What are the precise temporal dynamics of astrocyte ketone production decline during neurodegeneration progression?
Analysis ID: SDA-2026-04-15-gap-debate-20260410-112330-9abf86eb | Domain: neurodegeneration | Status: completed | Created: 2026-04-15T13:22:12.380659
Knowledge Graph: 2 edges — View JSON
Top Hypotheses (2 total)
#1 Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone Deficiency to Neuroinflammation
0.645
HCAR2
Beyond serving as metabolic fuel, β-hydroxybutyrate (BHB) signals through hydroxycarboxylic acid receptor 2 (HCAR2/GPR109A) on astrocytes to suppress NF-κB activation and reduce neuroinflammation. The
#2 Integrated Biomarker Panel for Therapeutic Window Identification
0.615
CHI3L1
Plasma CHI3L1/YKL-40 elevation combined with declining βHB defines the closing therapeutic window. The therapeutic window can be precisely identified using a biomarker panel combining: (1) rising plas