| #1 |
Gamma entrainment therapy to restore hippocampal-cortical synchrony |
SST |
0.692 |
$0.69 |
| 40Hz gamma oscillation entrainment can restore circuit-level synchrony between hippocampus and prefrontal cortex, reducing amyloid burden and improving cognitive function. Mechanism: gamma drives micr... |
| #2 |
Hippocampal CA3-CA1 circuit rescue via neurogenesis and synaptic preservation |
BDNF |
0.633 |
$0.63 |
| The CA3-CA1 circuit is critical for memory encoding but shows early disruption in AD. Combining neurogenesis enhancement (via BDNF/Wnt signaling) with synaptic preservation (via PSD95 stabilization) c... |
| #3 |
Prefrontal sensory gating circuit restoration via PV interneuron enhancement |
PVALB |
0.629 |
$0.63 |
| Parvalbumin-expressing interneurons in prefrontal cortex mediate sensory gating. Their dysfunction in AD causes sensory overload and cognitive decline. Enhancing PV interneuron function through target... |