{"status":"CRITICAL","total_flags":757,"checked_at":"2026-04-15T22:12:51.643884","gates":{"missing_evidence":{"count":51,"items":[{"id":"SDA-00002","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-16 03:45:39"},{"id":"SDA-00001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-16 03:34:20"},{"id":"SDA-8a9f2c3d-e9b1-41c5-a2c0-3b8e1a7d2f4e","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-16 03:33:21"},{"id":"SDA-2024-0001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-16 03:29:07"},{"id":"SDA-2025-0147","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-16 03:28:54"},{"id":"exercise-bdnf-mitochondrial-resilience-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-16 03:18:25"},{"id":"h-lrp1-tau-001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-16 01:14:10"},{"id":"SDA-001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-16 00:47:15"},{"id":"SDA-005","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-16 00:46:58"},{"id":"SDA-004","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-16 00:46:17"},{"id":"hyp_24486","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-15 18:50:32"},{"id":"gba-pathway","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-15 07:12:50"},{"id":"test-h123","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 21:23:10"},{"id":"h-invalid-id-test-123","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 20:40:38"},{"id":"cgas-sting-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 19:46:12"},{"id":"SDA-2026-04-01-gap-001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 19:26:16"},{"id":"SDA-2026-04-02-hypo-001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 19:11:01"},{"id":"SDA-6f4e15","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 18:05:10"},{"id":"SDA-249a9e2f-774f-5ab6-a4cf-90b0e36ef6e8","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 17:21:19"},{"id":"h-1","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 16:15:49"},{"id":"SDA-043bc5c2-8af1-4f8b-8f36-9c81e09c38f4","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 16:12:18"},{"id":"SDA-1","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 16:01:40"},{"id":"SDA-466","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 16:00:45"},{"id":"h-81949907","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 11:51:41"},{"id":"h-14c98fa1","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 11:51:41"},{"id":"SDA-2026-04-13-H00001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 08:39:01"},{"id":"h-0000001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 06:37:10"},{"id":"SDA-2024-0097","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 03:55:28"},{"id":"H000001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 03:51:22"},{"id":"SDA-2025-0001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 03:46:06"},{"id":"test","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 01:33:09"},{"id":"h-0001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 00:43:29"},{"id":"astrocyte-neuron-metabolic-coupling-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 23:29:17"},{"id":"exercise-bdnf-axis-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 23:27:14"},{"id":"post-acute-viral-reservoir-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 23:22:27"},{"id":"wnt-beta-catenin-signaling-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 23:01:36"},{"id":"SDA-H00001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 23:01:10"},{"id":"alzheimer's-disease,-biomarker-events-occur","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 22:55:37"},{"id":"SDA-0001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 22:55:15"},{"id":"proteasome-ubiquitin-system-dysfunction-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 22:31:46"},{"id":"viral-trigger-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 22:08:36"},{"id":"synaptic-vesicle-trafficking-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 21:40:46"},{"id":"HYP-000001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 20:38:44"},{"id":"proteinopathic-processes-spread-through-brain","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 20:35:38"},{"id":"1","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 19:10:49"},{"id":"SDA-7a3b2c1d-4e5f-6g7h-8i9j-0k1l2m3n4o5p6","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 19:10:13"},{"id":"HYP-002","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 19:07:54"},{"id":"HYP-003","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 19:07:54"},{"id":"HYP-010","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 19:07:54"},{"id":"HYP-100","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 19:07:54"}]},"low_scores":{"count":0,"items":[]},"weak_debates":{"count":27,"items":[{"id":"sess_SDA-2026-04-15-gap-pubmed-20260411-075425-2feffb0c","question":"The abstract shows that acute neuroinflammation becomes persistent with a specific transcriptomic signature, but the mechanistic drivers of this transition are not explained. Understanding this switch is critical for developing interventions to prevent chronic sequelae.\n\nGap type: unexplained_observation\nSource paper: Deleterious effect of sustained neuroinflammation in pediatric traumatic brain injury. (2024, Brain, behavior, and immunity, PMID:38705494)","quality_score":null,"num_rounds":4,"created_at":"2026-04-15T21:29:29.493700"},{"id":"sess_SDA-2026-04-15-gap-pubmed-20260410-100455-ff18091d","question":"The abstract challenges the rationale for using microtubule-stabilizing drugs in tau diseases, since tau appears to destabilize rather than stabilize microtubules. This paradigm shift has immediate implications for therapeutic development but requires validation.\n\nGap type: open_question\nSource paper: Tau: It's Not What You Think. (2019, Trends Cell Biol, PMID:30929793)","quality_score":null,"num_rounds":4,"created_at":"2026-04-15T21:16:26.597902"},{"id":"sess_SDA-2026-04-15-gap-debate-20260410-112730-24052bbe","question":"The debate highlighted tau prion-like transmission but did not resolve how different tau conformations compete and which structural features determine propagation efficiency. Understanding these determinants is critical for predicting disease progression patterns.\n\nSource: Debate session sess_SDA-2026-04-02-gap-tau-propagation-20260402 (Analysis: SDA-2026-04-02-gap-tau-propagation-20260402)","quality_score":null,"num_rounds":4,"created_at":"2026-04-15T21:16:21.391924"},{"id":"sess_SDA-2026-04-15-gap-debate-20260410-112522-57d1cc4f","question":"While TREM2 was identified as critical for microglial senescence, the debate lacked fine-grained temporal data on when and how TREM2 signaling shifts from neuroprotective to pathogenic. Understanding this transition timing is essential for intervention strategies.\n\nSource: Debate session sess_SDA-2026-04-02-gap-aging-mouse-brain-v5-20260402 (Analysis: SDA-2026-04-02-gap-aging-mouse-brain-v5-20260402)","quality_score":null,"num_rounds":4,"created_at":"2026-04-15T20:45:27.581361"},{"id":"sess_SDA-2026-04-14-gap-pubmed-20260411-072446-a32fa49c","question":"The abstract shows TYROBP deficiency is neuroprotective despite being required for TREM2, CD33, and CR3 function - receptors associated with AD risk. This counterintuitive finding challenges current understanding of how these immune receptors contribute to AD pathogenesis.\n\nGap type: contradiction\nSource paper: Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology. (None, None, PMID:28612290)","quality_score":null,"num_rounds":4,"created_at":"2026-04-15T20:27:01.117334"},{"id":"sess_SDA-2026-04-14-gap-pubmed-20260410-191046-15921012","question":"The study demonstrates that exercise-conditioned plasma transfers cognitive benefits, but the identity of the active circulating factors remains unknown. Understanding these factors is critical for developing targeted therapeutic interventions for POCD without requiring exercise.\n\nGap type: unexplained_observation\nSource paper: Exercise-conditioned plasma ameliorates postoperative cognitive dysfunction by activating hippocampal cholinergic circuit and enhancing BDNF/TrkB signaling. (2024, Cell c","quality_score":null,"num_rounds":4,"created_at":"2026-04-15T18:55:55.168418"},{"id":"sess_SDA-2026-04-14-gap-pubmed-20260410-183021-c13d9f04","question":"The abstract describes astrocyte phenotypic heterogeneity (A1/A2) but doesn't explain the mechanistic switches governing this critical fate decision. Understanding these mechanisms is essential for therapeutic targeting of beneficial vs harmful astrocyte responses.\n\nGap type: unexplained_observation\nSource paper: Contribution of astrocytes to neuropathology of neurodegenerative diseases. (2021, Brain research, PMID:33516810)","quality_score":null,"num_rounds":4,"created_at":"2026-04-15T18:30:50.089030"},{"id":"sess_SDA-2026-04-02-gap-v2-e1e1b7c3","question":"","quality_score":null,"num_rounds":4,"created_at":"2026-04-15T18:21:45.569167"},{"id":"sess_SDA-2026-04-14-gap-pubmed-20260410-181356-57d1f917","question":"The study shows dramatic functional recovery and muscle re-innervation after cytoplasmic TDP-43 clearance, even following motor neuron death. The cellular and molecular mechanisms underlying this unexpected regenerative capacity in neurodegenerative disease are not explained.\n\nGap type: unexplained_observation\nSource paper: Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43. (2015, Acta neuropathologica, PMID:26197969)","quality_score":null,"num_rounds":4,"created_at":"2026-04-15T17:58:22.887795"},{"id":"sess_SDA-2026-04-14-gap-pubmed-20260410-180532-e8930cb8","question":"The abstract shows V1613M variant reduces amyloid plaques and damage in 5xFAD mice, yet ABCA7 loss-of-function mutations increase LOAD risk. This apparent contradiction suggests complex genotype-phenotype relationships that could inform therapeutic targeting.\n\nGap type: contradiction\nSource paper: The Abca7 (None, None, PMID:38506634)","quality_score":null,"num_rounds":4,"created_at":"2026-04-15T17:51:34.542866"},{"id":"sess_SDA-2026-04-14-gap-pubmed-20260410-174607-708e8d91","question":"The finding that Mertk/Axl deficiency increases viral susceptibility contradicts the established paradigm that TAM receptors dampen antiviral immunity. This unexpected protective role challenges current understanding of TAM receptor function in neuroinvasive infections.\n\nGap type: contradiction\nSource paper: The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity. (2015, Nature medicine, PMID:26523970)","quality_score":null,"num_rounds":4,"created_at":"2026-04-15T17:14:45.894224"},{"id":"sess_SDA-2026-04-13-gap-debate-20260412-094556-86f36bb3_20260414-011511","question":"The debate proposed K280 acetylation creates a β-sheet nucleation interface but lacks structural evidence. Without atomic-level understanding of how acetylation alters tau conformation, the mechanistic basis for aggregation templating remains unproven.\n\nSource: Debate session sess_SDA-2026-04-09-gap-debate-20260409-201742-1e8eb3bd_20260412-091505 (Analysis: SDA-2026-04-09-gap-debate-20260409-201742-1e8eb3bd)","quality_score":0.0,"num_rounds":4,"created_at":"2026-04-14T01:15:11.130392"},{"id":"sess_SDA-2026-04-03-test-enrollment-protocol","question":"Does neuroplasticity decline with age?","quality_score":0.5,"num_rounds":5,"created_at":"2026-04-11T22:46:14.225769+00:00"},{"id":"DA-2026-04-11-093252-90e0375b","question":"TDP-43 phase separation therapeutics for ALS-FTD","quality_score":0.5,"num_rounds":5,"created_at":"2026-04-11T20:12:49.581844+00:00"},{"id":"DA-2026-04-03-001","question":"What are novel CRISPR-based therapies for Huntington's disease?","quality_score":0.5,"num_rounds":5,"created_at":"2026-04-11T20:07:09.827841+00:00"},{"id":"debate-test-enrollment-protocol-6ecc51c9","question":"Does neuroplasticity decline with age?","quality_score":0.5,"num_rounds":6,"created_at":"2026-04-11T20:07:09.827369+00:00"},{"id":"debate-test-gap-enrollment-001-8bc0d274","question":"Test debate on neuroplasticity mechanisms","quality_score":0.5,"num_rounds":5,"created_at":"2026-04-11T20:07:09.826881+00:00"},{"id":"sess_SDA-2026-04-04-frontier-immunomics-e6f97b29","question":"How do peripheral immune system alterations influence CNS pathology and neurodegeneration in Alzheimer disease? Examine: (1) peripheral monocyte/macrophage trafficking across the blood-brain barrier, (2) T-cell infiltration patterns and CNS antigen recognition, (3) cytokine and chemokine signatures as fluid biomarkers (IL-6, TNF-alpha, CXCL10), (4) neutrophil extracellular trap (NET) formation and neurotoxicity, (5) alterations in meningeal lymphatic drainage and immune clearance, (6) gut microbiome-immune-brain axis disruptions. Can peripheral immune modulation slow CNS pathology?","quality_score":0.1,"num_rounds":4,"created_at":"2026-04-11T00:21:43.700437"},{"id":"sess_SDA-2026-04-04-frontier-connectomics-84acb35a","question":"How do structural and functional connectivity changes in the human brain connectome drive cognitive decline in Alzheimer disease? Investigate: (1) default mode network disruption and amyloid deposition patterns, (2) hippocampal-cortical memory circuit disconnection, (3) white matter tract degeneration measured by diffusion tensor imaging, (4) functional hyperconnectivity as compensatory mechanism vs early pathology marker, (5) sleep-wake cycle disruption and thalamic connectivity changes, (6) salience network alterations and behavioral symptoms. How can connectomics inform staging of AD and prediction of progression?","quality_score":0.1,"num_rounds":4,"created_at":"2026-04-11T00:20:51.033917"},{"id":"sess_SDA-2026-04-04-frontier-proteomics-1c3dba72","question":"What are the critical protein expression changes and post-translational modifications (phosphorylation, ubiquitination, glycosylation) at the aging synapse that drive early Alzheimer disease pathophysiology? Focus on: (1) synaptic vesicle proteins and their PTM states, (2) scaffold proteins and their altered interactions, (3) receptor tyrosine kinase signaling cascades, (4) mitochondrial proteins at the synapse, and (5) proteins involved in amyloid precursor protein processing. How do these proteomic changes correlate with cognitive decline and which represent therapeutic intervention points?","quality_score":0.1,"num_rounds":4,"created_at":"2026-04-11T00:20:13.233317"},{"id":"sess_SDA-2026-04-10-SDA-2026-04-09-gap-debate-20260409-201742-1e8eb3bd","question":"Which specific post-translational modifications on pathological tau create druggable epitopes absent in physiological tau?","quality_score":0.15,"num_rounds":4,"created_at":"2026-04-10T05:33:19.649965"},{"id":"sess_SDA-2026-04-02-26abc5e5f9f2","question":"Analyze circuit-level changes in neurodegeneration using Allen Institute Neural Dynamics data. Focus on: (1) hippocampal circuit disruption, (2) cortical dynamics alterations, (3) sensory processing changes. Identify circuit-based therapeutic targets connecting genes, proteins, and brain regions to neurodegeneration phenotypes.","quality_score":0.025,"num_rounds":4,"created_at":"2026-04-02T03:01:41.943540"},{"id":"sess_SDA-2026-04-02-gap-tau-propagation-20260402","question":"What are the mechanisms by which tau pathology spreads through connected brain regions via prion-like transmission, trans-synaptic transfer, and extracellular vesicles? What are the key interception points for therapeutic intervention at each propagation step?","quality_score":0.03,"num_rounds":4,"created_at":"2026-04-02T02:48:49.184788"},{"id":"sess_SDA-2026-04-02-gap-aging-mouse-brain-20260402","question":"What gene expression changes in the aging mouse brain predict neurodegenerative vulnerability? Use Allen Aging Mouse Brain Atlas data. Cross-reference with human AD datasets. Produce hypotheses about aging-neurodegeneration mechanisms.","quality_score":0.025,"num_rounds":4,"created_at":"2026-04-02T02:46:51.625896"},{"id":"sess_SDA-2026-04-02-gap-microglial-subtypes-20260402004119","question":"Analyze the spectrum of microglial