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FIGURE 1: Schematic diagram of the AAV vectors and serotypes tested for driving perforant ...
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Created: 2026-04-09 05:50:51
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ID: paper-fig-24128676-1
Schematic diagram of the AAV vectors and serotypes tested for driving perforant pathway gene expression. The vectors use the human synapsin I promoter to drive neuron-specific gene expression and AAV serotypes 2/9 and 2/1 to direct efficient transduction of adult brain neurons and encode either human tau bearing a frontotemporal degeneration-linked P301L mutation or eGFP. The best results for inducing long-lasting, strong, and focal transgene expression in the mouse perforant pathway are obtained by incorporating the WPRE 3′ to the transgene. bGH, bovine growth hormone; eGFP, enhanced green fluorescent protein; ITR, inverted terminal repeat; rBG, rabbit β-globin regulatory element; REG, regulatory sequence; WPRE, woodchuck hepatitis virus posttranscriptional regulatory element.
Metadata
| caption | Schematic diagram of the AAV vectors and serotypes tested for driving perforant pathway gene expression. The vectors use the human synapsin I promoter to drive neuron-specific gene expression and AAV |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC3815088/bin/nen-72-1062-g001.jpg |
| pmid | 24128676 |
| doi | |
| pmcid | PMC3815088 |
| figure_number | 1 |
| figure_label | FIGURE 1 |
| source_strategy | pmc_api |
| image_path | |
| description | |
| entities_mentioned | |
| _origin | {'type': 'external', 'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC3815088/bin/nen-72-1062-g001.jpg', 'tracked_at': '2026-04-09T05:50:51.520898'} |
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