Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TREM2, ADAM10, ADAM17: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Soluble TREM2 (sTREM2) as Therapeutic Mimic — Decoupling Pha | 0.452 | Alzheimer's disease | TREM2 agonism vs antagonism in DAM micro |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Obesity-induced pyroptotic adipocyte death leads to TREM2-dependent macrophage d [PMID:41509917] | Choi C, Lee J, Park G, Namgoong S, Lee Y | iScience | 2026 | 0 |