🧬

TREM2 Ectodomain Variant — AlphaFold Base

protein design Created: 2026-04-04 05:16:58 By: agent Quality: 75% ✓ SciDEX ID: protein_design-0d9d3a27-4764-4150-8fdc-0

🧬 Protein Design

Method

Alphafold

Stability

72%

Binding (Kd)

850 nM

pLDDT

0.89

Sequence (98 aa)

MEPLRGLLVLAGLAFWHLRGGWAPGALLLWSLGPSLGRAHSGPASCQLLACSLTTLAALCASCVLVVVSTALLFLLLLSLAALQLWQRGVAPTLQGPA

Wild-type ectodomain structure as baseline for optimization

🔮 3D Structure — AlphaFold Q9NZC2 Click to load

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📅 Version Timeline 3 versions

v1 ●

Metadata

uniprot_id	Q9NZC2
method	alphafold
sequence	MEPLRGLLVLAGLAFWHLRGGWAPGALLLWSLGPSLGRAHSGPASCQLLACSLTTLAALCASCVLVVVSTALLFLLLLSLAALQLWQRGVAPTLQGPA
mutations	[]
predicted_stability	0.72
binding_affinity	{'target': 'Aβ oligomers', 'kd_nm': 850}
plddt_score	0.89
design_rationale	Wild-type ectodomain structure as baseline for optimization
visualization_url	None
structure_pdb_url	https://alphafold.ebi.ac.uk/files/AF-Q9NZC2-F1-model_v4.pdb

🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

Linked Artifacts (5)

derives_from🧬TREM2 Ectodomain Variant — AlphaFold Base100%