activation states (DAM, homeostatic, inflammatory) and their distinct roles in AD, PD, and ALS. Identify pharmacological targets for shifting microglia toward protective phenotypes.","quality_score":0.02,"num_rounds":4,"created_at":"2026-04-02T00:45:41.300763"},{"id":"sess_SDA-2026-04-02-gap-20260402-003115","question":"Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidirectional relationship between sleep disorders (particularly circadian rhythm disruption and impaired glymphatic clearance) and neurodegenerative disease progression, focusing on amyloid-beta accumulation, tau pathology, and the therapeutic potential of sleep restoration interventions.","quality_score":0.025,"num_rounds":4,"created_at":"2026-04-02T00:32:45.316709"},{"id":"sess_SDA-2026-04-02-gap-20260402-003058","question":"Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidirectional relationship between sleep disorders (particularly circadian rhythm disruption and impaired glymphatic clearance) and neurodegenerative disease progression, focusing on amyloid-beta accumulation, tau pathology, and the therapeutic potential of sleep restoration interventions.","quality_score":0.025,"num_rounds":4,"created_at":"2026-04-02T00:31:42.392597"}]},"no_kg_edges":{"count":51,"items":[{"id":"SDA-2026-04-15-gap-debate-20260410-112607-0a3749ea","title":"What are the cell-type-specific transcriptomic signatures of vulnerability in SEA-AD data?","status":"completed","created_at":"2026-04-15T19:29:13.658392"},{"id":"SDA-2026-04-15-gap-debate-20260410-112545-377c1d9e","title":"How do synthetic EVs achieve brain-specific targeting while avoiding reticuloendothelial clearance?","status":"completed","created_at":"2026-04-15T18:49:05.098197"},{"id":"SDA-2026-04-15-gap-debate-20260410-112539-31f47880","title":"Are age-related static epigenetic patterns pathogenic or protective compensatory mechanisms?","status":"completed","created_at":"2026-04-15T17:33:10.879538"},{"id":"SDA-2026-04-15-gap-debate-20260410-112528-782f5aa2","title":"What determines the GPX4/ACSL4 balance that switches microglia from protective to ferroptotic states?","status":"completed","created_at":"2026-04-15T16:43:34.458619"},{"id":"SDA-2026-04-15-gap-pubmed-20260406-062118-e3613755","title":"What molecular mechanisms mediate SPP1-induced microglial phagocytic activation and synaptic targeting?","status":"completed","created_at":"2026-04-15T16:30:49.446480"},{"id":"SDA-2026-04-15-gap-debate-20260410-112441-f2afffb3","title":"Are interneuron oscillation deficits compensatory responses or primary pathological drivers in neurodegeneration?","status":"completed","created_at":"2026-04-15T15:03:34.678196"},{"id":"SDA-2026-04-15-gap-debate-20260410-112400-454036f1","title":"Do CXCL10-recruited CD8+ T cells provide neuroprotection or cause damage in aging white matter?","status":"completed","created_at":"2026-04-15T14:12:28.971841"},{"id":"SDA-2026-04-12-20260411-082446-2c1c9e2d","title":"Do β-amyloid plaques and neurofibrillary tangles cause or result from cholinergic dysfunction?","status":"completed","created_at":"2026-04-12T21:07:20.629461"},{"id":"SDA-2026-04-12-gap-debate-20260410-113021-6fbc6da4","title":"Do SCFAs directly modulate α-synuclein aggregation in vivo at physiologically relevant brain concentrations?","status":"completed","created_at":"2026-04-12T20:44:16.010329"},{"id":"SDA-2026-04-12-gap-pubmed-20260410-184126-b2c3e2e8","title":"How does APOE4's beneficial immune function reconcile with its established role as the strongest AD risk factor?","status":"completed","created_at":"2026-04-12T19:17:33.787365"},{"id":"SDA-2026-04-12-gap-debate-20260410-145418-c1527e7b","title":"Why have numerous phase 3 clinical trials failed despite advances in understanding AD pathobiology?","status":"completed","created_at":"2026-04-12T16:27:18.738472"},{"id":"sda-2026-04-12-ev-ad-biomarkers","title":"Extracellular vesicle biomarkers for early AD detection","status":"completed","created_at":"2026-04-12T15:26:07.868977"},{"id":"SDA-2026-04-12-gap-debate-20260410-112927-b4535f82","title":"Do bacterial curli amyloids cross the blood-brain barrier to directly seed α-synuclein aggregation in humans?","status":"completed","created_at":"2026-04-12T07:46:38.896216"},{"id":"SDA-2026-04-12-gap-debate-20260410-112908-13c403ee","title":"What is the actual quantitative contribution of FcRn-mediated transcytosis to BBB antibody transport in humans?","status":"completed","created_at":"2026-04-12T06:36:59.243036"},{"id":"SDA-2026-04-11-gap-debate-20260410-111558-f9487fea","title":"Does reduced Prevotellaceae abundance cause PD pathology or result from it?","status":"completed","created_at":"2026-04-11T10:52:24.611991"},{"id":"SDA-2026-04-09-gap-debate-20260409-201742-ca7016f1","title":"Can nanobodies achieve selective membrane penetration into tau-containing vesicles without affecting normal cellular vesicles?","status":"completed","created_at":"2026-04-09T22:44:41.179392"},{"id":"SDA-2026-04-09-gap-debate-20260409-201742-1e8eb3bd","title":"Which specific post-translational modifications on pathological tau create druggable epitopes absent in physiological tau?","status":"completed","created_at":"2026-04-09T22:09:58.613574"},{"id":"SDA-2026-04-09-gap-debate-20260409-201742-d279750b","title":"Do tau-containing vesicles exhibit unique surface glycosylation patterns that distinguish them from normal vesicles?","status":"completed","created_at":"2026-04-09T21:30:36.661766"},{"id":"SDA-2026-04-09-gap-debate-20260409-201742-5407d57d","title":"What are the minimal structural requirements for HSP70/HSP90 inhibitors to achieve tau-selectivity over essential cellular functions?","status":"completed","created_at":"2026-04-09T20:50:14.085960"},{"id":"SDA-2026-04-08-gap-pubmed-20260406-062218-5c7f15f4","title":"What neural circuits encode and maintain multi-generational migratory route memory?","status":"completed","created_at":"2026-04-08T17:19:19.232388"},{"id":"SDA-2026-04-08-gap-pubmed-20260406-062111-db808ee9","title":"Why do clinical manifestations overlap despite distinct underlying etiologies in immune-mediated myelopathies?","status":"completed","created_at":"2026-04-08T16:44:42.352621"},{"id":"SDA-2026-04-08-gap-debate-20260406-062033-fecb8755","title":"Which specific metabolic pathways in APOE4+ microglia are most therapeutically tractable?","status":"completed","created_at":"2026-04-08T16:05:17.837826"},{"id":"SDA-2026-04-08-gap-pubmed-20260406-062218-580b17ef","title":"How does ADCY8 mechanistically regulate long-term memory formation in migratory navigation?","status":"completed","created_at":"2026-04-08T15:29:32.692392"},{"id":"SDA-2026-04-08-gap-pubmed-20260406-062207-5a703c17","title":"What determines the selectivity and efficiency of intercellular transmission pathways for different misfolded proteins?","status":"completed","created_at":"2026-04-08T14:54:45.693879"},{"id":"SDA-2026-04-08-gap-pubmed-20260406-062128-34a47c4e","title":"Why does prolonged anesthesia cause both cognitive dysfunction and anxiety through the same synaptic mechanism?","status":"completed","created_at":"2026-04-08T14:19:38.511594"},{"id":"SDA-2026-04-08-gap-pubmed-20260406-062122-bfac06c8","title":"How does SPI1 transcriptionally regulate C1QA and C1QC expression in atherosclerotic contexts?","status":"completed","created_at":"2026-04-08T13:44:34.533167"},{"id":"SDA-2026-04-08-gap-debate-20260406-062101-7751c220","title":"Can metabolic interventions truly reverse established cellular senescence or only prevent progression?","status":"completed","created_at":"2026-04-08T13:09:54.436536"},{"id":"SDA-2026-04-08-gap-debate-20260406-062052-81a54bfd","title":"How can ESCRT or SNARE targeting achieve tau-specific effects without disrupting essential cellular processes?","status":"completed","created_at":"2026-04-08T12:30:38.838087"},{"id":"SDA-2026-04-08-gap-debate-20260406-062045-ce866189","title":"Why do systemic anti-inflammatory drugs fail in AD despite cardiovascular efficacy if neuroinflammation is central?","status":"completed","created_at":"2026-04-08T11:50:47.488475"},{"id":"SDA-2026-04-08-gap-debate-20260406-062039-f02efa4b","title":"Do different priming stimuli require distinct therapeutic approaches or share common epigenetic pathways?","status":"completed","created_at":"2026-04-08T11:10:05.189847"},{"id":"SDA-2026-04-08-gap-debate-20260406-062033-16eccec1","title":"Can circadian interventions reverse microglial priming independent of sleep disruption effects?","status":"completed","created_at":"2026-04-08T10:30:03.494683"},{"id":"SDA-2026-04-08-gap-pubmed-20260406-062212-b66510d9","title":"How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pathogenesis?","status":"completed","created_at":"2026-04-08T09:54:44.426374"},{"id":"SDA-2026-04-08-gap-pubmed-20260406-062207-b800e5d3","title":"How do host cell factors influence the conformation and propagation properties of transmitted pathological seeds?","status":"completed","created_at":"2026-04-08T09:15:51.347811"},{"id":"SDA-2026-04-08-gap-pubmed-20260406-062229-3ab00c95","title":"What determines the specificity of DDR protein recruitment to dilncRNA-induced condensates?","status":"completed","created_at":"2026-04-08T07:15:17.133975"},{"id":"SDA-2026-04-08-gap-pubmed-20260406-062222-cc3bcb47","title":"How do protein-protein interactions determine subcellular localization and function specificity?","status":"completed","created_at":"2026-04-08T06:36:02.030946"},{"id":"SDA-2026-04-08-gap-pubmed-20260406-062229-35a642ca","title":"How do dilncRNAs specifically drive molecular crowding and phase separation of DDR proteins?","status":"completed","created_at":"2026-04-08T03:30:02.543273"},{"id":"SDA-2026-04-08-gap-pubmed-20260406-062222-b5f44522","title":"What molecular mechanisms drive tissue-specific phenotypes in Mendelian neurological diseases?","status":"completed","created_at":"2026-04-08T00:19:36.364383"},{"id":"SDA-2026-04-04-gap-neuroinflammation-microglial-20260404","title":"Neuroinflammation and microglial priming in early AD","status":"completed","created_at":"2026-04-04T10:26:14.684927"},{"id":"SDA-2026-04-04-analysis_sea_ad_001","title":"SEA-AD Single-Cell Analysis: Cell-Type Vulnerability in Alzheimer's Disease","status":"completed","created_at":"2026-04-04T02:24:23.896821"},{"id":"SDA-2026-04-04-frontier-proteomics-1c3dba72","title":"Quantitative proteomics of the aging synapse in early Alzheimer disease","status":"completed","created_at":"2026-04-04 20:48:55"},{"id":"SDA-2026-04-04-frontier-lipidomics-dcdbc360","title":"Lipid metabolism dysregulation and membrane integrity in Alzheimer disease","status":"completed","created_at":"2026-04-04 20:48:43"},{"id":"SDA-2026-04-04-frontier-connectomics-84acb35a","title":"Human connectome alterations and network-level dysfunction in Alzheimer disease","status":"completed","created_at":"2026-04-04 20:48:43"},{"id":"SDA-2026-04-04-frontier-immunomics-e6f97b29","title":"Systemic immune profiling and peripheral immune contributions to neurodegeneration","status":"completed","created_at":"2026-04-04 20:48:43"},{"id":"SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402","title":"Immune atlas neuroinflammation analysis in neurodegeneration","status":"completed","created_at":"2026-04-03T18:53:43.401867"},{"id":"SDA-2026-04-03-gap-seaad-20260402025452","title":"Cell type vulnerability in Alzheimer's Disease (SEA-AD data)","status":"completed","created_at":"2026-04-03T18:19:03.485104"},{"id":"sda-2026-04-01-003","title":"Gut-Brain Axis Therapeutics for AD","status":"completed","created_at":"2026-04-01T21:40:04.034917"},{"id":"sda-2026-04-01-002","title":"GBA-Synuclein Loop Therapeutics for PD","status":"completed","created_at":"2026-04-01T21:26:06.749557"},{"id":"sda-2026-04-01-001","title":"TREM2 Therapeutic Strategy Post-INVOKE-2","status":"completed","created_at":"2026-04-01T21:15:14.648684"},{"id":"sda-2026-04-01-gap-20260401-225149","title":"What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's disease pathogenesis through the gut-brain axis?","status":"completed","created_at":"2026-04-01 12:00:00"},{"id":"gba-pd","title":"GBA-Synuclein Loop: Therapeutic Strategies for Parkinson's Disease","status":"completed","created_at":"2026-04-01 12:00:00"}]},"low_validation":{"count":14,"items":[{"id":"h-84808267","title":"Synthetic Biology BBB Endothelial Cell Reprogramming","composite_score":0.565113686511056,"evidence_validation_score":0.031},{"id":"h-aa2d317c","title":"Magnetosonic-Triggered Transferrin Receptor Clustering","composite_score":0.46950719894005777,"evidence_validation_score":0.274},{"id":"h-e6437136","title":"Ephrin-B2/EphB4 Axis Manipulation","composite_score":0.39864890714739004,"evidence_validation_score":0.282},{"id":"h-49791706","title":"Biorhythmic Interference via Controlled Sleep Oscillations","composite_score":0.41178132870428963,"evidence_validation_score":0.291},{"id":"h-0758b337","title":"Purinergic Signaling Polarization Control","composite_score":0.5544567777998322,"evidence_validation_score":0.293},{"id":"h-5dbfd3aa","title":"Heat Shock Protein 70 Disaggregase Amplification","composite_score":0.5112707821122461,"evidence_validation_score":0.303},{"id":"h-fffd1a74","title":"RNA Granule Nucleation Site Modulation","composite_score":0.47937570929549617,"evidence_validation_score":0.311},{"id":"h-05b8894a","title":"Netrin-1 Gradient Restoration","composite_score":0.32667637702690805,"evidence_validation_score":0.325},{"id":"h-7e0b5ade","title":"Circadian-Synchronized LRP1 Pathway Activation","composite_score":0.5259995365081646,"evidence_validation_score":0.328},{"id":"h-aa8b4952","title":"Mitochondrial Calcium Buffering Enhancement via MCU Modulation","composite_score":0.37626774981044436,"evidence_validation_score":0.337},{"id":"h-5a55aabc","title":"Complement C1q Subtype Switching","composite_score":0.4366166106071316,"evidence_validation_score":0.364},{"id":"h-5daecb6e","title":"Microglial Purinergic Reprogramming","composite_score":0.4834165537317655,"evidence_validation_score":0.367},{"id":"h-69d383ea","title":"Low Complexity Domain Cross-Linking Inhibition","composite_score":0.4153074086197477,"evidence_validation_score":0.375},{"id":"h-ec731b7a","title":"Phase-Separated Organelle Targeting","composite_score":0.5209345175589797,"evidence_validation_score":0.375}]},"failed_analyses":{"count":200,"items":[{"id":"SDA-2026-04-15-gap-pubmed-20260411-093843-0a9326c2","title":"What are the physiological functions of BACE1 beyond APP processing that could cause side effects from therapeutic inhibition?","question":"The abstract identifies BACE1 as an attractive drug target but doesn't address its normal physiological roles. Understanding these functions is critical to predict potential adverse effects of BACE1 inhibitors in therapeutic development.\n\nGap type: open_question\nSource paper: BACE1: the beta-secretase enzyme in Alzheimer's disease. (2004, Journal of molecular neuroscience : MN, PMID:15126696)","created_at":"2026-04-15T11:17:39.198768","failure_reason":null},{"id":"SDA-2026-04-15-gap-pubmed-20260411-092119-691e1977","title":"Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers despite reducing iron levels?","question":"The study shows deferiprone rescues wild-type cells but exacerbates toxicity in H63D HFE cells, contradicting the assumption that iron reduction is universally protective in neurodegeneration. This paradox has critical implications for personalized Parkinson's treatment strategies.\n\nGap type: contradiction\nSource paper: H63D variant of the homeostatic iron regulator (HFE) gene alters α-synuclein expression, aggregation, and toxicity. (2020, Journal of neurochemistry, PMID:32574378)","created_at":"2026-04-15T10:26:18.727264","failure_reason":null},{"id":"SDA-2026-04-15-gap-pubmed-20260411-090658-7651c1d2","title":"What upstream mechanisms trigger p53 activation specifically in response to poly(PR) dipeptide repeats?","question":"The abstract shows p53 is a central regulator of C9orf72-mediated neurodegeneration but doesn't explain how poly(PR) specifically activates p53. Understanding this upstream trigger mechanism is critical for developing targeted therapeutic interventions.