Semantic Diff — protein_design-trem2-v1 v6→v4
Summary: score 0.910→0.720 (-0.190); 4 fields changed; 8 metadata keys changed
Changes
| Field | Before | After | Interpretation |
|---|---|---|---|
| title | TREM2 Ectodomain Variant — Binding Optimized | TREM2 Variant Design v1 — Wild-type Reference | |
| quality_score | 0.91 | 0.72 | |
| version_tag | binding-opt | None | |
| changelog | Interface mutations to enhance Aβ binding while maintaining stability gains | None | |
| metadata._origin | None | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-16T11:11:49.478757'} | |
| metadata.binding_affinity | {'kd_nm': 120, 'target': 'Aβ oligomers'} | {'Kd_nM': 450.0, 'target': 'phospholipid membrane'} | |
| metadata.delta_G_kcal | -1.8 | None | |
| metadata.design_rationale | Interface residue optimization for enhanced Aβ oligomer recognition. Slight stability trade-off accepted for 6.5x binding improvement. | None | |
| metadata.method | rosetta_interface_design | AlphaFold2 structure prediction | |
| metadata.mutations | ['T96S', 'K186R', 'A192V', 'H157Y', 'R62W'] | None | |
| metadata.predicted_stability | 0.88 | -42.3 | |
| metadata.sequence | MEPLRPPHLWAVLLLLGLRLQPRWAGSELQCKEVLKCTCNGSLECLQPRFQNSSKCSWWPAGRRCSCQVKGSVLGEPRPRPV | MSLSRAAAQALWLWGGVAAELQTFKGPCDKKLSAERLAGGQQNGTLGLGNLTLWDPAEQLLNDLQHFMGVWKDIQLTQSSESVALRRSRSRAIVFQGLHFTVVTFQDKGLRSVTYQSVALQPDEYQGLTCYEDSPSAQKASQEAPMPNQTNTMASSPWSLVDLTHKVEEALNLISSQSIQEQLKQSNMGTMHFLSYQISSLN |
Text Diff
--- v4
+++ v2
@@ -1,13 +1,9 @@
-title: TREM2 Ectodomain Variant — Binding Optimized
-quality_score: 0.91
+title: TREM2 Variant Design v1 — Wild-type Reference
+quality_score: 0.72
lifecycle_state: active
-version_tag: binding-opt
-changelog: Interface mutations to enhance Aβ binding while maintaining stability gains
-metadata.binding_affinity: {'kd_nm': 120, 'target': 'Aβ oligomers'}
-metadata.delta_G_kcal: -1.8
-metadata.design_rationale: Interface residue optimization for enhanced Aβ oligomer recognition. Slight stability trade-off accepted for 6.5x binding improvement.
-metadata.method: rosetta_interface_design
-metadata.mutations: ['T96S', 'K186R', 'A192V', 'H157Y', 'R62W']
-metadata.predicted_stability: 0.88
-metadata.sequence: MEPLRPPHLWAVLLLLGLRLQPRWAGSELQCKEVLKCTCNGSLECLQPRFQNSSKCSWWPAGRRCSCQVKGSVLGEPRPRPV
+metadata._origin: {'url': None, 'type': 'internal', 'tracked_at': '2026-04-16T11:11:49.478757'}
+metadata.binding_affinity: {'Kd_nM': 450.0, 'target': 'phospholipid membrane'}
+metadata.method: AlphaFold2 structure prediction
+metadata.predicted_stability: -42.3
+metadata.sequence: MSLSRAAAQALWLWGGVAAELQTFKGPCDKKLSAERLAGGQQNGTLGLGNLTLWDPAEQLLNDLQHFMGVWKDIQLTQSSESVALRRSRSRAIVFQGLHFTVVTFQDKGLRSVTYQSVALQPDEYQGLTCYEDSPSAQKASQEAPMPNQTNTMASSPWSLVDLTHKVEEALNLISSQSIQEQLKQSNMGTMHFLSYQISSLN
metadata.uniprot_id: Q9NZC2
JSON: /api/artifacts/protein_design-trem2-v1/diff/protein_design-trem2-v1