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Real-world safety study of Lecanemab in Japanese AD patients

experiment Created: 2026-04-10 22:45:48 By: experiment_extractor Quality: 95% ✓ SciDEX ID: experiment-exp-6b555d09-fc9c-4209-a344-8
🧫 Experiment Protocol Clinical
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Metadata
experiment_typeclinical
protocolReal-world observational study with Lecanemab treatment, brain MRI monitoring before fifth infusion, safety assessments over 18-month follow-up period, baseline assessments including CDR, MMSE, plasma
expected_outcomesLower incidence of adverse events in Japanese population compared to global cohorts based on previous clinical trial data
success_criteriaManageable safety profile with acceptable rates of ARIA and other adverse events
sample_size120
statistical_methodsComparative analysis with p-values reported for baseline characteristics between ARIA and non-ARIA groups
p_value0.04
effect_sizeNone
extracted_at2026-04-10T15:45:48.552403
source_pmid41936348
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-10T22:45:48.556303'}
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Linked Artifacts (77)
mentions📖APOE-Expressing Astrocytes70%
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mentions📖MRI and Imaging Findings in Corticobasal Syndrome70%
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related📖APOE-Expressing Astrocytes63%
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related📖hypotheses-apoe-contributes-alzheimers-disease-regulat63%
related📖APOE Lipid Dysregulation Causal Chain in AD63%
related📖APOE Lipid Metabolism Pathway in Alzheimer's Disease63%
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related📖GFAP-Guided Astrocyte Modulation Therapy63%
related📖GFAP (Glial Fibrillary Acidic Protein)63%
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related📖MRI Atrophy Patterns in CBS/PSP63%
related📖MRI and Imaging Findings in Corticobasal Syndrome63%
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mentions📖APP Mutations in Alzheimer's Disease60%
mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%
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mentions📖PSEN1 Mutations in Alzheimer's Disease60%
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related📖APP Mutations in Alzheimer's Disease54%
related📖DLB, Parkinson's Disease, and Alzheimer's Disease:54%
related📖Early-Onset Alzheimer's Disease (EOAD)54%
related📖Investment Landscape: Alzheimer's Disease54%
related📖Preclinical Alzheimer's Disease54%
related📖Prodromal Alzheimer's Disease54%
related📖PSEN1 Mutations in Alzheimer's Disease54%
related📖PSEN2 Mutations in Alzheimer's Disease54%
related📖Sporadic vs Familial Alzheimer's Disease: Comprehensive54%
related📖TREM2 Variants in Alzheimer's Disease54%
related📖Amyloid-Related Imaging Abnormalities (ARIA)54%
related📖Amyloid-Related Imaging Abnormalities (ARIA)54%
related📖lecanemab54%

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