\n\nGap type: unexplained_observation\nSource paper: p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR). (None, None, PMID:33482083)","created_at":"2026-04-15T09:38:39.085404","failure_reason":null},{"id":"SDA-2026-04-15-gap-pubmed-20260411-084510-fbfafe2c","title":"How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cells during neurogenesis?","question":"This study reveals SYNGAP1 expression and function in radial glia before synaptogenesis, contradicting its classification as purely a synaptic protein. The molecular mechanisms underlying this non-synaptic role remain unexplained, which is critical for understanding ASD pathophysiology.\n\nGap type: contradiction\nSource paper: Non-synaptic function of the autism spectrum disorder-associated gene SYNGAP1 in cortical neurogenesis. (None, None, PMID:37946050)","created_at":"2026-04-15T08:47:08.451118","failure_reason":null},{"id":"SDA-2026-04-15-gap-pubmed-20260411-083737-59771b32","title":"What molecular mechanisms link elevated sphingomyelin synthase activity to increased amyloid-beta generation?","question":"The study demonstrates that SGMS1 elevation correlates with increased Aβ and that SGMS inhibition reduces Aβ production, but the specific biochemical pathways connecting sphingomyelin metabolism to APP processing remain unexplained. Understanding this mechanism is critical for developing targeted therapeutic interventions.\n\nGap type: unexplained_observation\nSource paper: Elevation in sphingomyelin synthase activity is associated with increases in amyloid-beta peptide generation. (None, None, PMID:23977395)","created_at":"2026-04-15T07:54:51.820729","failure_reason":null},{"id":"SDA-2026-04-15-gap-pubmed-20260411-083043-759b4c5e","title":"What molecular mechanisms explain how apoE promotes cerebral amyloid angiopathy formation?","question":"The study demonstrates that apoE is absolutely required for CAA development, as apoE knockout completely prevents CAA formation. However, the specific molecular pathways by which apoE facilitates Aβ deposition in vessel walls remain unexplained, limiting therapeutic target identification.\n\nGap type: unexplained_observation\nSource paper: Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice. (2003, The Journal of neuroscience : the official journal of the Society for Neuroscience, PMID:12944519)","created_at":"2026-04-15T07:01:19.965994","failure_reason":null},{"id":"SDA-2026-04-15-gap-pubmed-20260411-082509-118fcb37","title":"Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondrial depletion in tauopathy?","question":"The abstract reveals an unexpected contradiction where PRKN activation, normally considered neuroprotective through damaged mitochondria removal, actually depletes healthy mitochondria from synapses in tauopathy. This challenges the established view of mitophagy as purely beneficial and suggests context-dependent mechanisms that remain unexplained.\n\nGap type: contradiction\nSource paper: Broad activation of the PRKN pathway triggers synaptic failure by disrupting synaptic mitochondrial supply in early tauopathy. (None, None, PMID:35188059)","created_at":"2026-04-15T06:41:56.990970","failure_reason":null},{"id":"SDA-2026-04-15-gap-pubmed-20260411-082435-2ccbb742","title":"What molecular mechanisms cause iPLA2β deficiency to specifically damage mitochondrial inner membranes?","question":"The abstract shows that damaged mitochondrial inner membranes appear early in PLA2G6 KO mice, but the specific biochemical pathways linking phospholipase deficiency to selective inner membrane damage remain unexplained. Understanding this mechanism is critical for developing targeted therapies for PLAN and related neurodegenerative diseases.\n\nGap type: unexplained_observation\nSource paper: Neuroaxonal dystrophy in PLA2G6 knockout mice. (2015, Neuropathology : official journal of the Japanese Society of Neuropathology, PMID:25950622)","created_at":"2026-04-15T06:00:23.843903","failure_reason":null},{"id":"SDA-2026-04-15-gap-pubmed-20260411-080155-ea072afc","title":"What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding to pTau?","question":"The abstract shows that Gal3 binding to pTau greatly enhances tau fibrillation, but the specific molecular interactions and structural changes driving this enhancement are not explained. Understanding this mechanism is critical for developing targeted therapeutics that could disrupt this pathogenic interaction.\n\nGap type: unexplained_observation\nSource paper: Galectin-3 aggravates microglial activation and tau transmission in tauopathy. (2024, The Journal of clinical investigation, PMID:37988169)","created_at":"2026-04-15T05:17:17.010066","failure_reason":null},{"id":"SDA-2026-04-15-gap-pubmed-20260411-075425-2feffb0c","title":"What molecular mechanisms drive the transition from acute to persistent neuroinflammation in pediatric TBI?","question":"The abstract shows that acute neuroinflammation becomes persistent with a specific transcriptomic signature, but the mechanistic drivers of this transition are not explained. Understanding this switch is critical for developing interventions to prevent chronic sequelae.\n\nGap type: unexplained_observation\nSource paper: Deleterious effect of sustained neuroinflammation in pediatric traumatic brain injury. (2024, Brain, behavior, and immunity, PMID:38705494)","created_at":"2026-04-15T04:23:20.656737","failure_reason":null},{"id":"SDA-2026-04-15-gap-pubmed-20260411-075356-20920528","title":"Why does autophagy inhibition improve neuronal survival when autophagy is typically neuroprotective?","question":"This finding contradicts the established paradigm that autophagy is generally protective in neurons and neurodegenerative diseases. The counterintuitive result that blocking autophagy reduces neuronal death challenges current therapeutic approaches targeting autophagy enhancement.\n\nGap type: contradiction\nSource paper: Autophagy fails to prevent glucose deprivation/glucose reintroduction-induced neuronal death due to calpain-mediated lysosomal dysfunction in cortical neurons. (2017, Cell death & disease, PMID:28661473)","created_at":"2026-04-15T03:30:31.310158","failure_reason":null},{"id":"SDA-2026-04-15-gap-pubmed-20260411-075338-35f913fb","title":"What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic function?","question":"The abstract shows HDAC9 overexpression reduces Aβ deposition and improves synaptic deficits, but the underlying molecular pathways are not explained. Understanding these mechanisms is critical for developing HDAC9-targeted therapeutics for AD.\n\nGap type: unexplained_observation\nSource paper: Neuronal HDAC9: A key regulator of cognitive and synaptic aging, rescuing Alzheimer's disease-related phenotypes. (2026, Mol Psychiatry, PMID:41935184)","created_at":"2026-04-15T02:41:39.122685","failure_reason":"Orchestrator error: All tool-capable LLM providers failed. Last error: CLI harness codex_cli returned exit 1: Reading prompt from stdin...\nOpenAI Codex v0.118.0 (research preview)\n--------\nworkdir: /home/ubuntu/scidex\nmodel: gpt-5.4\nprovider: openai\napproval: never\nsandbox: workspace-write [workdir, /tmp, $TMPDIR, /home/ubuntu/.codex/memories]\nreasoning effort: none\nreasoning summaries: none\nsession id: 019d9060-81d4-7e42-817b-2ad416a0b132\n--------\nuser\n<system>You are a rigorous scientific skeptic. Your role is to"},{"id":"SDA-2026-04-14-gap-pubmed-20260411-075338-35f913fb","title":"What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic function?","question":"The abstract shows HDAC9 overexpression reduces Aβ deposition and improves synaptic deficits, but the underlying molecular pathways are not explained. Understanding these mechanisms is critical for developing HDAC9-targeted therapeutics for AD.\n\nGap type: unexplained_observation\nSource paper: Neuronal HDAC9: A key regulator of cognitive and synaptic aging, rescuing Alzheimer's disease-related phenotypes. (2026, Mol Psychiatry, PMID:41935184)","created_at":"2026-04-14T23:33:55.491783","failure_reason":"Orchestrator error: All tool-capable LLM providers failed. Last error: CLI harness codex_cli returned exit 1: Reading prompt from stdin...\nOpenAI Codex v0.118.0 (research preview)\n--------\nworkdir: /home/ubuntu/scidex\nmodel: gpt-5.4\nprovider: openai\napproval: never\nsandbox: workspace-write [workdir, /tmp, $TMPDIR, /home/ubuntu/.codex/memories]\nreasoning effort: none\nreasoning summaries: none\nsession id: 019d8fd8-9cc5-79d0-a60e-9f09fbe7effc\n--------\nuser\n<system>You are a rigorous scientific skeptic. Your role is to"},{"id":"SDA-2026-04-14-gap-pubmed-20260411-072446-a32fa49c","title":"Why is TYROBP deficiency neuroprotective when TYROBP is an adapter for multiple AD risk receptors?","question":"The abstract shows TYROBP deficiency is neuroprotective despite being required for TREM2, CD33, and CR3 function - receptors associated with AD risk. This counterintuitive finding challenges current understanding of how these immune receptors contribute to AD pathogenesis.\n\nGap type: contradiction\nSource paper: Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology. (None, None, PMID:28612290)","created_at":"2026-04-14T22:48:54.079867","failure_reason":"Orchestrator error: All tool-capable LLM providers failed. Last error: CLI harness codex_cli returned exit 1: Reading prompt from stdin...\nOpenAI Codex v0.118.0 (research preview)\n--------\nworkdir: /home/ubuntu/scidex\nmodel: gpt-5.4\nprovider: openai\napproval: never\nsandbox: workspace-write [workdir, /tmp, $TMPDIR, /home/ubuntu/.codex/memories]\nreasoning effort: none\nreasoning summaries: none\nsession id: 019d8f88-b176-7631-8db5-19117ad511f6\n--------\nuser\n<system>You are a creative scientific theorist. Your role is t"},{"id":"SDA-2026-04-14-gap-pubmed-20260411-065157-53c2c658","title":"Why does Metformin fail to delay CJD progression despite improving anti-aging hallmarks like Nano-PSO?","question":"Both compounds similarly reduced aging hallmarks (AMPK, Nrf2, COX IV1) and inflammation, yet only Nano-PSO delayed disease progression. This discordance challenges the assumption that anti-aging interventions are therapeutically equivalent and suggests unknown mechanistic differences critical for prion disease treatment.\n\nGap type: contradiction\nSource paper: Comparing anti-aging hallmark activities of Metformin and Nano-PSO in a mouse model of genetic Creutzfeldt-Jakob Disease. (2022, Neurobiology of aging, PMID:34875507)","created_at":"2026-04-14T17:49:01.148084","failure_reason":"Orchestrator error: All tool-capable LLM providers failed. Last error: CLI harness codex_cli returned exit 1: Reading prompt from stdin...\nOpenAI Codex v0.118.0 (research preview)\n--------\nworkdir: /home/ubuntu/scidex\nmodel: gpt-5.4\nprovider: openai\napproval: never\nsandbox: workspace-write [workdir, /tmp, $TMPDIR, /home/ubuntu/.codex/memories]\nreasoning effort: none\nreasoning summaries: none\nsession id: 019d8e72-b936-79a3-84d0-15810194e9b4\n--------\nuser\n<system>You are a scientific falsifier — an adversarial red-te"},{"id":"SDA-2026-04-14-gap-pubmed-20260410-193701-11582758","title":"Does clusterin exacerbate or protect against neuronal death in neurodegeneration?","question":"The abstract reveals contradictory evidence where clusterin is proposed as a protective chaperone protein, yet knockout studies show it exacerbates neuronal death in hypoxia-ischemia. This fundamental contradiction undermines therapeutic targeting strategies.\n\nGap type: contradiction\nSource paper: Clusterin. (None, None, PMID:11906815)","created_at":"2026-04-14T16:11:15.482097","failure_reason":null},{"id":"SDA-2026-04-14-gap-pubmed-20260410-193244-89904941","title":"What specific molecular mechanisms link APOE4 to cholesterol dysregulation in oligodendrocytes?","question":"The abstract identifies APOE4's primary effect on oligodendrocyte cholesterol metabolism but doesn't explain the mechanistic pathway. Understanding this mechanism is critical for developing targeted therapeutics that address the root cause rather than downstream effects.\n\nGap type: unexplained_observation\nSource paper: APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes (2022, Nature, PMID:34788101)","created_at":"2026-04-14T15:21:23.583818","failure_reason":null},{"id":"SDA-2026-04-14-gap-pubmed-20260410-193006-09757220","title":"How does pericyte senescence mechanistically promote glioma cell growth and invasion?","question":"The abstract reports that pericyte senescence contributes to glioma growth and invasion, but the specific molecular mechanisms linking senescent pericytes to tumor progression are not explained. This gap is critical for understanding how radiation therapy may paradoxically promote tumor aggressiveness.\n\nGap type: unexplained_observation\nSource paper: Defective autophagy of pericytes enhances radiation-induced senescence promoting radiation brain injury. (2024, Neuro-oncology, PMID:39110121)","created_at":"2026-04-14T14:38:54.198945","failure_reason":null},{"id":"SDA-2026-04-14-gap-pubmed-20260410-191132-d67a1191","title":"What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effects against dementia?","question":"The study demonstrates significant reduction in dementia risk (HR 0.63) with GLP-1RA treatment, but the underlying neuroprotective mechanisms remain unexplained. Understanding these pathways is critical for optimizing therapeutic targeting and developing next-generation neuroprotective agents.\n\nGap type: unexplained_observation\nSource paper: Neurodegeneration and Stroke After Semaglutide and Tirzepatide in Patients With Diabetes and Obesity. (2025, JAMA network open, PMID:40663350)","created_at":"2026-04-14T13:55:55.047426","failure_reason":null},{"id":"SDA-2026-04-14-gap-pubmed-20260410-191046-15921012","title":"What are the specific circulating factors in exercise-conditioned plasma that mediate neuroprotection against POCD?","question":"The study demonstrates that exercise-conditioned plasma transfers cognitive benefits, but the identity of the active circulating factors remains unknown. Understanding these factors is critical for developing targeted therapeutic interventions for POCD without requiring exercise.\n\nGap type: unexplained_observation\nSource paper: Exercise-conditioned plasma ameliorates postoperative cognitive dysfunction by activating hippocampal cholinergic circuit and enhancing BDNF/TrkB signaling. (2024, Cell communication and signaling : CCS, PMID:39558340)","created_at":"2026-04-14T13:05:51.980108","failure_reason":null},{"id":"SDA-2026-04-14-gap-pubmed-20260410-185318-186b0446","title":"What genetic risk factors predispose individuals to developing CTE following repetitive brain trauma?","question":"The abstract explicitly states the critical need to identify genetic risk factors for CTE, but these remain unknown. Understanding genetic susceptibility could enable risk stratification and personalized prevention strategies for athletes and military personnel.\n\nGap type: open_question\nSource paper: The neuropathology of chronic traumatic encephalopathy. (2015, Brain pathology (Zurich, Switzerland), PMID:25904048)","created_at":"2026-04-14T12:12:29.481144","failure_reason":null},{"id":"SDA-2026-04-14-gap-pubmed-20260410-184233-98bf553f","title":"Why do p300/CBP inhibitors reduce both AD incidence and clinically diagnosed TBI in human patients?","question":"The observation that salsalate and diflunisal decrease both AD and TBI incidence suggests these drugs may prevent injury occurrence, not just treat consequences. This unexpected finding challenges the assumed mechanism of action and has major therapeutic implications.