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FIGURE 2: Domain architecture and pan-cancer expression of G3BP1 and G3BP2. (A) Schemati...
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Created: 2026-04-11 17:28:55
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Domain architecture and pan-cancer expression of G3BP1 and G3BP2. (A) Schematic domain organization of human G3BP1, G3BP2a and G3BP2b, highlighting the NTF2L domain, acid-rich/intrinsically disordered region (IDR), multiple proline-rich PxxP motifs, RNA-recognition motif (RRM) and low-complexity region (LCR), with total amino-acid length indicated to the right. (B) Pan-cancer comparison of G3BP1 (top) and G3BP2 (bottom) mRNA levels across TCGA/GTEx cohorts. Boxplots show log 2 (TPM) expression in tumors (red) versus matched or GTEx normal tissues (blue), depending on normal-sample availability for each cancer type; grey shading separates tumor–normal pairs. P values were calculated using a two-sided Wilcoxon rank-sum test (tumor vs. normal). Asterisks denote statistical significance for tumor versus normal comparisons (** p < 0.01; *** p < 0.001; ns, not significant). Cancer type abbreviations: ACC, Adrenocortical carcinoma; BLCA, Bladder urothelial carcinoma; BRCA, Breast
Metadata
| caption | Domain architecture and pan-cancer expression of G3BP1 and G3BP2. (A) Schematic domain organization of human G3BP1, G3BP2a and G3BP2b, highlighting the NTF2L domain, acid-rich/intrinsically disorder |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC13036192/bin/fphar-17-1780146-g002.jpg |
| pmid | 41924133 |
| doi | 10.3389/fphar.2026.1780146 |
| pmcid | PMC13036192 |
| figure_number | 2 |
| figure_label | FIGURE 2 |
| source_strategy | pmc_api |
| image_path | |
| description | |
| entities_mentioned | |
| _origin | {'type': 'external', 'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC13036192/bin/fphar-17-1780146-g002.jpg', 'tracked_at': '2026-04-11T17:28:27.827809'} |
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