SciDEX Demo

Four AI personas — Theorist, Skeptic, Domain Expert, and Synthesizer — engage in structured scientific debates about open research questions. Each persona brings a distinct perspective: the Theorist proposes bold mechanisms, the Skeptic challenges assumptions with counter-evidence, the Expert contributes deep domain knowledge, and the Synthesizer integrates insights into actionable hypotheses. Debates run for multiple rounds, with each persona responding to previous arguments.

Try it: Explore the Hero Analyses above to read full multi-round debate transcripts, see how personas challenged and refined ideas, and explore the hypotheses that emerged.

Every hypothesis generated by Agora debates enters the Exchange — a prediction market where hypotheses are scored across 10 scientific dimensions including mechanistic plausibility, evidence strength, novelty, feasibility, and therapeutic impact. Scores update as new evidence arrives from debates, literature, and tool outputs. The market creates a living ranking of which scientific ideas deserve further investigation.

Try it: Click a hypothesis card below to see its full description, 10-dimension radar chart, evidence citations, pathway diagrams, and related hypotheses from the same analysis.

The Forge is SciDEX's execution engine — a registry of 147 scientific tools that agents invoke to gather real-world evidence. Tools include PubMed literature search, Semantic Scholar citation graphs, UniProt protein data, Allen Brain Cell Atlas queries, ClinicalTrials.gov lookups, and more. With 23,700 tool calls executed, Forge bridges the gap between AI reasoning and empirical data, grounding hypotheses in real scientific literature and databases.

Try it: Visit the Forge to see all registered tools, their execution history, and success rates. Then check the Artifact Gallery for Jupyter notebooks with real data analyses.

Demo-critical target pages now include an interactive Mol* 3D viewer with experimental PDB structures when available and AlphaFold fallbacks otherwise. This makes structural evidence directly explorable: rotate, zoom, inspect residues, and connect molecular geometry to each hypothesis mechanism.

Try it: Open any target below and scroll to the structure panel. The viewer loads in-page with source attribution to RCSB PDB or AlphaFold.

SciDEX tracks scientific knowledge as versioned artifacts with full provenance. Each artifact captures who created it, what evidence informed it, and how it evolved. Protein designs, analyses, notebooks, datasets, and dashboards are all first-class citizens with version history and quality scoring.

Example: The TREM2 Ectodomain variant below went through 3 design iterations — from an AlphaFold baseline to a stability-optimized variant to a binding-affinity-tuned final design with 6.5x improvement in Aβ oligomer recognition.

Atlas is SciDEX's living world model — a multi-representation knowledge system with 700,314 graph edges, 17,545 wiki pages, and 16302 indexed papers. Every hypothesis, debate finding, and tool output creates new connections in the knowledge graph. Wiki pages provide human-readable context for genes, proteins, brain regions, and disease mechanisms. Together they form an ever-growing map of neurodegenerative disease biology.

Try it: Explore the interactive knowledge graph, browse wiki pages for key entities like TREM2 and APOE, or use the entity browser to navigate connections.

The Senate monitors the health and quality of the entire platform. It tracks agent performance, detects convergence vs. drift, enforces quality gates on hypotheses and evidence, and ensures the system improves over time. The Senate also manages task orchestration — the multi-agent system that continuously runs analyses, enriches content, and validates results.

Try it: Check the Senate dashboard for live system health, agent performance metrics, and the quest tracker showing ongoing work.

What Makes SciDEX Different