\n\nGap type: unexplained_observation\nSource paper: Reducing acetylated tau is neuroprotective in brain injury. (2021, Cell, PMID:33852912)","created_at":"2026-04-14T11:22:14.211882","failure_reason":null},{"id":"SDA-2026-04-14-gap-pubmed-20260410-184155-2ff305ca","title":"How does FUS loss-of-function in TAZ regulation contribute to ALS/FTD pathogenesis?","question":"The abstract reveals FUS has a chaperone-like function regulating TAZ condensate dynamics, but doesn't address how FUS mutations in ALS/FTD might disrupt this function. This gap is critical since FUS mutations cause neurodegeneration, yet this newly discovered role in transcriptional regulation remains unexplored in disease context.\n\nGap type: open_question\nSource paper: A chaperone-like function of FUS ensures TAZ condensate dynamics and transcriptional activation. (None, None, PMID:38172614)","created_at":"2026-04-14T10:32:15.956982","failure_reason":null},{"id":"SDA-2026-04-14-gap-pubmed-20260410-184126-b2c3e2e8","title":"How does APOE4's beneficial immune function reconcile with its established role as the strongest AD risk factor?","question":"This study shows APOE4 carriers have enhanced beneficial innate immune responses, directly contradicting the established view of APOE4 as purely detrimental in neurodegeneration. This paradox challenges fundamental assumptions about APOE4's role in AD pathogenesis.\n\nGap type: contradiction\nSource paper: APOE genotype-specific differences in the innate immune response (2021, JAMA Neurology, PMID:33432245)","created_at":"2026-04-14T09:42:10.231745","failure_reason":null},{"id":"SDA-2026-04-14-gap-pubmed-20260410-183548-043c7918","title":"How do ALS-associated OPTN mutations mechanistically disrupt Rab8a binding and cellular function?","question":"The authors evaluate several ALS-associated mutations in OPTN's leucine-zipper domain but don't fully explain how these mutations mechanistically lead to disease pathogenesis. Understanding this link is critical for developing targeted ALS therapies.\n\nGap type: unexplained_observation\nSource paper: Molecular Basis of the Recognition of the Active Rab8a by Optineurin. (2024, Journal of molecular biology, PMID:39374890)","created_at":"2026-04-14T08:49:54.086044","failure_reason":null},{"id":"SDA-2026-04-14-gap-pubmed-20260410-183021-c13d9f04","title":"What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic A1 vs neuroprotective A2 phenotypes?","question":"The abstract describes astrocyte phenotypic heterogeneity (A1/A2) but doesn't explain the mechanistic switches governing this critical fate decision. Understanding these mechanisms is essential for therapeutic targeting of beneficial vs harmful astrocyte responses.\n\nGap type: unexplained_observation\nSource paper: Contribution of astrocytes to neuropathology of neurodegenerative diseases. (2021, Brain research, PMID:33516810)","created_at":"2026-04-14T07:55:48.214009","failure_reason":null},{"id":"SDA-2026-04-14-gap-pubmed-20260410-181356-57d1f917","title":"What molecular mechanisms enable functional recovery and muscle re-innervation after motor neuron loss in ALS/FTLD?","question":"The study shows dramatic functional recovery and muscle re-innervation after cytoplasmic TDP-43 clearance, even following motor neuron death. The cellular and molecular mechanisms underlying this unexpected regenerative capacity in neurodegenerative disease are not explained.\n\nGap type: unexplained_observation\nSource paper: Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43. (2015, Acta neuropathologica, PMID:26197969)","created_at":"2026-04-14T07:01:00.577106","failure_reason":null},{"id":"SDA-2026-04-14-gap-pubmed-20260410-181258-df5eee45","title":"What signals trigger microglia to specifically recognize and phagocytose LC axons in early AD?","question":"The study shows that OB microglia phagocytose LC axons before amyloid plaque formation, but the molecular signals that mark these axons for destruction are unknown. Understanding this mechanism could reveal early therapeutic targets to prevent noradrenergic denervation.\n\nGap type: unexplained_observation\nSource paper: Early Locus Coeruleus noradrenergic axon loss drives olfactory dysfunction in Alzheimer's disease. (2025, Nature communications, PMID:40781079)","created_at":"2026-04-14T06:15:01.629476","failure_reason":null},{"id":"SDA-2026-04-14-gap-pubmed-20260410-181156-feec7bd3","title":"How do P/Q channel deficits paradoxically increase thalamic excitability despite impairing neurotransmitter release?","question":"The abstract describes a counterintuitive finding where loss-of-function P/Q mutations that impair transmitter release somehow increase rather than decrease thalamic excitability. The molecular mechanisms underlying this paradoxical effect remain unexplained despite its central role in absence epilepsy pathogenesis.\n\nGap type: contradiction\nSource paper: Presynaptic P/Q calcium channel deficit promotes postsynaptic excitability remodeling and neurogenesis in developing thalamic circuitry. (2026, Neuron, PMID:41932329)","created_at":"2026-04-14T05:19:34.416277","failure_reason":null},{"id":"SDA-2026-04-14-gap-pubmed-20260410-180532-e8930cb8","title":"Why does the V1613M variant reduce amyloid pathology when ABCA7 loss-of-function increases AD risk?","question":"The abstract shows V1613M variant reduces amyloid plaques and damage in 5xFAD mice, yet ABCA7 loss-of-function mutations increase LOAD risk. This apparent contradiction suggests complex genotype-phenotype relationships that could inform therapeutic targeting.\n\nGap type: contradiction\nSource paper: The Abca7 (None, None, PMID:38506634)","created_at":"2026-04-14T04:26:48.693793","failure_reason":null},{"id":"SDA-2026-04-14-gap-pubmed-20260410-174607-708e8d91","title":"Why do TAM receptors protect against neuroinvasive viruses despite their known immunosuppressive role?","question":"The finding that Mertk/Axl deficiency increases viral susceptibility contradicts the established paradigm that TAM receptors dampen antiviral immunity. This unexpected protective role challenges current understanding of TAM receptor function in neuroinvasive infections.\n\nGap type: contradiction\nSource paper: The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity. (2015, Nature medicine, PMID:26523970)","created_at":"2026-04-14T03:32:45.617665","failure_reason":"Orchestrator error: All tool-capable LLM providers failed. Last error: CLI harness codex_cli returned exit 1: Reading prompt from stdin...\nOpenAI Codex v0.118.0 (research preview)\n--------\nworkdir: /home/ubuntu/scidex\nmodel: gpt-5.4\nprovider: openai\napproval: never\nsandbox: workspace-write [workdir, /tmp, $TMPDIR, /home/ubuntu/.codex/memories]\nreasoning effort: none\nreasoning summaries: none\nsession id: 019d8b62-fcc9-72f0-93da-d60aeb539e4c\n--------\nuser\n<system>You are a domain expert in neuroscience, molecular bio"},{"id":"SDA-2026-04-13-gap-pubmed-20260410-174607-708e8d91","title":"Why do TAM receptors protect against neuroinvasive viruses despite their known immunosuppressive role?","question":"The finding that Mertk/Axl deficiency increases viral susceptibility contradicts the established paradigm that TAM receptors dampen antiviral immunity. This unexpected protective role challenges current understanding of TAM receptor function in neuroinvasive infections.\n\nGap type: contradiction\nSource paper: The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity. (2015, Nature medicine, PMID:26523970)","created_at":"2026-04-13T23:47:06.675082","failure_reason":"Orchestrator error: All tool-capable LLM providers failed. Last error: CLI harness codex_cli returned exit 1: Reading prompt from stdin...\nOpenAI Codex v0.118.0 (research preview)\n--------\nworkdir: /home/ubuntu/scidex\nmodel: gpt-5.4\nprovider: openai\napproval: never\nsandbox: workspace-write [workdir, /tmp, $TMPDIR, /home/ubuntu/.codex/memories]\nreasoning effort: none\nreasoning summaries: none\nsession id: 019d8abe-5d0f-7f01-91c0-cd3f4a826e18\n--------\nuser\n<system>You are a scientific falsifier — an adversarial red-te"},{"id":"SDA-2026-04-13-gap-pubmed-20260410-173045-28238f1f","title":"What molecular mechanisms explain how KCNJ2 inhibition mitigates TBI-induced neurodegeneration?","question":"The study identifies KCNJ2 as a therapeutic target through CRISPR screening but doesn't explain the mechanistic pathway by which this mechanosensory channel inhibition reduces neuronal death and proteinopathy. Understanding this mechanism is critical for rational drug development and predicting off-target effects.\n\nGap type: unexplained_observation\nSource paper: KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury. (2024, Cell stem cell, PMID:38579683)","created_at":"2026-04-13T22:26:35.994277","failure_reason":null},{"id":"SDA-2026-04-13-gap-pubmed-20260410-173032-9318ca0d","title":"How does PSEN2 mechanistically regulate α-synuclein expression and pathology in neurons?","question":"The study shows PSEN2 is essential in cortical and dopaminergic neurons and regulates αS expression, but the molecular mechanism linking PSEN2 to synuclein biology remains unexplained. This is critical since PSEN2 mutations cause diffuse synucleinopathy independent of AD pathology.\n\nGap type: unexplained_observation\nSource paper: Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathies. (2026, bioRxiv : the preprint server for biology, PMID:38496508)","created_at":"2026-04-13T21:44:58.933162","failure_reason":null},{"id":"SDA-2026-04-13-gap-pubmed-20260410-171918-9936a995","title":"What molecular mechanisms drive neuron-to-glioma synapse formation in high-neural glioblastomas?","question":"The study demonstrates that high-neural glioblastoma cells form synapses with neurons both in vitro and in vivo, but the underlying molecular mechanisms are not explained. Understanding these mechanisms could reveal novel therapeutic targets to disrupt this tumor-promoting interaction.\n\nGap type: unexplained_observation\nSource paper: A prognostic neural epigenetic signature in high-grade glioma. (None, None, PMID:38760585)","created_at":"2026-04-13T20:36:53.193483","failure_reason":null},{"id":"SDA-2026-04-13-gap-pubmed-20260410-171850-e91bcc0d","title":"Why does PGC-1α overexpression paradoxically increase MPTP toxicity despite enhancing antioxidant defenses?","question":"PGC-1α is known to enhance mitochondrial function and antioxidant responses, yet overexpression increased susceptibility to MPTP-induced neuronal death. This contradicts the expected neuroprotective role and challenges PGC-1α as a therapeutic target in PD.\n\nGap type: contradiction\nSource paper: Pgc-1α overexpression downregulates Pitx3 and increases susceptibility to MPTP toxicity associated with decreased Bdnf. (2012, PloS one, PMID:23145024)","created_at":"2026-04-13T19:49:00.210235","failure_reason":null},{"id":"SDA-2026-04-13-gap-pubmed-20260410-170325-196c7ee5","title":"What is the molecular mechanism by which oligodendroglial MCT1 disruption causes axon damage and neuron loss?","question":"The study shows that MCT1 disruption leads to axon degeneration and neuron death, but the specific molecular pathways linking lactate transport dysfunction to neuronal damage remain unexplained. Understanding this mechanism is critical for developing targeted neuroprotective therapies.\n\nGap type: unexplained_observation\nSource paper: Oligodendroglia metabolically support axons and contribute to neurodegeneration. (2012, Nature, PMID:22801498)","created_at":"2026-04-13T18:51:13.780662","failure_reason":"Orchestrator error: All tool-capable LLM providers failed. Last error: CLI harness codex_cli returned exit 1: Reading prompt from stdin...\nOpenAI Codex v0.118.0 (research preview)\n--------\nworkdir: /home/ubuntu/scidex\nmodel: gpt-5.4\nprovider: openai\napproval: never\nsandbox: workspace-write [workdir, /tmp, $TMPDIR, /home/ubuntu/.codex/memories]\nreasoning effort: none\nreasoning summaries: none\nsession id: 019d8986-7aed-73d3-bc7c-66fff2c8a004\n--------\nuser\n<system>You are a creative scientific theorist. Your role is t"},{"id":"SDA-2026-04-13-gap-pubmed-20260410-170057-1bea7d88","title":"What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activation under normoxic conditions?","question":"The study shows VCP-mutant astrocytes exhibit hypoxia response activation without actual hypoxia, but the mechanistic link between VCP dysfunction and HIF-1α stabilization remains unexplained. Understanding this connection is critical for developing targeted therapies that could prevent early pathogenic events in VCP-ALS.\n\nGap type: unexplained_observation\nSource paper: Hypoxic stress is an early pathogenic event in human VCP-mutant ALS astrocytes. (2026, Stem cell reports, PMID:41349534)","created_at":"2026-04-13T17:25:04.702967","failure_reason":null},{"id":"SDA-2026-04-13-gap-pubmed-20260410-165527-8256a071","title":"How do the seven novel ALS genes function in animal models to cause neurodegeneration?","question":"The authors explicitly state that the effects of these novel genes (MATR3, CHCHD10, TBK1, TUBA4A, NEK1, C21orf2, and CCNF) have not yet been investigated in animal models. This is critical for understanding pathogenic mechanisms and translating findings to clinical practice.\n\nGap type: open_question\nSource paper: Novel genes associated with amyotrophic lateral sclerosis: diagnostic and clinical implications. (2018, The Lancet. Neurology, PMID:29154141)","created_at":"2026-04-13T16:33:38.738578","failure_reason":null},{"id":"SDA-2026-04-13-gap-pubmed-20260410-165345-41805e1b","title":"What molecular mechanisms enable microglia to neutralize OxPC-mediated neurodegeneration?","question":"The abstract shows microglia ameliorate OxPC toxicity to neurons and oligodendrocytes, but the specific neutralization mechanisms are not explained. Understanding these pathways could reveal therapeutic targets for MS neurodegeneration.\n\nGap type: unexplained_observation\nSource paper: Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia. (None, None, PMID:33603230)","created_at":"2026-04-13T15:40:19.433068","failure_reason":null},{"id":"SDA-2026-04-13-gap-pubmed-20260410-155308-2c6815fb","title":"Does TRT-induced erythrocytosis actually increase venous thromboembolism risk in clinical practice?","question":"Despite FDA warnings and a 315% increased erythrocytosis risk with TRT, the association between elevated hematocrit and actual VTE events remains inconclusive. This uncertainty hampers evidence-based risk-benefit decisions for millions of aging men considering TRT.\n\nGap type: open_question\nSource paper: Erythrocytosis and Polycythemia Secondary to Testosterone Replacement Therapy in the Aging Male. (2015, Sexual medicine reviews, PMID:27784544)","created_at":"2026-04-13T14:49:50.926431","failure_reason":null},{"id":"SDA-2026-04-13-gap-pubmed-20260410-150500-e110aab9","title":"How do oligodendrocytes initiate neuroinflammation in PD when microglia are traditionally considered primary drivers?","question":"This study identifies oligodendrocytes as drivers of neuroinflammation in PD, contradicting the established paradigm that microglia are the primary neuroinflammatory cells. Understanding this cell-type hierarchy is crucial for targeting the right therapeutic cells.\n\nGap type: contradiction\nSource paper: Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson's disease via the prosaposin-GPR37-IL-6 axis. (2025, Cell Rep, PMID:39913287)","created_at":"2026-04-13T13:58:38.565303","failure_reason":null},{"id":"SDA-2026-04-13-gap-pubmed-20260410-145531-5c4e7b59","title":"What molecular mechanisms underlie Atremorine's dramatic dopamine enhancement in Parkinson's patients?","question":"The abstract reports extraordinary dopamine increases (>500-fold in drug-free patients) but provides no mechanistic explanation for how Atremorine achieves this effect. Understanding these mechanisms is critical for optimizing therapeutic applications and predicting safety profiles.