Semantic Diff — protein_design-931cb202-ba5f-4010-8fd5-4246d76d7d44 v4→v5
Summary: score 0.720→0.820 (+0.100); 4 fields changed; 8 metadata keys changed
Changes
| Field | Before | After | Interpretation |
|---|---|---|---|
| title | TREM2 Variant Design v1 — Wild-type Reference | TREM2 Ectodomain Variant — Stability Optimized | |
| quality_score | 0.72 | 0.82 | |
| version_tag | None | stability-opt | |
| changelog | None | Introduced 3 stabilizing mutations from Rosetta energy minimization | |
| metadata._origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-16T11:11:49.478757'} | None | |
| metadata.binding_affinity | {'Kd_nM': 450.0, 'target': 'phospholipid membrane'} | {'kd_nm': 780, 'target': 'Aβ oligomers'} | |
| metadata.delta_G_kcal | None | -2.3 | |
| metadata.design_rationale | None | Rosetta-guided mutations to improve thermostability without disrupting binding interface | |
| metadata.method | AlphaFold2 structure prediction | rosetta_relax | |
| metadata.mutations | None | ['T96S', 'K186R', 'A192V'] | |
| metadata.predicted_stability | -42.3 | 0.91 | |
| metadata.sequence | MSLSRAAAQALWLWGGVAAELQTFKGPCDKKLSAERLAGGQQNGTLGLGNLTLWDPAEQLLNDLQHFMGVWKDIQLTQSSESVALRRSRSRAIVFQGLHFTVVTFQDKGLRSVTYQSVALQPDEYQGLTCYEDSPSAQKASQEAPMPNQTNTMASSPWSLVDLTHKVEEALNLISSQSIQEQLKQSNMGTMHFLSYQISSLN | MEPLRPPHLWAVLLLLGLRLQPRWAGSELQCKEVLKCTCNGSLECLQPRFQNSSKCSWWPAGRRCSCQVKGSVLGEPRPRPV |
Text Diff
--- v2
+++ v3
@@ -1,9 +1,13 @@
-title: TREM2 Variant Design v1 — Wild-type Reference
-quality_score: 0.72
+title: TREM2 Ectodomain Variant — Stability Optimized
+quality_score: 0.82
lifecycle_state: active
-metadata._origin: {'url': None, 'type': 'internal', 'tracked_at': '2026-04-16T11:11:49.478757'}
-metadata.binding_affinity: {'Kd_nM': 450.0, 'target': 'phospholipid membrane'}
-metadata.method: AlphaFold2 structure prediction
-metadata.predicted_stability: -42.3
-metadata.sequence: MSLSRAAAQALWLWGGVAAELQTFKGPCDKKLSAERLAGGQQNGTLGLGNLTLWDPAEQLLNDLQHFMGVWKDIQLTQSSESVALRRSRSRAIVFQGLHFTVVTFQDKGLRSVTYQSVALQPDEYQGLTCYEDSPSAQKASQEAPMPNQTNTMASSPWSLVDLTHKVEEALNLISSQSIQEQLKQSNMGTMHFLSYQISSLN
+version_tag: stability-opt
+changelog: Introduced 3 stabilizing mutations from Rosetta energy minimization
+metadata.binding_affinity: {'kd_nm': 780, 'target': 'Aβ oligomers'}
+metadata.delta_G_kcal: -2.3
+metadata.design_rationale: Rosetta-guided mutations to improve thermostability without disrupting binding interface
+metadata.method: rosetta_relax
+metadata.mutations: ['T96S', 'K186R', 'A192V']
+metadata.predicted_stability: 0.91
+metadata.sequence: MEPLRPPHLWAVLLLLGLRLQPRWAGSELQCKEVLKCTCNGSLECLQPRFQNSSKCSWWPAGRRCSCQVKGSVLGEPRPRPV
metadata.uniprot_id: Q9NZC2