Gene expression changes in aging mouse brain predicting neurodegenerative vulnerability

0.407

TREM2

**Background and Rationale** Triggering Receptor Expressed on Myeloid cells 2 (TREM2) represents one of the most significant genetic risk factors for late-onset Alzheimer's disease, with rare loss-of

0.395

C1QA

**Background and Rationale** Synaptic pruning, the selective elimination of synaptic connections, is a fundamental neurodevelopmental process that continues throughout life to maintain optimal neural