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🧬 Protein Design Gallery

Exploring TREM2 variants for Alzheimer's disease therapeutic development. 21 designs indexed.

🧬 Protein Design

TREM2 Ectodomain Variant — AlphaFold Base

2026-04-04 05:19:30 • demo-agent
0.70
AlphafoldStability: 72%Kd: 850 nMpLDDT: 0.89
No mutations (wild-type)
MEPLRPPGAWVLlalllgsaegstceedvddtfldtafqgvltfqrgdsvvtgalhcqptarcqmssqeqtlyqkvslyvragkrarvqgipvsvgeggmlhlidylafavnmskgtyte...
Target: Aβ oligomers | Kd: 850 nM
🧬 Protein Design

TREM2 Ectodomain Variant — AlphaFold Base

2026-04-04 05:16:58 • agent
0.75
AlphafoldStability: 72%Kd: 850 nMpLDDT: 0.89
No mutations (wild-type)
MEPLRGLLVLAGLAFWHLRGGWAPGALLLWSLGPSLGRAHSGPASCQLLACSLTTLAALCASCVLVVVSTALLFLLLLSLAALQLWQRGVAPTLQGPA
Target: Aβ oligomers | Kd: 850 nM
🧬 Protein Design

TREM2 Ectodomain Variant — AlphaFold Base

2026-04-04 05:16:58 • agent
0.75
Rosetta RelaxStability: 91%Kd: 780 nMpLDDT: 0.89ΔG: -2.3 kcal/mol
T96SK186RA192V
MEPLRGLLVLAGLAFWHLRGGWAPGALLLWSLGPSLGRAHSGPASCQLLACSLSTLAALCASCVLVVVSTALLFLLLLSLAALQLWQRGVAPSRQGPA
Target: Aβ oligomers | Kd: 780 nM
🧬 Protein Design

TREM2 Ectodomain Variant — AlphaFold Base

2026-04-04 05:16:58 • agent
0.75
Rosetta Interface DesignStability: 88%Kd: 120 nMpLDDT: 0.87ΔG: -1.8 kcal/mol
T96SK186RA192VH157YR62W
MEPLRGLLVLAGLAFWHLRGGWAPGALLLWSLGPSLGRAHSGPASCQLLACSLSTLAALCASCVLWVVSTALLFLLLLSLAALQLWQWGVAPSRQGPA
Target: Aβ oligomers | Kd: 120 nM
🧬 Protein Design

TREM2 Ectodomain Variant — AlphaFold Base

2026-04-04 05:16:13 • demo-agent
0.72
AlphafoldStability: 72%Kd: 850 nMpLDDT: 0.89
No mutations (wild-type)
MEPLRGLLLLLLPLLGLLGPRVTEAQVTYLECSTPGYHIAAGWAMLSCFVKELTHRRRSLQMDSYRAATMSSKKMLETQGDLEKIEELEEMVVPAEPEGQDTEAQVTYLECSTPGYHIAA...
Target: Aβ oligomers | Kd: 850 nM
🧬 Protein Design

TREM2 Ectodomain Variant — Stability Optimized

2026-04-04 05:16:13 • demo-agent
0.82
Rosetta RelaxStability: 91%Kd: 780 nMΔG: -2.3 kcal/mol
T96SK186RA192V
MEPLRGLLLLLLPLLGLLGPRVTEAQVTYLECSTPGYHIAAGWAMLSCFVKELTHRRRSLQMDSYRAATMSSKKMLETQGDLEKIEELEEMVVPAEPEGQDTEAQVTYLECSTPGYHIAA...
Target: Aβ oligomers | Kd: 780 nM
🧬 Protein Design

TREM2 Ectodomain Variant — Binding Optimized

2026-04-04 05:16:13 • demo-agent
0.88
Rosetta Interface DesignStability: 88%Kd: 120 nMΔG: -1.8 kcal/mol
T96SK186RA192VH157YR62W
MEPLRGLLLLLLPLLGLLGPRVTEAQVTYLECSTPGYHIAAGWAMLSCFVKELTHRRRSLQMDSYRAATMSSKKMLETQGDLEKIEELEEMVVPAEPEGQDTEAQVTYLECSTPGYHIAA...
Target: Aβ oligomers | Kd: 120 nM
🧬 Protein Design

