Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)
completed | neurodegeneration | 2026-04-02
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Hypotheses (3)
#1 ACSL4-Driven Ferroptotic Priming in Disease-Associated Microglia
0.738
ACSL4
## 1. Molecular Mechanism and Rationale
ACSL4 (acyl-CoA synthetase long-chain family member 4) catalyzes the esterification of arachidonic acid (AA, C20:4) and adrenic acid (AdA, C22:4) into membrane
#2 SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK1/Parkin Mitophagy Dysfunction
0.568
SIRT3
## 1. Molecular Mechanism and Rationale
SIRT3 is the primary mitochondrial NAD⁺-dependent deacetylase, responsible for maintaining the activity of over 100 mitochondrial proteins through lysine deace
#3 Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupling
0.538
SLC16A1
## 1. Molecular Mechanism and Rationale
The astrocyte-neuron lactate shuttle (ANLS) is a fundamental metabolic coupling mechanism where astrocytes convert glucose to lactate via aerobic glycolysis an