Semantic Diff — protein_design-0d9d3a27-4764-4150-8fdc-031c4e82a9b4 v5→v4
Summary: 2 fields changed; 9 metadata keys changed
Changes
| Field | Before | After | Interpretation |
|---|---|---|---|
| version_tag | stability-opt | None | |
| changelog | Introduced 3 stabilizing mutations from Rosetta energy minimization | None | |
| metadata.binding_affinity | {'kd_nm': 780, 'target': 'Aβ oligomers'} | {'kd_nm': 850, 'target': 'Aβ oligomers'} | |
| metadata.delta_G_kcal | -2.3 | None | |
| metadata.design_rationale | Rosetta-guided mutations to improve thermostability without disrupting binding interface | Wild-type ectodomain structure as baseline for optimization | |
| metadata.method | rosetta_relax | alphafold | |
| metadata.mutations | ['T96S', 'K186R', 'A192V'] | [] | |
| metadata.predicted_stability | 0.91 | 0.72 | |
| metadata.rosetta_energy | -45.2 | None | |
| metadata.sequence | MEPLRGLLVLAGLAFWHLRGGWAPGALLLWSLGPSLGRAHSGPASCQLLACSLSTLAALCASCVLVVVSTALLFLLLLSLAALQLWQRGVAPSRQGPA | MEPLRGLLVLAGLAFWHLRGGWAPGALLLWSLGPSLGRAHSGPASCQLLACSLTTLAALCASCVLVVVSTALLFLLLLSLAALQLWQRGVAPTLQGPA | |
| metadata.structure_pdb_url | None | https://alphafold.ebi.ac.uk/files/AF-Q9NZC2-F1-model_v4.pdb |
Text Diff
--- v3
+++ v2
@@ -1,16 +1,13 @@
title: TREM2 Ectodomain Variant — AlphaFold Base
quality_score: 0.75
lifecycle_state: active
-version_tag: stability-opt
-changelog: Introduced 3 stabilizing mutations from Rosetta energy minimization
-metadata.binding_affinity: {'kd_nm': 780, 'target': 'Aβ oligomers'}
-metadata.delta_G_kcal: -2.3
-metadata.design_rationale: Rosetta-guided mutations to improve thermostability without disrupting binding interface
-metadata.method: rosetta_relax
-metadata.mutations: ['T96S', 'K186R', 'A192V']
+metadata.binding_affinity: {'kd_nm': 850, 'target': 'Aβ oligomers'}
+metadata.design_rationale: Wild-type ectodomain structure as baseline for optimization
+metadata.method: alphafold
+metadata.mutations: []
metadata.plddt_score: 0.89
-metadata.predicted_stability: 0.91
-metadata.rosetta_energy: -45.2
-metadata.sequence: MEPLRGLLVLAGLAFWHLRGGWAPGALLLWSLGPSLGRAHSGPASCQLLACSLSTLAALCASCVLVVVSTALLFLLLLSLAALQLWQRGVAPSRQGPA
-metadata.structure_pdb_url: None
+metadata.predicted_stability: 0.72
+metadata.sequence: MEPLRGLLVLAGLAFWHLRGGWAPGALLLWSLGPSLGRAHSGPASCQLLACSLTTLAALCASCVLVVVSTALLFLLLLSLAALQLWQRGVAPTLQGPA
+metadata.structure_pdb_url: https://alphafold.ebi.ac.uk/files/AF-Q9NZC2-F1-model_v4.pdb
metadata.uniprot_id: Q9NZC2
+metadata.visualization_url: None