Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NOXO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | NOXO1 |
| Full Name | NADPH Oxidase Organizer 1 |
| Function | is a protein encoded by the NOXO1 gene that ### NOX1 Complex Organization |
| Molecular Weight | 41.1 kDa |
| Amino Acids | 366 aa |
| UniProt ID | [Q8NFA2](https://www.uniprot.org/uniprotkb/Q8NFA2) |
| GeneCards | NOXO1 |
| Human Protein Atlas | NOXO1 |
| Proline-rich regions | Mediate binding to NOXA1 |
| PB1 domain | Similar to p47phox but constitutively active |
| Oxidative stress | NOXO1/NOX1 contributes to AD oxidative damage |
| [Tau](/proteins/tau) phosphorylation | ROS from NOX1 affects kinase/phosphatase balance |
| Dopaminergic vulnerability | ROS from NOX1 may damage dopaminergic neurons |
| Neuroinflammation | Contributes to microglial ROS production |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NOXO1["NOXO1"]
neurodegeneration["neurodegeneration"]
NOXO1 -->|"implicated_in"| neurodegeneration
style NOXO1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||