# Autophagy-Senescence Axis Therapeutic Window: Sequential Targeting of ATG7 and BCL-2 Family Proteins in Neurodegeneration
## Background and Conceptual Framework
The interplay between autophagy dysfunction and cellular senescence represents an emerging frontier in understanding neurodegenerative disease pathogenesis. Research indicates that these two fundamental cellular processes exist in a bidirectional relationship, where impaired autophagy promotes senescence accumulation, while senescent
Radar Chart — 10 Dimensions
Score Comparison Bars
Mechanistic
0.80
Evidence
0.70
Novelty
0.80
Feasibility
0.60
Impact
0.00
Druggability
0.70
Safety
0.70
Competition
0.60
Data
0.70
Reproducible
0.60
Score Breakdown
Dimension
Autophagy-Senescence Axis Ther
Mechanistic
0.800
Evidence
0.700
Novelty
0.800
Feasibility
0.600
Impact
0.000
Druggability
0.700
Safety
0.700
Competition
0.600
Data
0.700
Reproducible
0.600
Evidence
Autophagy-Senescence Axis Therapeutic Window
Supporting Evidence
PubMed search found: m(6)A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7.PMID:31451060Autophagy 2020
PubMed search found: ATM-CHK2-TRIM32 axis regulates ATG7 ubiquitination to initiate autophagy under oxidative stress.PMID:37943659Cell Rep 2023
PubMed search found: Deacetylation of ATG7 drives the induction of macroautophagy and LC3-associated microautophagy.PMID:37999993Autophagy 2024
PubMed search found: Ablation of endothelial Atg7 inhibits ischemia-induced angiogenesis by upregulating Stat1 that suppPMID:36300763Autophagy 2023
PubMed search found: Role of ATG7-dependent non-autophagic pathway in angiogenesis.PMID:38269279Front Pharmacol 2023
Contradicting Evidence
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauPMID:31238788
Pathogenetic Involvement of Autophagy and Mitophagy in Primary Progressive Multiple Sclerosis.PMID:40257374