Epigenetic reprogramming in aging neurons

0.734

SIRT1

**Molecular Mechanism and Rationale** The nutrient-sensing epigenetic circuit centered on AMPK-SIRT1-PGC1α represents a fundamental regulatory network that governs cellular energy homeostasis and met

0.671

HDAC3

**Molecular Mechanism and Rationale** Histone deacetylase 3 (HDAC3) represents a critical epigenetic regulator that orchestrates chromatin remodeling through targeted deacetylation of lysine residues

0.657

BRD4

**Molecular Mechanism and Rationale** BRD4 functions as a master epigenetic regulator through its unique ability to recognize and bind acetylated histone marks via two tandem bromodomains (BD1 and BD

0.477

SIRT3

## Molecular Mechanism and Rationale The mitochondrial-nuclear epigenetic cross-talk restoration hypothesis centers on the coordinated dysfunction of SIRT3, a critical NAD+-dependent deacetylase loca

0.468

OCT4

The hypothesis of partial neuronal reprogramming via a modified Yamanaka cocktail represents a paradigm shift in approaching neurodegeneration through epigenetic rejuvenation while preserving neuronal

0.405

TET2

## Molecular Mechanism and Rationale The temporal TET2-mediated hydroxymethylation cycling hypothesis centers on the dysregulation of Ten-Eleven Translocation 2 (TET2) enzyme activity in aged neurons