\n\nGap type: unexplained_observation\nSource paper: Atremorine in Parkinson's disease: From dopaminergic neuroprotection to pharmacogenomics. (2021, Med Res Rev, PMID:34106485)","created_at":"2026-04-13T13:06:34.003375","failure_reason":null},{"id":"SDA-2026-04-13-gap-pubmed-20260410-145358-185db2c8","title":"What molecular mechanisms underlie the dose-dependent protective effects of the R136S mutation against APOE4 toxicity?","question":"The study shows homozygous R136S fully rescues APOE4-driven pathology while heterozygous provides only partial protection, but the mechanistic basis for this gene dosage effect is unexplained. Understanding this mechanism is critical for developing therapeutic strategies that could mimic R136S protection.\n\nGap type: unexplained_observation\nSource paper: The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation. (2023, Nature neuroscience, PMID:37957317)","created_at":"2026-04-13T12:11:41.190355","failure_reason":null},{"id":"SDA-2026-04-13-gap-pubmed-20260410-143119-8ae42941","title":"How does PIKFYVE inhibition activate unconventional protein clearance via exocytosis?","question":"The abstract describes a novel mechanism where PIKFYVE inhibition triggers exocytosis of aggregation-prone proteins, but the molecular pathway is not explained. Understanding this mechanism is critical since protein aggregation is central to ALS pathogenesis and this represents a potentially new therapeutic approach.\n\nGap type: unexplained_observation\nSource paper: PIKFYVE inhibition mitigates disease in models of diverse forms of ALS. (2023, Cell, PMID:36754049)","created_at":"2026-04-13T11:18:07.555331","failure_reason":null},{"id":"SDA-2026-04-13-gap-pubmed-20260410-142329-c1db787b","title":"How do B cells mechanistically orchestrate tolerance to AQP4 and prevent autoimmunity in healthy individuals?","question":"The title suggests B cells actively maintain tolerance to AQP4, but the specific molecular mechanisms by which B cells prevent anti-AQP4 autoimmunity are not detailed. Understanding this tolerance mechanism is critical for developing targeted therapies for neuromyelitis optica.\n\nGap type: unexplained_observation\nSource paper: B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4. (2024, Nature, PMID:38383779)","created_at":"2026-04-13T10:27:16.367397","failure_reason":null},{"id":"SDA-2026-04-13-gap-pubmed-20260410-110327-26e1d6c7","title":"How does HDAC1/2 deletion specifically enhance microglial amyloid phagocytosis capacity?","question":"While the study shows HDAC1/2 deletion improves amyloid clearance and cognition, the specific epigenetic and transcriptional changes that enhance phagocytic function are not mechanistically defined. This knowledge gap limits translation to targeted therapeutic approaches.\n\nGap type: unexplained_observation\nSource paper: Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner. (2018, Immunity, PMID:29548672)","created_at":"2026-04-13T09:35:25.233416","failure_reason":null},{"id":"SDA-2026-04-13-gap-pubmed-20260410-105951-ce87670d","title":"What mechanisms explain how IDH1/IDH2 mutations with reduced enzymatic activity lead to better patient outcomes?","question":"The abstract shows that IDH mutations reduce protein enzymatic activity yet paradoxically correlate with improved prognosis. This counterintuitive finding suggests unknown mechanisms by which metabolic dysfunction may actually benefit patients or reflect less aggressive tumor biology.\n\nGap type: unexplained_observation\nSource paper: IDH1 and IDH2 mutations in gliomas. (2009, N Engl J Med, PMID:19228619)","created_at":"2026-04-13T08:53:57.818619","failure_reason":null},{"id":"SDA-2026-04-13-gap-debate-20260412-094638-cd9ef05d","title":"Do astrocytes functionally express TRIM46, and can PKCα phosphorylate it to drive TNT formation?","question":"The P2X7 hypothesis relies on TRIM46-mediated actin polymerization in astrocytes, but TRIM46 is established as neuronal-specific for microtubule organization. This fundamental molecular gap undermines the proposed mechanism and requires direct validation in astrocytic cultures.\n\nSource: Debate session sess_sda-2026-04-01-gap-20260401231108_20260412-084542 (Analysis: sda-2026-04-01-gap-20260401231108)","created_at":"2026-04-13T08:12:55.325358","failure_reason":null},{"id":"SDA-2026-04-13-gap-debate-20260412-094612-a2e3bd09","title":"Which tau PTMs are both disease-specific and druggable with selective small molecule inhibitors?","question":"The debate highlighted promising PTMs like K280 acetylation and O-GlcNAcylation but didn't resolve which modifications can be selectively targeted without affecting physiological tau function. This specificity gap is critical for developing PTM-based therapeutics that avoid broad cellular toxicity.\n\nSource: Debate session sess_SDA-2026-04-09-gap-debate-20260409-201742-1e8eb3bd_20260412-091129 (Analysis: SDA-2026-04-09-gap-debate-20260409-201742-1e8eb3bd)","created_at":"2026-04-13T07:17:37.206803","failure_reason":null}]},"orphaned_hypotheses":{"count":62,"items":[{"id":"SDA-00002","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-16 03:45:39"},{"id":"SDA-00001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-16 03:34:20"},{"id":"SDA-8a9f2c3d-e9b1-41c5-a2c0-3b8e1a7d2f4e","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-16 03:33:21"},{"id":"SDA-2024-0001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-16 03:29:07"},{"id":"SDA-2025-0147","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-16 03:28:54"},{"id":"exercise-bdnf-mitochondrial-resilience-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-16 03:18:25"},{"id":"h-lrp1-tau-001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-16 01:14:10"},{"id":"SDA-001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-16 00:47:15"},{"id":"SDA-005","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-16 00:46:58"},{"id":"SDA-004","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-16 00:46:17"},{"id":"hyp_24486","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-15 18:50:32"},{"id":"gba-pathway","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-15 07:12:50"},{"id":"test-h123","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 21:23:10"},{"id":"h-invalid-id-test-123","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 20:40:38"},{"id":"cgas-sting-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 19:46:12"},{"id":"SDA-2026-04-01-gap-001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 19:26:16"},{"id":"SDA-2026-04-02-hypo-001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 19:11:01"},{"id":"SDA-6f4e15","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 18:05:10"},{"id":"SDA-249a9e2f-774f-5ab6-a4cf-90b0e36ef6e8","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 17:21:19"},{"id":"h-1","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 16:15:49"},{"id":"SDA-043bc5c2-8af1-4f8b-8f36-9c81e09c38f4","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 16:12:18"},{"id":"SDA-1","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 16:01:40"},{"id":"SDA-466","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 16:00:45"},{"id":"h-81949907","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 11:51:41"},{"id":"h-14c98fa1","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 11:51:41"},{"id":"SDA-2026-04-13-H00001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 08:39:01"},{"id":"h-0000001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 06:37:10"},{"id":"SDA-2024-0097","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 03:55:28"},{"id":"H000001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 03:51:22"},{"id":"SDA-2025-0001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 03:46:06"},{"id":"test","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 01:33:09"},{"id":"h-0001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 00:43:29"},{"id":"h-48d1115a","title":"Dual-Receptor Antibody Shuttling","composite_score":0.64,"created_at":"2026-04-13T14:04:05.423359"},{"id":"h-11ba42d0","title":"APOE4-Specific Lipidation Enhancement Therapy","composite_score":0.845,"created_at":"2026-04-13T14:04:05.423170"},{"id":"astrocyte-neuron-metabolic-coupling-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 23:29:17"},{"id":"exercise-bdnf-axis-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 23:27:14"},{"id":"post-acute-viral-reservoir-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 23:22:27"},{"id":"wnt-beta-catenin-signaling-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 23:01:36"},{"id":"SDA-H00001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 23:01:10"},{"id":"alzheimer's-disease,-biomarker-events-occur","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 22:55:37"},{"id":"SDA-0001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 22:55:15"},{"id":"proteasome-ubiquitin-system-dysfunction-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 22:31:46"},{"id":"viral-trigger-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 22:08:36"},{"id":"synaptic-vesicle-trafficking-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 21:40:46"},{"id":"HYP-000001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 20:38:44"},{"id":"proteinopathic-processes-spread-through-brain","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 20:35:38"},{"id":"1","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 19:10:49"},{"id":"SDA-7a3b2c1d-4e5f-6g7h-8i9j-0k1l2m3n4o5p6","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 19:10:13"},{"id":"HYP-002","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 19:07:54"},{"id":"HYP-003","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 19:07:54"}]},"thin_descriptions":{"count":60,"items":[{"id":"h-7c93c300","title":"Parvalbumin Interneuron Vulnerability Links Lactate Transport to Gamma Oscillation Dysfunction","composite_score":0.569,"desc_len":4},{"id":"prion-vs-tau-alpha-syn-spread-comparison","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"h-abc","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"HYP-0001","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"h-var-9151baec88","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"SDA-a0b1c2d3-e4f5-6789-abcd-ef0123456789","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"h-001","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"hyp-001","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"h-56634f41","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"HYP-001","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"HYP-002","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"HYP-003","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"HYP-010","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"HYP-100","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"SDA-7a3b2c1d-4e5f-6g7h-8i9j-0k1l2m3n4o5p6","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"1","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"proteinopathic-processes-spread-through-brain","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"HYP-000001","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"synaptic-vesicle-trafficking-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"viral-trigger-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"proteasome-ubiquitin-system-dysfunction-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"SDA-0001","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"alzheimer's-disease,-biomarker-events-occur","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"SDA-H00001","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"wnt-beta-catenin-signaling-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"post-acute-viral-reservoir-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"exercise-bdnf-axis-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"astrocyte-neuron-metabolic-coupling-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"h-0001","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"test","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"SDA-2025-0001","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"H000001","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"SDA-2024-0097","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"h-0000001","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"SDA-2026-04-13-H00001","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"h-81949907","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"h-14c98fa1","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"SDA-466","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"SDA-1","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"SDA-043bc5c2-8af1-4f8b-8f36-9c81e09c38f4","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"h-1","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"SDA-249a9e2f-774f-5ab6-a4cf-90b0e36ef6e8","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"SDA-6f4e15","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"SDA-2026-04-02-hypo-001","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"SDA-2026-04-01-gap-001","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"cgas-sting-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"h-invalid-id-test-123","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"test-h123","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"gba-pathway","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0},{"id":"hyp_24486","title":"[Archived Hypothesis]","composite_score":0.0,"desc_len":0}]},"no_synthesis":{"count":1,"items":[{"id":"debate-seaad-20260402","question":"Cell-type specific expression patterns of neurodegeneration genes in SEA-AD","quality_score":0.65,"num_rounds":3,"created_at":"2026-04-02T11:29:58.522815"}]},"no_gene":{"count":64,"items":[{"id":"h-48d1115a","title":"Dual-Receptor Antibody Shuttling","composite_score":0.64,"created_at":"2026-04-13T14:04:05.423359"},{"id":"h-af4b7555","title":"EPO Set Point Calibration Hypothesis","composite_score":0.572,"created_at":"2026-04-13 21:49:52"},{"id":"h-699c0d72","title":"Dual Calpain/Cathepsin B Inhibition as Primary Neuroprotective Strategy","composite_score":0.557,"created_at":"2026-04-15 10:30:31"},{"id":"h-7c80747e","title":"Hepcidin-Iron Set Point Hypothesis","composite_score":0.511,"created_at":"2026-04-13 21:57:52"},{"id":"hyp_test_0a572efb","title":"Test: TREM2 enhances amyloid clearance","composite_score":0.4051,"created_at":"2026-04-04 05:28:01"},{"id":"prion-vs-tau-alpha-syn-spread-comparison","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 18:55:01"},{"id":"h-abc","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 18:56:44"},{"id":"HYP-0001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 18:57:26"},{"id":"h-var-9151baec88","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 18:59:35"},{"id":"SDA-a0b1c2d3-e4f5-6789-abcd-ef0123456789","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 19:02:06"},{"id":"h-001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 19:04:30"},{"id":"hyp-001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 19:04:33"},{"id":"h-56634f41","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 19:06:33"},{"id":"HYP-001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 19:07:22"},{"id":"HYP-002","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 19:07:54"},{"id":"HYP-003","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 19:07:54"},{"id":"HYP-010","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 19:07:54"},{"id":"HYP-100","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 19:07:54"},{"id":"SDA-7a3b2c1d-4e5f-6g7h-8i9j-0k1l2m3n4o5p6","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 19:10:13"},{"id":"1","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 19:10:49"},{"id":"proteinopathic-processes-spread-through-brain","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 20:35:38"},{"id":"HYP-000001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 20:38:44"},{"id":"synaptic-vesicle-trafficking-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 21:40:46"},{"id":"viral-trigger-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 22:08:36"},{"id":"proteasome-ubiquitin-system-dysfunction-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 