Scientific Papers

Browse 16,302 PubMed-sourced papers powering SciDEX hypotheses and knowledge graph.

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Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules.

4 hypothesises
Yang C, Wang Z, Kang Y, Yi Q, Wang T, Bai Y, Liu Y
Autophagy 2023 3 citations PMID: 36692217

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules.

5 hypothesises
Yang P, Mathieu C, Kolaitis RM, Zhang P, Messing J, Yurtsever U, Yang Z, Wu J, Li Y, Pan Q
Cell 2020 3 citations PMID: 32302571

Aquaporin-4 in glymphatic system, and its implication for central nervous system disorders.

2 hypothesises
Peng S, Liu J, Liang C, Yang L, Wang G
Neurobiol Dis 2023 2 citations PMID: 36796590

Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease.

4 hypothesises
De Schepper S, Ge JZ, Sierksma A, Crowley G, Ferreira LSS, Garceau D, Toomey CE, Sokolova D, Rueda-Carrasco J, Shin SH
Nat Neurosci 2023 2 citations PMID: 36747024

An integrative analysis of single-cell and bulk transcriptome and bidirectional mendelian randomization analysis identified C1Q as a novel stimulated risk gene for Atherosclerosis.

2 hypothesises
Cui HK, Tang CJ, Gao Y, Li ZA, Zhang J, Li YD
Front Immunol 2023 2 citations PMID: 38179058

Prolonged anesthesia induces neuroinflammation and complement-mediated microglial synaptic elimination involved in neurocognitive dysfunction and anxiety-like behaviors.

3 hypothesises
Xu F, Han L, Wang Y, Deng D, Ding Y, Zhao S, Zhang Q, Ma L, Chen X
BMC Med 2023 2 citations PMID: 36600274

Autophagy and ALS: mechanistic insights and therapeutic implications.

9 hypothesises
Chua JP, De Calbiac H, Kabashi E, Barmada SJ
Autophagy 2022 2 citations PMID: 34057020

The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis.

3 hypothesises
Pi S, Mao L, Chen J, Shi H, Liu Y, Guo X, Li Y, Zhou L, He H, Yu C
Autophagy 2021 2 citations PMID: 32160082

Beyond Activation: Characterizing Microglial Functional Phenotypes.

3 hypothesises
Lier J, Streit WJ, Bechmann I
Cells 2021 2 citations PMID: 34571885

Uncommon inflammatory/immune-related myelopathies.

2 hypothesises
Valencia-Sanchez C, Flanagan EP
J Neuroimmunol 2021 2 citations PMID: 34715593

Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.

5 hypothesises
Yao RQ, Ren C, Xia ZF, Yao YM
Autophagy 2021 2 citations PMID: 32048886

TDP-43 Pathology in Alzheimer's Disease.

5 hypothesises
Meneses A, Koga S, O'Leary J, Dickson DW, Bu G, Zhao N
Mol Neurodegener 2021 2 citations PMID: 34930382

Climate-driven flyway changes and memory-based long-distance migration.

["Gu Z", "Pan S", "Lin Z", "Hu L", "Dai X", "Chang J", "Xue Y", "Su H", "Long J", "Sun M", "Ganusevich S", "Sokolov V",
Nature 2021 2 citations PMID: 33658718

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS.

4 hypothesises
Yu CH, Davidson S, Harapas CR, Hilton JB, Mlodzianoski MJ, Laohamonthonkul P, Louis C, Low RRJ, Moecking J, De Nardo D
Cell 2020 2 citations PMID: 33031745

Protein transmission in neurodegenerative disease.

5 hypothesises
Peng C, Trojanowski JQ, Lee VM
Nat Rev Neurol 2020 2 citations PMID: 32203399

Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors.

["Pessina F", "Giavazzi F", "Yin Y", "Gioia U", "Vitelli V", "Galbiati A", "Barozzi S", "Garre M", "Oldani A", "Flaus A"
Nature cell biology 2020 2 citations PMID: 31570834

Precursor exhausted T cells: key to successful immunotherapy?

["Kallies A", "Zehn D", "Utzschneider DT"]
Nature reviews. Immunology 2020 2 citations PMID: 31591533

miR-130a and Tgfβ Content in Extracellular Vesicles Derived from the Serum of Subjects at High Cardiovascular Risk Predicts their In-Vivo Angiogenic Potential.

["Cavallari C", "Figliolini F", "Tapparo M", "Cedrino M", "Trevisan A", "Positello L", "Rispoli P", "Solini A", "Migliar
Scientific reports 2020 2 citations PMID: 31959759

An autoimmune mechanism may underlie most cases of primary MPGN and C3G.

Carney EF
Nature reviews. Nephrology 2020 2 citations PMID: 31969712

A reference map of the human binary protein interactome.

["Luck K", "Kim DK", "Lambourne L", "Spirohn K", "Begg BE", "Bian W", "Brignall R", "Cafarelli T", "Campos-Laborie FJ",
Nature 2020 2 citations PMID: 32296183

Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.

