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Figure 1: A schematic representation depicting a healthy neuron (left) and an ALS/FTD-affe...
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Created: 2026-04-11 08:06:52
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ID: paper-fig-37720552-1
A schematic representation depicting a healthy neuron (left) and an ALS/FTD-affected neuron (right) along with the major differences in RBPs and RNP condensates under physiologic and pathologic conditions. 1. Physiological RBPs are found predominantly in the nucleus whereas RBPs are mislocalized to cytoplasm in disease. 2. Resistance to proteasomal degradation: Aggregates composed of RBPs in affected neurons show increased resistance to degradation by the cellular proteasome system. 3. Defects in mRNA/protein transport: There is impaired stability and transport of mRNA. 4. Defects in local translation: Affected neurons show deficiencies in local translation. The bottom of the figure represents several therapeutic options to target neurodegenerative diseases aimed to resolve aberrant RNP condensates and prevent the aggregation of RBPs in the affected neurons.
Metadata
| caption | A schematic representation depicting a healthy neuron (left) and an ALS/FTD-affected neuron (right) along with the major differences in RBPs and RNP condensates under physiologic and pathologic condit |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC10502346/bin/fnmol-16-1242925-g001.jpg |
| pmid | 37720552 |
| doi | |
| pmcid | PMC10502346 |
| figure_number | 1 |
| figure_label | Figure 1 |
| source_strategy | pmc_api |
| image_path | |
| description | |
| entities_mentioned | |
| _origin | {'type': 'external', 'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC10502346/bin/fnmol-16-1242925-g001.jpg', 'tracked_at': '2026-04-11T08:06:52.326864'} |
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