22:31:46"},{"id":"SDA-0001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 22:55:15"},{"id":"alzheimer's-disease,-biomarker-events-occur","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 22:55:37"},{"id":"SDA-H00001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 23:01:10"},{"id":"wnt-beta-catenin-signaling-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 23:01:36"},{"id":"post-acute-viral-reservoir-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 23:22:27"},{"id":"exercise-bdnf-axis-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 23:27:14"},{"id":"astrocyte-neuron-metabolic-coupling-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-13 23:29:17"},{"id":"h-0001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 00:43:29"},{"id":"test","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 01:33:09"},{"id":"SDA-2025-0001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 03:46:06"},{"id":"H000001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 03:51:22"},{"id":"SDA-2024-0097","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 03:55:28"},{"id":"h-0000001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 06:37:10"},{"id":"SDA-2026-04-13-H00001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 08:39:01"},{"id":"h-81949907","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 11:51:41"},{"id":"h-14c98fa1","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 11:51:41"},{"id":"SDA-466","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 16:00:45"},{"id":"SDA-1","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 16:01:40"},{"id":"SDA-043bc5c2-8af1-4f8b-8f36-9c81e09c38f4","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 16:12:18"},{"id":"h-1","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 16:15:49"},{"id":"SDA-249a9e2f-774f-5ab6-a4cf-90b0e36ef6e8","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 17:21:19"},{"id":"SDA-6f4e15","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 18:05:10"},{"id":"SDA-2026-04-02-hypo-001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 19:11:01"},{"id":"SDA-2026-04-01-gap-001","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 19:26:16"},{"id":"cgas-sting-parkinsons","title":"[Archived Hypothesis]","composite_score":0.0,"created_at":"2026-04-14 19:46:12"}]},"duplicate_hypotheses":{"count":27,"items":[{"h1_id":"h-var-bed9f3b7ed","h1_title":"TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration","h1_score":0.6119705367787808,"h2_id":"h-var-66156774e7","h2_title":"TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration","h2_score":0.607019,"similarity":1.0,"shared_gene":true},{"h1_id":"h-var-bed9f3b7ed","h1_title":"TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration","h1_score":0.6119705367787808,"h2_id":"h-var-7e118a66d8","h2_title":"TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration","h2_score":0.5853276030181884,"similarity":1.0,"shared_gene":true},{"h1_id":"h-var-bed9f3b7ed","h1_title":"TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration","h1_score":0.6119705367787808,"h2_id":"h-var-a065d9bdf2","h2_title":"TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration","h2_score":0.5798422551254339,"similarity":1.0,"shared_gene":true},{"h1_id":"h-var-66156774e7","h1_title":"TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration","h1_score":0.607019,"h2_id":"h-var-7e118a66d8","h2_title":"TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration","h2_score":0.5853276030181884,"similarity":1.0,"shared_gene":true},{"h1_id":"h-var-66156774e7","h1_title":"TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration","h1_score":0.607019,"h2_id":"h-var-a065d9bdf2","h2_title":"TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration","h2_score":0.5798422551254339,"similarity":1.0,"shared_gene":true},{"h1_id":"h-var-7e118a66d8","h1_title":"TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration","h1_score":0.5853276030181884,"h2_id":"h-var-a065d9bdf2","h2_title":"TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration","h2_score":0.5798422551254339,"similarity":1.0,"shared_gene":true},{"h1_id":"h-test-full-8d254307","h1_title":"EV-Mediated Epigenetic Reprogramming","h1_score":0.49008811585869394,"h2_id":"h-test-8d254307","h2_title":"EV-Mediated Epigenetic Reprogramming","h2_score":0.4861573707606547,"similarity":1.0,"shared_gene":true},{"h1_id":"h-fa7ac9cb","h1_title":"Oligodendrocyte DNA Repair Enhancement Therapy","h1_score":0.4622864365787302,"h2_id":"h-43ec636e","h2_title":"Oligodendrocyte DNA Repair Enhancement","h2_score":0.378,"similarity":0.8,"shared_gene":false},{"h1_id":"h-var-3b982ec3d2","h1_title":"Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and restore perforant-path gamma gating in AD","h1_score":0.697222,"h2_id":"h-var-55da4f915d","h2_title":"Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma gating and block tau propagation in AD","h2_score":0.697041,"similarity":0.789,"shared_gene":true},{"h1_id":"h-var-a4975bdd96","h1_title":"Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via cholecystokinin interneuron neuromodulation in Alzheimer's disease","h1_score":0.6331771370371327,"h2_id":"h-var-ea70ada256","h2_title":"Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via somatostatin interneuron disinhibition in Alzheimer's disease","h2_score":0.613865,"similarity":0.778,"shared_gene":false},{"h1_id":"h-var-6957745fea","h1_title":"Mitochondrial DAMPs-Driven AIM2 Inflammasome Activation in Neurodegeneration","h1_score":0.5819538290849932,"h2_id":"h-var-d04a952932","h2_title":"Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neurodegeneration","h2_score":0.5796347813832503,"similarity":0.75,"shared_gene":true},{"h1_id":"h-var-ce41f0efd7","h1_title":"Microglial-Mediated Tau Clearance Dysfunction via TREM2 Signaling","h1_score":0.532945,"h2_id":"h-var-c46786d2ab","h2_title":"Astrocytic-Mediated Tau Clearance Dysfunction via TREM2 Signaling","h2_score":0.434093,"similarity":0.75,"shared_gene":true},{"h1_id":"h-var-c56b26facf","h1_title":"LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Substrate Pools in Disease-Associated Microglia","h1_score":0.4913714151052559,"h2_id":"h-var-70a95f9d57","h2_title":"LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability in Disease-Associated Microglia","h2_score":0.48541120278849553,"similarity":0.75,"shared_gene":true},{"h1_id":"h-var-6612521a02","h1_title":"Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via direct PV interneuron recruitment in Alzheimer's disease","h1_score":0.708725,"h2_id":"h-var-a4975bdd96","h2_title":"Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via cholecystokinin interneuron neuromodulation in Alzheimer's disease","h2_score":0.6331771370371327,"similarity":0.737,"shared_gene":false},{"h1_id":"h-var-6612521a02","h1_title":"Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via direct PV interneuron recruitment in Alzheimer's disease","h1_score":0.708725,"h2_id":"h-var-ea70ada256","h2_title":"Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via somatostatin interneuron disinhibition in Alzheimer's disease","h2_score":0.613865,"similarity":0.737,"shared_gene":false},{"h1_id":"h-cd60e2ec","h1_title":"Thalamocortical Synchrony Restoration via NMDA Modulation","h1_score":0.541786,"h2_id":"h-var-5e33600319","h2_title":"Cortico-Striatal Synchrony Restoration via NMDA Modulation","h2_score":0.500157,"similarity":0.714,"shared_gene":true},{"h1_id":"h-var-de1677a080","h1_title":"TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegeneration","h1_score":0.638541,"h2_id":"h-var-bed9f3b7ed","h2_title":"TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration","h2_score":0.6119705367787808,"similarity":0.667,"shared_gene":true},{"h1_id":"h-var-de1677a080","h1_title":"TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegeneration","h1_score":0.638541,"h2_id":"h-var-66156774e7","h2_title":"TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration","h2_score":0.607019,"similarity":0.667,"shared_gene":true},{"h1_id":"h-var-de1677a080","h1_title":"TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegeneration","h1_score":0.638541,"h2_id":"h-var-7e118a66d8","h2_title":"TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration","h2_score":0.5853276030181884,"similarity":0.667,"shared_gene":true},{"h1_id":"h-var-de1677a080","h1_title":"TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegeneration","h1_score":0.638541,"h2_id":"h-var-a065d9bdf2","h2_title":"TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration","h2_score":0.5798422551254339,"similarity":0.667,"shared_gene":true},{"h1_id":"h-var-ce41f0efd7","h1_title":"Microglial-Mediated Tau Clearance Dysfunction via TREM2 Signaling","h1_score":0.532945,"h2_id":"h-var-59fc393ba6","h2_title":"Microglial-Mediated Tau Clearance Dysfunction via TREM2 Receptor Impairment","h2_score":0.488684,"similarity":0.667,"shared_gene":false},{"h1_id":"h-var-7c976d9fb7","h1_title":"TREM2-Mediated Microglial Dysfunction Disrupts Perivascular Tau Clearance","h1_score":0.527435,"h2_id":"h-var-5aec85b987","h2_title":"TREM2-Mediated Microglial Dysfunction Disrupts Oligodendrocyte Tau Clearance Networks","h2_score":0.4523515335038041,"similarity":0.667,"shared_gene":true},{"h1_id":"h-var-f110ef2e0a","h1_title":"Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to prevent tau propagation and restore entorhinal-hippocampal gamma synchrony in early Alzheimer's disease","h1_score":0.612488,"h2_id":"h-var-ee70969116","h2_title":"Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with real-time gamma feedback to prevent tau propagation and restore hippocampal-prefrontal synchrony in Alzheimer's disease","h2_score":0.508045,"similarity":0.63,"shared_gene":false},{"h1_id":"h-var-3b982ec3d2","h1_title":"Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and restore perforant-path gamma gating in AD","h1_score":0.697222,"h2_id":"h-var-4eca108177","h2_title":"Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhythmogenesis and block tau AIS disruption in AD","h2_score":0.659816,"similarity":0.619,"shared_gene":false},{"h1_id":"h-d9604ebf","h1_title":"Myelin Sulfatide Restoration","h1_score":0.4422944593525564,"h2_id":"h-d16c2411","h2_title":"Oligodendrocyte-Targeted Myelin Sulfatide Restoration Therapy","h2_score":0.4342976722039621,"similarity":0.6,"shared_gene":false},{"h1_id":"h-40ad6ac6","h1_title":"Gut-Brain Axis M-Cell Modulation","h1_score":0.42666666666666664,"h2_id":"h-48775971","h2_title":"Gut-Brain Axis Microbiome Modulation","h2_score":0.42081794871794875,"similarity":0.6,"shared_gene":false},{"h1_id":"h-250b34ab","h1_title":"RAB27A-dependent extracellular vesicle engineering for mitochondrial cargo delivery","h1_score":0.41386385745923376,"h2_id":"h-d78123d1","h2_title":"Microglia-Derived Extracellular Vesicle Engineering for Targeted Mitochondrial Delivery","h2_score":0.37032336307991565,"similarity":0.6,"shared_gene":false}]},"debate_reruns_needed":{"count":48,"items":[{"id":"h-11ba42d0","title":"APOE4-Specific Lipidation Enhancement Therapy","analysis_id":null,"composite_score":0.845,"target_gene":"APOE","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-66078909","title":"H2: Indole-3-Propionate (IPA) as the Actual Neuroprotective Effector","analysis_id":"SDA-2026-04-15-gap-pubmed-20260411-093924-7330920b","composite_score":0.675,"target_gene":"PXR (NR1I2), IDO1","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-7d24e096","title":"CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Window Identification","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112522-57d1cc4f","composite_score":0.674,"target_gene":"sTREM2/membrane-TREM2/ADAM10","best_quality":0,"debate_count":1,"last_debate_at":"2026-04-15T20:45:27.581361"},{"id":"h-2ca830cd","title":"STMN2 Restoration as a Prerequisite for Axon Growth After TDP-43 Clearance","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-181356-57d1f917","composite_score":0.658,"target_gene":"STMN2","best_quality":0,"debate_count":1,"last_debate_at":"2026-04-15T17:58:22.887795"},{"id":"h-48d1115a","title":"Dual-Receptor Antibody Shuttling","analysis_id":null,"composite_score":0.64,"target_gene":null,"best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-dca86efa","title":"TREM2-Dependent Microglial Phagocytosis Acts as a Strain Selection Filter","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112730-24052bbe","composite_score":0.636,"target_gene":"TREM2","best_quality":0,"debate_count":1,"last_debate_at":"2026-04-15T21:16:21.391924"},{"id":"h-bc635955","title":"CSF Biomarker-Guided ABCA7 Therapeutic Dosing","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-180532-e8930cb8","composite_score":0.619,"target_gene":"ABCA7 with biomarker-guided dosing","best_quality":0,"debate_count":1,"last_debate_at":"2026-04-15T17:51:34.542866"},{"id":"h-917f37cf","title":"DLK MAPK Pathway Inhibition to Block Tau-Induced Neurotoxicity Without Directly Targeting Tau","analysis_id":"SDA-2026-04-15-gap-pubmed-20260410-100455-ff18091d","composite_score":0.609,"target_gene":"MAP2K7/MAP3K12","best_quality":0,"debate_count":1,"last_debate_at":"2026-04-15T21:16:26.597902"},{"id":"h-6756097b","title":"ASO-Mediated Exon Skipping to Restore FUS-TAZ Chaperone Axis","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-184155-2ff305ca","composite_score":0.606,"target_gene":"FUS","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-ed960965","title":"STING Antagonism Prevents Acute-to-Chronic Neuroinflammation Transition via Interruption of IFN-I Feedback Looping","analysis_id":"SDA-2026-04-15-gap-pubmed-20260411-075425-2feffb0c","composite_score":0.605,"target_gene":"TMEM173 (STING)","best_quality":0,"debate_count":1,"last_debate_at":"2026-04-15T21:29:29.493700"},{"id":"h-2ff49342","title":"TREM2-Microglial Clearance Enhancement as Common Mechanism for Injury Prevention","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-184233-98bf553f","composite_score":0.604,"target_gene":"TREM2","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-796cfd1c","title":"SMPD1 (Acid Sphingomyelinase) Inhibition for Ceramide Reduction and BACE1 Regulation","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112819-e40e0fa2","composite_score":0.596,"target_gene":"SMPD1","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-48b29b62","title":"C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward Neurotoxic Loop","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-183021-c13d9f04","composite_score":0.596,"target_gene":"C3AR1, C3, NFKB1","best_quality":0,"debate_count":1,"last_debate_at":"2026-04-15T18:30:50.089030"},{"id":"h-a5186bb8","title":"H7: Enteric Nervous System Alpha-Synuclein Propagation Blocker via Gut Barrier Restoration","analysis_id":"SDA-2026-04-15-gap-pubmed-20260411-093924-7330920b","composite_score":0.595,"target_gene":"IL-22, REG3G, zonulin","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-423b50a1","title":"Aryl Hydrocarbon Receptor (AhR) Activation by Microbiome Metabolites Promotes A2 Polarization","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-183021-c13d9f04","composite_score":0.593,"target_gene":"AHR, CYP1A1, NFKB1, IL6","best_quality":0,"debate_count":1,"last_debate_at":"2026-04-15T18:30:50.089030"},{"id":"h-d4d93da2","title":"M1 Muscarinic Receptor Agonism as Pharmacological Exercise Substitute","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-191046-15921012","composite_score":0.589,"target_gene":"CHRM1","best_quality":0,"debate_count":1,"last_debate_at":"2026-04-15T18:55:55.168418"},{"id":"h-8efcb4cf","title":"H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from Synapse Pruning to Amyloid Clearance","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-184126-b2c3e2e8","composite_score":0.588,"target_gene":"TREM2","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-e14a97bf","title":"Timed Senolytic Therapy Eliminates p16^Ink4a/p21^Cip1-Senescent Microglia to Prevent SASP-Driven Complement Cascade