6 hypothesises
Rusmini P, Cortese K, Crippa V, Cristofani R, Cicardi ME, Ferrari V, Vezzoli G, Tedesco B, Meroni M, Messi E
Autophagy 2019 2 citations PMID: 30335591

Common variants on 6q16.2, 12q24.31 and 16p13.3 are associated with major depressive disorder.

["Li X", "Luo Z", "Gu C", "Hall LS", "McIntosh AM", "Zeng Y", "Porteous DJ", "Hayward C", "Li M", "Yao YG", "Zhang C", "
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2019 2 citations PMID: 29728651

Clinical practice guideline: tonsillitis I. Diagnostics and nonsurgical management.

["Windfuhr JP", "Toepfner N", "Steffen G", "Waldfahrer F", "Berner R"]
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2016 2 citations PMID: 26755048

Erythrocytosis and Polycythemia Secondary to Testosterone Replacement Therapy in the Aging Male.

Jones S, Dukovac T, Sangkum P, Yafi F, Hellstrom W
Sexual medicine reviews 2015 2 citations PMID: 27784544

Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double

Jesús F San-Miguel, Vânia T M Hungria, Sung-Soo Yoon, Meral Beksac, Meletios Athanasios Dimopoulos et al.
The Lancet. Oncology 2014 2 citations PMID: 25242045

Canonical and atypical E2Fs regulate the mammalian endocycle.

["Chen HZ", "Ouseph MM", "Li J", "Pécot T", "Chokshi V", "Kent L", "Bae S", "Byrne M", "Duran C", "Comstock G", "Tr
Nature cell biology 2013 2 citations PMID: 23064266

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Unknown 1 citations PMID: 31171062

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Unknown 1 citations PMID: 32296184

Clonal Hematopoiesis in Nonmalignant Disease: Functional Consequences of Mutated Immune Cells by Clonal Hematopoiesis in the Diseased Tissue.

1 hypothesis
Koh Y, Tengesdal IW, Jaiswal S
Annu Rev Pathol 2026 1 citations PMID: 40929507

HK1 and HK2 Beyond Glycolysis: Mitochondrial Interactions and Dual Roles in Metabolism and Cell Fate.

4 hypothesises
Pesce NA, Seminara G, Giarrusso G, Tomasello MF
Adv Biol (Weinh) 2026 1 citations PMID: 41387352

Hypoxia-driven phase separation of the PABP1/eIF4B complex forms stress granules and activates ChaC2 translation to promote polyunsaturated lipids-supported peritoneal metastasis in gastric cancer.

1 hypothesis
Lin Z, Gao Y, Zhang Q, Yang S, Chen Y, Ding H, Peng W, Zhang X, Nurzat Y, Hu J
Cancer Lett 2026 1 citations PMID: 41780839

Brain Capillary Ion Channels: Physiology and Channelopathies.

1 hypothesis
Harraz OF, Hashad AM
Physiology (Bethesda) 2026 1 citations PMID: 40748720

Meta-analysis of mRNA dysregulation associated with Parkinson's disease and other neurological disorders.

3 hypothesises
Lin Aung T, Aung YW, Shi X
Biomed Phys Eng Express 2026 1 citations PMID: 41183391

Complement, Inflammasome, and Microglial Crosstalk in Glaucoma: From Neurodegeneration to Immune-Based Precision Therapy.

2 hypothesises
Chen TY, Wu N, Sun X
Life (Basel) 2026 1 citations PMID: 41900887

PAD4 promotes macrophage migration to aggravate tubulointerstitial injury in diabetic kidney disease.

1 hypothesis
Xiong Y, Li R, Chen X, Peng C, Zeng Q, Zhu S, He F, Wu J, Lei J, Chen M
Mol Ther 2026 1 citations PMID: 41054305

Allosteric properties of mammalian ALOX15 orthologs.

6 hypothesises
Yang J, Borchert A, Kuhn H
J Biol Chem 2026 1 citations PMID: 41654134

Bergenin attenuates traumatic brain injury via inhibition of microglial PFKFB3-driven glycolytic-inflammatory crosstalk.

1 hypothesis
Sun B, Zhang A, Feng S, Jamali AW, Jia Z, Xu Y, Wang Z, Zhao J, Sun G, Liu L
Int Immunopharmacol 2026 1 citations PMID: 41520557

Astrocytic Connexin43 in Alzheimer's disease: mechanisms, interaction with P2 receptors, and therapeutic potential.

2 hypothesises
Xiong W, Su Y, Verkhratsky A, Yi C
Neuropharmacology 2026 1 citations PMID: 41062060

Complement C1q-Targeted Microglial Membrane Camouflaged Nanolipid Carriers for Synaptic Protection in Alzheimer's Disease: A Bioinspired Alectinib Delivery Strategy.

1 hypothesis
Ding YN, Li MQ, Ding PT, Wang P, Guan PP
Nano letters 2026 1 citations PMID: 41114949

Tau and MAP6 establish labile and stable domains on microtubules.

1 hypothesis
Kirimtay K, Huang W, Sun X, Qiang L, Wang DV, Sprouse CT, Craig EM, Baas PW
iScience 2025 1 citations PMID: 40040809
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