SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas

completed | neurodegeneration | 2026-04-02

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Hypotheses (1)

#1 Excitatory Neuron Vulnerability via SLC17A7 Downregulation
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SLC17A7
SLC17A7 (also known as VGLUT1, vesicular glutamate transporter 1) shows significant downregulation (log2FC = -1.7) in the SEA-AD dataset, specifically in layer 3 and layer 5 excitatory neurons of the