Figure 4: H3K4me3-marked nucleosome positioning reveals dynamic changes in underlying sequ...

H3K4me3-marked nucleosome positioning reveals dynamic changes in underlying sequence signature and relation to TSS during MZT a , Frequency of dinucleotides centred on +1 nucleosome of constitutively active promoters in maternal (512 cells) and zygotic (prim 6) stage. Centres of nucleosomes were estimated from subtracted H3K4me3 coverage (gray). Density of maternal and zygotic transcription start sites is shown in light blue and light red, respectively. b , H3K4me3 signal at promoters of constitutively present transcripts sorted by the time of activation of their zygotic component. Horizontal lines separate groups of promoters that activate zygotic component at a denoted developmental stage. c , H3K4me3 signal at TBP-dependent promoters in non-injected embryos (top), embryos injected with mismatch morpholino (middle) or TBP-targeting morpholino (bottom), sorted by TBP expression fold-change between knockdown and wild type embryos. d , Summary of transcription initiation, TSS configu

🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found