| #1 |
Heat Shock Protein 70 Disaggregase Amplification |
HSPA1A |
0.645 |
$0.65 |
| Targeted upregulation of HSP70 family members (HSPA1A, HSPA8) with HSP40 co-chaperones to actively disaggregate pathological TDP-43 condensates... |
| #2 |
PARP1 Inhibition Therapy |
PARP1 |
0.634 |
$0.63 |
| Use FDA-approved PARP1 inhibitors to prevent TDP-43 recruitment to DNA damage sites and reduce cytoplasmic mislocalization... |
| #3 |
Arginine Methylation Enhancement Therapy |
PRMT1 |
0.621 |
$0.62 |
| Pharmacological enhancement of PRMT1/CARM1 activity to reduce TDP-43 RNA-binding avidity and prevent pathological phase separation... |
| #4 |
RNA Granule Nucleation Site Modulation |
G3BP1 |
0.575 |
$0.57 |
| Selective inhibition of G3BP1/G3BP2 to prevent TDP-43 recruitment to pathological stress granules... |
| #5 |
Glycine-Rich Domain Competitive Inhibition |
TARDBP |
0.531 |
$0.53 |
| Engineered peptide mimetics to competitively inhibit TDP-43 intermolecular interactions through the glycine-rich domain... |
| #6 |
Serine/Arginine-Rich Protein Kinase Modulation |
SRPK1 |
0.519 |
$0.52 |
| Modulation of SRPK1/CLK1 to alter splicing regulator phosphorylation and reduce TDP-43 multivalent RNA interactions... |
| #7 |
Low Complexity Domain Cross-Linking Inhibition |
TGM2 |
0.500 |
$0.50 |
| Selective TGM2 inhibition to prevent TDP-43 cross-linking and maintain dynamic condensate properties... |