Hypothesis Comparison

graph TD
    A["Iron Uptake via<br/>Transferrin Receptor 1<br/>(TfR1)"] -->|"increases"| B["Intracellular Iron<br/>Accumulation<br/>(Fe2+/Fe3+)"]
    B -->|"catalyzes"| C["Fenton Reaction<br/>Fe2+ + H2O2 -> OH•<br/>+ Fe3+ + OH-"]
    C -->|"generates"| D["Reactive Oxygen<br/>Species (ROS)<br/>Hydroxyl Radicals"]
    
    E["System Xc- Antiporter<br/>(SLC7A11/SLC3A2)<br/>Cystine Import"] -->|"provides"| F["Cysteine for<br/>Glutathione (GSH)<br/>Synthesis"]
    F -->|"maintains"| G["GPX4 Enzymatic<br/>Activity and<br/>GSH Pool"]
    
    G -->|"reduces"| H["Phospholipid<br/>Hydroperoxides<br/>(PL-OOH) to PL-OH"]
    D -->|"oxidizes"| I["Polyunsaturated<br/>Fatty Acids (PUFAs)<br/>in Membranes"]
    I -->|"forms"| J["Lipid Peroxyl<br/>Radicals (LOO•)<br/>Chain Reaction"]
    
    K["Ferroptosis Inhibitors<br/>(Ferrostatin-1,<br/>Liproxstatin-1)"] -->|"blocks"| J
    L["GPX4 Overexpression<br/>or Activation"] -->|"enhances"| H
    
    J -->|"when uncontrolled"| M["Membrane Lipid<br/>Peroxidation and<br/>Damage"]
    H -->|"prevents"| M
    
    M -->|"triggers"| N["Ferroptotic Cell<br/>Death Execution<br/>Pathway"]
    
    O["Alpha-Synuclein<br/>Protein Aggregation<br/>and Misfolding"] -->|"promotes"| P["Mitochondrial<br/>Dysfunction and<br/>Iron Dysregulation"]
    P -->|"amplifies"| B
    
    N -->|"causes"| Q["Neuronal Death<br/>and Synaptic<br/>Loss"]
    O -->|"accelerates"| Q
    
    Q -->|"leads to"| R["Neurodegeneration<br/>and Clinical<br/>Symptoms"]
    
    S["Therapeutic<br/>GPX4 Enhancement<br/>Strategy"] -->|"targets"| L
    S -->|"combined with"| K
    
classDef normal fill:#4fc3f7,stroke:#2196f3
classDef therapeutic fill:#81c784,stroke:#4caf50
classDef pathology fill:#ef5350,stroke:#f44336
classDef outcome fill:#ffd54f,stroke:#ff9800
classDef molecular fill:#ce93d8,stroke:#9c27b0

class A,B,C,D,E,F,I,J normal
class K,L,S therapeutic
class M,N,O,P,Q pathology
class R outcome
class G,H molecular