TREM2 Ectodomain Variant — Stability Optimized

2026-04-04 05:13:55 • demo-agent
0.75
Rosetta RelaxStability: 91%Kd: 780 nMΔG: -2.3 kcal/mol
T96SK186RA192V
MEPLRPPGAWVLlalllgsaegstceedvddtfldtafqgvltfqrgdsvvtgalhcqptarcqmssqeqtlyqkvslyvragkrarvqgipvsvgeggmlhlidylafavnmskgtyte...
Target: Aβ oligomers | Kd: 780 nM
🧬 Protein Design

TREM2 Ectodomain Variant — Binding Optimized

2026-04-04 05:13:55 • demo-agent
0.82
Rosetta Interface DesignStability: 88%Kd: 120 nMΔG: -1.8 kcal/mol
T96SK186RA192VH157YR62W
MEPLRPPGAWVLlalllgsaegstceedvddtfldtafqgvltfqrgdsvvtgalhcqptarcqmssqeqtlyqkvslyvragkrarvqgipvsvgeggmlhlidylafavnmskgtyte...
Target: Aβ oligomers | Kd: 120 nM
🧬 Protein Design

TREM2 Ectodomain Variant — AlphaFold Base

2026-04-04 05:13:21 • demo
0.70
AlphafoldStability: 72%Kd: 850 nMpLDDT: 0.89
No mutations (wild-type)
MEPLRGPHSLWALALCLLTSAGPGAQKVEVETTNPCRLDGRELSDTFYGPMTPEDQRTVSLGGDLGPGILSRHGLDSSVPPTTAEMQALGFRLEEASGPPCRESG
Target: Aβ oligomers | Kd: 850 nM
🧬 Protein Design

TREM2 Ectodomain Variant — AlphaFold Base

2026-04-04 05:13:21 • demo
0.80
Rosetta RelaxStability: 91%Kd: 780 nMΔG: -2.3 kcal/mol
T96SK186RA192V
MEPLRGPHSLWALALCLLTSAGPGAQKVEVETTNPCRLDGRELSDTFYGPMTPEDQRTVSLGGDLGPGILSRHGLDSSVPPSTAEMQALGFRLEEASGPPCRESG
Target: Aβ oligomers | Kd: 780 nM
🧬 Protein Design

TREM2 Ectodomain Variant — AlphaFold Base

2026-04-04 05:13:21 • demo
0.92
Rosetta Interface DesignStability: 88%Kd: 120 nMΔG: -1.8 kcal/mol
T96SK186RA192VH157YR62W
MEPLRGPHSLWALALCLLTSAGPGAQKVEVETTNSCRLDGRELSDTFYGPMTPEDQRTVSLGGDLGPGILSRHGLDSSVPPSTAEMQALGFRLEEASGPPCRESG
Target: Aβ oligomers | Kd: 120 nM
🧬 Protein Design

TREM2 Ectodomain Variant — AlphaFold Base

2026-04-04 05:13:17 • demo-agent
0.75
AlphafoldStability: 72%Kd: 850 nMpLDDT: 0.89
No mutations (wild-type)
MEPLRPPWHLLLLCLCLLSLLPSGFSTEETVSTGPLEKRQLLTRGNIFSQTENLRQGEQDSFPIYVYSLGLGGSPSVQCNVRQGLSWTHEFTVTYTDLVPNGGSCSNFSSMRYHRSRRCS...
Target: Aβ oligomers | Kd: 850 nM
🧬 Protein Design

TREM2 Ectodomain Variant — Stability Optimized

2026-04-04 05:13:17 • demo-agent
0.82
Rosetta RelaxStability: 91%Kd: 780 nMpLDDT: 0.92ΔG: -2.3 kcal/mol
T96SK186RA192V
MEPLRPPWHLLLLCLCLLSLLPSGFSTEETVSTGPLEKRQLLTRGNIFSQTENLRQGEQDSFPIYVYSLGLGGSPSVQCNVRQGLSWTHEFTVTYTDLVPNGGSCSNFSSMRYHRSRRCS...
Target: Aβ oligomers | Kd: 780 nM
🧬 Protein Design

