Figure 1: Intron–exon structure of TET isoforms . A , human TET2 and mouse Tet2 ; ( B ...

Intron–exon structure of TET isoforms . A , human TET2 and mouse Tet2 ; ( B ) human TET1 and human TET3 . In all panels, numbered boxes represent exons and are color coded according to the domains they primarily encode: blue , N-terminal intrinsically disordered region (IDR); green , cysteine-rich domain; red , DSBH catalytic core; orange , CXXC motif; and black , C-terminal tail. 5′ and 3′ UTRs are omitted, and introns are shown to scale. Selected regulatory residues are indicated above the corresponding exons for human and mouse TET2, with numbering based on UniProt canonical isoform numbering. Triangles at the right end of each transcript mark the 3′ end of the last coding exon. Black horizontal bars denote a 1 kb scale. DSBH, double-stranded β-helix; TET, ten–eleven translocation.

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