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Figure 1: Examples of epigenetic changes and factors affected by accelerated aging at diff...

paper figure Created: 2026-04-07 01:19:46 By: paper_figures_pipeline Quality: 50% 🔗 External ID: paper-fig-37887295-1

Examples of epigenetic changes and factors affected by accelerated aging at different levels that could serve as potential biomarkers of aging. ( I ) DNA nucleotide modification level: cytosine (C) can be converted to 5-methylcytosine (5-mC) and oxidised further to 5-hydroxymethylcytosine (5-hmC). ( II ) Histone modification level: Three examples of histone 3 (H3) lysine methylation marks are indicated. Lysine 4 (K4) H3K4me3 mark is associated with active genes, lysine 9 (K9) H3K9me3 is an established mark of transcriptionally repressed heterochromatin and lysine 27 (K27) H3K27me3 mark is linked to both transcriptional activation and repression. ( III ) Regulatory RNAs level: several types of ncRNAs, long non-coding RNA (lnc RNA), microRNA (miRNA), small interfering RNA (siRNA), circular RNA (circRNA), shown schematically.

PubMed: 37887295

Metadata

caption	Examples of epigenetic changes and factors affected by accelerated aging at different levels that could serve as potential biomarkers of aging. ( I ) DNA nucleotide modification level: cytosine (C) ca
image_url	https://www.ebi.ac.uk/europepmc/articles/PMC10605227/bin/cells-12-02451-g001.jpg
pmid	37887295
doi	10.3390/cells12202451
pmcid	PMC10605227
figure_number	1
figure_label	Figure 1
source_strategy	pmc_api
image_path
description
entities_mentioned
_origin	{'type': 'external', 'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC10605227/bin/cells-12-02451-g001.jpg', 'tracked_at': '2026-04-07T01:19:46.022669'}

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