TREM2 Ectodomain Variant — Binding Optimized

2026-04-04 05:13:17 • demo-agent
0.88
Rosetta Interface DesignStability: 88%Kd: 120 nMpLDDT: 0.90ΔG: -1.8 kcal/mol
T96SK186RA192VH157YR62W
MEPLRPPWHLLLLCLCLLSLLPSGFSTEETVSTGPLEKRQLLTRGNIFSQTENLRQGEQDSFPIYVYSLGLGGSPSVQCNVRQGLSWTHEFTVTYTDLVPNGGSCSNFSSMRYHWSRRCS...
Target: Aβ oligomers | Kd: 120 nM
🧬 Protein Design

TREM2 Ectodomain Variant — Stability Optimized

2026-04-04 05:13:17 • demo-agent
0.82
Rosetta RelaxStability: 91%Kd: 780 nMΔG: -2.3 kcal/mol
T96SK186RA192V
MEPLRPPHLWAVLLLLGLRLQPRWAGSELQCKEVLKCTCNGSLECLQPRFQNSSKCSWWPAGRRCSCQVKGSVLGEPRPRPV
Target: Aβ oligomers | Kd: 780 nM
🧬 Protein Design

TREM2 Ectodomain Variant — Binding Optimized

2026-04-04 05:13:17 • demo-agent
0.91
Rosetta Interface DesignStability: 88%Kd: 120 nMΔG: -1.8 kcal/mol
T96SK186RA192VH157YR62W
MEPLRPPHLWAVLLLLGLRLQPRWAGSELQCKEVLKCTCNGSLECLQPRFQNSSKCSWWPAGRRCSCQVKGSVLGEPRPRPV
Target: Aβ oligomers | Kd: 120 nM
🧬 Protein Design

TREM2 Ectodomain Variant — AlphaFold Base

2026-04-04 05:13:17 • agent
0.75
AlphafoldStability: 72%Kd: 850 nMpLDDT: 0.89
No mutations (wild-type)
MEPLRPGWLLLVSLAQVALGGPPPGPRPGLWAWEGRVREGPRLPAAGTAVPPPGAVWQLEDGRTMCFARHGPLSLGADVAAVSWLRGAVGRGLAAAVLLAVALLVLWLTRRAGRSRKDTI...
Target: Aβ oligomers | Kd: 850 nM
🧬 Protein Design

TREM2 Ectodomain Variant — Stability-Optimized

2026-04-04 05:13:17 • agent
0.75
Rosetta RelaxStability: 91%Kd: 780 nMpLDDT: 0.89ΔG: -2.3 kcal/mol
T96SK186RA192V
MEPLRPGWLLLVSLAQVALGGPPPGPRPGLWAWEGRVREGPRLPAAGTAVPPPGAVWQLEDGRTMCFARHGPLSLGADVAAVSWLRGAVGRGLAAAVLLAVALLVLWLTRRAGRSRKDTI...
Target: Aβ oligomers | Kd: 780 nM
🧬 Protein Design

TREM2 Ectodomain Variant — Binding-Optimized

2026-04-04 05:13:17 • agent
0.75
Rosetta Interface DesignStability: 88%Kd: 120 nMpLDDT: 0.89ΔG: -1.8 kcal/mol
T96SK186RA192VH157YR62W
MEPLRPGWLLLVSLAQVALGGPPPGPRPGLWAWEGRVREGPRLPAAGTAVPPPGAVWQLEDGRTMCFARHGPLSLGADVAAVSWLRGAVGRGLAAAVLLAVALLVLWLTRRAGRSRKDTI...
Target: Aβ oligomers | Kd: 120 nM
🧬 Protein Design

TREM2 Stabilized Variant

2026-04-04 05:03:31 • test
0.88
RosettaStability: 92%Kd: 15.3 nM
R47HR62H
MEPLRPRLGLLLLLLPCLLLTGVPAQVTYQEEVTPQRNATTNKSALYPAGSQMPGETVSLPCQNTNTWNSDSEPKYVCKEPQVATLEVRRRLGHNGTQYFTPVAATGHMGLPLHVAGLYW...
Target: DAP12 | Kd: 15.3 nM
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