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Atlas

Living Knowledge Graph — 700,314 edges connecting 50 entities

Full Graph Wiki Trials
700,314
KG Edges
17,545
Wiki Pages
16,302
Papers
512
Hypotheses
45,764
Entities

Edge Types

pubmed cooccurrence
233,645
pubmed abstract nlp
89,637
pubmed v5 extraction
46,631
cooccurrence
44,675
pubmed v4 extraction
32,427
co occurrence
28,959
pubmed extraction
25,984
pubmed cooccurrence v3
24,809
association
11,546
pubmed v12 nlp
11,253
pubmed abstract top50 v3
9,913
dataset row
9,412

Relation Types

activates
139,098
associated_with
103,270
regulates
73,449
inhibits
57,548
interacts_with
51,332
expressed_in
45,719
therapeutic_target
44,935
causes
23,481
co_discussed
17,100
contributes_to
16,904

Top Entities by Connections

Als 9,930
disease
ALZHEIMER 9,339
disease
ALS 8,483
disease
AUTOPHAGY 7,580
entity
ALZHEIMER'S DISEASE 7,323
disease
APOPTOSIS 7,055
entity
INFLAMMATION 6,960
gene
NEURODEGENERATION 6,771
concept
Cancer 6,327
disease
Neurodegeneration 6,175
disease
PARKINSON 6,056
disease
MICROGLIA 5,972
cell type
Autophagy 5,941
entity
MTOR 5,929
entity
Alzheimer 5,895
disease
Inflammation 5,806
disease
AKT 5,720
entity
TNF 5,551
entity
Ms 5,499
disease
TAU 5,378
entity
NEURON 5,277
cell type
PI3K 5,220
entity
AMYLOID 5,145
disease
OXIDATIVE STRESS 5,078
entity
Aging 4,818
disease
NLRP3 4,809
entity
APOE 4,776
entity
AGING 4,776
entity
BDNF 4,734
entity
Tumor 4,721
disease
AMPK 4,696
entity
Neuroinflammation 4,676
disease
NEUROINFLAMMATION 4,643
concept
Neuron 4,529
cell type
PARKINSON'S DISEASE 4,474
disease
Apoptosis 4,440
entity
APP 4,431
entity
ROS 4,418
drug
CYTOKINES 4,349
concept
DEMENTIA 4,214
disease
MITOCHONDRIA 4,157
cell type
ASTROCYTES 4,155
cell type
NEURODEGENERATIVE DISEASES 4,117
disease
SQSTM1 4,026
entity
UBIQUITIN 4,017
entity
Parkinson 3,769
disease
Oxidative Stress 3,731
entity
TREM2 3,620
entity
PINK1 3,597
entity
STAT3 3,571
entity

Recent Edges

Source Relation Target Date
sTREM2/membrane-TREM2/ADAM10 promoted: CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Window Identification neuroimmunology 2026-04-15 23:01
TREM2/ACAT1/LXR promoted: TREM2 R47H Metabolic Lock-in at Cholesterol Ester Accumulation neuroimmunology 2026-04-15 22:53
HCAR2 promoted: Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone Deficiency to Neuroinflammation neurodegeneration 2026-04-15 20:30
CHI3L1 promoted: Integrated Biomarker Panel for Therapeutic Window Identification neurodegeneration 2026-04-15 20:22
DAPK1 promoted: DAPK1 Inhibition as Dual-Mechanism Neuroprotection Against Tau-Induced Destabilization neurodegeneration 2026-04-15 19:40
MAP2K7/MAP3K12 promoted: DLK MAPK Pathway Inhibition to Block Tau-Induced Neurotoxicity Without Directly Targeting Tau neurodegeneration 2026-04-15 19:32
PXR (NR1I2), IDO1 promoted: H2: Indole-3-Propionate (IPA) as the Actual Neuroprotective Effector neurodegeneration 2026-04-15 19:14
IL-22, REG3G, zonulin promoted: H7: Enteric Nervous System Alpha-Synuclein Propagation Blocker via Gut Barrier Restoration neurodegeneration 2026-04-15 19:06
DDIT4 (REDD1), MTOR promoted: REDD1-mTOR Axis as the Master Regulator — Preservation Over Chelation neurodegeneration 2026-04-15 17:34
HFE (H63D variant) promoted: ER Stress Reduction as Adjunctive Therapy to Support Autophagy neurodegeneration 2026-04-15 17:26
SYNGAP1 promoted: Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Assembly During Development neurodevelopment 2026-04-15 15:47
TMEM173 (STING) promoted: STING Antagonism Prevents Acute-to-Chronic Neuroinflammation Transition via Interruption of IFN-I Fe neuroinflammation 2026-04-15 11:31
CDKN2A (p16^Ink4a), CDKN1A (p21^Cip1/Waf1) promoted: Timed Senolytic Therapy Eliminates p16^Ink4a/p21^Cip1-Senescent Microglia to Prevent SASP-Driven Com neuroinflammation 2026-04-15 11:23
MEF2C promoted: MEF2C-Dependent Synaptic Gene Regulation neurodegeneration 2026-04-15 09:41
TREM2 promoted: TREM2 Signaling Bifurcation with Independent TYROBP-Independent Homeostatic Maintenance neuroinflammation 2026-04-15 05:56
SYK, TREM2 promoted: SYK-Independent TREM2 Pathways Remain Functional in TYROBP Deficiency neuroinflammation 2026-04-15 05:48
C1QA promoted: Complement C1q Suppression as Mechanism Linking Exercise Plasma to PV Interneuron Protection neurodegeneration 2026-04-14 20:13
CHRM1 promoted: M1 Muscarinic Receptor Agonism as Pharmacological Exercise Substitute neurodegeneration 2026-04-14 20:05
FUS promoted: ASO-Mediated Exon Skipping to Restore FUS-TAZ Chaperone Axis neurodegeneration 2026-04-14 17:32
AHR, CYP1A1, NFKB1, IL6 promoted: Aryl Hydrocarbon Receptor (AhR) Activation by Microbiome Metabolites Promotes A2 Polarization neuroinflammation 2026-04-14 15:03
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