ATROPHIN1

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATROPHIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    ATN1["ATROPHIN1"]
    DRPLA["Dentatorubral-pallidoluysian atrophy"]
    CAG_EXP["CAG repeat expansion"]
    POLYQ["Polyglutamine tract"]
    PROT_AGG["Protein aggregation"]
    NUCL_INCL["Nuclear inclusions"]
    TRANS_DYS["Transcriptional dysregulation"]
    HDAC_INT["HDAC interaction"]
    CHROM_REM["Chromatin remodeling"]
    NEURON_LOSS["Neuronal loss"]
    MOTOR_SYM["Motor symptoms"]
    COGN_DEC["Cognitive decline"]
    EPILEPSY["Epilepsy"]
    AUTOPHAGY["Autophagy"]
    UPS["Ubiquitin-proteasome system"]

    CAG_EXP -->|"causes"| POLYQ
    POLYQ -->|"alters"| ATN1
    ATN1 -->|"causes"| DRPLA
    ATN1 -->|"forms"| PROT_AGG
    PROT_AGG -->|"leads to"| NUCL_INCL
    ATN1 -->|"disrupts"| TRANS_DYS
    ATN1 -->|"interacts with"| HDAC_INT
    HDAC_INT -->|"affects"| CHROM_REM
    TRANS_DYS -->|"causes"| NEURON_LOSS
    NUCL_INCL -->|"contributes to"| NEURON_LOSS
    NEURON_LOSS -->|"results in"| MOTOR_SYM
    NEURON_LOSS -->|"results in"| COGN_DEC
    NEURON_LOSS -->|"results in"| EPILEPSY
    AUTOPHAGY -->|"clears"| PROT_AGG
    UPS -->|"degrades"| ATN1

    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:2px
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px
    classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px

    class ATN1 central
    class CAG_EXP,POLYQ,PROT_AGG,NUCL_INCL,TRANS_DYS,NEURON_LOSS pathological
    class AUTOPHAGY,UPS protective
    class DRPLA,MOTOR_SYM,COGN_DEC,EPILEPSY disease