Amplification","analysis_id":"SDA-2026-04-15-gap-pubmed-20260411-075425-2feffb0c","composite_score":0.587,"target_gene":"CDKN2A (p16^Ink4a), CDKN1A (p21^Cip1/Waf1)","best_quality":0,"debate_count":1,"last_debate_at":"2026-04-15T21:29:29.493700"},{"id":"h-894b633a","title":"REDD1-mTOR Axis as the Master Regulator — Preservation Over Chelation","analysis_id":"SDA-2026-04-15-gap-pubmed-20260411-092119-691e1977","composite_score":0.586,"target_gene":"DDIT4 (REDD1), MTOR","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-6d411c20","title":"GDNF Gradient Establishment by Schwann Cells Enables Motor Re-innervation","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-181356-57d1f917","composite_score":0.585,"target_gene":"GDNF","best_quality":0,"debate_count":1,"last_debate_at":"2026-04-15T17:58:22.887795"},{"id":"h-ec79168b","title":"GPC4/HSPGs Collaborate with ApoE Isoforms to Dictate Tau Conformational Strain Uptake Efficiency","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112730-24052bbe","composite_score":0.583,"target_gene":"GPC4/APOE","best_quality":0,"debate_count":1,"last_debate_at":"2026-04-15T21:16:21.391924"},{"id":"h-1da06f38","title":"DAPK1 Inhibition as Dual-Mechanism Neuroprotection Against Tau-Induced Destabilization","analysis_id":"SDA-2026-04-15-gap-pubmed-20260410-100455-ff18091d","composite_score":0.579,"target_gene":"DAPK1","best_quality":0,"debate_count":1,"last_debate_at":"2026-04-15T21:16:26.597902"},{"id":"h-0b9e4152","title":"MEF2C-Dependent Synaptic Gene Regulation","analysis_id":"SDA-2026-04-15-gap-pubmed-20260411-075338-35f913fb","composite_score":0.578,"target_gene":"MEF2C","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-0bcda2e0","title":"CLU/APOE Duality in Amyloid Clearance Determines Cell-Type-Specific Vulnerability Thresholds","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112607-0a3749ea","composite_score":0.576,"target_gene":"APOE, CLU","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-2698e999","title":"Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Assembly During Development","analysis_id":"SDA-2026-04-15-gap-pubmed-20260411-084510-fbfafe2c","composite_score":0.576,"target_gene":"SYNGAP1","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-9c857387","title":"TREM2 Signaling Bifurcation with Independent TYROBP-Independent Homeostatic Maintenance","analysis_id":"SDA-2026-04-14-gap-pubmed-20260411-072446-a32fa49c","composite_score":0.567,"target_gene":"TREM2","best_quality":0,"debate_count":1,"last_debate_at":"2026-04-15T20:27:01.117334"},{"id":"h-e7f5985c","title":"ER Stress Reduction as Adjunctive Therapy to Support Autophagy","analysis_id":"SDA-2026-04-15-gap-pubmed-20260411-092119-691e1977","composite_score":0.566,"target_gene":"HFE (H63D variant)","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-76ea1f28","title":"TREM2 R47H Metabolic Lock-in at Cholesterol Ester Accumulation","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112522-57d1cc4f","composite_score":0.563,"target_gene":"TREM2/ACAT1/LXR","best_quality":0,"debate_count":1,"last_debate_at":"2026-04-15T20:45:27.581361"},{"id":"h-737c3be8","title":"PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Subsequent p53 Activation","analysis_id":"SDA-2026-04-15-gap-pubmed-20260411-090658-7651c1d2","composite_score":0.562,"target_gene":"PARP1","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-b5723774","title":"Complement C1q Suppression as Mechanism Linking Exercise Plasma to PV Interneuron Protection","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-191046-15921012","composite_score":0.56,"target_gene":"C1QA","best_quality":0,"debate_count":1,"last_debate_at":"2026-04-15T18:55:55.168418"},{"id":"h-699c0d72","title":"Dual Calpain/Cathepsin B Inhibition as Primary Neuroprotective Strategy","analysis_id":"SDA-2026-04-15-gap-pubmed-20260411-075356-20920528","composite_score":0.557,"target_gene":"","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-69ce9196","title":"SYK-Independent TREM2 Pathways Remain Functional in TYROBP Deficiency","analysis_id":"SDA-2026-04-14-gap-pubmed-20260411-072446-a32fa49c","composite_score":0.555,"target_gene":"SYK, TREM2","best_quality":0,"debate_count":1,"last_debate_at":"2026-04-15T20:27:01.117334"},{"id":"h-23e3985d","title":"APOE4 Isoform Correction via Lipidation Enhancement as CTE Risk Mitigation","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-185318-186b0446","composite_score":0.552,"target_gene":"APOE","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-ef5f2ec0","title":"CLU-APOE-TREM2 Tripartite Axis as a Coordinate Therapeutic Target","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-193701-11582758","composite_score":0.548,"target_gene":"CLU-APOE-TREM2 axis (LXR/RXR pathway)","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-ed8dee29","title":"HDL/apoE Particle Remodeling as a Therapeutic Switch for CAA Prevention","analysis_id":"SDA-2026-04-15-gap-pubmed-20260411-083043-759b4c5e","composite_score":0.544,"target_gene":"ABCA1","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-a6e77292","title":"SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysosomal Degradation via Autophagosome-Lysosome Fusion Dysfunction","analysis_id":"SDA-2026-04-15-gap-pubmed-20260411-083737-59771b32","composite_score":0.542,"target_gene":"SGMS1, BECN1","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-ebfa8ea3","title":"ABCA7-TREM2 Co-Targeting for Microglial Lipid Handling","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-180532-e8930cb8","composite_score":0.538,"target_gene":"ABCA7 + TREM2 (combinatorial)","best_quality":0,"debate_count":1,"last_debate_at":"2026-04-15T17:51:34.542866"},{"id":"h-73124693","title":"BACE1/NRG1 Axis Dysfunction Drives Excitatory/Inhibitory Imbalance via PV Interneuron Hypofunction","analysis_id":"SDA-2026-04-15-gap-pubmed-20260411-093843-0a9326c2","composite_score":0.527,"target_gene":"NRG1/ERBB4","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-b3f9d8eb","title":"HCN1-Selective Blockade Normalizes Thalamic Rebound Bursting in P/Q Channel Deficiency","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-181156-feec7bd3","composite_score":0.526,"target_gene":"HCN1","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-985b8091","title":"TREM2 Agonism to Redirect Microglia from Synaptic Pruning to OPTN-Deficient Neuron Protection","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-183548-043c7918","composite_score":0.521,"target_gene":"TREM2","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-b9f5438c","title":"TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimination Through Type I IFN Hyperactivation","analysis_id":"SDA-2026-04-13-gap-pubmed-20260410-165527-8256a071","composite_score":0.52,"target_gene":"TBK1","best_quality":0.36,"debate_count":1,"last_debate_at":"2026-04-14T01:34:29.955890"},{"id":"h-900f7a86","title":"Granzyme B Inhibition with Serpina3n to Preserve Axonal Integrity Against Cytotoxic Attack","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112400-454036f1","composite_score":0.514,"target_gene":"GZMB","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-a1552ac3","title":"LXRβ-Selective Agonism as a Precision Therapeutic for APOE4-Driven Myelin Deficits","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-193244-89904941","composite_score":0.505,"target_gene":"NR1H2 (LXRβ)","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-315367de","title":"TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Function by Suppressing IL-1β-Mediated Inflammatory Damage","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-174607-708e8d91","composite_score":0.499,"target_gene":"TYRO3","best_quality":0,"debate_count":1,"last_debate_at":"2026-04-15T17:14:45.894224"},{"id":"h-929f356e","title":"GAS6/TAM Axis Activation Stabilizes Blood-Brain Barrier to Reduce Neuroinflammatory Cell Infiltration in Alzheimer's Disease","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-174607-708e8d91","composite_score":0.498,"target_gene":"GAS6/TAM receptor complex","best_quality":0,"debate_count":1,"last_debate_at":"2026-04-15T17:14:45.894224"},{"id":"h-73e9899e","title":"C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV Interneuron Input Elimination in Alzheimer's Disease","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112441-f2afffb3","composite_score":0.497,"target_gene":"C1QA, C1QB","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-ae924ee8","title":"C1q Inhibition Prevents Synaptic Mitochondrial Dysfunction via Microglial-Neuronal Cross-Talk Normalization","analysis_id":"SDA-2026-04-15-gap-pubmed-20260411-082509-118fcb37","composite_score":0.455,"target_gene":"C1QA/C1QB/C1QC","best_quality":null,"debate_count":null,"last_debate_at":null},{"id":"h-e165e0e6","title":"PGC1α Activation in PV+ Interneurons Bypasses Mitophagy Deficit to Restore Gamma Oscillations","analysis_id":"SDA-2026-04-15-gap-pubmed-20260411-082509-118fcb37","composite_score":0.455,"target_gene":"PPARGC1A","best_quality":null,"debate_count":null,"last_debate_at":null}]},"stale_market_updates":{"count":23,"items":[{"id":"h-ed960965","title":"STING Antagonism Prevents Acute-to-Chronic Neuroinflammation Transition via Interruption of IFN-I Feedback Looping","analysis_id":"SDA-2026-04-15-gap-pubmed-20260411-075425-2feffb0c","composite_score":0.605,"best_quality":0,"last_debate_at":"2026-04-15T21:29:29.493700","last_price_at":"2026-04-15T13:31:49.773815","price_event_count":1},{"id":"h-e14a97bf","title":"Timed Senolytic Therapy Eliminates p16^Ink4a/p21^Cip1-Senescent Microglia to Prevent SASP-Driven Complement Cascade Amplification","analysis_id":"SDA-2026-04-15-gap-pubmed-20260411-075425-2feffb0c","composite_score":0.587,"best_quality":0,"last_debate_at":"2026-04-15T21:29:29.493700","last_price_at":"2026-04-15T11:25:22.020952","price_event_count":3},{"id":"h-917f37cf","title":"DLK MAPK Pathway Inhibition to Block Tau-Induced Neurotoxicity Without Directly Targeting Tau","analysis_id":"SDA-2026-04-15-gap-pubmed-20260410-100455-ff18091d","composite_score":0.609,"best_quality":0,"last_debate_at":"2026-04-15T21:16:26.597902","last_price_at":"2026-04-15T19:34:40.039111","price_event_count":3},{"id":"h-1da06f38","title":"DAPK1 Inhibition as Dual-Mechanism Neuroprotection Against Tau-Induced Destabilization","analysis_id":"SDA-2026-04-15-gap-pubmed-20260410-100455-ff18091d","composite_score":0.579,"best_quality":0,"last_debate_at":"2026-04-15T21:16:26.597902","last_price_at":null,"price_event_count":0},{"id":"h-dca86efa","title":"TREM2-Dependent Microglial Phagocytosis Acts as a Strain Selection Filter","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112730-24052bbe","composite_score":0.636,"best_quality":0,"last_debate_at":"2026-04-15T21:16:21.391924","last_price_at":null,"price_event_count":0},{"id":"h-7d24e096","title":"CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Window Identification","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112522-57d1cc4f","composite_score":0.674,"best_quality":0,"last_debate_at":"2026-04-15T20:45:27.581361","last_price_at":null,"price_event_count":0},{"id":"h-9c857387","title":"TREM2 Signaling Bifurcation with Independent TYROBP-Independent Homeostatic Maintenance","analysis_id":"SDA-2026-04-14-gap-pubmed-20260411-072446-a32fa49c","composite_score":0.567,"best_quality":0,"last_debate_at":"2026-04-15T20:27:01.117334","last_price_at":"2026-04-15T13:31:49.773815","price_event_count":1},{"id":"h-69ce9196","title":"SYK-Independent TREM2 Pathways Remain Functional in TYROBP Deficiency","analysis_id":"SDA-2026-04-14-gap-pubmed-20260411-072446-a32fa49c","composite_score":0.555,"best_quality":0,"last_debate_at":"2026-04-15T20:27:01.117334","last_price_at":"2026-04-15T05:50:54.887819","price_event_count":3},{"id":"h-d4d93da2","title":"M1 Muscarinic Receptor Agonism as Pharmacological Exercise Substitute","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-191046-15921012","composite_score":0.589,"best_quality":0,"last_debate_at":"2026-04-15T18:55:55.168418","last_price_at":"2026-04-14T20:07:53.441082","price_event_count":3},{"id":"h-b5723774","title":"Complement C1q Suppression as Mechanism Linking Exercise Plasma to PV Interneuron Protection","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-191046-15921012","composite_score":0.56,"best_quality":0,"last_debate_at":"2026-04-15T18:55:55.168418","last_price_at":"2026-04-15T13:31:49.773815","price_event_count":1},{"id":"h-48b29b62","title":"C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward Neurotoxic Loop","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-183021-c13d9f04","composite_score":0.596,"best_quality":0,"last_debate_at":"2026-04-15T18:30:50.089030","last_price_at":"2026-04-14T14:57:49.099769","price_event_count":3},{"id":"h-423b50a1","title":"Aryl Hydrocarbon Receptor (AhR) Activation by Microbiome Metabolites Promotes A2 Polarization","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-183021-c13d9f04","composite_score":0.593,"best_quality":0,"last_debate_at":"2026-04-15T18:30:50.089030","last_price_at":"2026-04-15T13:31:49.773815","price_event_count":1},{"id":"h-2ca830cd","title":"STMN2 Restoration as a Prerequisite for Axon Growth After TDP-43 Clearance","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-181356-57d1f917","composite_score":0.658,"best_quality":0,"last_debate_at":"2026-04-15T17:58:22.887795","last_price_at":"2026-04-14T14:03:01.953998","price_event_count":3},{"id":"h-6d411c20","title":"GDNF Gradient Establishment by Schwann Cells Enables Motor Re-innervation","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-181356-57d1f917","composite_score":0.585,"best_quality":0,"last_debate_at":"2026-04-15T17:58:22.887795","last_price_at":"2026-04-15T13:31:49.773815","price_event_count":1},{"id":"h-bc635955","title":"CSF Biomarker-Guided ABCA7 Therapeutic Dosing","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-180532-e8930cb8","composite_score":0.619,"best_quality":0,"last_debate_at":"2026-04-15T17:51:34.542866","last_price_at":"2026-04-15T07:55:43.837200","price_event_count":15},{"id":"h-ebfa8ea3","title":"ABCA7-TREM2 Co-Targeting for Microglial Lipid Handling","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-180532-e8930cb8","composite_score":0.538,"best_quality":0,"last_debate_at":"2026-04-15T17:51:34.542866","last_price_at":"2026-04-15T13:31:49.773815","price_event_count":1},{"id":"h-315367de","title":"TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Function by Suppressing IL-1β-Mediated Inflammatory Damage","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-174607-708e8d91","composite_score":0.499,"best_quality":0,"last_debate_at":"2026-04-15T17:14:45.894224","last_price_at":null,"price_event_count":0},{"id":"h-929f356e","title":"GAS6/TAM Axis Activation Stabilizes Blood-Brain Barrier to Reduce Neuroinflammatory Cell Infiltration in Alzheimer's Disease","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-174607-708e8d91","composite_score":0.498,"best_quality":0,"last_debate_at":"2026-04-15T17:14:45.894224","last_price_at":"2026-04-14T10:34:48.591575","price_event_count":3},{"id":"h-5b35f7a5","title":"Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone Deficiency to Neuroinflammation","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112330-9abf86eb","composite_score":0.645,"best_quality":1.0,"last_debate_at":"2026-04-15T16:54:31.865396","last_price_at":null,"price_event_count":0},{"id":"h-655c7f33","title":"Temporal SPP1 Inhibition During Critical Windows","analysis_id":"SDA-2026-04-15-gap-pubmed-20260406-062118-e3613755","composite_score":0.65,"best_quality":0.55,"last_debate_at":"2026-04-15T16:30:49.447123","last_price_at":null,"price_event_count":0},{"id":"h-645cc2de","title":"TREM2-SYK Signaling Axis Couples OxPC Recognition to Phagocytic Clearance","analysis_id":"SDA-2026-04-13-gap-pubmed-20260410-165345-41805e1b","composite_score":0.505,"best_quality":0.55,"last_debate_at":"2026-04-14T00:51:03.321911","last_price_at":"2026-04-13T23:06:29.961965","price_event_count":4},{"id":"h-95fb48b4","title":"Complement