year = {2021},
  pmid = {33958804},
  doi = {10.1038/s41593-021-00851-3},
  url = {https://pubmed.ncbi.nlm.nih.gov/33958804/},
}

@article{pmid34157306,
  title = {Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms.},
  author = {Shi Y, Andhey PS, Ising C, Wang K, Snipes LL, Boyer K, Lawson S, Yamada K, Qin W, Manis M, Serrano JR, Benitez BA, Schmidt RE, Artyomov M, Ulrich JD, Holtzman DM},
  journal = {Neuron},
  year = {2021},
  pmid = {34157306},
  doi = {10.1016/j.neuron.2021.05.034},
  url = {https://pubmed.ncbi.nlm.nih.gov/34157306/},
}

@article{pmid34788101,
  title = {Re-identification of individuals in genomic datasets using public face images.},
  author = {Venkatesaramani R, Malin BA, Vorobeychik Y},
  journal = {Science advances},
  year = {2021},
  pmid = {34788101},
  doi = {10.1126/sciadv.abg3296},
  url = {https://pubmed.ncbi.nlm.nih.gov/34788101/},
}

@article{pmid30078714,
  title = {Breast cancer treatment and its effects on aging.},
  author = {Chang L, Weiner LS, Hartman SJ, Horvath S, Jeste D, Mischel PS, Kado DM},
  journal = {Journal of geriatric oncology},
  year = {2019},
  pmid = {30078714},
  doi = {10.1016/j.jgo.2018.07.010},
  url = {https://pubmed.ncbi.nlm.nih.gov/30078714/},
}

@article{pmid31127130,
  title = {GABA (γ-aminobutyric acid), as a thermo-protectant, to improve the reproductive function of heat-stressed mungbean plants.},
  author = {Priya M, Sharma L, Kaur R, Bindumadhava H, Nair RM, Siddique KHM, Nayyar H},
  journal = {Scientific reports},
  year = {2019},
  pmid = {31127130},
  doi = {10.1038/s41598-019-44163-w},
  url = {https://pubmed.ncbi.nlm.nih.gov/31127130/},
}

@article{pmid31515478,
  title = {A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein.},
  author = {Tang A, Chen Z, Cox KS, Su HP, Callahan C, Fridman A, Zhang L, Patel SB, Cejas PJ, Swoyer R, Touch S, Citron MP, Govindarajan D, Luo B, Eddins M, Reid JC, Soisson SM, Galli J, Wang D, Wen Z, Heidecker GJ, Casimiro DR, DiStefano DJ, Vora KA},
  journal = {Nature communications},
  year = {2019},
  pmid = {31515478},
  doi = {10.1038/s41467-019-12137-1},
  url = {https://pubmed.ncbi.nlm.nih.gov/31515478/},
}

@article{pmid30573750,
  title = {Author Correction: Distinct effects of social motivation on face evaluations in adolescents with and without autism.},
  author = {Safra L, Ioannou C, Amsellem F, Delorme R, Chevallier C},
  journal = {Scientific reports},
  year = {2018},
  pmid = {30573750},
  doi = {10.1038/s41598-018-37593-5},
  url = {https://pubmed.ncbi.nlm.nih.gov/30573750/},
}

@article{pmid28487471,
  title = {Using DTI to assess white matter microstructure in cerebral small vessel disease (SVD) in multicentre studies.},
  author = {Croall ID, Lohner V, Moynihan B, Khan U, Hassan A, O'Brien JT, Morris RG, Tozer DJ, Cambridge VC, Harkness K, Werring DJ, Blamire AM, Ford GA, Barrick TR, Markus HS},
  journal = {Clinical science (London, England : 1979)},
  year = {2017},
  pmid = {28487471},
  doi = {10.1042/CS20170146},
  url = {https://pubmed.ncbi.nlm.nih.gov/28487471/},
}

@article{pmid28930663,
  title = {The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.},
  author = {Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z},
  journal = {Immunity},
  year = {2017},
  pmid = {28930663},
  doi = {10.1016/j.immuni.2017.08.008},
  url = {https://pubmed.ncbi.nlm.nih.gov/28930663},
}