Cascade Activation Bridges Microglial OxPC Sensing to Synaptic Vulnerability","analysis_id":"SDA-2026-04-13-gap-pubmed-20260410-165345-41805e1b","composite_score":0.452,"best_quality":0.55,"last_debate_at":"2026-04-14T00:51:03.321911","last_price_at":"2026-04-13T23:06:29.961965","price_event_count":1},{"id":"h-3fdee932","title":"Selective Tau Kinase Inhibition in Vulnerable Neuronal Subtypes","analysis_id":"SDA-2026-04-03-gap-seaad-v4-20260402065846","composite_score":0.504,"best_quality":0.6,"last_debate_at":"2026-04-03T16:33:37.274848","last_price_at":null,"price_event_count":0}]},"no_predictions":{"count":129,"items":[{"id":"h-0e675a41","title":"Selective HDAC3 Inhibition with Cognitive Enhancement","composite_score":0.5628163396447607,"created_at":"2026-04-02 15:09:22","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-addc0a61","title":"Chromatin Accessibility Restoration via BRD4 Modulation","composite_score":0.5594131357230342,"created_at":"2026-04-02 15:09:22","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-8fe389e8","title":"Astrocyte-Mediated Neuronal Epigenetic Rescue","composite_score":0.4785233409219482,"created_at":"2026-04-02 15:09:22","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-0e614ae4","title":"Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration","composite_score":0.4481747476414628,"created_at":"2026-04-02 15:09:22","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-a90e2e89","title":"Temporal TET2-Mediated Hydroxymethylation Cycling","composite_score":0.4081801367845517,"created_at":"2026-04-02 15:09:22","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-baba5269","title":"Partial Neuronal Reprogramming via Modified Yamanaka Cocktail","composite_score":0.3993782262294119,"created_at":"2026-04-02 15:09:22","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-seaad-51323624","title":"Cell-Type Specific TREM2 Upregulation in DAM Microglia","composite_score":0.5190617293390547,"created_at":"2026-04-02 19:52:13","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-seaad-56fa6428","title":"GFAP-Positive Reactive Astrocyte Subtype Delineation","composite_score":0.5176365414984487,"created_at":"2026-04-02 19:52:13","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-seaad-7f15df4c","title":"Excitatory Neuron Vulnerability via SLC17A7 Downregulation","composite_score":0.44466930365245844,"created_at":"2026-04-02 19:52:13","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-seaad-5b3cb8ea","title":"Complement C1QA Spatial Gradient in Cortical Layers","composite_score":0.4280140521327384,"created_at":"2026-04-02 19:52:13","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-seaad-fa5ea82d","title":"APOE Isoform Expression Across Glial Subtypes","composite_score":0.4763712632443578,"created_at":"2026-04-02 19:52:13","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-a8165b3b","title":"Complement-Mediated Synaptic Pruning Dysregulation","composite_score":0.3982938132559295,"created_at":"2026-04-02 20:53:07","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-e5a1c16b","title":"TFEB-PGC1α Mitochondrial-Lysosomal Decoupling","composite_score":0.39831214116414015,"created_at":"2026-04-02 20:53:07","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-06cb8e75","title":"Oligodendrocyte White Matter Vulnerability","composite_score":0.3983121361642208,"created_at":"2026-04-02 20:53:07","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-e3e8407c","title":"The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction","composite_score":0.39831214600277176,"created_at":"2026-04-02 20:53:07","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-075f1f02","title":"Brain Insulin Resistance with Glucose Transporter Dysfunction","composite_score":0.39831213938997523,"created_at":"2026-04-02 20:53:07","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-4b517512","title":"The Glial Ketone Metabolic Shunt Hypothesis","composite_score":0.3983121379383857,"created_at":"2026-04-02 20:53:07","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-b234254c","title":"TREM2-mediated microglial tau clearance enhancement","composite_score":0.4868360779030523,"created_at":"2026-04-02T01:01:46.340241","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-55ef81c5","title":"Extracellular Vesicle Biogenesis Modulation","composite_score":0.3402856582616538,"created_at":"2026-04-02T01:01:46.340398","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-18a0fcc6","title":"VCP-Mediated Autophagy Enhancement","composite_score":0.41486121025819844,"created_at":"2026-04-02T01:01:46.340489","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-0f00fd75","title":"HSP90-Tau Disaggregation Complex Enhancement","composite_score":0.4422956702975434,"created_at":"2026-04-02T01:01:46.340562","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-73e29e3a","title":"Synaptic Vesicle Tau Capture Inhibition","composite_score":0.34028565782973497,"created_at":"2026-04-02T01:01:46.340635","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-fdaae8d9","title":"Trans-Synaptic Adhesion Molecule Modulation","composite_score":0.3402856576137756,"created_at":"2026-04-02T01:01:46.340708","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-seaad-v4-5a7a4079","title":"SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK1/Parkin Mitophagy Dysfunction","composite_score":0.5089580151329726,"created_at":"2026-04-02T19:54:17.418841","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-seaad-v4-29e81bbc","title":"Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupling","composite_score":0.4551270839928589,"created_at":"2026-04-02T19:54:17.418841","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-3616325a","title":"Microglial TREM2-Complement Axis Modulation","composite_score":0.5265576673275343,"created_at":"2026-04-04 13:07:19","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-fa7ac9cb","title":"Oligodendrocyte DNA Repair Enhancement Therapy","composite_score":0.4622864365787302,"created_at":"2026-04-04 13:07:24","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-e064f134","title":"BMP4 Pathway Inhibition for Oligodendrocyte Myelination Support","composite_score":0.45428964539794275,"created_at":"2026-04-04 13:07:29","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-019c56c1","title":"Cross-Cell Type Synaptic Rescue via Tripartite Synapse Restoration","composite_score":0.45382709604640625,"created_at":"2026-04-04 13:07:34","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-5137be61","title":"Neuronal Integrated Stress Response Modulation","composite_score":0.4522904449011766,"created_at":"2026-04-04 13:07:39","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-d8f2bbc9","title":"Astrocyte Metabolic Reprogramming via APOE4 Correction","composite_score":0.4514656700926278,"created_at":"2026-04-04 13:07:44","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-0bdc3803","title":"Spatial Transcriptome-Guided Precision Cell Therapy","composite_score":0.41230650915820466,"created_at":"2026-04-04 13:07:49","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-6f1e8d32","title":"Cardiovascular-Neuroinflammatory Dual Targeting","composite_score":0.4622864359335793,"created_at":"2026-04-04 13:12:22","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-6880f29b","title":"IGFBPL1-Mediated Microglial Reprogramming","composite_score":0.4142908816639973,"created_at":"2026-04-04 13:12:22","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-f19b8ac8","title":"Complement-Mediated Synaptic Protection","composite_score":0.4102890170959295,"created_at":"2026-04-04 13:12:22","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-69bde12f","title":"APOE4-Lipid Metabolism Correction","composite_score":0.4252678069449606,"created_at":"2026-04-04 13:12:22","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-6f21f62a","title":"Microbiota-Microglia Axis Modulation","composite_score":0.4756927559429548,"created_at":"2026-04-04 13:12:22","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-ea3274ff","title":"TREM2-P2RY12 Balance Restoration Therapy","composite_score":0.36621032327320185,"created_at":"2026-04-04 13:12:22","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-8f9633d9","title":"Perinatal Immune Challenge Prevention","composite_score":0.41582028400849314,"created_at":"2026-04-04 13:12:22","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-cd60e2ec","title":"Thalamocortical Synchrony Restoration via NMDA Modulation","composite_score":0.541786,"created_at":"2026-04-04 13:35:27","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-f8316acf","title":"Differential Interneuron Optogenetic Restoration Therapy","composite_score":0.429727,"created_at":"2026-04-04 13:35:32","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-23b94ed8","title":"Locus Coeruleus-Hippocampal Circuit Protection","composite_score":0.479823,"created_at":"2026-04-04 13:35:37","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-62c78d8b","title":"CaMKII-Dependent Synaptic Circuit Amplification","composite_score":0.444206,"created_at":"2026-04-04 13:35:42","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-a635d4e5","title":"Default Mode Network Circuit Stabilization","composite_score":0.42911,"created_at":"2026-04-04 13:35:47","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-7110565d","title":"Sensory-Motor Circuit Cross-Modal Compensation","composite_score":0.311593,"created_at":"2026-04-04 13:35:52","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-2c776894","title":"Ferroptosis Inhibition for α-Synuclein Neuroprotection","composite_score":0.5476300251265789,"created_at":"2026-04-04 13:36:10","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-9588dd18","title":"Early Proteasome Restoration Therapy","composite_score":0.49627278131510544,"created_at":"2026-04-04 13:36:15","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-724e3929","title":"White Matter Oligodendrocyte Protection via CXCL10 Inhibition","composite_score":0.4802792075017798,"created_at":"2026-04-04 13:36:20","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-0d576989","title":"Selective Cholinergic Protection via APP Pathway Modulation","composite_score":0.4270644612625487,"created_at":"2026-04-04 13:36:25","predictions_count":0,"gate_flags":"[\"no_predictions\"]"},{"id":"h-9a721223","title":"NOMO1-Mediated Neuronal Resilience Enhancement","composite_score":0.41230650754532744,"created_at":"2026-04-04 13:36:30","predictions_count":0,"gate_flags":"[\"no_predictions\"]"}]}},"recommendations":["Enrich 51 hypotheses with PubMed citations via evidence_validator.py","Re-run 27 incomplete debates through scidex_orchestrator.py","Extract KG edges from 51 completed analyses via enrich_kg_from_hypotheses.py","Re-validate 14 hypotheses with low evidence validation scores","Investigate and retry 200 failed analyses","Link 62 orphaned hypotheses to their parent analyses","Enrich descriptions for 60 hypotheses (currently < 100 chars)","Complete synthesis round for 1 debates missing synthesizer","Assign target genes to 64 hypotheses for specificity","Review 27 near-duplicate hypothesis pairs and merge or down-rank chaff","Re-run or strengthen debates for 48 high-value hypotheses with weak debate support","Reprice 23 hypotheses whose debates are newer than their market updates","Add explicit falsifiable predictions to 129 hypotheses to meet Senate quality standards"],"trending":[{"checked_at":"2026-04-14 00:09:06","total_flags":356,"status":"CRITICAL","missing_evidence":28,"low_scores":0,"weak_debates":19,"no_kg_edges":44,"low_validation":14,"failed_analyses":162},{"checked_at":"2026-04-14 01:32:31","total_flags":420,"status":"CRITICAL","missing_evidence":29,"low_scores":0,"weak_debates":19,"no_kg_edges":44,"low_validation":14,"failed_analyses":164},{"checked_at":"2026-04-14 03:27:19","total_flags":354,"status":"CRITICAL","missing_evidence":21,"low_scores":0,"weak_debates":15,"no_kg_edges":44,"low_validation":14,"failed_analyses":165},{"checked_at":"2026-04-14 04:37:34","total_flags":422,"status":"CRITICAL","missing_evidence":24,"low_scores":0,"weak_debates":16,"no_kg_edges":44,"low_validation":14,"failed_analyses":166},{"checked_at":"2026-04-14 05:39:50","total_flags":369,"status":"CRITICAL","missing_evidence":24,"low_scores":0,"weak_debates":15,"no_kg_edges":44,"low_validation":14,"failed_analyses":168},{"checked_at":"2026-04-14 06:55:48","total_flags":374,"status":"CRITICAL","missing_evidence":25,"low_scores":0,"weak_debates":15,"no_kg_edges":44,"low_validation":14,"failed_analyses":169},{"checked_at":"2026-04-14 08:33:05","total_flags":376,"status":"CRITICAL","missing_evidence":25,"low_scores":0,"weak_debates":16,"no_kg_edges":44,"low_validation":14,"failed_analyses":170},{"checked_at":"2026-04-14 09:52:22","total_flags":380,"status":"CRITICAL","missing_evidence":26,"low_scores":0,"weak_debates":16,"no_kg_edges":44,"low_validation":14,"failed_analyses":170},{"checked_at":"2026-04-14 11:04:48","total_flags":380,"status":"CRITICAL","missing_evidence":26,"low_scores":0,"weak_debates":16,"no_kg_edges":45,"low_validation":14,"failed_analyses":169},{"checked_at":"2026-04-14 13:34:13","total_flags":391,"status":"CRITICAL","missing_evidence":28,"low_scores":0,"weak_debates":16,"no_kg_edges":45,"low_validation":14,"failed_analyses":172},{"checked_at":"2026-04-14 15:12:28","total_flags":393,"status":"CRITICAL","missing_evidence":28,"low_scores":0,"weak_debates":16,"no_kg_edges":44,"low_validation":14,"failed_analyses":175},{"checked_at":"2026-04-14 16:38:47","total_flags":410,"status":"CRITICAL","missing_evidence":32,"low_scores":0,"weak_debates":16,"no_kg_edges":44,"low_validation":14,"failed_analyses":176},{"checked_at":"2026-04-14 18:50:11","total_flags":421,"status":"CRITICAL","missing_evidence":34,"low_scores":0,"weak_debates":16,"no_kg_edges":44,"low_validation":14,"failed_analyses":179},{"checked_at":"2026-04-14 20:38:37","total_flags":435,"status":"CRITICAL","missing_evidence":37,"low_scores":0,"weak_debates":16,"no_kg_edges":44,"low_validation":14,"failed_analyses":181},{"checked_at":"2026-04-15 12:03:15","total_flags":458,"status":"CRITICAL","missing_evidence":40,"low_scores":0,"weak_debates":16,"no_kg_edges":44,"low_validation":14,"failed_analyses":191},{"checked_at":"2026-04-15 16:58:03","total_flags":465,"status":"CRITICAL","missing_evidence":40,"low_scores":0,"weak_debates":16,"no_kg_edges":45,"low_validation":14,"failed_analyses":197},{"checked_at":"2026-04-15 18:08:31","total_flags":466,"status":"CRITICAL","missing_evidence":40,"low_scores":0,"weak_debates":16,"no_kg_edges":44,"low_validation":14,"failed_analyses":199},{"checked_at":"2026-04-15 19:32:17","total_flags":471,"status":"CRITICAL","missing_evidence":41,"low_scores":0,"weak_debates":16,"no_kg_edges":44,"low_validation":14,"failed_analyses":200},{"checked_at":"2026-04-15 22:34:56","total_flags":473,"status":"CRITICAL","missing_evidence":41,"low_scores":0,"weak_debates":16,"no_kg_edges":46,"low_validation":14,"failed_analyses":200},{"checked_at":"2026-04-15 23:43:13","total_flags":474,"status":"CRITICAL","missing_evidence":41,"low_scores":0,"weak_debates":16,"no_kg_edges":47,"low_validation":14,"failed_analyses":200},{"checked_at":"2026-04-16 01:21:25","total_flags":497,"status":"CRITICAL","missing_evidence":46,"low_scores":0,"weak_debates":19,"no_kg_edges":49,"low_validation":14,"failed_analyses":201},{"checked_at":"2026-04-16 02:55:17","total_flags":501,"status":"CRITICAL","missing_evidence":46,"low_scores":0,"weak_debates":22,"no_kg_edges":51,"low_validation":14,"failed_analyses":200},{"checked_at":"2026-04-16 04:04:47","total_flags":526,"status":"CRITICAL","missing_evidence":51,"low_scores":0,"weak_debates":24,"no_kg_edges":51,"low_validation":14,"failed_analyses":200},{"checked_at":"2026-04-16 05:05:53","total_flags":757,"status":"CRITICAL","missing_evidence":51,"low_scores":0,"weak_debates":27,"no_kg_edges":51,"low_validation":14,"failed_analyses":200}]}